SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6c5b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FPQ_A_SAMA1699_0
(ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE)		 6c5b METHYLTRANSFERASE
(Lysobacter
antibioticus) 		5 / 10 GLY A 182
ASP A 205
VAL A 209
ASP A 232
TRP A 253
 SAH  A 501 (-4.0A)
SAH  A 501 (-2.9A)
SAH  A 501 ( 4.9A)
SAH  A 501 (-3.5A)
None
 0.31A 1fpqA-6c5bA:
21.4		 1fpqA-6c5bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_1
(HIV-1 PROTEASE)		 6c5b METHYLTRANSFERASE
(Lysobacter
antibioticus) 		5 / 9 LEU A  29
GLY A  73
GLY A  84
ILE A  85
ILE A  69
 None
 0.96A 1hpvA-6c5bA:
undetectable		 1hpvA-6c5bA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_SAMA635_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 6c5b METHYLTRANSFERASE
(Lysobacter
antibioticus) 		5 / 12 GLY A 182
GLY A 184
ASP A 232
PHE A 233
TRP A 253
 SAH  A 501 (-4.0A)
SAH  A 501 (-3.3A)
SAH  A 501 (-3.5A)
SAH  A 501 (-3.5A)
None
 0.34A 1qzzA-6c5bA:
31.5		 1qzzA-6c5bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_A_SAMA5635_0
(PROTEIN RDMB)		 6c5b METHYLTRANSFERASE
(Lysobacter
antibioticus) 		6 / 12 GLY A 182
GLY A 184
ASP A 232
PHE A 233
SER A 247
TRP A 253
 SAH  A 501 (-4.0A)
SAH  A 501 (-3.3A)
SAH  A 501 (-3.5A)
SAH  A 501 (-3.5A)
SAH  A 501 (-2.8A)
None
 0.31A 1xdsA-6c5bA:
29.4		 1xdsA-6c5bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_B_SAMB9635_0
(PROTEIN RDMB)		 6c5b METHYLTRANSFERASE
(Lysobacter
antibioticus) 		6 / 12 GLY A 182
GLY A 184
ASP A 232
PHE A 233
SER A 247
TRP A 253
 SAH  A 501 (-4.0A)
SAH  A 501 (-3.3A)
SAH  A 501 (-3.5A)
SAH  A 501 (-3.5A)
SAH  A 501 (-2.8A)
None
 0.25A 1xdsB-6c5bA:
29.6		 1xdsB-6c5bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XR2_B_C2FB1201_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 6c5b METHYLTRANSFERASE
(Lysobacter
antibioticus) 		4 / 8 THR A 127
SER A 258
ARG A 257
GLU A 311
 None
 1.12A 1xr2B-6c5bA:
undetectable		 1xr2B-6c5bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F81_A_017A302_1
(POL POLYPROTEIN)		 6c5b METHYLTRANSFERASE
(Lysobacter
antibioticus) 		5 / 12 LEU A  29
GLY A  73
GLY A  84
ILE A  85
ILE A  69
 None
 0.96A 2f81A-6c5bA:
undetectable		 2f81A-6c5bA:
26.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEN_B_017B402_2
(PROTEASE)		 6c5b METHYLTRANSFERASE
(Lysobacter
antibioticus) 		5 / 12 LEU A  29
GLY A  73
GLY A  84
ILE A  85
ILE A  69
 None
 0.96A 2ienB-6c5bA:
undetectable		 2ienB-6c5bA:
26.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJ8_C_SPMC500_1
(DIAMINE
ACETYLTRANSFERASE 1)		 6c5b METHYLTRANSFERASE
(Lysobacter
antibioticus) 		4 / 6 ASP A 232
ASP A 205
LEU A 203
TRP A 253
 SAH  A 501 (-3.5A)
SAH  A 501 (-2.9A)
None
None
 1.15A 3bj8C-6c5bA:
undetectable
3bj8D-6c5bA:
undetectable		 3bj8C-6c5bA:
18.13
3bj8D-6c5bA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Z_B_017B201_2
(HIV-1 PROTEASE)		 6c5b METHYLTRANSFERASE
(Lysobacter
antibioticus) 		5 / 12 LEU A  29
GLY A  73
GLY A  84
ILE A  85
ILE A  69
 None
 0.98A 3d1zB-6c5bA:
undetectable		 3d1zB-6c5bA:
26.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_C_478C200_1
(PROTEASE)		 6c5b METHYLTRANSFERASE
(Lysobacter
antibioticus) 		6 / 10 LEU A  29
ALA A  70
GLY A  84
ILE A  85
ALA A  32
