SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6c6l'

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1A8U_A_BEZA295_0 (CHLOROPEROXIDASE T)	6c6l	V-TYPE PROTON ATPASE SUBUNIT A, VACUOLAR ISOFORM (Saccharomyces cerevisiae)	5 / 10	SER A 747 LEU A 750 TRP A 777 LEU A 785 HIS A 428	None	1.31A	1a8uA-6c6lA: undetectable	1a8uA-6c6lA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1A8U_B_BEZB294_0 (CHLOROPEROXIDASE T)	6c6l	V-TYPE PROTON ATPASE SUBUNIT A, VACUOLAR ISOFORM (Saccharomyces cerevisiae)	5 / 10	SER A 747 LEU A 750 TRP A 777 LEU A 785 HIS A 428	None	1.30A	1a8uB-6c6lA: undetectable	1a8uB-6c6lA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1AM6_A_HAEA555_1 (CARBONIC ANHYDRASE)	6c6l	V-TYPE PROTON ATPASE SUBUNIT A, VACUOLAR ISOFORM V-TYPE PROTON ATPASE SUBUNIT C'' (Saccharomyces cerevisiae)	4 / 7	LEU C 101 THR C  98 THR C  97 TRP A 802	None	0.86A	1am6A-6c6lC: undetectable	1am6A-6c6lC: 22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1BRP_A_RTLA183_0 (RETINOL BINDING PROTEIN)	6c6l	V-TYPE PROTON ATPASE SUBUNIT A, VACUOLAR ISOFORM (Saccharomyces cerevisiae)	5 / 12	LEU A 612 GLY A 584 TYR A 585 LEU A 638 GLN A 634	None	1.21A	1brpA-6c6lA: undetectable	1brpA-6c6lA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1C9S_S_TRPS81_0 (TRP RNA-BINDING ATTENUATION PROTEIN)	6c6l	V-TYPE PROTON ATPASE SUBUNIT C'' V-TYPE PROTON ATPASE SUBUNIT C' (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	5 / 9	GLY C 167 ALA D  39 THR C 169 ILE C 165 SER D  41	None	1.42A	1c9sS-6c6lC: undetectable 1c9sT-6c6lC: undetectable	1c9sS-6c6lC: undetectable 1c9sT-6c6lC: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1D0V_A_NIOA991_1 (NICOTINATE MONONUCLEOTIDE:5,6-D IMETHYLBENZIMIDAZOLE PHOSPHORIBOSYLTRANSF ERASE)	6c6l	V-TYPE PROTON ATPASE SUBUNIT A, VACUOLAR ISOFORM (Saccharomyces cerevisiae)	4 / 8	GLY A 339 GLY A  34 LEU A  33 GLY A  37	None	0.68A	1d0vA-6c6lA: undetectable	1d0vA-6c6lA: 14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EE2_A_CHDA1150_1 (ALCOHOL DEHYDROGENASE)	6c6l	V-TYPE PROTON ATPASE SUBUNIT A, VACUOLAR ISOFORM (Saccharomyces cerevisiae)	4 / 4	GLU A 789 MET A 794 LEU A 795 SER A 792	None	1.23A	1ee2B-6c6lA: undetectable	1ee2B-6c6lA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FDS_A_ESTA350_1 (17-BETA-HYDROXYSTERO ID-DEHYDROGENASE)	6c6l	V-TYPE PROTON ATPASE SUBUNIT A, VACUOLAR ISOFORM (Saccharomyces cerevisiae)	5 / 12	LEU A 736 GLY A 424 SER A 797 PHE A 419 MET A 543	None	1.45A	1fdsA-6c6lA: undetectable	1fdsA-6c6lA: 11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FML_B_RTLB501_0 (RETINOL DEHYDRATASE)	6c6l	V-TYPE PROTON ATPASE SUBUNIT A, VACUOLAR ISOFORM V-TYPE PROTON ATPASE SUBUNIT C'' (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	5 / 12	ILE A 541 LEU A 609 LEU A 612 LEU A 734 ILE C 116	None	1.05A	1fmlB-6c6lA: undetectable	1fmlB-6c6lA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1GTF_J_TRPJ81_0 (TRP RNA-BINDING ATTENUATION PROTEIN (TRAP))	6c6l	V-TYPE PROTON ATPASE SUBUNIT C'' V-TYPE PROTON ATPASE SUBUNIT C' (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	5 / 9	SER D  41 GLY C 167 ALA D  39 THR C 169 ILE C 165	None	1.42A	1gtfI-6c6lD: undetectable 1gtfJ-6c6lD: undetectable	1gtfI-6c6lD: undetectable 1gtfJ-6c6lD: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1GTF_T_TRPT81_0 (TRP RNA-BINDING ATTENUATION PROTEIN (TRAP))	6c6l	V-TYPE PROTON ATPASE SUBUNIT C'' V-TYPE PROTON ATPASE SUBUNIT C' (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	5 / 10	GLY C 167 ALA D  39 THR C 169 ILE C 165 SER D  41	None	1.45A	1gtfT-6c6lC: undetectable 1gtfU-6c6lC: undetectable	1gtfT-6c6lC: undetectable 1gtfU-6c6lC: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JHA_A_NIOA991_1 (NICOTINATE MONONUCLEOTIDE:5,6-D IMETHYLBENZIMIDAZOLE PHOSPHORIBOSYLTRANSF ERASE)	6c6l	V-TYPE PROTON ATPASE SUBUNIT A, VACUOLAR ISOFORM (Saccharomyces cerevisiae)	4 / 8	GLY A 339 GLY A  34 LEU A  33 GLY A  37	None	0.70A	1jhaA-6c6lA: undetectable	1jhaA-6c6lA: 14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ME7_A_MOAA600_1 (INOSINE-5'-MONOPHOSP HATE DEHYDROGENASE)	6c6l	V-TYPE PROTON ATPASE SUBUNIT C' V-TYPE PROTON ATPASE SUBUNIT C'' (Saccharomyces cerevisiae)	4 / 8	ASP D 121 SER D  41 GLY C 167 GLY D  47	None	0.77A	1me7A-6c6lD: undetectable	1me7A-6c6lD: 10.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1R15_C_NCAC439_0 (ADP-RIBOSYL CYCLASE)	6c6l	V-TYPE PROTON ATPASE SUBUNIT C'' (Saccharomyces cerevisiae)	3 / 3	TRP C  59 PHE C 146 TRP C 147	None	0.84A	1r15C-6c6lC: undetectable	1r15C-6c6lC: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1R15_F_NCAF469_0 (ADP-RIBOSYL CYCLASE)	6c6l	V-TYPE PROTON ATPASE SUBUNIT C'' (Saccharomyces cerevisiae)	3 / 3	TRP C  59 PHE C 146 TRP C 147	None	0.84A	1r15F-6c6lC: undetectable	1r15F-6c6lC: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1R15_G_NCAG479_0 (ADP-RIBOSYL CYCLASE)	6c6l	V-TYPE PROTON ATPASE SUBUNIT C'' (Saccharomyces cerevisiae)	3 / 3	TRP C  59 PHE C 146 TRP C 147	None	0.84A	1r15G-6c6lC: undetectable	1r15G-6c6lC: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1R15_H_NCAH489_0 (ADP-RIBOSYL CYCLASE)	6c6l	V-TYPE PROTON ATPASE SUBUNIT C'' (Saccharomyces cerevisiae)	3 / 3	TRP C  59 PHE C 146 TRP C 147	None	0.83A	1r15H-6c6lC: undetectable	1r15H-6c6lC: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RMT_B_ADNB1502_1 (CLASS B ACID PHOSPHATASE)	6c6l	V-TYPE PROTON ATPASE SUBUNIT A, VACUOLAR ISOFORM (Saccharomyces cerevisiae)	4 / 7	PHE A 236 GLU A 200 LEU A 203 THR A 215	None	1.26A	1rmtB-6c6lA: undetectable	1rmtB-6c6lA: 15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SBR_A_VIBA502_1 (YKOF)	6c6l	V-TYPE PROTON ATPASE SUBUNIT A, VACUOLAR ISOFORM (Saccharomyces cerevisiae)	4 / 6	ALA A 641 LEU A 642 ILE A 645 CYH A 726	None	0.95A	1sbrA-6c6lA: undetectable 1sbrB-6c6lA: undetectable	1sbrA-6c6lA: 17.00 1sbrB-6c6lA: 17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UTD_C_TRPC81_0 (TRANSCRIPTION ATTENUATION PROTEIN MTRB)	6c6l	V-TYPE PROTON ATPASE SUBUNIT C'' V-TYPE PROTON ATPASE SUBUNIT C' (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	5 / 9	GLY C 167 ALA D  39 THR C 169 ILE C 165 SER D  41	None	1.40A	1utdC-6c6lC: undetectable 1utdD-6c6lC: undetectable	1utdC-6c6lC: undetectable 1utdD-6c6lC: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UTD_D_TRPD81_0 (TRANSCRIPTION ATTENUATION PROTEIN MTRB)	6c6l	V-TYPE PROTON ATPASE SUBUNIT C'' V-TYPE PROTON ATPASE SUBUNIT C' (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	5 / 9	GLY C 167 ALA D  39 THR C 169 ILE C 165 SER D  41	None	1.43A	1utdD-6c6lC: undetectable 1utdE-6c6lC: undetectable	1utdD-6c6lC: undetectable 1utdE-6c6lC: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UTD_K_TRPK81_0 (TRANSCRIPTION ATTENUATION PROTEIN MTRB)	6c6l	V-TYPE PROTON ATPASE SUBUNIT C'' V-TYPE PROTON ATPASE SUBUNIT C' (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	5 / 9	SER D  41 GLY C 167 ALA D  39 THR C 169 ILE C 165	None	1.42A	1utdA-6c6lD: undetectable 1utdK-6c6lD: undetectable	1utdA-6c6lD: undetectable 1utdK-6c6lD: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1Y0X_X_T44X500_1 (THYROID HORMONE RECEPTOR BETA-1)	6c6l	V-TYPE PROTON ATPASE SUBUNIT D (Saccharomyces cerevisiae)	5 / 12	ILE B 200 ALA B 204 ARG B  18 PHE B 195 PHE B 192	None	1.33A	1y0xX-6c6lB: undetectable	1y0xX-6c6lB: 14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ZEA_A_DHIA6_0 (MONOCLONAL ANTI-CHOLERA TOXIN IGG1 KAPPA ANTIBODY, H CHAIN MONOCLONAL ANTI-CHOLERA TOXIN IGG1 KAPPA ANTIBODY, L CHAIN SHORT SYNTHETIC D-AMINO ACID PEPTIDE D2)	6c6l	V-TYPE PROTON ATPASE SUBUNIT D (Saccharomyces cerevisiae)	3 / 3	TRP B 312 ARG B  18 PHE B 300	None	1.30A	1zeaH-6c6lB: undetectable 1zeaL-6c6lB: undetectable	1zeaH-6c6lB: undetectable 1zeaL-6c6lB: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2BTE_A_LEUA1894_0 (AMINOACYL-TRNA SYNTHETASE)	6c6l	V-TYPE PROTON ATPASE SUBUNIT A, VACUOLAR ISOFORM (Saccharomyces cerevisiae)	4 / 8	TYR A 110 ASP A 312 SER A 308 TYR A  73	None	1.09A	2bteA-6c6lA: undetectable	2bteA-6c6lA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2BTE_D_LEUD1893_0 (AMINOACYL-TRNA SYNTHETASE)	6c6l	V-TYPE PROTON ATPASE SUBUNIT A, VACUOLAR ISOFORM (Saccharomyces cerevisiae)	4 / 8	TYR A 110 ASP A 312 SER A 308 TYR A  73	None	1.12A	2bteD-6c6lA: 2.1	2bteD-6c6lA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2BXE_A_1FLA2002_1 (SERUM ALBUMIN)	6c6l	V-TYPE PROTON ATPASE SUBUNIT C' (Saccharomyces cerevisiae)	5 / 10	PHE D  18 ALA D  21 ALA D  25 LEU D  29 LEU D 103	None	1.19A	2bxeA-6c6lD: undetectable	2bxeA-6c6lD: 9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2C49_A_ADNA1301_1 (SUGAR KINASE MJ0406)	6c6l	V-TYPE PROTON ATPASE SUBUNIT C'' V-TYPE PROTON ATPASE SUBUNIT D (Saccharomyces cerevisiae)	5 / 12	ALA C  89 GLY C  88 GLY B  15 ALA C 171 GLN B 303	None	0.97A	2c49A-6c6lC: undetectable	2c49A-6c6lC: 14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2F8L_A_SAMA400_0 (HYPOTHETICAL PROTEIN LMO1582)	6c6l	V-TYPE PROTON ATPASE SUBUNIT D (Saccharomyces cerevisiae)	6 / 12	ALA B 257 ASN B 226 LEU B 228 ASP B 240 LEU B 241 PRO B 235	None	1.31A	2f8lA-6c6lB: undetectable	2f8lA-6c6lB: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2JN3_A_JN3A131_2 (FATTY ACID-BINDING PROTEIN, LIVER)	6c6l	V-TYPE PROTON ATPASE SUBUNIT A, VACUOLAR ISOFORM (Saccharomyces cerevisiae)	4 / 6	LEU A  33 GLN A  23 ILE A  21 PHE A  19	None	1.12A	2jn3A-6c6lA: undetectable	2jn3A-6c6lA: 21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2M9Q_B_BEZB251_0 (SERINE PROTEASE INHIBITOR SERINE PROTEASE SUBUNIT NS2B, SERINE PROTEASE NS3)	6c6l	V-TYPE PROTON ATPASE SUBUNIT A, VACUOLAR ISOFORM (Saccharomyces cerevisiae)	5 / 9	LEU A 586 ILE A 582 PHE A 616 VAL A 727 LEU A 612	None	1.15A	2m9qA-6c6lA: undetectable	2m9qA-6c6lA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2M9Q_B_BEZB251_0 (SERINE PROTEASE INHIBITOR SERINE PROTEASE SUBUNIT NS2B, SERINE PROTEASE NS3)	6c6l	V-TYPE PROTON ATPASE SUBUNIT A, VACUOLAR ISOFORM V-TYPE PROTON ATPASE SUBUNIT F (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	5 / 9	LEU O  24 ILE A 755 PHE O  31 THR A 770 ALA O  58	None	1.05A	2m9qA-6c6lO: undetectable	2m9qA-6c6lO: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NNH_B_9CRB502_1 (CYTOCHROME P450 2C8)	6c6l	V-TYPE PROTON ATPASE SUBUNIT D (Saccharomyces cerevisiae)	5 / 10	ILE B 326 ILE B 323 LEU B  33 ASN B  32 ILE B  31	None	1.21A	2nnhB-6c6lB: undetectable	2nnhB-6c6lB: 11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V0M_B_KLNB1499_1 (CYTOCHROME P450 3A4)	6c6l	V-TYPE PROTON ATPASE SUBUNIT A, VACUOLAR ISOFORM (Saccharomyces cerevisiae)	4 / 7	PHE A 822 ILE A  25 