SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6c7y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		8 / 12 LEU A 881
GLY A 882
VAL A 889
ALA A 906
VAL A 938
ASN A1008
LEU A1010
ASP A1021
 ADP  A1201 ( 4.5A)
ADP  A1201 (-3.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
None
MG  A1202 ( 2.5A)
ADP  A1201 (-4.5A)
MG  A1203 (-1.8A)
 0.63A 1fmoE-6c7yA:
24.2		 1fmoE-6c7yA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		7 / 12 LEU A 881
VAL A 889
ALA A 906
GLU A 925
PHE A 958
GLY A 962
LEU A1010
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
None
None
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
 0.84A 1iepA-6c7yA:
28.4		 1iepA-6c7yA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		4 / 8 ASN A1008
ARG A1007
GLY A1023
THR A1025
 MG  A1202 ( 2.5A)
None
MG  A1203 ( 4.7A)
None
 0.76A 1jr1B-6c7yA:
undetectable		 1jr1B-6c7yA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_2
(ALPHA-AMYLASE)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		3 / 3 TRP A1065
TYR A1048
LEU A1104
 None
 0.81A 1kxhA-6c7yA:
undetectable		 1kxhA-6c7yA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		7 / 12 LEU A 881
ALA A 906
LYS A 908
GLU A 925
LEU A 954
GLY A 962
LEU A1010
 ADP  A1201 ( 4.5A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
None
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
 0.73A 1m17A-6c7yA:
32.9		 1m17A-6c7yA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
SUPPRESSOR OF
CYTOKINE SIGNALING 1
(Homo
sapiens;
Gallus
gallus) 		4 / 5 SER A1043
PHE A1058
VAL A1101
PHE B  55
 None
 1.46A 1oipA-6c7yA:
undetectable		 1oipA-6c7yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_A_STIA3_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		7 / 12 LEU A 881
VAL A 889
ALA A 906
GLU A 925
VAL A 938
PHE A 958
LEU A1010
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
None
None
None
ADP  A1201 (-4.5A)
 0.71A 1opjA-6c7yA:
28.1		 1opjA-6c7yA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_B_BEZB1503_0
(RAS-RELATED PROTEIN
RAB-9A)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
SUPPRESSOR OF
CYTOKINE SIGNALING 1
(Homo
sapiens;
Gallus
gallus) 		4 / 6 VAL A1101
THR A1102
LEU A1053
PHE B  58
 None
 1.08A 1s8fB-6c7yA:
undetectable		 1s8fB-6c7yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		9 / 12 LEU A 881
VAL A 889
ALA A 906
LYS A 908
GLU A 925
LEU A 929
VAL A 938
GLY A 962
LEU A1010
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
None
None
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
 0.72A 1t46A-6c7yA:
28.4		 1t46A-6c7yA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDN_A_LEUA487_0
(L-AMINO ACID OXIDASE)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		4 / 7 ASN A1008
HIS A1001
PHE A1022
ILE A 987
 MG  A1202 ( 2.5A)
None
None
None
 1.21A 1tdnA-6c7yA:
undetectable		 1tdnA-6c7yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		6 / 12 ALA A 906
GLU A 925
LEU A 929
LEU A 994
HIS A1001
GLY A1020
 ADP  A1201 (-3.4A)
None
None
None
None
None
 0.90A 1uwhA-6c7yA:
26.0		 1uwhA-6c7yA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		7 / 12 ALA A 906
LYS A 908
GLU A 925
LEU A 929
LEU A 994
HIS A1001
GLY A1020
 ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
None
None
None
None
 0.85A 1uwhB-6c7yA:
25.7		 1uwhB-6c7yA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		6 / 12 VAL A 889
ALA A 906
GLU A 925
LEU A 994
HIS A1001
GLY A1020
 ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
None
None
None
None
 0.76A 1uwjA-6c7yA:
7.1		 1uwjA-6c7yA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		6 / 12 VAL A 889
ALA A 906
GLU A 925
LEU A 994
HIS A1001
GLY A1020
 ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
None
None
None
None
 0.76A 1uwjB-6c7yA:
24.8		 1uwjB-6c7yA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		6 / 9 LEU A 881
VAL A 889
ALA A 906
MET A 956
GLY A 962
LEU A1010
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-4.2A)
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
 0.64A 1xbbA-6c7yA:
32.8		 1xbbA-6c7yA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		7 / 11 GLY A 882
GLY A 884
VAL A 889
ALA A 906
MET A 956
SER A 963
LEU A1010
 ADP  A1201 (-3.5A)
ADP  A1201 (-3.3A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-4.2A)
ADP  A1201 (-3.3A)
ADP  A1201 (-4.5A)
 0.75A 2evaA-6c7yA:
26.6		 2evaA-6c7yA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_C_MIXC2539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		6 / 12 LEU A 881
GLY A 882
VAL A 889
ALA A 906
MET A 956
ASN A1008
 ADP  A1201 ( 4.5A)
ADP  A1201 (-3.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-4.2A)
MG  A1202 ( 2.5A)
 0.61A 2fumC-6c7yA:
15.1		 2fumC-6c7yA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		7 / 12 LEU A 881
GLY A 882
GLY A 884
VAL A 889
ALA A 906
MET A 956
ASN A1008
 ADP  A1201 ( 4.5A)
ADP  A1201 (-3.5A)
ADP  A1201 (-3.3A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-4.2A)
MG  A1202 ( 2.5A)
 0.77A 2fumD-6c7yA:
24.3		 2fumD-6c7yA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GQG_A_1N1A501_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		8 / 12 LEU A 881
ALA A 906
LYS A 908
GLU A 925
VAL A 938
PHE A 958
GLY A 962
LEU A1010
 ADP  A1201 ( 4.5A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
None
None
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
