SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6c66'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_B_ACAB90_1
(PLASMINOGEN)		 6c66 CRISPR-ASSOCIATED
PROTEIN, CAS5E
FAMILY
CRISPR-ASSOCIATED
PROTEIN, CSE4 FAMILY
(Thermobifida
fusca) 		4 / 7 ARG B  37
ASP B  20
ASP B  21
TYR M 107
 None
None
C  J   9 ( 4.5A)
None
 1.34A 1ceaB-6c66B:
undetectable		 1ceaB-6c66B:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9Y_B_HAEB800_1
(UREASE SUBUNIT BETA)		 6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
(Thermobifida
fusca) 		4 / 5 HIS G  83
HIS G 115
HIS G 149
ASP G 215
 FE  G1002 ( 3.5A)
FE  G1001 (-4.4A)
FE  G1001 (-3.2A)
FE  G1002 ( 2.7A)
 0.81A 1e9yB-6c66G:
undetectable		 1e9yB-6c66G:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)		 6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
(Thermobifida
fusca) 		4 / 8 ASP G  84
HIS G  83
HIS G 149
HIS G  37
 FE  G1001 ( 2.0A)
FE  G1002 ( 3.5A)
FE  G1001 (-3.2A)
FE  G1002 (-3.4A)
 0.84A 1ei6D-6c66G:
undetectable		 1ei6D-6c66G:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FWE_C_HAEC989_1
(UREASE)		 6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
(Thermobifida
fusca) 		5 / 6 HIS G  83
HIS G  37
HIS G 115
HIS G 149
ASP G 215
 FE  G1002 ( 3.5A)
FE  G1002 (-3.4A)
FE  G1001 (-4.4A)
FE  G1001 (-3.2A)
FE  G1002 ( 2.7A)
 1.01A 1fweC-6c66G:
undetectable		 1fweC-6c66G:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MSK_A_SAMA1301_0
(COBALAMIN-DEPENDENT
METHIONINE SYNTHASE)		 6c66 CRISPR-ASSOCIATED
PROTEIN, CSE4 FAMILY
(Thermobifida
fusca) 		5 / 10 ARG B 352
ALA B 338
TYR B 356
PRO B 357
ALA B 358
 None
 1.35A 1mskA-6c66B:
0.3		 1mskA-6c66B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_A_SAMA401_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 6c66 CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
CRISPR-ASSOCIATED
PROTEIN, CAS5E
FAMILY
(Thermobifida
fusca;
Thermobifida
fusca) 		5 / 12 THR M  75
GLY M  77
GLY M  79
VAL M  86
GLN A 161
 C  J   9 ( 3.4A)
G  J   8 ( 3.5A)
G  J   8 ( 3.1A)
None
None
 1.24A 1n2xA-6c66M:
undetectable		 1n2xA-6c66M:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NR6_A_DIFA501_1
(CYTOCHROME P450 2C5)		 6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
(Thermobifida
fusca) 		5 / 9 LEU G  46
ALA G 214
GLY G  81
ALA G  80
LEU G 210
 None
 1.15A 1nr6A-6c66G:
undetectable		 1nr6A-6c66G:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		 6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
(Thermobifida
fusca) 		3 / 3 GLU G  24
TRP G  21
LYS G 411
 None
 1.29A 1qu2A-6c66G:
undetectable		 1qu2A-6c66G:
6.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S19_A_MC9A500_1
(VITAMIN D3 RECEPTOR)		 6c66 UNCHARACTERIZED
PROTEIN
(Thermobifida
fusca) 		4 / 5 TYR I 182
SER I 156
ARG I 160
HIS I 218
 None
 1.47A 1s19A-6c66I:
undetectable		 1s19A-6c66I:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1300_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 6c66 CRISPR-ASSOCIATED
PROTEIN, CAS5E
FAMILY
(Thermobifida
fusca) 		5 / 11 GLY M  37
ALA M  41
PHE M  39
ALA M  42
LEU M 129
 U  J   2 ( 3.3A)
A  J   1 ( 3.1A)
None
None
None
 1.07A 1ukbA-6c66M:
undetectable		 1ukbA-6c66M:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_Q_TRPQ81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
(Thermobifida
fusca) 		5 / 10 GLY G 147
HIS G 149
HIS G 150
ALA G 118
HIS G  83
 None
FE  G1001 (-3.2A)
None
None
FE  G1002 ( 3.5A)
 1.27A 1utdQ-6c66G:
undetectable
1utdR-6c66G:
undetectable		 1utdQ-6c66G:
undetectable
1utdR-6c66G:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_A_TFPA202_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
(Thermobifida
fusca) 		5 / 9 LEU G 684
GLN G 685
MET G 673
SER G 675
GLU G 663
 None
 1.48A 1wrlA-6c66G:
undetectable
1wrlB-6c66G:
undetectable		 1wrlA-6c66G:
21.51
1wrlB-6c66G:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X1A_A_SAMA4264_0
(CRTF-RELATED PROTEIN)		 6c66 CRISPR-ASSOCIATED
PROTEIN, CSE4 FAMILY
(Thermobifida
fusca) 		5 / 12 ALA B 366
GLY B 350
GLY B 336
ILE B 334
ASP B 345
 None
 0.85A 1x1aA-6c66B:
undetectable		 1x1aA-6c66B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 6c66 CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		5 / 12 ILE A  71
LEU A 273
ALA A 268
VAL A 182
LEU A  44
 None
 0.99A 1xdkA-6c66A:
undetectable		 1xdkA-6c66A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_E_9CRE1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 6c66 CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		5 / 12 ILE A  71
LEU A 273
ALA A 268
VAL A 182
LEU A  44
 None
 0.99A 1xdkE-6c66A:
undetectable		 1xdkE-6c66A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		 6c66 CRISPR-ASSOCIATED
PROTEIN, CAS5E
FAMILY
(Thermobifida
fusca) 		4 / 7 PRO M 136
LEU M 138
GLY M  10
LEU M 149
 U  J   2 ( 4.8A)
None
None
None
 0.93A 1ya4B-6c66M:
undetectable		 1ya4B-6c66M:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		 6c66 CRISPR-ASSOCIATED
PROTEIN, CAS5E
FAMILY
(Thermobifida
fusca) 		4 / 4 LEU M 162
PRO M  66
ILE M 185
LEU M 184
 None
 1.13A 1ya4C-6c66M:
undetectable		 1ya4C-6c66M:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZEA_A_DHIA6_0
(MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
H CHAIN
MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
L CHAIN
SHORT SYNTHETIC
D-AMINO ACID PEPTIDE
D2)		 6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
(Thermobifida
fusca) 		3 / 3 TRP G 888
ARG G 622
PHE G 944
 None
 1.39A 1zeaH-6c66G:
undetectable
1zeaL-6c66G:
undetectable		 1zeaH-6c66G:
undetectable
1zeaL-6c66G:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFM_A_TOPA1290_1
(PTERIDINE REDUCTASE
1)		 6c66 CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		5 / 9 PHE A 248
LEU A 254
LEU A 138
LEU A 281
ARG A 137
 None
 1.42A 2bfmA-6c66A:
undetectable
2bfmD-6c66A:
undetectable		 2bfmA-6c66A:
14.48
2bfmD-6c66A:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFM_B_TOPB1290_1
(PTERIDINE REDUCTASE
1)		 6c66 CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		5 / 9 PHE A 248
LEU A 254
LEU A 138
LEU A 281
ARG A 137
 None
 1.38A 2bfmB-6c66A:
0.0
2bfmC-6c66A:
0.0		 2bfmB-6c66A:
14.48
2bfmC-6c66A:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CBR_A_A80A201_1
(PROTEIN (CRABP-I))		 6c66 CRISPR-ASSOCIATED
PROTEIN, CAS5E
FAMILY
CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		5 / 12 VAL M  71
LEU M  70
VAL M  68
GLY A 469
LEU A 338
 None
 1.18A 2cbrA-6c66M:
undetectable		 2cbrA-6c66M:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7F_A_NIOA601_1
(NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE)		 6c66 CRISPR-ASSOCIATED
PROTEIN, CSE3 FAMILY
(Thermobifida
fusca) 		4 / 6 SER O 180
GLY O  24
THR O  22
ARG O 172
 G  J  61 ( 3.1A)
None
None
None
 1.23A 2f7fA-6c66O:
undetectable		 2f7fA-6c66O:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_2
(VITAMIN D RECEPTOR)		 6c66 CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		4 / 7 LEU A  44
ILE A  49
ARG A  50
SER A  51
 None
 1.15A 2hc4A-6c66A:
undetectable		 2hc4A-6c66A:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_D_CHDD702_0
(FERROCHELATASE)		 6c66 CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		3 / 3 ARG A 414
GLY A 499
PRO A 500
 None
 0.66A 2hreD-6c66A:
undetectable		 2hreD-6c66A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_C_TPFC2471_1
(CYTOCHROME P450 121)		 6c66 CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		4 / 8 THR A 516
VAL A 515
VAL A 466
ALA A 508
 None
 1.13A 2ij7C-6c66A:
undetectable		 2ij7C-6c66A:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_D_DVAD6_0
(GRAMICIDIN D)		 6c66 CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		3 / 3 TRP A 183
ALA A 187
VAL A 182
 None
 0.98A 2izqC-6c66A:
undetectable
2izqD-6c66A:
undetectable		 2izqC-6c66A:
undetectable
2izqD-6c66A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_4
(PROTEASE RETROPEPSIN)		 6c66 CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		3 / 3 ASP A 347
THR A 395
PRO A 396
 None
 0.53A 2q64B-6c66A:
undetectable		 2q64B-6c66A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		 6c66 CRISPR-ASSOCIATED
PROTEIN, CAS5E
FAMILY
(Thermobifida
fusca) 		4 / 6 LEU M 200
ASP M 202
ILE M 219
ARG M  32
 None
 1.00A 2rlfA-6c66M:
undetectable
2rlfB-6c66M:
undetectable		 2rlfA-6c66M:
19.28
2rlfB-6c66M:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)		 6c66 CRISPR-ASSOCIATED
PROTEIN, CAS5E
FAMILY
(Thermobifida
fusca) 		4 / 6 LEU M 200
ASP M 202
ILE M 219
ARG M  32
 None
 0.93A 2rlfC-6c66M:
undetectable
2rlfD-6c66M:
undetectable		 2rlfC-6c66M:
19.28
2rlfD-6c66M:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_G_BEZG1222_0
(PEROXIREDOXIN 6.)		 6c66 CRISPR-ASSOCIATED
PROTEIN, CAS5E
FAMILY
(Thermobifida
fusca) 		4 / 8 THR M  88
PRO M  87
VAL M  86
ALA M  99
 None
 1.15A 2v41G-6c66M:
undetectable
2v41H-6c66M:
undetectable		 2v41G-6c66M:
undetectable
2v41H-6c66M:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_GLYA502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6c66 CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		4 / 7 SER A 220
HIS A 222
ARG A  70
TYR A 191
 None
 1.24A 2vmyA-6c66A:
undetectable
2vmyB-6c66A:
undetectable		 2vmyA-6c66A:
undetectable
2vmyB-6c66A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6c66 CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		4 / 8 TYR A 191
SER A 220
HIS A 222
ARG A  70
 None
 1.23A 2vmyA-6c66A:
undetectable
2vmyB-6c66A:
undetectable		 2vmyA-6c66A:
undetectable
2vmyB-6c66A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_E_GCSE710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
(Thermobifida
fusca) 		4 / 8 HIS G 149
ASP G 215
HIS G 115
ASP G  84
 FE  G1001 (-3.2A)
FE  G1002 ( 2.7A)
FE  G1001 (-4.4A)
FE  G1001 ( 2.0A)
 1.00A 2xadA-6c66G:
undetectable		 2xadA-6c66G:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_F_GCSF710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
(Thermobifida
fusca) 		4 / 8 HIS G 149
ASP G 215
HIS G 115
ASP G  84
 FE  G1001 (-3.2A)
FE  G1002 ( 2.7A)
FE  G1001 (-4.4A)
FE  G1001 ( 2.0A)
 1.01A 2xadB-6c66G:
undetectable		 2xadB-6c66G:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_G_GCSG710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
(Thermobifida
fusca) 		4 / 8 HIS G 149