ILE A 357 GLY A  34	None	0.88A	2v0mB-6c6lA: undetectable	2v0mB-6c6lA: 10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2W9S_A_TOPA1160_1 (DIHYDROFOLATE REDUCTASE TYPE 1 FROM TN4003)	6c6l	V-TYPE PROTON ATPASE SUBUNIT D (Saccharomyces cerevisiae)	5 / 11	ILE B 200 LEU B 212 ILE B  98 PHE B  94 THR B 197	None	0.99A	2w9sA-6c6lB: undetectable	2w9sA-6c6lB: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2W9S_B_TOPB1160_1 (DIHYDROFOLATE REDUCTASE TYPE 1 FROM TN4003)	6c6l	V-TYPE PROTON ATPASE SUBUNIT D (Saccharomyces cerevisiae)	5 / 11	ILE B 200 LEU B 212 ILE B  98 PHE B  94 THR B 197	None	0.96A	2w9sB-6c6lB: undetectable	2w9sB-6c6lB: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2X2I_C_QPSC1060_1 (ALPHA-1,4-GLUCAN LYASE ISOZYME 1)	6c6l	V-TYPE PROTON ATPASE SUBUNIT A, VACUOLAR ISOFORM (Saccharomyces cerevisiae)	5 / 12	PHE A 143 ASN A 259 VAL A 190 GLY A 189 ALA A 235	None	1.19A	2x2iC-6c6lA: undetectable	2x2iC-6c6lA: 6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZJ0_D_2FAD500_2 (ADENOSYLHOMOCYSTEINA SE)	6c6l	V-TYPE PROTON ATPASE SUBUNIT A, VACUOLAR ISOFORM V-TYPE PROTON ATPASE SUBUNIT D (Saccharomyces cerevisiae)	4 / 4	LEU A 256 GLN A 201 THR A 198 THR B 138	None	1.49A	2zj0D-6c6lA: undetectable	2zj0D-6c6lA: 9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZW9_B_SAMB801_0 (LEUCINE CARBOXYL METHYLTRANSFERASE 2)	6c6l	V-TYPE PROTON ATPASE SUBUNIT C' (Saccharomyces cerevisiae)	5 / 12	GLY D 123 GLY D 120 ASP D 121 LEU D 141 LEU D 133	None	0.94A	2zw9B-6c6lD: undetectable	2zw9B-6c6lD: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3A50_D_VD3D2001_1 (VITAMIN D HYDROXYLASE)	6c6l	V-TYPE PROTON ATPASE SUBUNIT A, VACUOLAR ISOFORM V-TYPE PROTON ATPASE SUBUNIT F (Saccharomyces cerevisiae)	5 / 12	PRO O  45 ILE A 755 LEU O  30 ASN O  34 LEU O  24	None	1.03A	3a50D-6c6lO: undetectable	3a50D-6c6lO: 12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3A50_E_VD3E2001_1 (VITAMIN D HYDROXYLASE)	6c6l	V-TYPE PROTON ATPASE SUBUNIT A, VACUOLAR ISOFORM V-TYPE PROTON ATPASE SUBUNIT F (Saccharomyces cerevisiae)	5 / 12	PRO O  45 ILE A 755 LEU O  30 ASN O  34 LEU O  24	None	1.06A	3a50E-6c6lO: undetectable	3a50E-6c6lO: 12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BOG_D_DHID8_0 (6.5 KDA GLYCINE-RICH ANTIFREEZE PROTEIN)	6c6l	V-TYPE PROTON ATPASE SUBUNIT A, VACUOLAR ISOFORM (Saccharomyces cerevisiae)	4 / 4	SER A 472 GLY A 469 GLY A 476 GLY A 427	None	0.88A	3bogB-6c6lA: undetectable 3bogD-6c6lA: undetectable	3bogB-6c6lA: undetectable 3bogD-6c6lA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3DZU_A_9CRA7223_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	6c6l	V-TYPE PROTON ATPASE SUBUNIT D (Saccharomyces cerevisiae)	5 / 12	ILE B 221 ALA B 224 LEU B 256 HIS B 287 LEU B 284	None	1.11A	3dzuA-6c6lB: undetectable	3dzuA-6c6lB: 11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3E9R_A_ACTA700_0 (PURINE-NUCLEOSIDE PHOSPHORYLASE)	6c6l	V-TYPE PROTON ATPASE SUBUNIT D (Saccharomyces cerevisiae)	4 / 6	GLY B  11 GLU B  14 GLY B  15 ASN B   7	None	0.82A	3e9rA-6c6lB: undetectable	3e9rA-6c6lB: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3E9R_C_ACTC700_0 (PURINE-NUCLEOSIDE PHOSPHORYLASE)	6c6l	V-TYPE PROTON ATPASE SUBUNIT D (Saccharomyces cerevisiae)	4 / 6	GLY B  11 GLU B  14 GLY B  15 ASN B   7	None	0.83A	3e9rC-6c6lB: undetectable	3e9rC-6c6lB: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HCN_A_CHDA3_0 (FERROCHELATASE, MITOCHONDRIAL)	6c6l	V-TYPE PROTON ATPASE SUBUNIT C' (Saccharomyces cerevisiae)	4 / 7	LEU D  55 ARG D 125 PRO D  62 GLY D  42	None	1.02A	3hcnA-6c6lD: undetectable	3hcnA-6c6lD: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3IB1_A_IMNA701_1 (LACTOTRANSFERRIN)	6c6l	V-TYPE PROTON ATPASE SUBUNIT A, VACUOLAR ISOFORM (Saccharomyces cerevisiae)	4 / 4	PRO A 816 THR A 379 GLY A 408 THR A 411	None	1.18A	3ib1A-6c6lA: undetectable	3ib1A-6c6lA: 12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KEE_B_30BB500_2 (GENOME POLYPROTEIN)	6c6l	V-TYPE PROTON ATPASE SUBUNIT A, VACUOLAR ISOFORM (Saccharomyces cerevisiae)	3 / 3	PHE A 545 TYR A 552 LEU A 736	None	0.77A	3keeB-6c6lA: undetectable	3keeB-6c6lA: 15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LS4_H_TCIH220_2 (HEAVY CHAIN OF ANTIBODY FAB FRAGMENT LIGHT CHAIN OF ANTIBODY FAB FRAGMENT)	6c6l	V-TYPE PROTON ATPASE SUBUNIT A, VACUOLAR ISOFORM (Saccharomyces cerevisiae)	4 / 5	TYR A 550 ILE A   8 LEU A 409 PHE A 554	None	1.26A	3ls4L-6c6lA: undetectable	3ls4L-6c6lA: 21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NDT_D_ROCD100_1 (PROTEASE)	6c6l	V-TYPE PROTON ATPASE SUBUNIT C'' (Saccharomyces cerevisiae)	5 / 12	LEU C 203 GLY C 114 ILE C 150 GLY C  63 ILE C  64	None	0.86A	3ndtC-6c6lC: undetectable	3ndtC-6c6lC: 20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NDU_D_ROCD100_1 (PROTEASE)	6c6l	V-TYPE PROTON ATPASE SUBUNIT C'' (Saccharomyces cerevisiae)	5 / 12	LEU C 203 GLY C 114 ILE C 150 GLY C  63 ILE C  64	None	0.85A	3nduC-6c6lC: undetectable	3nduC-6c6lC: 20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OXC_A_ROCA401_3 (PROTEASE)	6c6l	V-TYPE PROTON ATPASE SUBUNIT C'' (Saccharomyces cerevisiae)	5 / 12	LEU C 203 GLY C 114 ILE C 150 GLY C  63 ILE C  64	None	1.02A	3oxcB-6c6lC: undetectable	3oxcB-6c6lC: 20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3P2K_C_SAMC6735_1 (16S RRNA