 0.77A 2gqgA-6c7yA:
26.6		 2gqgA-6c7yA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GQG_B_1N1B502_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		7 / 12 LEU A 881
VAL A 889
ALA A 906
GLU A 925
VAL A 938
GLY A 962
LEU A1010
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
None
None
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
 0.48A 2gqgB-6c7yA:
32.8		 2gqgB-6c7yA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GQG_B_1N1B502_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		7 / 12 LEU A 881
VAL A 889
ALA A 906
LYS A 908
GLU A 925
VAL A 938
GLY A 962
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
None
ADP  A1201 ( 4.1A)
 0.60A 2gqgB-6c7yA:
32.8		 2gqgB-6c7yA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		6 / 12 VAL A 889
ALA A 906
GLU A 925
PHE A 958
GLY A 962
LEU A1010
 ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
None
None
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
 0.83A 2hyyB-6c7yA:
20.9		 2hyyB-6c7yA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		7 / 12 LEU A 881
ALA A 906
LYS A 908
GLU A 925
LEU A 954
GLY A 962
LEU A1010
 ADP  A1201 ( 4.5A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
None
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
 0.79A 2itoA-6c7yA:
31.1		 2itoA-6c7yA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITY_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		9 / 12 LEU A 881
VAL A 889
ALA A 906
LYS A 908
GLU A 925
LEU A 954
GLY A 962
LEU A1010
ASP A1021
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
None
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
MG  A1203 (-1.8A)
 0.84A 2ityA-6c7yA:
30.9		 2ityA-6c7yA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		8 / 12 LEU A 881
VAL A 889
ALA A 906
LYS A 908
GLU A 925
GLY A 962
LEU A1010
ASP A1021
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
MG  A1203 (-1.8A)
 0.72A 2itzA-6c7yA:
31.0		 2itzA-6c7yA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		6 / 12 LEU A 881
GLY A 882
VAL A 889
LYS A 908
GLU A 925
LEU A1010
 ADP  A1201 ( 4.5A)
ADP  A1201 (-3.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-2.8A)
None
ADP  A1201 (-4.5A)
 0.55A 2ivuA-6c7yA:
33.9		 2ivuA-6c7yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_CCSB417_0
(ESTROGEN RECEPTOR)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		3 / 3 GLN A 986
LYS A1018
VAL A1009
 None
 0.65A 2jfaB-6c7yA:
undetectable		 2jfaB-6c7yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 6c7y SUPPRESSOR OF
CYTOKINE SIGNALING 1
(Gallus
gallus) 		4 / 8 ARG B 104
HIS B  90
SER B 125
ALA B 114
 ACT  B 202 (-2.6A)
None
ACT  B 202 ( 4.2A)
ACT  B 202 ( 3.9A)
 0.96A 2rk8A-6c7yB:
undetectable		 2rk8A-6c7yB:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		7 / 9 LEU A 881
VAL A 889
ALA A 906
GLY A 962
LEU A1010
GLY A1020
ASP A1021
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
None
MG  A1203 (-1.8A)
 0.60A 2xp2A-6c7yA:
9.3		 2xp2A-6c7yA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVA_A_1N1A513_1
(TYROSINE-PROTEIN
KINASE LYN)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		7 / 12 LEU A 881
ALA A 906
LYS A 908
GLU A 925
VAL A 938
GLY A 962
LEU A1010
 ADP  A1201 ( 4.5A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
None
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
 0.64A 2zvaA-6c7yA:
30.8		 2zvaA-6c7yA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		7 / 10 ARG A 879
LEU A 881
ALA A 906
LYS A 908
VAL A 938
GLY A 962
LEU A1010
 None
ADP  A1201 ( 4.5A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
 0.76A 3aoxA-6c7yA:
27.8		 3aoxA-6c7yA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS8_A_BRLA503_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		5 / 12 GLY A1023
LEU A1010
MET A 956
LEU A 932
LEU A 994
 MG  A1203 ( 4.7A)
ADP  A1201 (-4.5A)
ADP  A1201 (-4.2A)
None
None
 0.98A 3cs8A-6c7yA:
undetectable		 3cs8A-6c7yA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_A_NILA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		5 / 10 LEU A 881
VAL A 889
LYS A 908
VAL A 938
PHE A 958
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-2.8A)
None
None
 0.50A 3cs9A-6c7yA:
20.7		 3cs9A-6c7yA:
13.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		11 / 12 LEU A 881
GLY A 882
GLY A 884
GLY A 887
VAL A 889
ALA A 906
LYS A 908
MET A 956
SER A 963
ASN A1008
LEU A1010
 ADP  A1201 ( 4.5A)
ADP  A1201 (-3.5A)
ADP  A1201 (-3.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
ADP  A1201 (-4.2A)
ADP  A1201 (-3.3A)
MG  A1202 ( 2.5A)
ADP  A1201 (-4.5A)
 0.63A 3eygA-6c7yA:
30.5		 3eygA-6c7yA:
95.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		11 / 12 LEU A 881
GLY A 882
GLY A 884
GLY A 887
VAL A 889
ALA A 906
LYS A 908
SER A 963
ASN A1008
LEU A1010
ASP A1021
 ADP  A1201 ( 4.5A)
ADP  A1201 (-3.5A)
ADP  A1201 (-3.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
ADP  A1201 (-3.3A)
MG  A1202 ( 2.5A)
ADP  A1201 (-4.5A)
MG  A1203 (-1.8A)
 0.72A 3eygA-6c7yA:
30.5		 3eygA-6c7yA:
95.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		10 / 12 LEU A 881
GLY A 882
GLY A 884
GLY A 887
VAL A 889
ALA A 906
LYS A 908
MET A 956
SER A 963
LEU A1010
 ADP  A1201 ( 4.5A)
ADP  A1201 (-3.5A)
ADP  A1201 (-3.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
ADP  A1201 (-4.2A)
