SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6c5c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 6c5c 3-DEHYDROQUINATE
SYNTHASE
(Candida
albicans) 		5 / 10 ALA A 348
ALA A 269
LEU A 386
VAL A 385
ILE A 266
 None
 1.32A 1claA-6c5cA:
undetectable		 1claA-6c5cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3004_1
(SERUM ALBUMIN)		 6c5c 3-DEHYDROQUINATE
SYNTHASE
(Candida
albicans) 		4 / 6 PHE A 214
PHE A 185
VAL A 142
MET A 141
 None
 1.04A 1hk1A-6c5cA:
undetectable		 1hk1A-6c5cA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))		 6c5c 3-DEHYDROQUINATE
SYNTHASE
(Candida
albicans) 		4 / 4 HIS A 165
ALA A 122
PHE A 125
GLY A 128
 None
 1.35A 1mj2B-6c5cA:
undetectable		 1mj2B-6c5cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_1
(PROTEIN (METHIONINE
REPRESSOR))		 6c5c 3-DEHYDROQUINATE
SYNTHASE
(Candida
albicans) 		4 / 4 HIS A 165
ALA A 122
PHE A 125
GLY A 128
 None
 1.33A 1mj2D-6c5cA:
undetectable		 1mj2D-6c5cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)		 6c5c 3-DEHYDROQUINATE
SYNTHASE
(Candida
albicans) 		4 / 4 HIS A 165
ALA A 122
PHE A 125
GLY A 128
 None
 1.36A 1mjoB-6c5cA:
undetectable		 1mjoB-6c5cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)		 6c5c 3-DEHYDROQUINATE
SYNTHASE
(Candida
albicans) 		4 / 4 HIS A 165
ALA A 122
PHE A 125
GLY A 128
 None
 1.39A 1mjoA-6c5cA:
undetectable		 1mjoA-6c5cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)		 6c5c 3-DEHYDROQUINATE
SYNTHASE
(Candida
albicans) 		4 / 4 HIS A 165
ALA A 122
PHE A 125
GLY A 128
 None
 1.35A 1mjoD-6c5cA:
undetectable		 1mjoD-6c5cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_A_ADNA1301_1
(SUGAR KINASE MJ0406)		 6c5c 3-DEHYDROQUINATE
SYNTHASE
(Candida
albicans) 		5 / 12 GLY A 111
GLY A 110
THR A 179
PHE A 176
ASP A  42
 NAD  A 401 (-3.1A)
None
NAD  A 401 (-3.8A)
None
NAD  A 401 (-2.7A)
 1.06A 2c49A-6c5cA:
undetectable		 2c49A-6c5cA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 6c5c 3-DEHYDROQUINATE
SYNTHASE
(Candida
albicans) 		5 / 10 THR A 195
VAL A 246
GLY A 245
VAL A 146
ASP A 143
 None
None
None
EDO  A 405 ( 3.9A)
EDO  A 409 ( 3.0A)
 1.27A 2cp4A-6c5cA:
undetectable		 2cp4A-6c5cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_A_097A1001_1
(ADAMTS-1)		 6c5c 3-DEHYDROQUINATE
SYNTHASE
(Candida
albicans) 		5 / 9 LEU A 279
HIS A 280
GLU A 271
HIS A 268
HIS A 264
 None
None
None
None
EDO  A 409 ( 4.8A)
 1.44A 2jihA-6c5cA:
undetectable		 2jihA-6c5cA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_B_LEIB16_0
(COIL SER L16D-PEN)		 6c5c 3-DEHYDROQUINATE
SYNTHASE
(Candida
albicans) 		4 / 5 LEU A 386
LYS A 379
GLN A 380
LEU A 382
 None
 1.06A 3h5gA-6c5cA:
undetectable
3h5gB-6c5cA:
undetectable		 3h5gA-6c5cA:
undetectable
3h5gB-6c5cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_A_CL6A506_1
(CHOLESTEROL
24-HYDROXYLASE)		 6c5c 3-DEHYDROQUINATE
SYNTHASE
(Candida
albicans) 		5 / 9 LEU A 309
LEU A 207
ALA A 190
ALA A 196
THR A 195
 None
 1.08A 3mdvA-6c5cA:
undetectable		 3mdvA-6c5cA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A201_2
(POL POLYPROTEIN)		 6c5c 3-DEHYDROQUINATE
SYNTHASE
(Candida
albicans) 		5 / 9 ARG A 183
ALA A 190
GLY A 267
ILE A 270
LEU A 279
 None
 1.14A 3u7sB-6c5cA:
undetectable		 3u7sB-6c5cA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_0
(MNMC2)		 6c5c 3-DEHYDROQUINATE
SYNTHASE
(Candida
albicans) 		5 / 12 HIS A 280
GLY A 263
GLY A 267
LYS A 290
ALA A 292
 None
 1.22A 3vywD-6c5cA:
2.4		 3vywD-6c5cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 6c5c 3-DEHYDROQUINATE
SYNTHASE
(Candida
albicans) 		3 / 3 HIS A 280
GLU A  80
ASN A 159
 None
NAD  A 401 (-2.7A)
NAD  A 401 (-3.2A)
 0.86A 4bupB-6c5cA:
undetectable		 4bupB-6c5cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6c5c 3-DEHYDROQUINATE
SYNTHASE
(Candida
albicans) 		5 / 12 VAL A 170
LEU A   9
VAL A 247
GLY A 245
ALA A 244
 None
 1.32A 5iktB-6c5cA:
undetectable		 5iktB-6c5cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 6c5c 3-DEHYDROQUINATE
SYNTHASE
(Candida
albicans) 		3 / 3 HIS A 280
GLU A  80
ASN A 159
 None
NAD  A 401 (-2.7A)
NAD  A 401 (-3.2A)
 0.78A 5wbvA-6c5cA:
undetectable		 5wbvA-6c5cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 6c5c 3-DEHYDROQUINATE
SYNTHASE
(Candida
albicans) 		3 / 3 HIS A 280
GLU A  80
ASN A 159
 None
NAD  A 401 (-2.7A)
NAD  A 401 (-3.2A)
 0.78A 5wbvB-6c5cA:
undetectable		 5wbvB-6c5cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 6c5c 3-DEHYDROQUINATE
SYNTHASE
(Candida
albicans) 		3 / 3 HIS A 264
HIS A 280
HIS A 268
 EDO  A 409 ( 4.8A)
None
None
 0.72A 6giqa-6c5cA:
undetectable		 6giqa-6c5cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_E_AM2E301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 6c5c 3-DEHYDROQUINATE
SYNTHASE
(Candida
albicans) 		4 / 7 THR A  87
HIS A 280
GLU A  80
ASP A 153
 None
None
NAD  A 401 (-2.7A)
None
 1.19A 6mn4E-6c5cA:
undetectable		 6mn4E-6c5cA:
undetectable