METHYLASE)	6c6l	V-TYPE PROTON ATPASE SUBUNIT D V-TYPE PROTON ATPASE SUBUNIT C'' (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	4 / 5	ASN B  22 ASP C 174 GLU C 188 THR C  82	None	1.31A	3p2kC-6c6lB: undetectable	3p2kC-6c6lB: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3P2K_D_SAMD6735_1 (16S RRNA METHYLASE)	6c6l	V-TYPE PROTON ATPASE SUBUNIT D V-TYPE PROTON ATPASE SUBUNIT C'' (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	4 / 4	ASN B  22 ASP C 174 GLU C 188 THR C  82	None	1.27A	3p2kD-6c6lB: undetectable	3p2kD-6c6lB: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3P50_A_PFLA319_1 (GLR4197 PROTEIN)	6c6l	V-TYPE PROTON ATPASE SUBUNIT C'' (Saccharomyces cerevisiae)	4 / 7	ILE C 184 LEU C 185 THR C 169 ASN C 100	None	0.88A	3p50A-6c6lC: 3.5	3p50A-6c6lC: 13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3P50_B_PFLB319_1 (GLR4197 PROTEIN)	6c6l	V-TYPE PROTON ATPASE SUBUNIT C'' (Saccharomyces cerevisiae)	4 / 7	ILE C 184 LEU C 185 THR C 169 ASN C 100	None	0.89A	3p50B-6c6lC: 3.5	3p50B-6c6lC: 13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3P50_C_PFLC319_1 (GLR4197 PROTEIN)	6c6l	V-TYPE PROTON ATPASE SUBUNIT C'' (Saccharomyces cerevisiae)	4 / 7	ILE C 184 LEU C 185 THR C 169 ASN C 100	None	0.89A	3p50C-6c6lC: 3.5	3p50C-6c6lC: 13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3P50_D_PFLD320_1 (GLR4197 PROTEIN)	6c6l	V-TYPE PROTON ATPASE SUBUNIT C'' (Saccharomyces cerevisiae)	4 / 7	ILE C 184 LEU C 185 THR C 169 ASN C 100	None	0.89A	3p50D-6c6lC: 3.5	3p50D-6c6lC: 13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3P50_E_PFLE319_1 (GLR4197 PROTEIN)	6c6l	V-TYPE PROTON ATPASE SUBUNIT C'' (Saccharomyces cerevisiae)	4 / 7	ILE C 184 LEU C 185 THR C 169 ASN C 100	None	0.91A	3p50E-6c6lC: 3.5	3p50E-6c6lC: 13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PFG_A_SAMA264_1 (N-METHYLTRANSFERASE)	6c6l	V-TYPE PROTON ATPASE SUBUNIT D (Saccharomyces cerevisiae)	3 / 3	TYR B  97 TYR B 161 GLU B 198	None	0.91A	3pfgA-6c6lB: undetectable	3pfgA-6c6lB: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3SUG_A_SUEA1201_2 (NS3 PROTEASE, NS4A PROTEIN)	6c6l	V-TYPE PROTON ATPASE SUBUNIT D (Saccharomyces cerevisiae)	4 / 5	GLN B 258 PHE B 254 LEU B 241 LYS B 238	None	1.49A	3sugA-6c6lB: undetectable	3sugA-6c6lB: 16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3T3Z_A_9PLA501_1 (CYTOCHROME P450 2E1)	6c6l	V-TYPE PROTON ATPASE SUBUNIT A, VACUOLAR ISOFORM V-TYPE PROTON ATPASE SUBUNIT E (Saccharomyces cerevisiae)	5 / 6	LEU M  46 PHE A 417 ALA A 420 THR A 475 LEU A 539	None	1.42A	3t3zA-6c6lM: undetectable	3t3zA-6c6lM: 8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3T3Z_A_9PLA501_1 (CYTOCHROME P450 2E1)	6c6l	V-TYPE PROTON ATPASE SUBUNIT A, VACUOLAR ISOFORM V-TYPE PROTON ATPASE SUBUNIT E (Saccharomyces cerevisiae)	5 / 6	LEU M  46 PHE A 417 ALA A 420 THR A 475 LEU A 736	None	1.41A	3t3zA-6c6lM: undetectable	3t3zA-6c6lM: 8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3T3Z_B_9PLB501_1 (CYTOCHROME P450 2E1)	6c6l	V-TYPE PROTON ATPASE SUBUNIT A, VACUOLAR ISOFORM V-TYPE PROTON ATPASE SUBUNIT E (Saccharomyces cerevisiae)	5 / 6	LEU M  46 PHE A 417 ALA A 420 THR A 475 LEU A 539	None	1.40A	3t3zB-6c6lM: undetectable	3t3zB-6c6lM: 8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3T3Z_B_9PLB501_1 (CYTOCHROME P450 2E1)	6c6l	V-TYPE PROTON ATPASE SUBUNIT A, VACUOLAR ISOFORM V-TYPE PROTON ATPASE SUBUNIT E (Saccharomyces cerevisiae)	5 / 6	LEU M  46 PHE A 417 ALA A 420 THR A 475 LEU A 736	None	1.41A	3t3zB-6c6lM: undetectable	3t3zB-6c6lM: 8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3T3Z_C_9PLC501_1 (CYTOCHROME P450 2E1)	6c6l	V-TYPE PROTON ATPASE SUBUNIT A, VACUOLAR ISOFORM (Saccharomyces cerevisiae)	4 / 5	PHE A 417 ALA A 420 THR A 475 LEU A 736	None	1.15A	3t3zC-6c6lA: undetectable	3t3zC-6c6lA: 10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3T3Z_D_9PLD501_1 (CYTOCHROME P450 2E1)	6c6l	V-TYPE PROTON ATPASE SUBUNIT A, VACUOLAR ISOFORM V-TYPE PROTON ATPASE SUBUNIT E (Saccharomyces cerevisiae)	5 / 6	LEU M  46 PHE A 417 ALA A 420 THR A 475 LEU A 539	None	1.46A	3t3zD-6c6lM: undetectable	3t3zD-6c6lM: 8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3T3Z_D_9PLD501_1 (CYTOCHROME P450 2E1)	6c6l	V-TYPE PROTON ATPASE SUBUNIT A, VACUOLAR ISOFORM V-TYPE PROTON ATPASE SUBUNIT E (Saccharomyces cerevisiae)	5 / 6	LEU M  46 PHE A 417 ALA A 420 THR A 475 LEU A 736	None	1.38A	3t3zD-6c6lM: undetectable	3t3zD-6c6lM: 8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3U7S_A_017A202_1 (POL POLYPROTEIN)	6c6l	V-TYPE PROTON ATPASE SUBUNIT C'' (Saccharomyces cerevisiae)	5 / 9	LEU C 199 ILE C 150 GLY C  63 ILE C  64 LEU C 203	None	1.13A	3u7sA-6c6lC: undetectable	3u7sA-6c6lC: 21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3W1W_A_CHDA1507_0 (FERROCHELATASE, MITOCHONDRIAL)	6c6l	V-TYPE PROTON ATPASE SUBUNIT F (Saccharomyces cerevisiae)	3 / 3	ARG O   2 LYS O   2 ARG O  77	None	1.07A	3w1wA-6c6lO: undetectable 3w1wB-6c6lO: undetectable	3w1wA-6c6lO: undetectable 3w1wB-6c6lO: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3W1W_B_CHDB506_0 (FERROCHELATASE, MITOCHONDRIAL)	6c6l	V-TYPE PROTON ATPASE SUBUNIT F (Saccharomyces cerevisiae)	3 / 3	ARG O  77 ARG O   2 LYS O   2	None	1.12A	3w1wA-6c6lO: undetectable 3w1wB-6c6lO: undetectable	3w1wA-6c6lO: undetectable 