ASP G 215
HIS G 115
ASP G  84
 FE  G1001 (-3.2A)
FE  G1002 ( 2.7A)
FE  G1001 (-4.4A)
FE  G1001 ( 2.0A)
 1.00A 2xadC-6c66G:
undetectable		 2xadC-6c66G:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_H_GCSH710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
(Thermobifida
fusca) 		4 / 8 HIS G 149
ASP G 215
HIS G 115
ASP G  84
 FE  G1001 (-3.2A)
FE  G1002 ( 2.7A)
FE  G1001 (-4.4A)
FE  G1001 ( 2.0A)
 1.00A 2xadD-6c66G:
undetectable		 2xadD-6c66G:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1303_1
(LYSR-TYPE REGULATORY
PROTEIN)		 6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
(Thermobifida
fusca) 		4 / 7 SER G 536
PRO G 520
GLY G 521
TRP G 522
 None
 0.98A 2y7kA-6c66G:
undetectable		 2y7kA-6c66G:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1001_1
(LYSR-TYPE REGULATORY
PROTEIN)		 6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
(Thermobifida
fusca) 		4 / 6 SER G 536
PRO G 520
GLY G 521
TRP G 522
 None
 0.98A 2y7pA-6c66G:
undetectable		 2y7pA-6c66G:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZAW_A_CAMA422_0
(CYTOCHROME P450-CAM)		 6c66 CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
(Thermobifida
fusca;
Thermobifida
fusca) 		4 / 6 TYR G 459
LEU G 431
VAL G 799
VAL A 323
 None
 1.18A 2zawA-6c66G:
undetectable		 2zawA-6c66G:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB5_0
(FERROCHELATASE)		 6c66 CRISPR-ASSOCIATED
PROTEIN, CAS5E
FAMILY
(Thermobifida
fusca) 		3 / 3 PRO M 204
LEU M  51
ARG M  53
 None
 0.84A 3aqiB-6c66M:
undetectable		 3aqiB-6c66M:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_1
(PHOSPHOLIPASE A2)		 6c66 CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		4 / 5 VAL A 148
THR A 198
THR A 156
ARG A 155
 None
 1.14A 3bjwA-6c66A:
undetectable		 3bjwA-6c66A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_1
(PHOSPHOLIPASE A2)		 6c66 CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		4 / 5 VAL A 148
THR A 198
THR A 156
ARG A 155
 None
 1.13A 3bjwC-6c66A:
undetectable		 3bjwC-6c66A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_1
(N,N-DIMETHYLTRANSFER
ASE)		 6c66 CRISPR-ASSOCIATED
PROTEIN, CSE4 FAMILY
CRISPR-ASSOCIATED
PROTEIN, CAS5E
FAMILY
(Thermobifida
fusca;
Thermobifida
fusca) 		3 / 3 TYR B 232
GLU B 301
ASP M  64
 None
 0.82A 3bxoA-6c66B:
undetectable		 3bxoA-6c66B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 6c66 UNCHARACTERIZED
PROTEIN
(Thermobifida
fusca) 		5 / 12 HIS I  48
ALA I  38
GLY I  36
VAL I  35
GLY I  34
 None
 1.05A 3f8wC-6c66I:
undetectable		 3f8wC-6c66I:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_H_TOPH200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 6c66 CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		5 / 9 ALA A 426
GLU A 427
ILE A 419
LEU A 399
PHE A 481
 None
 1.27A 3fl9H-6c66A:
undetectable		 3fl9H-6c66A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 6c66 UNCHARACTERIZED
PROTEIN
(Thermobifida
fusca) 		5 / 12 ILE I 164
LEU I 195
GLN I 215
ARG I 201
VAL I 172
 None
 1.17A 3ix9B-6c66I:
undetectable		 3ix9B-6c66I:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_B_ACTB601_0
(CHOLINE OXIDASE)		 6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
(Thermobifida
fusca) 		4 / 5 TRP G 934
ILE G 943
VAL G 592
HIS G 620
 None
 1.39A 3nneB-6c66G:
undetectable		 3nneB-6c66G:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_A_ADNA506_2
(ADENOSYLHOMOCYSTEINA
SE)		 6c66 CRISPR-ASSOCIATED
PROTEIN, CAS5E
FAMILY
CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		3 / 3 GLN M 218
THR M 216
LEU A  54
 None
 0.68A 3ondA-6c66M:
undetectable		 3ondA-6c66M:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_B_ADNB507_2
(ADENOSYLHOMOCYSTEINA
SE)		 6c66 CRISPR-ASSOCIATED
PROTEIN, CAS5E
FAMILY
CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		3 / 3 GLN M 218
THR M 216
LEU A  54
 None
 0.67A 3ondB-6c66M:
undetectable		 3ondB-6c66M:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_B_SALB301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
(Thermobifida
fusca) 		4 / 8 ARG G 622
VAL G 883
ILE G 914
GLN G 916
 None
 1.03A 3remB-6c66G:
undetectable		 3remB-6c66G:
28.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3O_A_DLUA399_1
(PFV INTEGRASE)		 6c66 CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		4 / 7 ASP A 256
GLN A 251
GLU A 253
ARG A 200
 None
 1.13A 3s3oA-6c66A:
undetectable		 3s3oA-6c66A:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 6c66 CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		3 / 3 HIS A  52
SER A 231
GLU A 230
 None
 0.89A 3s8pA-6c66A:
undetectable		 3s8pA-6c66A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_3
(PROTEASE)		 6c66 CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		3 / 3 ASP A 347
THR A 395
PRO A 396
 None
 0.54A 3tkgD-6c66A:
undetectable		 3tkgD-6c66A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_A_SALA404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 6c66 CRISPR-ASSOCIATED
PROTEIN, CAS5E
FAMILY
CRISPR-ASSOCIATED
PROTEIN, CSE4 FAMILY
(Thermobifida
fusca) 		4 / 7 ALA B 297
PRO B 298
ALA M   9
ARG M   7
 None
 0.98A 3twpA-6c66B:
undetectable		 3twpA-6c66B:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_B_SALB404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 6c66 CRISPR-ASSOCIATED
PROTEIN, CAS5E
FAMILY
CRISPR-ASSOCIATED
PROTEIN, CSE4 FAMILY
(Thermobifida
fusca) 		4 / 7 ALA B 297
PRO B 298
ALA M   9
ARG M   7
 None
 1.02A 3twpB-6c66B:
undetectable		 3twpB-6c66B:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_C_SALC404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 6c66 CRISPR-ASSOCIATED
PROTEIN, CAS5E
FAMILY
CRISPR-ASSOCIATED
PROTEIN, CSE4 FAMILY
(Thermobifida
fusca) 		4 / 7 ALA B 297
PRO B 298
ALA M   9
ARG M   7
 None
 1.02A 3twpC-6c66B:
undetectable		 3twpC-6c66B:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFG_B_LEUB289_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 6c66 CRISPR-ASSOCIATED
PROTEIN, CSE4 FAMILY
(Thermobifida
fusca) 		3 / 3 PHE B 231
SER B  15
SER B 227
 None
 0.70A 3ufgB-6c66B:
undetectable		 3ufgB-6c66B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_2
(ADENOSINE KINASE,
PUTATIVE)		 6c66 CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		4 / 5 LEU A  68
ALA A  66
PHE A 377
ASN A 235
 None
 1.44A 3uq6A-6c66A:
undetectable		 3uq6A-6c66A:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA505_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 6c66 CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
CRISPR-ASSOCIATED
PROTEIN, CAS5E
FAMILY
(Thermobifida
fusca;
Thermobifida
fusca) 		3 / 3 THR M 216
ASN M 201
GLU A  58
 None
G  J   3 ( 4.3A)
None
 0.75A 3v4tA-6c66M:
undetectable
3v4tC-6c66M:
undetectable		 3v4tA-6c66M:
undetectable
3v4tC-6c66M:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_B_SAMB801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 6c66 CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
(Thermobifida
fusca;
Thermobifida
fusca) 		5 / 11 GLY G 503
ASP G 804
ASP G 802
ASN A  87
PRO A  85
 None
 1.24A 3v8vB-6c66G:
undetectable		 3v8vB-6c66G:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_A_ADNA401_2
(PUTATIVE ADENOSINE
KINASE)		 6c66 CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		4 / 4 LEU A  68
ALA A  66
PHE A 377
ASN A 235
 None
 1.48A 3vasA-6c66A:
undetectable		 3vasA-6c66A:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_B_NCAB300_0
(PROTOGLOBIN)		 6c66 CRISPR-ASSOCIATED
PROTEIN, CSE4 FAMILY
(Thermobifida
fusca) 		4 / 7 VAL B 186
PHE B 170
VAL B  51
ILE B   6
 None
 0.95A 3zjqB-6c66B:
undetectable		 3zjqB-6c66B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
(Thermobifida
fusca) 		3 / 3 HIS G  74
GLU G  69
ASN G  50
 None
 1.00A 4bupB-6c66G:
1.2		 4bupB-6c66G:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
(Thermobifida
fusca) 		4 / 7 VAL G 558
VAL G 556
LEU G 555
VAL G 553
 None
 1.13A 4e1gB-6c66G:
1.0		 4e1gB-6c66G:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H9M_A_HAEA929_1
(UREASE)		 6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
(Thermobifida
fusca) 		4 / 5 HIS G  83
HIS G 115
HIS G 149
ASP G 215
 FE  G1002 ( 3.5A)
FE  G1001 (-4.4A)
FE  G1001 (-3.2A)
FE  G1002 ( 2.7A)
 0.83A 4h9mA-6c66G:
undetectable		 4h9mA-6c66G:
7.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		 6c66 CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		4 / 7 ARG A 203
VAL A 202
GLU A 141
ARG A 200
 None
 1.31A 4mv7A-6c66A:
undetectable		 4mv7A-6c66A:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		4 / 7 GLU G 106
THR G  89
THR A 541
LEU A 421
 None
 1.12A 4pfjA-6c66G:
undetectable		 4pfjA-6c66G:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_A_3CJA607_1
(LACTOPEROXIDASE)		 6c66 CRISPR-ASSOCIATED
PROTEIN, CAS5E
FAMILY
CRISPR-ASSOCIATED
PROTEIN, CSE4 FAMILY
(Thermobifida
fusca) 		3 / 3 GLN B  41
HIS M  74
ARG M 105
 C  J   7 ( 4.6A)
C  J   7 ( 3.4A)
C  J   7 ( 3.7A)
 1.16A 4qyqA-6c66B:
undetectable		 4qyqA-6c66B:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_B_3CJB607_1
(LACTOPEROXIDASE)		 6c66 CRISPR-ASSOCIATED
PROTEIN, CAS5E
FAMILY
CRISPR-ASSOCIATED
PROTEIN, CSE4 FAMILY
(Thermobifida
fusca) 		3 / 3 GLN B  41
HIS M  74
ARG M 105
 C  J   7 ( 4.6A)
C  J   7 ( 3.4A)
C  J   7 ( 3.7A)
 1.05A 4qyqB-6c66B:
undetectable		 4qyqB-6c66B:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 6c66 CRISPR-ASSOCIATED
PROTEIN, CAS5E
FAMILY
(Thermobifida
fusca) 		5 / 12 LEU M  27
GLY M  37
ALA M  40
GLU M 121
PHE M 207
 None
U  J   2 ( 3.3A)
A  J   1 ( 4.0A)
None
U  J   2 ( 4.1A)
 1.25A 4retA-6c66M:
undetectable		 4retA-6c66M:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 6c66 CRISPR-ASSOCIATED
PROTEIN, CAS5E
FAMILY
(Thermobifida
fusca) 		5 / 12 LEU M  27
GLY M  37
ALA M  40
GLU M 121
PHE M 207
 None
U  J   2 ( 3.3A)
A  J   1 ( 4.0A)
None
U  J   2 ( 4.1A)
 1.25A 4retC-6c66M:
undetectable		 4retC-6c66M:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RMJ_A_NCAA402_0
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2)		 6c66 UNCHARACTERIZED
PROTEIN
(Thermobifida
fusca) 		4 / 7 LEU I 199
LEU I 139
ILE I 190
ASP I 191
 None
 0.83A 4rmjA-6c66I:
undetectable		 4rmjA-6c66I:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_1
(HYDG PROTEIN)		 6c66 CRISPR-ASSOCIATED
PROTEIN, CSE3 FAMILY
(Thermobifida
