SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6c6k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 6c6k INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 1
(Homo
sapiens) 		4 / 7 GLY A 356
GLN A 393
PHE A 389
PHE A 365
 None
 1.08A 2qx4A-6c6kA:
undetectable
2qx4B-6c6kA:
undetectable		 2qx4A-6c6kA:
16.44
2qx4B-6c6kA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A65_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 6c6k INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 1
(Homo
sapiens) 		5 / 12 ALA A 181
VAL A 223
ASN A 218
GLY A 182
ILE A 185
 None
 1.27A 3a65A-6c6kA:
undetectable		 3a65A-6c6kA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_0
(N,N-DIMETHYLTRANSFER
ASE)		 6c6k INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 1
(Homo
sapiens) 		5 / 12 ALA A 407
HIS A 385
LEU A 405
SER A 420
LEU A 451
 None
 1.34A 3bxoA-6c6kA:
undetectable		 3bxoA-6c6kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_0
(N,N-DIMETHYLTRANSFER
ASE)		 6c6k INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 1
(Homo
sapiens) 		5 / 12 GLY A 387
HIS A 385
LEU A 405
SER A 420
LEU A 451
 None
 1.16A 3bxoA-6c6kA:
undetectable		 3bxoA-6c6kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_0
(YAEB-LIKE PROTEIN
RPA0152)		 6c6k INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 1
(Homo
sapiens) 		3 / 3 LYS A 338
ARG A  40
LYS A 261
 U  E   3 (-2.6A)
A  E   2 (-3.3A)
A  E   4 ( 3.0A)
 1.38A 3okxA-6c6kA:
undetectable		 3okxA-6c6kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWQ_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 6c6k INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 1
(Homo
sapiens) 		5 / 12 ALA A 181
TYR A 258
ASN A 218
GLY A 182
ILE A 185
 None
U  E   3 ( 4.4A)
None
None
None
 1.27A 3vwqA-6c6kA:
undetectable		 3vwqA-6c6kA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1507_0
(FERROCHELATASE,
MITOCHONDRIAL)		 6c6k INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 1
(Homo
sapiens) 		3 / 3 ARG A 388
LYS A 419
ARG A 350
 G  E   8 ( 2.7A)
G  E   8 ( 3.1A)
G  E   6 ( 3.9A)
 1.38A 3w1wA-6c6kA:
undetectable
3w1wB-6c6kA:
undetectable		 3w1wA-6c6kA:
undetectable
3w1wB-6c6kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 6c6k INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 1
(Homo
sapiens) 		3 / 3 ARG A 350
ARG A 388
LYS A 419
 G  E   6 ( 3.9A)
G  E   8 ( 2.7A)
G  E   8 ( 3.1A)
 1.44A 3w1wA-6c6kA:
undetectable
3w1wB-6c6kA:
undetectable		 3w1wA-6c6kA:
undetectable
3w1wB-6c6kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 6c6k INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 1
(Homo
sapiens) 		5 / 9 LEU A 459
ILE A 401
LEU A 405
ILE A 408
ILE A 421
 None
 1.28A 3zosB-6c6kA:
undetectable		 3zosB-6c6kA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 6c6k INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 1
(Homo
sapiens) 		4 / 6 LEU A  59
ASN A 102
LEU A  77
GLU A  79
 None
 1.17A 4nc3A-6c6kA:
undetectable		 4nc3A-6c6kA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_B_ML1B302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 6c6k INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 1
(Homo
sapiens) 		4 / 6 GLY A 356
GLN A 393
PHE A 389
PHE A 365
 None
 1.06A 4qogA-6c6kA:
undetectable
4qogB-6c6kA:
undetectable		 4qogA-6c6kA:
16.37
4qogB-6c6kA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X61_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 6c6k INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 1
(Homo
sapiens) 		5 / 12 LEU A  42
ASN A  58
GLU A  38
LEU A  37
CYH A 154
 None
 1.26A 4x61A-6c6kA:
undetectable		 4x61A-6c6kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_1
(PROTEIN CYP51)		 6c6k INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 1
(Homo
sapiens) 		5 / 12 ALA A 104
ALA A 164
ALA A 162
LEU A  27
THR A  99
 None
 1.06A 5tl8A-6c6kA:
undetectable		 5tl8A-6c6kA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB306_0
(WELO5)		 6c6k INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 1
(Homo
sapiens) 		3 / 3 GLU A 124
ARG A 135
TYR A 136
 None
 0.49A 5trqB-6c6kA:
undetectable		 5trqB-6c6kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 6c6k INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 1
(Homo
sapiens) 		3 / 3 LYS A 222
ASN A 218
SER A 250
 None
 0.91A 5yw0A-6c6kA:
undetectable		 5yw0A-6c6kA:
undetectable