3w1wB-6c6lO: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DR5_A_SRYA1860_1 (16S RRNA 30S RIBOSOMAL PROTEIN S12)	6c6l	V-TYPE PROTON ATPASE SUBUNIT C' V-TYPE PROTON ATPASE SUBUNIT D (Saccharomyces cerevisiae)	3 / 3	LYS B   2 PRO B 203 LYS D  40	None	0.97A	4dr5L-6c6lB: undetectable	4dr5L-6c6lB: 19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DR6_A_SRYA1956_1 (16S RRNA 30S RIBOSOMAL PROTEIN S12)	6c6l	V-TYPE PROTON ATPASE SUBUNIT C' V-TYPE PROTON ATPASE SUBUNIT D (Saccharomyces cerevisiae)	3 / 3	LYS B   2 PRO B 203 LYS D  40	None	0.98A	4dr6L-6c6lB: undetectable	4dr6L-6c6lB: 19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DUZ_A_SRYA1601_1 (16S RRNA RIBOSOMAL PROTEIN S12)	6c6l	V-TYPE PROTON ATPASE SUBUNIT C' V-TYPE PROTON ATPASE SUBUNIT D (Saccharomyces cerevisiae)	3 / 3	LYS B   2 PRO B 203 LYS D  40	None	1.15A	4duzL-6c6lB: undetectable	4duzL-6c6lB: 19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DV7_A_SRYA1601_1 (16S RRNA RIBOSOMAL PROTEIN S12)	6c6l	V-TYPE PROTON ATPASE SUBUNIT C' V-TYPE PROTON ATPASE SUBUNIT D (Saccharomyces cerevisiae)	3 / 3	LYS B   2 PRO B 203 LYS D  40	None	0.89A	4dv7L-6c6lB: undetectable	4dv7L-6c6lB: 19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4E47_A_SAMA401_0 (HISTONE-LYSINE N-METHYLTRANSFERASE SETD7)	6c6l	V-TYPE PROTON ATPASE SUBUNIT C'' V-TYPE PROTON ATPASE SUBUNIT C' (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	5 / 11	ILE C  81 ALA C 168 GLY C 167 GLU C 188 GLY D  44	None	1.23A	4e47A-6c6lC: undetectable	4e47A-6c6lC: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4E47_B_SAMB800_0 (HISTONE-LYSINE N-METHYLTRANSFERASE SETD7)	6c6l	V-TYPE PROTON ATPASE SUBUNIT C'' V-TYPE PROTON ATPASE SUBUNIT C' (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	5 / 11	ILE C  81 ALA C 168 GLY C 167 GLU C 188 GLY D  44	None	1.22A	4e47B-6c6lC: undetectable	4e47B-6c6lC: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4E47_C_SAMC800_0 (HISTONE-LYSINE N-METHYLTRANSFERASE SETD7)	6c6l	V-TYPE PROTON ATPASE SUBUNIT C'' V-TYPE PROTON ATPASE SUBUNIT C' (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	5 / 11	ILE C  81 ALA C 168 GLY C 167 GLU C 188 GLY D  44	None	1.23A	4e47C-6c6lC: undetectable	4e47C-6c6lC: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4F4D_B_CHDB503_0 (FERROCHELATASE, MITOCHONDRIAL)	6c6l	V-TYPE PROTON ATPASE SUBUNIT A, VACUOLAR ISOFORM V-TYPE PROTON ATPASE SUBUNIT D V0 ASSEMBLY PROTEIN 1 (Saccharomyces cerevisiae; Saccharomyces cerevisiae; Saccharomyces cerevisiae)	4 / 8	ILE A 202 ARG A 205 PRO N 260 TRP B 132	None	0.99A	4f4dB-6c6lA: undetectable	4f4dB-6c6lA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FGL_A_CLQA303_0 (RIBOSYLDIHYDRONICOTI NAMIDE DEHYDROGENASE [QUINONE])	6c6l	V-TYPE PROTON ATPASE SUBUNIT C'' V-TYPE PROTON ATPASE SUBUNIT C' (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	5 / 12	GLY C 195 ASN C 156 ILE C 193 VAL D  75 ILE C 200	None	1.20A	4fglA-6c6lC: undetectable 4fglB-6c6lC: undetectable	4fglA-6c6lC: undetectable 4fglB-6c6lC: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FIA_A_0U9A601_1 (CHOLESTEROL 24-HYDROXYLASE)	6c6l	V-TYPE PROTON ATPASE SUBUNIT D (Saccharomyces cerevisiae)	5 / 12	PHE B 288 TYR B 275 LEU B 269 VAL B 272 ALA B 252	None	1.21A	4fiaA-6c6lB: undetectable	4fiaA-6c6lB: 10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FIA_A_198A602_1 (CHOLESTEROL 24-HYDROXYLASE)	6c6l	V-TYPE PROTON ATPASE SUBUNIT D (Saccharomyces cerevisiae)	5 / 12	PHE B 288 TYR B 275 LEU B 269 VAL B 272 ALA B 252	None	1.21A	4fiaA-6c6lB: undetectable	4fiaA-6c6lB: 10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FWD_A_BO2A801_1 (TTC1975 PEPTIDASE)	6c6l	V-TYPE PROTON ATPASE SUBUNIT C'' (Saccharomyces cerevisiae)	5 / 9	VAL C 201 VAL C 120 ILE C 117 GLY C 153 SER C 155	None	1.22A	4fwdA-6c6lC: undetectable	4fwdA-6c6lC: 9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_B_15UB402_1 (PROTHROMBIN)	6c6l	V-TYPE PROTON ATPASE SUBUNIT C' V-TYPE PROTON ATPASE SUBUNIT C'' (Saccharomyces cerevisiae)	5 / 12	ALA C 162 ILE C 184 ASP D 121 GLY D  42 GLY D  44	None	1.24A	4hfpB-6c6lC: undetectable	4hfpB-6c6lC: 17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IB4_A_ERMA2001_2 (CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 2B AND E. COLI SOLUBLE CYTOCHROME B562)	6c6l	V-TYPE PROTON ATPASE SUBUNIT A, VACUOLAR ISOFORM (Saccharomyces cerevisiae)	4 / 7	THR A 549 LEU A 586 GLN A 634 LEU A 637	None	1.10A	4ib4A-6c6lA: undetectable	4ib4A-6c6lA: 10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4JDS_A_SAMA401_0 (HISTONE-LYSINE N-METHYLTRANSFERASE SETD7)	6c6l	V-TYPE PROTON ATPASE SUBUNIT C'' V-TYPE PROTON ATPASE SUBUNIT C' (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	5 / 11	ILE C  81 ALA C 168 GLY C 167 GLU C 188 GLY D  44	None	1.20A	4jdsA-6c6lC: undetectable	4jdsA-6c6lC: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4JDS_B_SAMB401_0 (HISTONE-LYSINE N-METHYLTRANSFERASE SETD7)	6c6l	V-TYPE PROTON ATPASE SUBUNIT C'' V-TYPE PROTON ATPASE SUBUNIT C' (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	5 / 11	ILE C  81 ALA C 168 GLY C 167 GLU C 188 GLY D  44	None	1.20A	4jdsB-6c6lC: undetectable	4jdsB-6c6lC: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4JDS_C_SAMC401_0 (HISTONE-LYSINE N-METHYLTRANSFERASE SETD7)	6c6l	V-TYPE PROTON ATPASE SUBUNIT C'' V-TYPE PROTON ATPASE SUBUNIT