fusca) 		3 / 3 GLU O  56
ARG O 105
GLN O  85
 None
 0.98A 4rtbA-6c66O:
undetectable		 4rtbA-6c66O:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBP_C_HAEC800_1
(PROTEIN (UREASE
(CHAIN C)))		 6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
(Thermobifida
fusca) 		5 / 6 HIS G  83
HIS G  37
HIS G 115
HIS G 149
ASP G 215
 FE  G1002 ( 3.5A)
FE  G1002 (-3.4A)
FE  G1001 (-4.4A)
FE  G1001 (-3.2A)
FE  G1002 ( 2.7A)
 0.96A 4ubpC-6c66G:
undetectable		 4ubpC-6c66G:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_1
(THYROXINE-BINDING
GLOBULIN)		 6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
(Thermobifida
fusca) 		5 / 10 LEU G 213
LEU G 210
SER G  54
LEU G  53
TRP G  49
 None
 1.19A 4yiaA-6c66G:
undetectable		 4yiaA-6c66G:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 6c66 CRISPR-ASSOCIATED
PROTEIN, CSE4 FAMILY
(Thermobifida
fusca) 		4 / 6 PRO B 298
LEU B 318
GLU B 317
TYR B 321
 None
 1.32A 4z4cA-6c66B:
undetectable		 4z4cA-6c66B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 6c66 CRISPR-ASSOCIATED
PROTEIN, CAS5E
FAMILY
CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		4 / 5 VAL M  68
TYR A 486
ILE A 415
THR A 395
 None
 1.06A 4ze1A-6c66M:
undetectable		 4ze1A-6c66M:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 6c66 CRISPR-ASSOCIATED
PROTEIN, CAS5E
FAMILY
(Thermobifida
fusca) 		4 / 5 ALA M  40
ARG M  53
ALA M 128
GLU M 121
 A  J   1 ( 4.0A)
None
None
None
 1.47A 5a06C-6c66M:
undetectable
5a06D-6c66M:
undetectable		 5a06C-6c66M:
undetectable
5a06D-6c66M:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		4 / 5 GLU G 106
THR G  89
THR A 541
LEU A 421
 None
 1.25A 5axaA-6c66G:
undetectable		 5axaA-6c66G:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		4 / 5 GLU G 106
THR G  89
THR A 541
LEU A 421
 None
 1.28A 5axaC-6c66G:
undetectable		 5axaC-6c66G:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_F_MFXF2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
(Thermobifida
fusca) 		4 / 6 SER G 205
ASP G 804
GLY G 500
GLU G 499
 None
 0.91A 5cdqA-6c66G:
undetectable
5cdqC-6c66G:
undetectable
5cdqD-6c66G:
undetectable		 5cdqA-6c66G:
11.40
5cdqC-6c66G:
11.40
5cdqD-6c66G:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP3_A_YTZA301_1
(LIGHT CHAIN OF
ANTIGEN-BINDING
FRAGMENT OF
MONOCLONAL ANTIBODY
OF 4C7
HEAVY CHAIN OF
ANTIGEN-BINDING
FRAGMENT OF
MONOCLONAL ANTIBODY
OF 4C7)		 6c66 CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		5 / 11 LEU A 273
ARG A 272
HIS A 222
ALA A  66
TYR A 312
 None
 1.38A 5cp3A-6c66A:
undetectable
5cp3H-6c66A:
undetectable		 5cp3A-6c66A:
16.28
5cp3H-6c66A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_M_TRPM101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
(Thermobifida
fusca) 		5 / 9 GLY G 147
HIS G 149
HIS G 150
ALA G 118
HIS G  83
 None
FE  G1001 (-3.2A)
None
None
FE  G1002 ( 3.5A)
 1.47A 5eeuL-6c66G:
undetectable
5eeuM-6c66G:
undetectable		 5eeuL-6c66G:
undetectable
5eeuM-6c66G:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
(Thermobifida
fusca) 		5 / 10 GLY G 147
HIS G 149
HIS G 150
ALA G 118
HIS G  83
 None
FE  G1001 (-3.2A)
None
None
FE  G1002 ( 3.5A)
 1.46A 5eeuN-6c66G:
undetectable
5eeuO-6c66G:
undetectable		 5eeuN-6c66G:
undetectable
5eeuO-6c66G:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
(Thermobifida
fusca) 		5 / 10 GLY G 147
HIS G 149
HIS G 150
ALA G 118
HIS G  83
 None
FE  G1001 (-3.2A)
None
None
FE  G1002 ( 3.5A)
 1.44A 5eeuP-6c66G:
undetectable
5eeuQ-6c66G:
undetectable		 5eeuP-6c66G:
undetectable
5eeuQ-6c66G:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_M_TRPM101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
(Thermobifida
fusca) 		5 / 9 GLY G 147
HIS G 149
HIS G 150
ALA G 118
HIS G  83
 None
FE  G1001 (-3.2A)
None
None
FE  G1002 ( 3.5A)
 1.47A 5eevL-6c66G:
undetectable
5eevM-6c66G:
undetectable		 5eevL-6c66G:
undetectable
5eevM-6c66G:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
(Thermobifida
fusca) 		5 / 10 GLY G 147
HIS G 149
HIS G 150
ALA G 118
HIS G  83
 None
FE  G1001 (-3.2A)
None
None
FE  G1002 ( 3.5A)
 1.47A 5eevN-6c66G:
undetectable
5eevO-6c66G:
undetectable		 5eevN-6c66G:
undetectable
5eevO-6c66G:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
(Thermobifida
fusca) 		5 / 10 GLY G 147
HIS G 149
HIS G 150
ALA G 118
HIS G  83
 None
FE  G1001 (-3.2A)
None
None
FE  G1002 ( 3.5A)
 1.44A 5eevP-6c66G:
undetectable
5eevQ-6c66G:
undetectable		 5eevP-6c66G:
undetectable
5eevQ-6c66G:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_M_TRPM101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
(Thermobifida
fusca) 		5 / 9 GLY G 147
HIS G 149
HIS G 150
ALA G 118
HIS G  83
 None
FE  G1001 (-3.2A)
None
None
FE  G1002 ( 3.5A)
 1.47A 5eewL-6c66G:
undetectable
5eewM-6c66G:
undetectable		 5eewL-6c66G:
undetectable
5eewM-6c66G:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
(Thermobifida
fusca) 		5 / 10 GLY G 147
HIS G 149
HIS G 150
ALA G 118
HIS G  83
 None
FE  G1001 (-3.2A)
None
None
FE  G1002 ( 3.5A)
 1.47A 5eewN-6c66G:
undetectable
5eewO-6c66G:
undetectable		 5eewN-6c66G:
undetectable
5eewO-6c66G:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