ADP  A1201 (-3.3A)
ADP  A1201 (-4.5A)
 0.76A 3fupA-6c7yA:
30.2		 3fupA-6c7yA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		9 / 12 LEU A 881
GLY A 882
GLY A 884
VAL A 889
ALA A 906
LYS A 908
VAL A 938
MET A 956
LEU A 959
 ADP  A1201 ( 4.5A)
ADP  A1201 (-3.5A)
ADP  A1201 (-3.3A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
ADP  A1201 (-4.2A)
ADP  A1201 (-4.6A)
 0.57A 3fupB-6c7yA:
27.9		 3fupB-6c7yA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		9 / 12 LEU A 881
GLY A 882
VAL A 889
ALA A 906
LYS A 908
VAL A 938
MET A 956
LEU A 959
LEU A1010
 ADP  A1201 ( 4.5A)
ADP  A1201 (-3.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
ADP  A1201 (-4.2A)
ADP  A1201 (-4.6A)
ADP  A1201 (-4.5A)
 0.55A 3fupB-6c7yA:
27.9		 3fupB-6c7yA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		7 / 12 LEU A 881
VAL A 889
ALA A 906
GLU A 925
VAL A 938
GLY A 962
LEU A1010
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
None
None
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
 0.51A 3g5dA-6c7yA:
29.8		 3g5dA-6c7yA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		8 / 12 LEU A 881
VAL A 889
ALA A 906
LYS A 908
GLU A 925
VAL A 938
GLY A 962
LEU A1010
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
None
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
 0.62A 3g5dB-6c7yA:
29.8		 3g5dB-6c7yA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GVU_A_STIA1001_1
(TYROSINE-PROTEIN
KINASE ABL2)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		6 / 12 LEU A 881
VAL A 889
ALA A 906
GLU A 925
VAL A 938
LEU A1010
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
None
None
ADP  A1201 (-4.5A)
 0.65A 3gvuA-6c7yA:
28.4		 3gvuA-6c7yA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		7 / 12 LEU A 881
ALA A 906
LYS A 908
GLU A 925
VAL A 938
GLY A 962
LEU A1010
 ADP  A1201 ( 4.5A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
None
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
 0.62A 3k54A-6c7yA:
27.8		 3k54A-6c7yA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		6 / 12 VAL A 889
ALA A 906
GLU A 925
PHE A 958
GLY A 962
LEU A1010
 ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
None
None
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
 0.80A 3k5vB-6c7yA:
27.9		 3k5vB-6c7yA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO201_1
(PROTEIN S100-A4)		 6c7y SUPPRESSOR OF
CYTOKINE SIGNALING 1
TYROSINE-PROTEIN
KINASE JAK1
(Gallus
gallus;
Homo
sapiens) 		4 / 8 GLY B  82
PHE A1088
PHE A1046
GLY A1097
 None
 0.98A 3ko0O-6c7yB:
undetectable
3ko0Q-6c7yB:
undetectable		 3ko0O-6c7yB:
17.82
3ko0Q-6c7yB:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		7 / 12 LEU A 881
GLY A 882
VAL A 889
ALA A 906
LYS A 908
VAL A 938
MET A 956
 ADP  A1201 ( 4.5A)
ADP  A1201 (-3.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
ADP  A1201 (-4.2A)
 0.50A 3lxkA-6c7yA:
29.6		 3lxkA-6c7yA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		7 / 12 LEU A 881
GLY A 882
GLY A 884
VAL A 889
ALA A 906
SER A 963
LEU A1010
 ADP  A1201 ( 4.5A)
ADP  A1201 (-3.5A)
ADP  A1201 (-3.3A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-3.3A)
ADP  A1201 (-4.5A)
 0.52A 3lxnA-6c7yA:
27.2		 3lxnA-6c7yA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		7 / 12 LEU A 881
GLY A 882
VAL A 889
ALA A 906
LYS A 908
SER A 963
LEU A1010
 ADP  A1201 ( 4.5A)
ADP  A1201 (-3.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
ADP  A1201 (-3.3A)
ADP  A1201 (-4.5A)
 0.59A 3lxnA-6c7yA:
27.2		 3lxnA-6c7yA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		6 / 11 ALA A 906
LYS A 908
VAL A 938
PHE A 958
GLY A 962
LEU A1010
 ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
None
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
 0.62A 3miyA-6c7yA:
29.7		 3miyA-6c7yA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		5 / 9 ALA A 906
LYS A 908
PHE A 958
GLY A 962
LEU A1010
 ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
 0.60A 3miyB-6c7yA:
29.4		 3miyB-6c7yA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		6 / 12 LEU A 881
VAL A 889
ALA A 906
GLU A 925
PHE A 958
LEU A1010
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
None
None
ADP  A1201 (-4.5A)
 0.78A 3ms9A-6c7yA:
20.9		 3ms9A-6c7yA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		6 / 12 LEU A 881
VAL A 889
ALA A 906
GLU A 925
PHE A 958
LEU A1010
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
None
None
ADP  A1201 (-4.5A)
 0.81A 3mssA-6c7yA:
21.0		 3mssA-6c7yA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		6 / 12 LEU A 881
VAL A 889
ALA A 906
GLU A 925
PHE A 958
LEU A1010
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
None
None
ADP  A1201 (-4.5A)
 0.82A 3mssC-6c7yA:
15.2		 3mssC-6c7yA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		6 / 12 LEU A 881
ALA A 906
GLU A 925
PHE A 958
GLY A 962
LEU A1010
 ADP  A1201 ( 4.5A)
ADP  A1201 (-3.4A)
None
None
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
 0.78A 3mssD-6c7yA:
20.8		 3mssD-6c7yA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		6 / 12 LEU A 881
ALA A 906
ILE A 928
PHE A 958
GLY A 962
LEU A1010
 ADP  A1201 ( 4.5A)
ADP  A1201 (-3.4A)
None
None
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
 0.88A 3mssD-6c7yA:
20.8		 3mssD-6c7yA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_1
(TYROSINE-PROTEIN