C' (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	5 / 11	ILE C  81 ALA C 168 GLY C 167 GLU C 188 GLY D  44	None	1.21A	4jdsC-6c6lC: undetectable	4jdsC-6c6lC: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4JLG_A_SAMA401_0 (HISTONE-LYSINE N-METHYLTRANSFERASE SETD7)	6c6l	V-TYPE PROTON ATPASE SUBUNIT C'' V-TYPE PROTON ATPASE SUBUNIT C' (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	5 / 12	ILE C  81 ALA C 168 GLY C 167 GLU C 188 GLY D  44	None	1.24A	4jlgA-6c6lC: undetectable	4jlgA-6c6lC: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4JVL_A_ESTA702_1 (ESTROGEN SULFOTRANSFERASE)	6c6l	V-TYPE PROTON ATPASE SUBUNIT A, VACUOLAR ISOFORM (Saccharomyces cerevisiae)	4 / 9	PHE A 583 CYH A 726 PHE A 616 ILE A 645	None	1.19A	4jvlA-6c6lA: undetectable	4jvlA-6c6lA: 12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4L4C_B_CAMB502_0 (CAMPHOR 5-MONOOXYGENASE)	6c6l	V-TYPE PROTON ATPASE SUBUNIT C'' V0 ASSEMBLY PROTEIN 1 (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	4 / 8	LEU C 157 VAL C  73 VAL N 239 ILE N 236	None	0.84A	4l4cB-6c6lC: undetectable	4l4cB-6c6lC: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MK4_A_CHDA503_0 (FERROCHELATASE, MITOCHONDRIAL)	6c6l	V-TYPE PROTON ATPASE SUBUNIT A, VACUOLAR ISOFORM V-TYPE PROTON ATPASE SUBUNIT D (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	5 / 10	LEU A 207 LEU A 203 LEU A 199 ILE A 245 VAL B 141	None	1.39A	4mk4A-6c6lA: undetectable	4mk4A-6c6lA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4NQA_H_9CRH501_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	6c6l	V-TYPE PROTON ATPASE SUBUNIT D (Saccharomyces cerevisiae)	5 / 12	ILE B 221 ALA B 224 LEU B 256 HIS B 287 LEU B 284	None	0.99A	4nqaH-6c6lB: undetectable	4nqaH-6c6lB: 14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4R3A_B_RBFB402_2 (BLUE-LIGHT-ACTIVATED HISTIDINE KINASE 2)	6c6l	V-TYPE PROTON ATPASE SUBUNIT A, VACUOLAR ISOFORM V-TYPE PROTON ATPASE SUBUNIT C' V-TYPE PROTON ATPASE SUBUNIT C'' (Saccharomyces cerevisiae)	5 / 12	ALA D  77 LEU D  74 ALA C 206 ILE A 613 LEU A 617	None	0.96A	4r3aB-6c6lD: undetectable	4r3aB-6c6lD: 11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XP6_A_B40A601_1 (TRANSPORTER)	6c6l	V-TYPE PROTON ATPASE SUBUNIT C' V-TYPE PROTON ATPASE SUBUNIT D (Saccharomyces cerevisiae)	4 / 5	ASP B 298 VAL D 122 ASP D 121 GLY D  44	None	1.13A	4xp6A-6c6lB: undetectable	4xp6A-6c6lB: 11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XR4_B_AG2B511_1 (HOMOSPERMIDINE SYNTHASE)	6c6l	V-TYPE PROTON ATPASE SUBUNIT A, VACUOLAR ISOFORM (Saccharomyces cerevisiae)	3 / 3	VAL A 216 PHE A 151 ARG A 270	None	0.90A	4xr4B-6c6lA: undetectable	4xr4B-6c6lA: 11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YFB_L_PACL601_0 (PROTEIN RELATED TO PENICILLIN ACYLASE)	6c6l	V-TYPE PROTON ATPASE SUBUNIT A, VACUOLAR ISOFORM (Saccharomyces cerevisiae)	5 / 12	PRO A 416 PHE A 390 PHE A 386 ILE A 464 VAL A 470	None	1.29A	4yfbL-6c6lA: 0.7	4yfbL-6c6lA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Z4H_A_IPHA904_0 (PROTEIN ARGONAUTE-2)	6c6l	V-TYPE PROTON ATPASE SUBUNIT D V-TYPE PROTON ATPASE SUBUNIT C' (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	4 / 5	GLN B 302 PRO B 203 ILE D  43 ASP D 121	None	1.45A	4z4hA-6c6lB: undetectable	4z4hA-6c6lB: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5AQF_A_ADNA1382_1 (HEAT SHOCK COGNATE 71 KDA PROTEIN)	6c6l	V-TYPE PROTON ATPASE SUBUNIT C' (Saccharomyces cerevisiae)	5 / 10	GLY D  37 SER D  59 GLY D 120 SER D  41 ILE D  45	None	1.02A	5aqfA-6c6lD: undetectable	5aqfA-6c6lD: 12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5AQF_C_ADNC1382_1 (HEAT SHOCK COGNATE 71 KDA PROTEIN)	6c6l	V-TYPE PROTON ATPASE SUBUNIT C' (Saccharomyces cerevisiae)	5 / 10	GLY D  37 SER D  59 GLY D 120 SER D  41 ILE D  45	None	1.04A	5aqfC-6c6lD: undetectable	5aqfC-6c6lD: 12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5AYF_A_SAMA401_0 (HISTONE-LYSINE N-METHYLTRANSFERASE SETD7)	6c6l	V-TYPE PROTON ATPASE SUBUNIT C'' V-TYPE PROTON ATPASE SUBUNIT C' (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	5 / 11	ILE C  81 ALA C 168 GLY C 167 GLU C 188 GLY D  44	None	1.24A	5ayfA-6c6lC: undetectable	5ayfA-6c6lC: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CDN_N_EVPN2101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B,DNA GYRASE SUBUNIT B)	6c6l	V-TYPE PROTON ATPASE SUBUNIT D (Saccharomyces cerevisiae)	4 / 6	GLU B 317 GLY B  15 ARG B  18 GLY B  19	None	0.89A	5cdnR-6c6lB: 1.3 5cdnS-6c6lB: undetectable	5cdnR-6c6lB: 9.11 5cdnS-6c6lB: 15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CXV_A_0HKA501_2 (MUSCARINIC ACETYLCHOLINE RECEPTOR M1,ENDOLYSIN,MUSCARI NIC ACETYLCHOLINE RECEPTOR M1)	6c6l	V-TYPE PROTON ATPASE SUBUNIT A, VACUOLAR ISOFORM (Saccharomyces cerevisiae)	3 / 3	THR A 411 THR A 414 PHE A 419	None	0.60A	5cxvA-6c6lA: undetectable	5cxvA-6c6lA: 8.