ILE A  69
 None
 1.25A 3ekpC-6c5bA:
undetectable		 3ekpC-6c5bA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKV_A_478A200_1
(PROTEASE)		 6c5b METHYLTRANSFERASE
(Lysobacter
antibioticus) 		6 / 10 LEU A  29
GLY A  73
ALA A  70
GLY A  84
ILE A  85
ILE A  69
 None
 1.23A 3ekvA-6c5bA:
undetectable		 3ekvA-6c5bA:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_1
(O-METHYLTRANSFERASE)		 6c5b METHYLTRANSFERASE
(Lysobacter
antibioticus) 		3 / 3 ASP A 205
PHE A 233
SER A 247
 SAH  A 501 (-2.9A)
SAH  A 501 (-3.5A)
SAH  A 501 (-2.8A)
 0.41A 3i5uB-6c5bA:
36.0		 3i5uB-6c5bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 6c5b METHYLTRANSFERASE
(Lysobacter
antibioticus) 		4 / 6 PHE A  75
ILE A  37
ALA A  32
ALA A 104
 None
 0.94A 3mdrB-6c5bA:
undetectable		 3mdrB-6c5bA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_C_OBNC1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 6c5b METHYLTRANSFERASE
(Lysobacter
antibioticus) 		5 / 11 LEU A 188
VAL A 166
ALA A 165
PHE A 290
THR A 159
 FMT  A 502 (-4.4A)
None
None
None
SAH  A 501 (-3.0A)
 1.14A 3n23C-6c5bA:
undetectable		 3n23C-6c5bA:
6.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 6c5b METHYLTRANSFERASE
(Lysobacter
antibioticus) 		3 / 3 GLY A 184
ASP A 205
ASP A 232
 SAH  A 501 (-3.3A)
SAH  A 501 (-2.9A)
SAH  A 501 (-3.5A)
 0.18A 3ou7C-6c5bA:
14.9		 3ou7C-6c5bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_2
(HIV-1 PROTEASE)		 6c5b METHYLTRANSFERASE
(Lysobacter
antibioticus) 		5 / 10 ASP A 180
VAL A 178
ILE A 192
PRO A 174
VAL A 243
 FMT  A 502 (-2.6A)
None
None
None
None
 0.85A 3t3cB-6c5bA:
undetectable		 3t3cB-6c5bA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_1
(GLYCINE
N-METHYLTRANSFERASE)		 6c5b METHYLTRANSFERASE
(Lysobacter
antibioticus) 		3 / 3 LEU A 294
HIS A 297
MET A 298
 None
 0.81A 3thrD-6c5bA:
13.2		 3thrD-6c5bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1507_0
(FERROCHELATASE,
MITOCHONDRIAL)		 6c5b METHYLTRANSFERASE
(Lysobacter
antibioticus) 		3 / 3 ARG A 339
LYS A 274
ARG A 325
 None
 1.36A 3w1wA-6c5bA:
undetectable
3w1wB-6c5bA:
2.0		 3w1wA-6c5bA:
undetectable
3w1wB-6c5bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6D_A_SAMA1350_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 6c5b METHYLTRANSFERASE
(Lysobacter
antibioticus) 		6 / 12 PHE A 138
GLY A 182
GLY A 184
VAL A 209
PHE A 233
ASP A 252
 SAH  A 501 ( 3.9A)
SAH  A 501 (-4.0A)
SAH  A 501 (-3.3A)
SAH  A 501 ( 4.9A)
SAH  A 501 (-3.5A)
SAH  A 501 (-4.0A)
 0.55A 4a6dA-6c5bA:
36.0		 4a6dA-6c5bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 6c5b METHYLTRANSFERASE
(Lysobacter
antibioticus) 		7 / 12 PHE A 138
GLY A 182
GLY A 184
VAL A 209
PHE A 233
ASP A 252
TRP A 253
 SAH  A 501 ( 3.9A)
SAH  A 501 (-4.0A)
SAH  A 501 (-3.3A)
SAH  A 501 ( 4.9A)
SAH  A 501 (-3.5A)
SAH  A 501 (-4.0A)
None
 0.58A 4a6eA-6c5bA:
35.8		 4a6eA-6c5bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_B_SAMB401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 6c5b METHYLTRANSFERASE
(Lysobacter
antibioticus) 		6 / 12 ASP A 180
GLY A 182
ASP A 205
ASP A 232
ASP A 252
TRP A 253
 FMT  A 502 (-2.6A)
SAH  A 501 (-4.0A)
SAH  A 501 (-2.9A)
SAH  A 501 (-3.5A)
SAH  A 501 (-4.0A)
None
 0.54A 4pghB-6c5bA:
17.5		 4pghB-6c5bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_C_SAMC401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 6c5b METHYLTRANSFERASE
(Lysobacter
antibioticus) 		5 / 11 GLY A 182
ASP A 205
VAL A 209
ASP A 232
TRP A 253
 SAH  A 501 (-4.0A)
SAH  A 501 (-2.9A)
SAH  A 501 ( 4.9A)
SAH  A 501 (-3.5A)
None
 0.31A 4pghC-6c5bA:
26.1		 4pghC-6c5bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_F_SAMF301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 6c5b METHYLTRANSFERASE
(Lysobacter
antibioticus) 		5 / 12 THR A 159
GLY A 184
GLY A 186
LEU A 188
LEU A 249
 SAH  A 501 (-3.0A)
SAH  A 501 (-3.3A)
FMT  A 502 (-3.1A)
FMT  A 502 (-4.4A)
None
 0.93A 5c0oF-6c5bA:
11.6		 5c0oF-6c5bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		 6c5b METHYLTRANSFERASE
(Lysobacter
antibioticus) 		5 / 12 LYS A  63
VAL A  65
ILE A  69
ALA A  70
VAL A  31
 None
 0.84A 5j2tC-6c5bA:
undetectable		 5j2tC-6c5bA:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_2
(PROTEASE E35D-APV)		 6c5b METHYLTRANSFERASE
(Lysobacter
antibioticus) 		5 / 9 LEU A  29
GLY A  73
ALA A  70
GLY A  84
ILE A  85
 None
 0.97A 5kr0B-6c5bA:
undetectable		 5kr0B-6c5bA:
26.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHA_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 6c5b METHYLTRANSFERASE
(Lysobacter
antibioticus) 		3 / 3 VAL A 243
VAL A 178
GLN A 196
 None
 0.67A 5qhaA-6c5bA:
undetectable		 5qhaA-6c5bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7P_A_SAMA501_0
(OXAC)		 6c5b METHYLTRANSFERASE
(Lysobacter
antibioticus) 		5 / 12 PHE A 138
GLY A 184
PHE A 233
ASP A 252
TRP A 253
 SAH  A 501 ( 3.9A)
SAH  A 501 (-3.3A)
SAH  A 501 (-3.5A)
SAH  A 501 (-4.0A)
None
 0.85A 5w7pA-6c5bA:
31.3		 5w7pA-6c5bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7P_A_SAMA501_0
(OXAC)		 6c5b METHYLTRANSFERASE
(Lysobacter
antibioticus) 		5 / 12 PHE A 138
VAL A 209
PHE A 233
ASP A 252
TRP A 253
 SAH  A 501 ( 3.9A)
SAH  A 501 ( 4.9A)
SAH  A 501 (-3.5A)
SAH  A 501 (-4.0A)
None
 0.42A 5w7pA-6c5bA:
31.3		 5w7pA-6c5bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CLX_A_SAMA401_0
(O-METHYLTRANSFERASE)		 6c5b METHYLTRANSFERASE
(Lysobacter
antibioticus) 		6 / 12 ALA A 156
GLY A 182
GLY A 184
PHE A 233
ASP A 252
TRP A 253
 None
SAH  A 501 (-4.0A)
SAH  A 501 (-3.3A)
SAH  A 501 (-3.5A)
SAH  A 501 (-4.0A)
None
 1.00A 6clxA-6c5bA:
32.0		 6clxA-6c5bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 6c5b METHYLTRANSFERASE
(Lysobacter
antibioticus) 		5 / 10 LEU A 193
PHE A 172
VAL A 178
ALA A 183
LEU A 188
 None
None
None
FMT  A 502 ( 3.9A)
FMT  A 502 (-4.4A)
 0.97A 6h1lA-6c5bA:
undetectable		 6h1lA-6c5bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)		 6c5b METHYLTRANSFERASE
(Lysobacter
antibioticus) 		6 / 11 GLY A 182
GLY A 184
ASP A 205
VAL A 209
ASP A 232
ASP A 252
 SAH  A 501 (-4.0A)
SAH  A 501 (-3.3A)
SAH  A 501 (-2.9A)
SAH  A 501 ( 4.9A)
SAH  A 501 (-3.5A)
SAH  A 501 (-4.0A)
 0.53A 6i5zD-6c5bA:
25.6		 6i5zD-6c5bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 6c5b METHYLTRANSFERASE
(Lysobacter
antibioticus) 		5 / 12 ASP A 180
GLY A 182
GLY A 184
ASP A 232
PHE A 233
 FMT  A 502 (-2.6A)
SAH  A 501 (-4.0A)
SAH  A 501 (-3.3A)
SAH  A 501 (-3.5A)
SAH  A 501 (-3.5A)
 0.79A 6nj9K-6c5bA:
8.5		 6nj9K-6c5bA:
undetectable