KINASE BTK)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		7 / 12 LEU A 881
VAL A 889
ALA A 906
LYS A 908
VAL A 938
GLY A 962
LEU A1010
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
 0.54A 3octA-6c7yA:
9.8		 3octA-6c7yA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_B_STIB4_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		6 / 12 LEU A 881
VAL A 889
ALA A 906
GLU A 925
VAL A 938
LEU A1010
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
None
None
ADP  A1201 (-4.5A)
 0.68A 3pyyB-6c7yA:
28.3		 3pyyB-6c7yA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		8 / 12 LEU A 881
VAL A 889
ALA A 906
LYS A 908
GLU A 925
VAL A 938
GLY A 962
LEU A1010
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
None
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
 0.69A 3qlgA-6c7yA:
28.3		 3qlgA-6c7yA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLG_B_1N1B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		7 / 12 LEU A 881
VAL A 889
ALA A 906
GLU A 925
VAL A 938
GLY A 962
LEU A1010
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
None
None
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
 0.57A 3qlgB-6c7yA:
29.5		 3qlgB-6c7yA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXR_A_1N1A1_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		6 / 12 LEU A 881
VAL A 889
ALA A 906
VAL A 938
GLY A 962
LEU A1010
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
None
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
 0.38A 3sxrA-6c7yA:
30.7		 3sxrA-6c7yA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXR_B_1N1B2_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		6 / 12 LEU A 881
VAL A 889
ALA A 906
VAL A 938
GLY A 962
LEU A1010
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
None
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
 0.40A 3sxrB-6c7yA:
30.4		 3sxrB-6c7yA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI1_A_B49A299_1
(CYCLIN-DEPENDENT
KINASE 2)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		5 / 9 ALA A 906
VAL A 938
PHE A 958
LYS A 965
LEU A1010
 ADP  A1201 (-3.4A)
None
None
None
ADP  A1201 (-4.5A)
 0.56A 3ti1A-6c7yA:
23.3		 3ti1A-6c7yA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UE4_A_DB8A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		7 / 12 LEU A 881
ALA A 906
LYS A 908
VAL A 938
PHE A 958
GLY A 962
LEU A1010
 ADP  A1201 ( 4.5A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
None
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
 0.70A 3ue4A-6c7yA:
25.4		 3ue4A-6c7yA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UE4_B_DB8B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		7 / 12 LEU A 881
VAL A 889
ALA A 906
GLU A 925
VAL A 938
PHE A 958
GLY A 962
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
None
None
None
ADP  A1201 ( 4.1A)
 0.76A 3ue4B-6c7yA:
31.4		 3ue4B-6c7yA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UE4_B_DB8B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		7 / 12 LEU A 881
VAL A 889
ALA A 906
VAL A 938
PHE A 958
GLY A 962
LEU A1010
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
None
None
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
 0.70A 3ue4B-6c7yA:
31.4		 3ue4B-6c7yA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG2_A_IREA1_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		7 / 12 LEU A 881
VAL A 889
ALA A 906
LYS A 908
LEU A 954
GLY A 962
LEU A1010
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
 0.91A 3ug2A-6c7yA:
27.9		 3ug2A-6c7yA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		6 / 12 LEU A 881
GLY A 882
ALA A 906
GLU A 925
LEU A 929
GLY A 962
 ADP  A1201 ( 4.5A)
ADP  A1201 (-3.5A)
ADP  A1201 (-3.4A)
None
None
ADP  A1201 ( 4.1A)
 0.74A 3wzdA-6c7yA:
27.8		 3wzdA-6c7yA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		6 / 12 LEU A 881
VAL A 889
ALA A 906
GLU A 925
LEU A 929
GLY A 962
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
None
None
ADP  A1201 ( 4.1A)
 0.69A 3wzdA-6c7yA:
27.8		 3wzdA-6c7yA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		4 / 5 LYS A 908
ILE A 928
LEU A1010
ASP A1021
 ADP  A1201 (-2.8A)
None
ADP  A1201 (-4.5A)
MG  A1203 (-1.8A)
 1.17A 3wzdA-6c7yA:
27.8		 3wzdA-6c7yA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		4 / 5 LYS A 908
ILE A 928
VAL A 938
LEU A1010
 ADP  A1201 (-2.8A)
None
None
ADP  A1201 (-4.5A)
 0.83A 3wzdA-6c7yA:
27.8		 3wzdA-6c7yA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		10 / 12 LEU A 881
VAL A 889
ALA A 906
LYS A 908
GLU A 925
LEU A 929
PHE A 958
GLY A 962
LEU A 994
HIS A1001
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
None
None
ADP  A1201 ( 4.1A)
None
None
 0.68A 3wzeA-6c7yA:
28.4		 3wzeA-6c7yA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		5 / 12 ALA A 906
GLY A 962
LEU A1010
GLY A1020
ASP A1021
 ADP  A1201 (-3.4A)
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
None
MG  A1203 (-1.8A)
 0.31A 3zbfA-6c7yA:
29.8		 3zbfA-6c7yA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		8 / 12 LEU A 881
ALA A 906
LYS A 908
GLU A 925
LEU A 994
HIS A1001
ARG A1002
LEU A1010
 ADP  A1201 ( 4.5A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
None
None
None
ADP  A1201 (-4.5A)
 1.10A 3zosA-6c7yA:
19.9		 3zosA-6c7yA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		5 / 9 LEU A 881
ILE A 928
LEU A 932
ILE A 937