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EEU_B_TRPB101_0 (TRANSCRIPTION ATTENUATION PROTEIN MTRB)	6c6l	V-TYPE PROTON ATPASE SUBUNIT C'' V-TYPE PROTON ATPASE SUBUNIT C' (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	5 / 9	SER D  41 GLY C 167 ALA D  39 THR C 169 ILE C 165	None	1.43A	5eeuB-6c6lD: undetectable 5eeuC-6c6lD: undetectable	5eeuB-6c6lD: undetectable 5eeuC-6c6lD: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EEV_B_TRPB101_0 (TRANSCRIPTION ATTENUATION PROTEIN MTRB)	6c6l	V-TYPE PROTON ATPASE SUBUNIT C'' V-TYPE PROTON ATPASE SUBUNIT C' (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	5 / 9	SER D  41 GLY C 167 ALA D  39 THR C 169 ILE C 165	None	1.43A	5eevB-6c6lD: undetectable 5eevC-6c6lD: undetectable	5eevB-6c6lD: undetectable 5eevC-6c6lD: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EEW_B_TRPB101_0 (TRANSCRIPTION ATTENUATION PROTEIN MTRB)	6c6l	V-TYPE PROTON ATPASE SUBUNIT C'' V-TYPE PROTON ATPASE SUBUNIT C' (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	5 / 9	SER D  41 GLY C 167 ALA D  39 THR C 169 ILE C 165	None	1.42A	5eewB-6c6lD: undetectable 5eewC-6c6lD: undetectable	5eewB-6c6lD: undetectable 5eewC-6c6lD: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EEX_B_TRPB101_0 (TRANSCRIPTION ATTENUATION PROTEIN MTRB)	6c6l	V-TYPE PROTON ATPASE SUBUNIT C'' V-TYPE PROTON ATPASE SUBUNIT C' (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	5 / 9	SER D  41 GLY C 167 ALA D  39 THR C 169 ILE C 165	None	1.42A	5eexB-6c6lD: undetectable 5eexC-6c6lD: undetectable	5eexB-6c6lD: undetectable 5eexC-6c6lD: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EEY_B_TRPB101_0 (TRANSCRIPTION ATTENUATION PROTEIN MTRB)	6c6l	V-TYPE PROTON ATPASE SUBUNIT C'' V-TYPE PROTON ATPASE SUBUNIT C' (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	5 / 9	SER D  41 GLY C 167 ALA D  39 THR C 169 ILE C 165	None	1.42A	5eeyB-6c6lD: undetectable 5eeyC-6c6lD: undetectable	5eeyB-6c6lD: undetectable 5eeyC-6c6lD: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EEZ_B_TRPB101_0 (TRANSCRIPTION ATTENUATION PROTEIN MTRB)	6c6l	V-TYPE PROTON ATPASE SUBUNIT C'' V-TYPE PROTON ATPASE SUBUNIT C' (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	5 / 9	SER D  41 GLY C 167 ALA D  39 THR C 169 ILE C 165	None	1.42A	5eezB-6c6lD: undetectable 5eezC-6c6lD: undetectable	5eezB-6c6lD: undetectable 5eezC-6c6lD: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EF0_B_TRPB101_0 (TRANSCRIPTION ATTENUATION PROTEIN MTRB)	6c6l	V-TYPE PROTON ATPASE SUBUNIT C'' V-TYPE PROTON ATPASE SUBUNIT C' (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	5 / 9	SER D  41 GLY C 167 ALA D  39 THR C 169 ILE C 165	None	1.42A	5ef0B-6c6lD: undetectable 5ef0C-6c6lD: undetectable	5ef0B-6c6lD: undetectable 5ef0C-6c6lD: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EF1_B_TRPB101_0 (TRANSCRIPTION ATTENUATION PROTEIN MTRB)	6c6l	V-TYPE PROTON ATPASE SUBUNIT C'' V-TYPE PROTON ATPASE SUBUNIT C' (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	5 / 9	SER D  41 GLY C 167 ALA D  39 THR C 169 ILE C 165	None	1.41A	5ef1B-6c6lD: undetectable 5ef1C-6c6lD: undetectable	5ef1B-6c6lD: undetectable 5ef1C-6c6lD: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EF2_B_TRPB101_0 (TRANSCRIPTION ATTENUATION PROTEIN MTRB)	6c6l	V-TYPE PROTON ATPASE SUBUNIT C'' V-TYPE PROTON ATPASE SUBUNIT C' (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	5 / 9	SER D  41 GLY C 167 ALA D  39 THR C 169 ILE C 165	None	1.41A	5ef2B-6c6lD: undetectable 5ef2C-6c6lD: undetectable	5ef2B-6c6lD: undetectable 5ef2C-6c6lD: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EF2_H_TRPH101_0 (TRANSCRIPTION ATTENUATION PROTEIN MTRB)	6c6l	V-TYPE PROTON ATPASE SUBUNIT C'' V-TYPE PROTON ATPASE SUBUNIT C' (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	5 / 9	SER D  41 GLY C 167 ALA D  39 THR C 169 ILE C 165	None	1.42A	5ef2H-6c6lD: undetectable 5ef2I-6c6lD: undetectable	5ef2H-6c6lD: undetectable 5ef2I-6c6lD: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EF3_B_TRPB101_0 (TRANSCRIPTION ATTENUATION PROTEIN MTRB)	6c6l	V-TYPE PROTON ATPASE SUBUNIT C'' V-TYPE PROTON ATPASE SUBUNIT C' (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	5 / 9	SER D  41 GLY C 167 ALA D  39 THR C 169 ILE C 165	None	1.41A	5ef3B-6c6lD: undetectable 5ef3C-6c6lD: undetectable	5ef3B-6c6lD: undetectable 5ef3C-6c6lD: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EF3_H_TRPH101_0 (TRANSCRIPTION ATTENUATION PROTEIN MTRB)	6c6l	V-TYPE PROTON ATPASE SUBUNIT C'' V-TYPE PROTON ATPASE SUBUNIT C' (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	5 / 9	SER D  41 GLY C 167 ALA D  39 THR C 169 ILE C 165	None	1.42A	5ef3H-6c6lD: undetectable 5ef3I-6c6lD: undetectable	5ef3H-6c6lD: undetectable 5ef3I-6c6lD: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ESG_A_1YNA701_1 (LANOSTEROL 14-ALPHA DEMETHYLASE)	6c6l	V-TYPE PROTON ATPASE SUBUNIT D (Saccharomyces cerevisiae)	5 / 12	GLU B 178 TYR B 249 PHE B 288 GLY B 277 LEU B 225	None	1.31A	5esgA-6c6lB: undetectable	5esgA-6c6lB: 10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HIE_A_P06A801_2 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	6c6l	V-TYPE PROTON ATPASE SUBUNIT C' V-TYPE PROTON ATPASE SUBUNIT C'' (Saccharomyces cerevisiae)	4 / 7	ILE D  43 GLY D  44 PHE C 106 PHE C 190	None	1.13A	5hieA-6c6lD: undetectable	5hieA-6c6lD: 12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IEN_A_VDYA201_2 (CDL2.2)	6c6l	V-TYPE PROTON ATPASE SUBUNIT A, VACUOLAR ISOFORM V-TYPE PROTON ATPASE SUBUNIT C'' (Saccharomyces cerevisiae)	5 / 12	ILE A 582 LEU A 617 ILE A 613 LEU C 203 LEU A 638	None	1.12A	5ienA-6c6lA: undetectable	5ienA-6c6lA: 19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IKT_B_TLFB601_1 (PROSTAGLANDIN G/H SYNTHASE 2)	6c6l	V-TYPE PROTON ATPASE