(Thermobifida
fusca) 		5 / 10 GLY G 147
HIS G 149
HIS G 150
ALA G 118
HIS G  83
 None
FE  G1001 (-3.2A)
None
None
FE  G1002 ( 3.5A)
 1.44A 5eewP-6c66G:
undetectable
5eewQ-6c66G:
undetectable		 5eewP-6c66G:
undetectable
5eewQ-6c66G:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_M_TRPM101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
(Thermobifida
fusca) 		5 / 9 GLY G 147
HIS G 149
HIS G 150
ALA G 118
HIS G  83
 None
FE  G1001 (-3.2A)
None
None
FE  G1002 ( 3.5A)
 1.47A 5eexL-6c66G:
undetectable
5eexM-6c66G:
undetectable		 5eexL-6c66G:
undetectable
5eexM-6c66G:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
(Thermobifida
fusca) 		5 / 10 GLY G 147
HIS G 149
HIS G 150
ALA G 118
HIS G  83
 None
FE  G1001 (-3.2A)
None
None
FE  G1002 ( 3.5A)
 1.47A 5eexN-6c66G:
undetectable
5eexO-6c66G:
undetectable		 5eexN-6c66G:
undetectable
5eexO-6c66G:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
(Thermobifida
fusca) 		5 / 10 GLY G 147
HIS G 149
HIS G 150
ALA G 118
HIS G  83
 None
FE  G1001 (-3.2A)
None
None
FE  G1002 ( 3.5A)
 1.43A 5eexP-6c66G:
undetectable
5eexQ-6c66G:
undetectable		 5eexP-6c66G:
undetectable
5eexQ-6c66G:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_M_TRPM101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
(Thermobifida
fusca) 		5 / 9 GLY G 147
HIS G 149
HIS G 150
ALA G 118
HIS G  83
 None
FE  G1001 (-3.2A)
None
None
FE  G1002 ( 3.5A)
 1.47A 5eeyL-6c66G:
undetectable
5eeyM-6c66G:
undetectable		 5eeyL-6c66G:
undetectable
5eeyM-6c66G:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
(Thermobifida
fusca) 		5 / 10 GLY G 147
HIS G 149
HIS G 150
ALA G 118
HIS G  83
 None
FE  G1001 (-3.2A)
None
None
FE  G1002 ( 3.5A)
 1.46A 5eeyN-6c66G:
undetectable
5eeyO-6c66G:
undetectable		 5eeyN-6c66G:
undetectable
5eeyO-6c66G:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
(Thermobifida
fusca) 		5 / 10 GLY G 147
HIS G 149
HIS G 150
ALA G 118
HIS G  83
 None
FE  G1001 (-3.2A)
None
None
FE  G1002 ( 3.5A)
 1.44A 5eeyP-6c66G:
undetectable
5eeyQ-6c66G:
undetectable		 5eeyP-6c66G:
undetectable
5eeyQ-6c66G:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_M_TRPM101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
(Thermobifida
fusca) 		5 / 9 GLY G 147
HIS G 149
HIS G 150
ALA G 118
HIS G  83
 None
FE  G1001 (-3.2A)
None
None
FE  G1002 ( 3.5A)
 1.47A 5eezL-6c66G:
undetectable
5eezM-6c66G:
undetectable		 5eezL-6c66G:
undetectable
5eezM-6c66G:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
(Thermobifida
fusca) 		5 / 10 GLY G 147
HIS G 149
HIS G 150
ALA G 118
HIS G  83
 None
FE  G1001 (-3.2A)
None
None
FE  G1002 ( 3.5A)
 1.46A 5eezN-6c66G:
undetectable
5eezO-6c66G:
undetectable		 5eezN-6c66G:
undetectable
5eezO-6c66G:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
(Thermobifida
fusca) 		5 / 10 GLY G 147
HIS G 149
HIS G 150
ALA G 118
HIS G  83
 None
FE  G1001 (-3.2A)
None
None
FE  G1002 ( 3.5A)
 1.44A 5eezP-6c66G:
undetectable
5eezQ-6c66G:
undetectable		 5eezP-6c66G:
undetectable
5eezQ-6c66G:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_M_TRPM101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
(Thermobifida
fusca) 		5 / 9 GLY G 147
HIS G 149
HIS G 150
ALA G 118
HIS G  83
 None
FE  G1001 (-3.2A)
None
None
FE  G1002 ( 3.5A)
 1.47A 5ef0L-6c66G:
undetectable
5ef0M-6c66G:
undetectable		 5ef0L-6c66G:
undetectable
5ef0M-6c66G:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
(Thermobifida
fusca) 		5 / 10 GLY G 147
HIS G 149
HIS G 150
ALA G 118
HIS G  83
 None
FE  G1001 (-3.2A)
None
None
FE  G1002 ( 3.5A)
 1.46A 5ef0N-6c66G:
undetectable
5ef0O-6c66G:
undetectable		 5ef0N-6c66G:
undetectable
5ef0O-6c66G:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
(Thermobifida
fusca) 		5 / 10 GLY G 147
HIS G 149
HIS G 150
ALA G 118
HIS G  83
 None
FE  G1001 (-3.2A)
None
None
FE  G1002 ( 3.5A)
 1.43A 5ef0P-6c66G:
undetectable
5ef0Q-6c66G:
undetectable		 5ef0P-6c66G:
undetectable
5ef0Q-6c66G:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_M_TRPM101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
(Thermobifida
fusca) 		5 / 9 GLY G 147
HIS G 149
HIS G 150
ALA G 118
HIS G  83
 None
FE  G1001 (-3.2A)
None
None
FE  G1002 ( 3.5A)
 1.47A 5ef1L-6c66G:
undetectable
5ef1M-6c66G:
undetectable		 5ef1L-6c66G:
undetectable
5ef1M-6c66G:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
(Thermobifida
fusca) 		5 / 10 GLY G 147
HIS G 149
HIS G 150
ALA G 118
HIS G  83
 None
FE  G1001 (-3.2A)
None
None
FE  G1002 ( 3.5A)
 1.47A 5ef1N-6c66G:
undetectable
5ef1O-6c66G:
undetectable		 5ef1N-6c66G:
undetectable
5ef1O-6c66G:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
(Thermobifida
fusca) 		5 / 10 GLY G 147
HIS G 149
HIS G 150
ALA G 118
HIS G  83
 None
FE  G1001 (-3.2A)
None
None
FE  G1002 ( 3.5A)
 1.44A 5ef1P-6c66G:
undetectable
5ef1Q-6c66G:
undetectable		 5ef1P-6c66G:
undetectable
5ef1Q-6c66G:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_M_TRPM101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
(Thermobifida
fusca) 		5 / 9 GLY G 147
HIS G 149
HIS G 150
ALA G 118
HIS G  83
 None
FE  G1001 (-3.2A)
None
None
FE  G1002 ( 3.5A)
 1.47A 5ef2L-6c66G:
undetectable
5ef2M-6c66G:
undetectable		 5ef2L-6c66G:
undetectable
5ef2M-6c66G:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
(Thermobifida
fusca) 		5 / 10 GLY G 147
HIS G 149
HIS G 150
ALA G 118
HIS G  83
 None
FE  G1001 (-3.2A)
None
None
FE  G1002 ( 3.5A)
 1.46A 5ef2N-6c66G:
undetectable
5ef2O-6c66G:
undetectable		 5ef2N-6c66G:
undetectable
5ef2O-6c66G:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
(Thermobifida
fusca) 		5 / 10 GLY G 147
HIS G 149
HIS G 150
ALA G 118
HIS G  83
 None
FE  G1001 (-3.2A)
None
None
FE  G1002 ( 3.5A)
 1.44A 5ef2P-6c66G:
undetectable
5ef2Q-6c66G:
undetectable		 5ef2P-6c66G:
undetectable
5ef2Q-6c66G:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_M_TRPM101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
(Thermobifida
fusca) 		5 / 9 GLY G 147
HIS G 149
HIS G 150
ALA G 118
HIS G  83
 None
FE  G1001 (-3.2A)
None
None
FE  G1002 ( 3.5A)
 1.47A 5ef3L-6c66G:
undetectable
5ef3M-6c66G:
undetectable		 5ef3L-6c66G:
undetectable
5ef3M-6c66G:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
(Thermobifida
fusca) 		5 / 10 GLY G 147
HIS G 149
HIS G 150
ALA G 118
HIS G  83
 None
FE  G1001 (-3.2A)
None
None
FE  G1002 ( 3.5A)
 1.46A 5ef3N-6c66G:
undetectable
5ef3O-6c66G:
undetectable		 5ef3N-6c66G:
undetectable
5ef3O-6c66G:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
(Thermobifida
fusca) 		5 / 10 GLY G 147
HIS G 149
HIS G 150
ALA G 118
HIS G  83
 None
FE  G1001 (-3.2A)
None
None
FE  G1002 ( 3.5A)
 1.44A 5ef3P-6c66G:
undetectable
5ef3Q-6c66G:
undetectable		 5ef3P-6c66G:
undetectable
5ef3Q-6c66G:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_2
(CYP51 VARIANT1)		 6c66 CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		3 / 3 PRO A 307
LEU A 260
SER A 264
 None
 0.72A 5fsaB-6c66A:
undetectable		 5fsaB-6c66A:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		4 / 5 GLU G 106
THR G  89
THR A 541
LEU A 421
 None
 1.23A 5hm8A-6c66G:
undetectable		 5hm8A-6c66G:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_B_ADNB501_2
(ADENOSYLHOMOCYSTEINA
SE)		 6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		4 / 5 GLU G 106
THR G  89
THR A 541
LEU A 421
 None
 1.23A 5hm8B-6c66G:
undetectable		 5hm8B-6c66G:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_C_ADNC501_2
(ADENOSYLHOMOCYSTEINA
SE)		 6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		4 / 5 GLU G 106
THR G  89
THR A 541
LEU A 421
 None
 1.23A 5hm8C-6c66G:
undetectable		 5hm8C-6c66G:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_D_ADND501_2
(ADENOSYLHOMOCYSTEINA
SE)		 6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		4 / 5 GLU G 106
THR G  89
THR A 541
LEU A 421
 None
 1.23A 5hm8D-6c66G:
undetectable		 5hm8D-6c66G:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_E_ADNE501_2
(ADENOSYLHOMOCYSTEINA
SE)		 6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		4 / 5 GLU G 106
THR G  89
THR A 541
LEU A 421
 None
 1.23A 5hm8E-6c66G:
undetectable		 5hm8E-6c66G:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_F_ADNF501_2
(ADENOSYLHOMOCYSTEINA
SE)		 6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		4 / 5 GLU G 106
THR G  89
THR A 541
LEU A 421
 None
 1.23A 5hm8F-6c66G:
undetectable		 5hm8F-6c66G:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_G_ADNG501_2
(ADENOSYLHOMOCYSTEINA
SE)		 6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		4 / 5 GLU G 106
THR G  89
THR A 541
LEU A 421
 None
 1.23A 5hm8G-6c66G:
undetectable		 5hm8G-6c66G:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_H_ADNH501_2
(ADENOSYLHOMOCYSTEINA
SE)		 6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		4 / 5 GLU G 106
THR G  89
THR A 541
LEU A 421
 None
 1.23A 5hm8H-6c66G:
undetectable		 5hm8H-6c66G:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_2
(CDL2.3B)		 6c66 UNCHARACTERIZED
PROTEIN
(Thermobifida
fusca) 		5 / 9 PRO I 137
MET I  88
VAL I  84
ILE I 196
LEU I 161
 None
 1.26A 5iepA-6c66I:
undetectable		 5iepA-6c66I:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JI0_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 6c66 CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		5 / 11 ILE A  71
LEU A 273
ALA A 268
VAL A 182
LEU A  44
 None
 1.03A 5ji0A-6c66A:
undetectable		 5ji0A-6c66A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB603_1
(PHIAB6 TAILSPIKE)		 6c66 CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		3 / 3 VAL A 485
GLU A 411
GLU A 406
 None
 0.72A 5jsdB-6c66A:
undetectable
5jsdC-6c66A:
undetectable		 5jsdB-6c66A:
6.60
5jsdC-6c66A:
6.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 6c66 CRISPR-ASSOCIATED
PROTEIN, CSE4 FAMILY
(Thermobifida
fusca) 		3 / 3 ASP B 345
ASN B 320
GLN B 316
 None
 0.83A 5k7uA-6c66B:
undetectable		 5k7uA-6c66B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 6c66 CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		4 / 6 LEU A 232
ILE A  29
MET A  41
TRP A 183
 None
 1.35A 5ljeA-6c66A:
undetectable		 5ljeA-6c66A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 6c66 UNCHARACTERIZED
PROTEIN
(Thermobifida
fusca) 		4 / 8 HIS I 162
LEU I 139
GLY I 140
VAL I 214
 None
 0.94A 5m8rC-6c66I:
undetectable		 5m8rC-6c66I:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NU7_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 4)		 6c66 CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		4 / 8 LEU A 186
ALA A  73
VAL A 182
HIS A 222
 None
 0.92A 5nu7A-6c66A:
undetectable		 5nu7A-6c66A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_B_TESB502_1
(-)		 6c66 CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		5 / 12 LEU A 186
LEU A 133
ILE A  75
ALA A 247
LEU A 271
 None
 1.03A 5og9B-6c66A:
undetectable		 5og9B-6c66A:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYF_B_TA1B502_1
(TUBULIN BETA CHAIN)		 6c66 CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		5 / 12 VAL A 219
ASP A 337
ARG A 373
PRO A 352
LEU A 355
 None
 1.28A 5syfB-6c66A:
undetectable		 5syfB-6c66A:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 6c66 CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		4 / 8 TRP A 441
TRP A 465
TYR A 519
ARG A 524
 None
 1.41A 5tzoB-6c66A:
undetectable		 5tzoB-6c66A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_A_9CRA503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 6c66 CRISPR-ASSOCIATED
PROTEIN, CAS5E
FAMILY
(Thermobifida
fusca) 		6 / 12 ALA M  42
ALA M  41
GLN M  43
PHE M  39
LEU M 129
ALA M 128
 None
A  J   1 ( 3.1A)
None
None
None
None
 1.25A 5uanA-6c66M:
undetectable		 5uanA-6c66M:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_A_ADNA502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		4 / 4 GLU G 106
THR G  89
THR A 541
LEU A 421
 None
 1.26A 5v96A-6c66G:
undetectable		 5v96A-6c66G:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_B_ADNB502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		4 / 4 GLU G 106
THR G  89
THR A 541
LEU A 421
 None
 1.25A 5v96B-6c66G:
undetectable		 5v96B-6c66G:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_C_ADNC502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		4 / 4 GLU G 106
THR G  89
THR A 541
LEU A 421
 None
 1.30A 5v96C-6c66G:
undetectable		 5v96C-6c66G:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_D_ADND502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		4 / 4 GLU G 106
THR G  89
THR A 541
LEU A 421
 None
 1.28A 5v96D-6c66G:
undetectable		 5v96D-6c66G:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_1
(REGULATORY PROTEIN
TETR)		 6c66 CRISPR-ASSOCIATED
PROTEIN, CAS5E
FAMILY
(Thermobifida
fusca) 		4 / 8 ILE M  36
TYR M 137
VAL M  45
ASP M  52
 None
U  J   2 ( 3.1A)
None
None
 1.13A 5vlmF-6c66M:
undetectable		 5vlmF-6c66M:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
(Thermobifida
fusca) 		3 / 3 HIS G  74
GLU G  69
ASN G  50
 None
 0.98A 5wbvA-6c66G:
undetectable		 5wbvA-6c66G:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
(Thermobifida
fusca) 		3 / 3 HIS G  74
GLU G  69
ASN G  50
 None
 0.98A 5wbvB-6c66G:
undetectable		 5wbvB-6c66G:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		5 / 12 GLU G 167
ASP A 347
GLY A 345
THR A 395
ALA A 425
 None
 1.14A 5x5qB-6c66G:
undetectable		 5x5qB-6c66G:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 6c66 CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		5 / 12 ALA A 422
GLY A 499
GLY A 501
LEU A 341
PHE A 481
 None
 1.04A 5ybbA-6c66A:
undetectable		 5ybbA-6c66A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 6c66 CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		5 / 12 ILE A  71
LEU A 273
ALA A 268
VAL A 182
LEU A  44
 None
 0.96A 5z12B-6c66A:
undetectable		 5z12B-6c66A:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BM5_A_SAMA1301_0
(METHIONINE SYNTHASE)		 6c66 CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		5 / 11 PRO A 352
PRO A  63
ALA A  65
ALA A 187
TYR A 191
 None
 1.39A 6bm5A-6c66A:
undetectable		 6bm5A-6c66A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BM5_A_SAMA1301_0
(METHIONINE SYNTHASE)		 6c66 CRISPR-ASSOCIATED
PROTEIN, CSE4 FAMILY
(Thermobifida
fusca) 		5 / 11 ARG B 352
ALA B 338
TYR B 356
PRO B 357
ALA B 358
 None
 1.36A 6bm5A-6c66B:
undetectable		 6bm5A-6c66B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 6c66 CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
CRISPR-ASSOCIATED
PROTEIN, CAS5E
FAMILY
(Thermobifida
fusca;
Thermobifida
fusca) 		3 / 3 ARG A 472
LYS A 476
ARG M 171
 None
 1.02A 6c06D-6c66A:
2.3		 6c06D-6c66A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 6c66 CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
(Thermobifida
fusca) 		4 / 8 ILE A 354
TRP A  69
ILE A 236
THR A  76
 None
 1.03A 6cduG-6c66A:
4.3
6cduH-6c66A:
4.3		 6cduG-6c66A:
undetectable
6cduH-6c66A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECF_I_DVAI3010_0
(VLM2
DODECADEPSIPEPTIDE)		 6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
(Thermobifida
fusca) 		3 / 3 PHE G 944
ARG G 884
ALA G 595
 None
 0.60A 6ecfB-6c66G:
undetectable		 6ecfB-6c66G:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N7F_A_RBFA502_0
(PUTATIVE GLUTATHIONE
REDUCTASE (GR))		 6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
(Thermobifida
fusca) 		4 / 7 GLY G 640
HIS G 695
GLU G 309
GLY G 308
 None
 0.91A 6n7fA-6c66G:
undetectable		 6n7fA-6c66G:
17.28