ILE A1019
 ADP  A1201 ( 4.5A)
None
None
None
None
 0.71A 3zosB-6c7yA:
20.0		 3zosB-6c7yA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		9 / 12 LEU A 881
VAL A 889
ALA A 906
LYS A 908
GLU A 925
VAL A 938
PHE A 958
GLY A 962
LEU A1010
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
None
None
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
 0.59A 4ag8A-6c7yA:
28.2		 4ag8A-6c7yA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		7 / 12 LEU A 881
VAL A 889
ALA A 906
LYS A 908
GLU A 925
GLY A 962
LEU A1010
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
 0.58A 4agcA-6c7yA:
27.7		 4agcA-6c7yA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		6 / 11 LEU A 881
ALA A 906
VAL A 938
PHE A 958
GLY A 962
LEU A1010
 ADP  A1201 ( 4.5A)
ADP  A1201 (-3.4A)
None
None
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
 0.55A 4agdA-6c7yA:
27.0		 4agdA-6c7yA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANQ_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		6 / 9 LEU A 881
VAL A 889
ALA A 906
GLY A 962
LEU A1010
ASP A1021
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
MG  A1203 (-1.8A)
 0.65A 4anqA-6c7yA:
28.8		 4anqA-6c7yA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANS_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		7 / 9 LEU A 881
VAL A 889
ALA A 906
MET A 956
GLY A 962
LEU A1010
ASP A1021
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-4.2A)
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
MG  A1203 (-1.8A)
 0.69A 4ansA-6c7yA:
28.7		 4ansA-6c7yA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		10 / 12 LEU A 881
VAL A 889
ALA A 906
LYS A 908
GLU A 925
LEU A 929
PHE A 958
GLY A 962
LEU A 994
HIS A1001
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
None
None
ADP  A1201 ( 4.1A)
None
None
 0.85A 4asdA-6c7yA:
27.8		 4asdA-6c7yA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		7 / 12 ALA A 906
LYS A 908
GLU A 925
LEU A 929
ILE A 937
HIS A1001
LEU A1010
 ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
None
None
None
ADP  A1201 (-4.5A)
 0.67A 4c8bB-6c7yA:
24.5		 4c8bB-6c7yA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		6 / 10 LEU A 881
GLY A 882
VAL A 889
ALA A 906
SER A 963
LEU A1010
 ADP  A1201 ( 4.5A)
ADP  A1201 (-3.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-3.3A)
ADP  A1201 (-4.5A)
 0.50A 4ckjA-6c7yA:
27.6		 4ckjA-6c7yA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		7 / 10 ALA A 906
VAL A 938
MET A 956
PHE A 958
LEU A 959
GLY A 962
LEU A1010
 ADP  A1201 (-3.4A)
None
ADP  A1201 (-4.2A)
None
ADP  A1201 (-4.6A)
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
 0.52A 4ks8A-6c7yA:
27.1		 4ks8A-6c7yA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		6 / 10 ALA A 906
VAL A 938
MET A 956
PHE A 958
LEU A1010
ASP A1021
 ADP  A1201 (-3.4A)
None
ADP  A1201 (-4.2A)
None
ADP  A1201 (-4.5A)
MG  A1203 (-1.8A)
 0.78A 4ks8A-6c7yA:
27.1		 4ks8A-6c7yA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_B_MXMB606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		5 / 12 ILE A1019
VAL A1009
LEU A 964
LEU A1004
ALA A 984
 None
 0.97A 4m11B-6c7yA:
undetectable		 4m11B-6c7yA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		8 / 12 LEU A 881
VAL A 889
ALA A 906
LYS A 908
GLU A 925
VAL A 938
GLY A 962
ASP A1021
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
None
ADP  A1201 ( 4.1A)
MG  A1203 (-1.8A)
 0.87A 4mxoA-6c7yA:
29.6		 4mxoA-6c7yA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXO_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		9 / 12 LEU A 881
VAL A 889
ALA A 906
LYS A 908
GLU A 925
VAL A 938
GLY A 962
LEU A1010
ASP A1021
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
None
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
MG  A1203 (-1.8A)
 0.87A 4mxoB-6c7yA:
29.5		 4mxoB-6c7yA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXX_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		7 / 12 LEU A 881
VAL A 889
ALA A 906
LYS A 908
VAL A 938
GLY A 962
LEU A1010
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
 0.85A 4mxxB-6c7yA:
27.6		 4mxxB-6c7yA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		8 / 12 LEU A 881
VAL A 889
ALA A 906
GLU A 925
VAL A 938
GLY A 962
LEU A1010
ASP A1021
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
None
None
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
MG  A1203 (-1.8A)
 0.80A 4mxyA-6c7yA:
30.2		 4mxyA-6c7yA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		8 / 12 LEU A 881
VAL A 889
ALA A 906
LYS A 908
VAL A 938
GLY A 962
LEU A1010
ASP A1021
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
MG  A1203 (-1.8A)
 0.78A 4mxyA-6c7yA:
30.2		 4mxyA-6c7yA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		8 / 12 LEU A 881
VAL A 889
ALA A 906
LYS A 908
VAL A 938
GLY A 962
LEU A1010
ASP A1021
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
MG  A1203 (-1.8A)
 0.80A 4mxyB-6c7yA:
29.6		 4mxyB-6c7yA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		8 / 12 LEU A 881
VAL A 889
ALA A 906
GLU A 925
VAL A 938
GLY A 962
LEU A1010
ASP A1021
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
None
None
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
MG  A1203 (-1.8A)
 0.80A 4mxzA-6c7yA:
30.2		 4mxzA-6c7yA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		8 / 12 LEU A 881
VAL A 889
