SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6c54'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_C_T44C128_1
(TRANSTHYRETIN)		 6c54 NUCLEOPROTEIN
(Zaire
ebolavirus) 		5 / 11 LEU A 245
ALA A 332
LEU A 321
SER A 317
THR A 249
 None
 1.20A 1ictA-6c54A:
undetectable
1ictC-6c54A:
undetectable		 1ictA-6c54A:
18.90
1ictC-6c54A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN)		 6c54 NUCLEOPROTEIN
(Zaire
ebolavirus) 		5 / 12 LEU A 214
LEU A 213
LEU A 151
ALA A 154
ILE A 200
 None
 1.05A 1tw4A-6c54A:
undetectable		 1tw4A-6c54A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHZ_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE)		 6c54 NUCLEOPROTEIN
(Zaire
ebolavirus) 		4 / 8 ASP A 226
GLY A 218
SER A 233
ILE A 232
 None
 0.89A 3ihzB-6c54A:
undetectable		 3ihzB-6c54A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 6c54 NUCLEOPROTEIN
(Zaire
ebolavirus) 		3 / 3 ARG A 260
GLU A 259
THR A 258
 None
 0.82A 3v4tA-6c54A:
undetectable		 3v4tA-6c54A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GBO_B_CUB301_0
(E7)		 6c54 NUCLEOPROTEIN
(Zaire
ebolavirus) 		4 / 5 HIS A  81
ALA A 147
HIS A  80
GLN A  84
 None
 1.08A 4gboB-6c54A:
undetectable		 4gboB-6c54A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		 6c54 NUCLEOPROTEIN
(Zaire
ebolavirus) 		5 / 12 SER A 155
LEU A 156
ALA A 227
GLY A 183
LEU A 184
 None
 1.27A 4j7xB-6c54A:
undetectable		 4j7xB-6c54A:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_2
(ADENOSINE KINASE)		 6c54 NUCLEOPROTEIN
(Zaire
ebolavirus) 		4 / 4 LEU A  74
SER A  72
LEU A 209
LEU A 203
 None
 0.98A 4n09A-6c54A:
undetectable		 4n09A-6c54A:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_2
(ADENOSINE KINASE)		 6c54 NUCLEOPROTEIN
(Zaire
ebolavirus) 		4 / 5 LEU A  74
SER A  72
LEU A 209
LEU A 203
 None
 0.98A 4n09B-6c54A:
undetectable		 4n09B-6c54A:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_2
(ADENOSINE KINASE)		 6c54 NUCLEOPROTEIN
(Zaire
ebolavirus) 		4 / 5 LEU A  74
SER A  72
LEU A 209
LEU A 203
 None
 0.96A 4n09D-6c54A:
undetectable		 4n09D-6c54A:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_C_ANWC601_0
(RHODOPSIN KINASE)		 6c54 NUCLEOPROTEIN
(Zaire
ebolavirus) 		4 / 6 ARG A 298
LEU A 244
ALA A 294
LEU A 284
 None
 0.73A 4wboC-6c54A:
undetectable		 4wboC-6c54A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_A_IPHA101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 6c54 NUCLEOPROTEIN
(Zaire
ebolavirus) 		4 / 4 CYH A  78
LEU A 214
LEU A 151
ALA A 154
 None
 0.98A 5hpuA-6c54A:
undetectable
5hpuB-6c54A:
undetectable		 5hpuA-6c54A:
undetectable
5hpuB-6c54A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_C_EPAC502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 6c54 NUCLEOPROTEIN
(Zaire
ebolavirus) 		4 / 8 LEU A  77
PHE A 150
ALA A  70
PHE A  60
 None
 0.77A 5m0oC-6c54A:
undetectable		 5m0oC-6c54A:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 6c54 NUCLEOPROTEIN
(Zaire
ebolavirus) 		5 / 12 LEU A  74
ILE A 176
ILE A 200
MET A 204
HIS A 179
 None
 1.22A 5y2tB-6c54A:
undetectable		 5y2tB-6c54A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 6c54 NUCLEOPROTEIN
(Zaire
ebolavirus) 		5 / 12 LEU A  74
PHE A  60
ILE A 176
ILE A 200
MET A 204
 None
 1.21A 5y2tB-6c54A:
undetectable		 5y2tB-6c54A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CHG_C_SAMC1101_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-4 SPECIFIC)		 6c54 NUCLEOPROTEIN
(Zaire
ebolavirus) 		5 / 12 ILE A 215
HIS A 216
SER A  93
TYR A  83
LEU A  99
 None
 1.36A 6chgC-6c54A:
undetectable		 6chgC-6c54A:
undetectable