SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6c4q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2EGV_A_SAMA1300_0 (UPF0088 PROTEIN AQ_165)	6c4q	POLYKETIDE SYNTHASE PKS13 (Mycobacterium tuberculosis)	5 / 12	LEU A 27 THR A 83 LEU A 87 THR A 89 ALA A 88	None	1.09A	2egvA-6c4qA: undetectable	2egvA-6c4qA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2EGV_B_SAMB1400_0 (UPF0088 PROTEIN AQ_165)	6c4q	POLYKETIDE SYNTHASE PKS13 (Mycobacterium tuberculosis)	5 / 12	LEU A 27 THR A 83 LEU A 87 THR A 89 ALA A 88	None	1.06A	2egvB-6c4qA: undetectable	2egvB-6c4qA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2EIN_W_CHDW1060_0 (CYTOCHROME C OXIDASE POLYPEPTIDE VIIA-HEART CYTOCHROME C OXIDASE SUBUNIT 1)	6c4q	POLYKETIDE SYNTHASE PKS13 (Mycobacterium tuberculosis)	4 / 6	ILE A 65 ARG A 24 THR A 19 LEU A 18	None	1.00A	2einN-6c4qA: undetectable 2einW-6c4qA: undetectable	2einN-6c4qA: undetectable 2einW-6c4qA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3DCM_X_SAMX5452_0 (UNCHARACTERIZED PROTEIN TM_1570)	6c4q	POLYKETIDE SYNTHASE PKS13 (Mycobacterium tuberculosis)	5 / 11	ALA A 62 LEU A 73 SER A 74 VAL A 75 ALA A 78	None None None None MPD A 201 ( 3.9A)	0.88A	3dcmX-6c4qA: undetectable	3dcmX-6c4qA: undetectable

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2EGV_A_SAMA1300_0","UPF0088 PROTEIN AQ_165","6c4q","POLYKETIDE SYNTHASE PKS13","Mycobacterium tuberculosis",5,"LEU A  27;THR A  83;LEU A  87;THR A  89;ALA A  88","None","1.09A","2egvA-6c4qA:undetectable","2egvA-6c4qA:undetectable"],["2EGV_B_SAMB1400_0","UPF0088 PROTEIN AQ_165","6c4q","POLYKETIDE SYNTHASE PKS13","Mycobacterium tuberculosis",5,"LEU A  27;THR A  83;LEU A  87;THR A  89;ALA A  88","None","1.06A","2egvB-6c4qA:undetectable","2egvB-6c4qA:undetectable"],["2EIN_W_CHDW1060_0","CYTOCHROME C OXIDASE POLYPEPTIDE VIIA-HEART;CYTOCHROME C OXIDASE SUBUNIT 1","6c4q","POLYKETIDE SYNTHASE PKS13","Mycobacterium tuberculosis",4,"ILE A  65;ARG A  24;THR A  19;LEU A  18","None","1.00A","2einN-6c4qA:undetectable;2einW-6c4qA:undetectable","2einN-6c4qA:undetectable;2einW-6c4qA:undetectable"],["3DCM_X_SAMX5452_0","UNCHARACTERIZED PROTEIN TM_1570","6c4q","POLYKETIDE SYNTHASE PKS13","Mycobacterium tuberculosis",5,"ALA A  62;LEU A  73;SER A  74;VAL A  75;ALA A  78","None;None;None;None;MPD A 201 ( 3.9A)","0.88A","3dcmX-6c4qA:undetectable","3dcmX-6c4qA:undetectable"]]