ALA A 906
LYS A 908
VAL A 938
GLY A 962
LEU A1010
ASP A1021
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
MG  A1203 (-1.8A)
 0.78A 4mxzA-6c7yA:
30.2		 4mxzA-6c7yA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		8 / 12 LEU A 881
VAL A 889
ALA A 906
LYS A 908
VAL A 938
GLY A 962
LEU A1010
ASP A1021
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
MG  A1203 (-1.8A)
 0.80A 4mxzB-6c7yA:
29.6		 4mxzB-6c7yA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
SUPPRESSOR OF
CYTOKINE SIGNALING 1
(Homo
sapiens;
Gallus
gallus) 		4 / 7 HIS B  54
PRO A1044
SER A 963
ASP A1003
 None
None
ADP  A1201 (-3.3A)
MG  A1203 (-4.7A)
 1.33A 4ndnC-6c7yB:
undetectable		 4ndnC-6c7yB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		7 / 11 LEU A 881
GLY A 882
VAL A 889
ALA A 906
LYS A 908
ASN A1008
LEU A1010
 ADP  A1201 ( 4.5A)
ADP  A1201 (-3.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
MG  A1202 ( 2.5A)
ADP  A1201 (-4.5A)
 0.75A 4o0sA-6c7yA:
26.6		 4o0sA-6c7yA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0W_A_ADNA501_1
(AURORA KINASE A)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		5 / 6 LEU A 881
GLY A 882
VAL A 889
ALA A 906
LEU A1010
 ADP  A1201 ( 4.5A)
ADP  A1201 (-3.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-4.5A)
 0.36A 4o0wA-6c7yA:
15.5		 4o0wA-6c7yA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODJ_A_SAMA500_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
SUPPRESSOR OF
CYTOKINE SIGNALING 1
(Homo
sapiens;
Gallus
gallus) 		4 / 7 HIS B  54
PRO A1044
SER A 963
ASP A1003
 None
None
ADP  A1201 (-3.3A)
MG  A1203 (-4.7A)
 1.29A 4odjA-6c7yB:
undetectable		 4odjA-6c7yB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		7 / 12 LEU A 881
GLY A 882
GLY A 884
GLY A 887
VAL A 889
ALA A 906
VAL A 938
 ADP  A1201 ( 4.5A)
ADP  A1201 (-3.5A)
ADP  A1201 (-3.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
None
 0.41A 4otiA-6c7yA:
19.0		 4otiA-6c7yA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		7 / 12 LEU A 881
GLY A 882
GLY A 884
VAL A 889
ALA A 906
LYS A 908
VAL A 938
 ADP  A1201 ( 4.5A)
ADP  A1201 (-3.5A)
ADP  A1201 (-3.3A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
 0.46A 4otiA-6c7yA:
19.0		 4otiA-6c7yA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		7 / 12 LEU A 881
VAL A 889
LYS A 908
VAL A 938
GLY A 962
LEU A1010
ASP A1021
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-2.8A)
None
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
MG  A1203 (-1.8A)
 0.95A 4otwA-6c7yA:
28.5		 4otwA-6c7yA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_1
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		6 / 12 VAL A 889
ALA A 906
LYS A 908
GLU A 925
LEU A1010
GLY A1020
 ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
ADP  A1201 (-4.5A)
None
 0.55A 4r7iA-6c7yA:
28.0		 4r7iA-6c7yA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		5 / 12 ALA A 906
LYS A 908
SER A 963
GLY A1020
PHE A1022
 ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
ADP  A1201 (-3.3A)
None
None
 0.93A 4rzvA-6c7yA:
7.6		 4rzvA-6c7yA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		6 / 12 VAL A 889
ALA A 906
LYS A 908
SER A 963
GLY A1020
GLY A1023
 ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
ADP  A1201 (-3.3A)
None
MG  A1203 ( 4.7A)
 1.39A 4rzvB-6c7yA:
13.5		 4rzvB-6c7yA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		8 / 12 LEU A 881
VAL A 889
ALA A 906
LYS A 908
PHE A 958
GLY A 962
LEU A1010
ASP A1021
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
MG  A1203 (-1.8A)
 0.62A 4twpA-6c7yA:
23.4		 4twpA-6c7yA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		8 / 12 LEU A 881
VAL A 889
ALA A 906
PHE A 958
GLY A 962
ASN A1008
LEU A1010
ASP A1021
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
None
ADP  A1201 ( 4.1A)
MG  A1202 ( 2.5A)
ADP  A1201 (-4.5A)
MG  A1203 (-1.8A)
 0.61A 4twpA-6c7yA:
23.4		 4twpA-6c7yA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		8 / 12 LEU A 881
VAL A 889
ALA A 906
LYS A 908
PHE A 958
GLY A 962
LEU A1010
ASP A1021
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
MG  A1203 (-1.8A)
 0.64A 4twpB-6c7yA:
32.3		 4twpB-6c7yA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		8 / 12 LEU A 881
VAL A 889
ALA A 906
PHE A 958
GLY A 962
ASN A1008
LEU A1010
ASP A1021
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
None
ADP  A1201 ( 4.1A)
MG  A1202 ( 2.5A)
ADP  A1201 (-4.5A)
MG  A1203 (-1.8A)
 0.54A 4twpB-6c7yA:
32.3		 4twpB-6c7yA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		4 / 6 LEU A 881
VAL A 889
ILE A 937
ILE A1019
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
None
None
 0.42A 4tyjA-6c7yA:
28.2		 4tyjA-6c7yA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		4 / 6 LEU A 881
VAL A 889
LYS A 908
ILE A 937
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-2.8A)
None
 0.61A 4tyjA-6c7yA:
28.2		 4tyjA-6c7yA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		7 / 10 LEU A 881
VAL A 889
GLU A 925
LEU A 932
ILE A 937
VAL A 938
ILE A1019
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
None
None
None
None
None
 0.68A 4u0iA-6c7yA:
28.1		 4u0iA-6c7yA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_2
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		6 / 12 ALA A 906
LYS A 908
LEU A 929
GLY A 962
HIS A1001
LEU A1010
 ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
ADP  A1201 ( 4.1A)
None
ADP  A1201 (-4.5A)
 0.65A 4u0iA-6c7yA:
28.1		 4u0iA-6c7yA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_C_ANWC601_0
(RHODOPSIN KINASE)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		5 / 6 ARG A 879
LEU A 881
ALA A 906
MET A 956
LEU A1010
 None
ADP  A1201 ( 4.5A)
ADP  A1201 (-3.4A)
ADP  A1201 (-4.2A)
ADP  A1201 (-4.5A)
 0.76A 4wboC-6c7yA:
22.5		 4wboC-6c7yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		6 / 12 LEU A 881
ALA A 906
LYS A 908
GLU A 925
GLY A 962
LEU A1010
 ADP  A1201 ( 4.5A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
 0.48A 4wkqA-6c7yA:
33.4		 4wkqA-6c7yA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_2
(ESTROGEN RECEPTOR)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		4 / 5 LEU A1010
GLU A1012
LEU A 929
HIS A1001
 ADP  A1201 (-4.5A)
None
None
None
 1.16A 4xi3B-6c7yA:
undetectable		 4xi3B-6c7yA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLI_B_1N1B600_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		7 / 12 LEU A 881
ALA A 906
LYS A 908
GLU A 925
VAL A 938
GLY A 962
LEU A1010
 ADP  A1201 ( 4.5A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
None
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
 0.59A 4xliB-6c7yA:
26.5		 4xliB-6c7yA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		6 / 12 VAL A 889
ALA A 906
LYS A 908
GLY A1020
ASP A1021
PHE A1022
 ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
MG  A1203 (-1.8A)
None
 0.68A 4xv2A-6c7yA:
25.8		 4xv2A-6c7yA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		6 / 12 ALA A 906
LYS A 908
LEU A 929
GLY A1020
ASP A1021
PHE A1022
 ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
None
MG  A1203 (-1.8A)
None
 1.02A 4xv2B-6c7yA:
17.3		 4xv2B-6c7yA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
SUPPRESSOR OF
CYTOKINE SIGNALING 1
(Homo
sapiens;
Gallus
gallus) 		4 / 7 HIS B  54
PRO A1044
SER A 963
ASP A1003
 None
None
ADP  A1201 (-3.3A)
MG  A1203 (-4.7A)
 1.28A 5a1iA-6c7yB:
undetectable		 5a1iA-6c7yB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		7 / 9 LEU A 881
VAL A 889
ALA A 906
GLY A 962
LEU A1010
GLY A1020
ASP A1021
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
None
MG  A1203 (-1.8A)
 0.63A 5aaaA-6c7yA:
29.1		 5aaaA-6c7yA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		8 / 10 LEU A 881
VAL A 889
ALA A 906
LYS A 908
GLY A 962
LEU A1010
GLY A1020
ASP A1021
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
None
MG  A1203 (-1.8A)
 0.80A 5aabA-6c7yA:
28.9		 5aabA-6c7yA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		7 / 10 LEU A 881
VAL A 889
ALA A 906
GLY A 962
LEU A1010
GLY A1020
ASP A1021
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
None
MG  A1203 (-1.8A)
 0.61A 5aacA-6c7yA:
28.9		 5aacA-6c7yA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		7 / 10 LEU A 881
VAL A 889
ALA A 906
LYS A 908
GLY A 962
LEU A1010
GLY A1020
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
None
 0.81A 5aacA-6c7yA:
28.9		 5aacA-6c7yA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		6 / 12 LEU A 881
ALA A 906
PHE A 958
GLY A 962
LEU A1010
ASP A1021
 ADP  A1201 ( 4.5A)
ADP  A1201 (-3.4A)
None
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
MG  A1203 (-1.8A)
 0.66A 5ajqA-6c7yA:
22.8		 5ajqA-6c7yA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		6 / 12 LEU A 881
GLY A 882
ALA A 906
PHE A 958
GLY A 962
LEU A1010
 ADP  A1201 ( 4.5A)
ADP  A1201 (-3.5A)
ADP  A1201 (-3.4A)
None
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
 0.72A 5ajqA-6c7yA:
22.8		 5ajqA-6c7yA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		6 / 12 VAL A 889
ALA A 906
LYS A 908
LEU A 929
GLY A1020
PHE A1022
 ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
None
None
 1.09A 5cswA-6c7yA:
25.4		 5cswA-6c7yA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		5 / 12 VAL A 889
ALA A 906
LYS A 908
GLY A1020
PHE A1022
 ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
None
 0.67A 5cswB-6c7yA:
25.5		 5cswB-6c7yA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		6 / 12 ARG A 879
LEU A 881
ALA A 906
GLY A 962
GLU A 966
LEU A1010
 None
ADP  A1201 ( 4.5A)
ADP  A1201 (-3.4A)
ADP  A1201 ( 4.1A)
ADP  A1201 (-3.5A)
ADP  A1201 (-4.5A)
 0.69A 5h2uC-6c7yA:
28.0		 5h2uC-6c7yA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		6 / 12 ARG A 879
LEU A 881
ALA A 906
GLY A 962
LEU A1010
GLY A1020
 None
ADP  A1201 ( 4.5A)
ADP  A1201 (-3.4A)
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
None
 0.63A 5h2uC-6c7yA:
28.0		 5h2uC-6c7yA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		6 / 12 ARG A 879
LEU A 881
GLY A 962
LEU A1010
GLY A1020
ASP A1021
 None
ADP  A1201 ( 4.5A)
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
None
MG  A1203 (-1.8A)
 0.92A 5h2uC-6c7yA:
28.0		 5h2uC-6c7yA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		6 / 12 LEU A 881
VAL A 889
ALA A 906
GLY A 962
LEU A1010
GLY A1020
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
None
 0.57A 5h2uD-6c7yA:
28.0		 5h2uD-6c7yA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		7 / 12 ALA A 906
LYS A 908
GLU A 925
LEU A 929
LEU A 994
HIS A1001
GLY A1020
 ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
None
None
None
None
 0.93A 5hi2A-6c7yA:
25.6		 5hi2A-6c7yA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