SUBUNIT A, VACUOLAR ISOFORM (Saccharomyces cerevisiae)	3 / 3	TYR A 733 TYR A 397 SER A 807	None	0.92A	5iktB-6c6lA: undetectable	5iktB-6c6lA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5N5D_A_SAMA306_1 (METHYLTRANSFERASE)	6c6l	V-TYPE PROTON ATPASE SUBUNIT A, VACUOLAR ISOFORM (Saccharomyces cerevisiae)	4 / 7	PHE A  19 SER A  29 ILE A 334 ASN A 327	None	0.94A	5n5dA-6c6lA: undetectable	5n5dA-6c6lA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NNW_D_GCSD302_1 (25 KDA PROTEIN ELICITOR)	6c6l	V-TYPE PROTON ATPASE SUBUNIT A, VACUOLAR ISOFORM (Saccharomyces cerevisiae)	4 / 7	ASP A 425 GLY A 427 HIS A 428 ASP A 481	None	1.07A	5nnwD-6c6lA: undetectable	5nnwD-6c6lA: 16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5TE8_A_08JA602_1 (CYTOCHROME P450 3A4)	6c6l	V-TYPE PROTON ATPASE SUBUNIT A, VACUOLAR ISOFORM V-TYPE PROTON ATPASE SUBUNIT D (Saccharomyces cerevisiae)	4 / 7	ARG A 248 SER B 147 THR B 114 LEU B 139	None	1.03A	5te8A-6c6lA: 0.2	5te8A-6c6lA: 10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VEU_B_RITB602_1 (CYTOCHROME P450 3A5)	6c6l	V-TYPE PROTON ATPASE SUBUNIT C' V-TYPE PROTON ATPASE SUBUNIT C'' (Saccharomyces cerevisiae)	5 / 12	SER D  59 LEU D  60 ILE D  56 ILE C 165 GLY C 167	None	1.06A	5veuB-6c6lD: undetectable	5veuB-6c6lD: 10.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VOO_E_C2FE3001_1 (5-METHYLTETRAHYDROFO LATE HOMOCYSTEINE S-METHYLTRANSFERASE)	6c6l	V-TYPE PROTON ATPASE SUBUNIT A, VACUOLAR ISOFORM (Saccharomyces cerevisiae)	4 / 5	ASN A 136 ASP A 137 ASN A 259 ASP A 257	None	1.20A	5vooE-6c6lA: undetectable	5vooE-6c6lA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VOP_A_C2FA3001_1 (5-METHYLTETRAHYDROFO LATE HOMOCYSTEINE S-METHYLTRANSFERASE)	6c6l	V-TYPE PROTON ATPASE SUBUNIT A, VACUOLAR ISOFORM (Saccharomyces cerevisiae)	3 / 3	ASP A 137 ASN A 259 ASP A 257	None	0.65A	5vopA-6c6lA: undetectable	5vopA-6c6lA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VOP_B_C2FB3001_1 (5-METHYLTETRAHYDROFO LATE HOMOCYSTEINE S-METHYLTRANSFERASE)	6c6l	V-TYPE PROTON ATPASE SUBUNIT A, VACUOLAR ISOFORM (Saccharomyces cerevisiae)	3 / 3	ASP A 137 ASN A 259 ASP A 257	None	0.74A	5vopB-6c6lA: undetectable	5vopB-6c6lA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XXI_A_LSNA501_2 (CYTOCHROME P450 2C9)	6c6l	V-TYPE PROTON ATPASE SUBUNIT A, VACUOLAR ISOFORM (Saccharomyces cerevisiae)	4 / 4	PHE A 213 LEU A 260 LEU A 199 VAL A 187	None	1.36A	5xxiA-6c6lA: undetectable	5xxiA-6c6lA: 9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Z6J_A_FOLA201_1 (DIHYDROFOLATE REDUCTASE)	6c6l	V-TYPE PROTON ATPASE SUBUNIT D V-TYPE PROTON ATPASE SUBUNIT C' (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	3 / 3	MET D 128 ASP B 298 ARG B  18	None	1.10A	5z6jA-6c6lD: undetectable	5z6jA-6c6lD: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Z6K_A_FOLA201_1 (DIHYDROFOLATE REDUCTASE)	6c6l	V-TYPE PROTON ATPASE SUBUNIT D V-TYPE PROTON ATPASE SUBUNIT C' (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	3 / 3	MET D 128 ASP B 298 ARG B  18	None	1.22A	5z6kA-6c6lD: undetectable	5z6kA-6c6lD: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BKL_C_EU7C101_0 (MATRIX PROTEIN 2)	6c6l	V-TYPE PROTON ATPASE SUBUNIT C'' V-TYPE PROTON ATPASE SUBUNIT C' (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	5 / 9	SER D  41 ALA C 162 ALA D  34 VAL D  63 SER D  66	None	1.24A	6bklA-6c6lD: undetectable 6bklB-6c6lD: undetectable 6bklC-6c6lD: undetectable 6bklD-6c6lD: undetectable	6bklA-6c6lD: undetectable 6bklB-6c6lD: undetectable 6bklC-6c6lD: undetectable 6bklD-6c6lD: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BKL_C_EU7C101_0 (MATRIX PROTEIN 2)	6c6l	V-TYPE PROTON ATPASE SUBUNIT C'' V-TYPE PROTON ATPASE SUBUNIT C' (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	5 / 9	SER D  41 ALA C 162 VAL D  63 SER D  66 GLY D 113	None	1.19A	6bklA-6c6lD: undetectable 6bklB-6c6lD: undetectable 6bklC-6c6lD: undetectable 6bklD-6c6lD: undetectable	6bklA-6c6lD: undetectable 6bklB-6c6lD: undetectable 6bklC-6c6lD: undetectable 6bklD-6c6lD: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6F6S_A_CXQA507_1 (ENVELOPE GLYCOPROTEIN,ENVELOP E GLYCOPROTEIN,GP1 ENVELOPE GLYCOPROTEIN)	6c6l	V-TYPE PROTON ATPASE SUBUNIT A, VACUOLAR ISOFORM (Saccharomyces cerevisiae)	4 / 5	ARG A 382 ALA A  12 TYR A 817 ILE A 341	None	1.35A	6f6sA-6c6lA: undetectable 6f6sB-6c6lA: 0.0	6f6sA-6c6lA: 11.25 6f6sB-6c6lA: 16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6G9B_B_IXXB705_1 (ENVELOPE GLYCOPROTEIN,ENVELOP E GLYCOPROTEIN ENVELOPE GLYCOPROTEIN)	6c6l	V-TYPE PROTON ATPASE SUBUNIT A, VACUOLAR ISOFORM (Saccharomyces cerevisiae)	4 / 5	ARG A 382 ALA A  12 TYR A 817 ILE A 341	None	1.22A	6g9bA-6c6lA: undetectable 6g9bB-6c6lA: undetectable	6g9bA-6c6lA: 11.25 6g9bB-6c6lA: 16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6GBN_C_ADNC501_2 (-)	6c6l	V-TYPE PROTON ATPASE SUBUNIT A, VACUOLAR ISOFORM (Saccharomyces cerevisiae)	4 / 5	GLN A  35 THR A  32 THR A 348 GLY A  96	None	1.19A	6gbnC-6c6lA: undetectable	6gbnC-6c6lA: 9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6HCX_A_ZMRA519_1 (NEURAMINIDASE)	6c6l	V-TYPE PROTON ATPASE SUBUNIT D V-TYPE PROTON ATPASE SUBUNIT C'' (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	3 / 3	TRP C  77 ILE C 161 GLU B   2	None	0.87A	6hcxA-6c6lC: undetectable	6hcxA-6c6lC: 18.00