SUPPRESSOR OF
CYTOKINE SIGNALING 1
(Homo
sapiens;
Gallus
gallus) 		5 / 12 ALA B  76
SER B  66
ILE B  67
PHE B  64
MET A1099
 None
 1.39A 5iwuA-6c7yB:
undetectable		 5iwuA-6c7yB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		6 / 11 LEU A 881
GLY A 882
VAL A 889
ALA A 906
VAL A 938
LEU A1010
 ADP  A1201 ( 4.5A)
ADP  A1201 (-3.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
None
ADP  A1201 (-4.5A)
 0.51A 5lvnA-6c7yA:
25.8		 5lvnA-6c7yA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_H_ADNH401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		5 / 9 GLY A 882
VAL A 889
ALA A 906
MET A 956
LEU A1010
 ADP  A1201 (-3.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-4.2A)
ADP  A1201 (-4.5A)
 0.96A 5lw1H-6c7yA:
21.0		 5lw1H-6c7yA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		5 / 10 LEU A 881
VAL A 889
GLU A 925
PHE A 958
GLY A 962
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
None
None
ADP  A1201 ( 4.1A)
 0.64A 5mo4A-6c7yA:
23.7		 5mo4A-6c7yA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		5 / 10 LEU A 881
VAL A 889
LYS A 908
GLU A 925
PHE A 958
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-2.8A)
None
None
 0.40A 5mo4A-6c7yA:
23.7		 5mo4A-6c7yA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		6 / 10 LEU A 881
VAL A 889
ALA A 906
VAL A 938
MET A 956
LEU A1010
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
None
ADP  A1201 (-4.2A)
ADP  A1201 (-4.5A)
 0.78A 5n3hA-6c7yA:
24.0		 5n3hA-6c7yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_1
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		7 / 12 LEU A 891
ALA A 906
GLU A 925
VAL A 938
PHE A 958
GLY A 962
LEU A1010
 None
ADP  A1201 (-3.4A)
None
None
None
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
 0.65A 5te0A-6c7yA:
24.2		 5te0A-6c7yA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		7 / 12 LEU A 881
ALA A 906
LYS A 908
GLU A 925
LEU A 954
GLY A 962
GLY A1020
 ADP  A1201 ( 4.5A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
None
ADP  A1201 ( 4.1A)
None
 1.22A 5vcvA-6c7yA:
24.0		 5vcvA-6c7yA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		7 / 12 LEU A 881
ALA A 906
LYS A 908
GLU A 925
VAL A 938
GLY A 962
GLY A1020
 ADP  A1201 ( 4.5A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
None
ADP  A1201 ( 4.1A)
None
 1.18A 5vcvA-6c7yA:
24.0		 5vcvA-6c7yA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		6 / 12 LEU A 881
VAL A 889
ALA A 906
LYS A 908
GLU A 925
LEU A 954
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
None
 0.77A 5vcyA-6c7yA:
24.2		 5vcyA-6c7yA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		7 / 12 ARG A 879
LEU A 881
VAL A 889
ALA A 906
GLU A 925
GLY A 962
LEU A1010
 None
ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
None
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
 0.69A 5y7zA-6c7yA:
23.6		 5y7zA-6c7yA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		7 / 12 ARG A 879
LEU A 881
VAL A 889
ALA A 906
GLU A 925
GLY A 962
LEU A1010
 None
ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
None
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
 0.69A 5y7zA-6c7yA:
23.6		 5y7zA-6c7yA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		7 / 12 ARG A 879
LEU A 881
VAL A 889
ALA A 906
LYS A 908
GLU A 925
GLY A 962
 None
ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
ADP  A1201 ( 4.1A)
 0.72A 5y7zA-6c7yA:
23.6		 5y7zA-6c7yA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		7 / 12 ARG A 879
LEU A 881
VAL A 889
ALA A 906
LYS A 908
GLU A 925
GLY A 962
 None
ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
ADP  A1201 ( 4.1A)
 0.72A 5y7zA-6c7yA:
23.6		 5y7zA-6c7yA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		7 / 12 LEU A 881
ALA A 906
GLU A 925
LEU A 954
GLY A 962
LEU A1010
ASP A1021
 ADP  A1201 ( 4.5A)
ADP  A1201 (-3.4A)
None
None
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
MG  A1203 (-1.8A)
 0.77A 5y7zB-6c7yA:
23.6		 5y7zB-6c7yA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		7 / 12 LEU A 881
ALA A 906
LYS A 908
GLU A 925
LEU A 954
GLY A 962
ASP A1021
 ADP  A1201 ( 4.5A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
None
ADP  A1201 ( 4.1A)
MG  A1203 (-1.8A)
 0.75A 5y7zB-6c7yA:
23.6		 5y7zB-6c7yA:
23.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		7 / 12 LEU A 881
GLY A 882
VAL A 889
ALA A 906
LYS A 908
MET A 956
LEU A1010
 ADP  A1201 ( 4.5A)
ADP  A1201 (-3.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
ADP  A1201 (-4.2A)
ADP  A1201 (-4.5A)
 1.05A 5yu9A-6c7yA:
28.6		 5yu9A-6c7yA:
30.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_A_ACTA404_0
(L-LYSINE
3-HYDROXYLASE)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		4 / 6 LEU A1024
VAL A1037
ARG A1041
SER A1043
 None
PTR  A1035 ( 3.1A)
None
None
 0.82A 6f6jA-6c7yA:
undetectable		 6f6jA-6c7yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G6R_A_SAMA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
SUPPRESSOR OF
CYTOKINE SIGNALING 1
(Homo
sapiens;
Gallus
gallus) 		4 / 7 HIS B  54
PRO A1044
SER A 963
ASP A1003
 None
None
ADP  A1201 (-3.3A)
MG  A1203 (-4.7A)
 1.29A 6g6rA-6c7yB:
undetectable		 6g6rA-6c7yB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_0
(TYROSINE-PROTEIN
KINASE ABL1)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		7 / 12 LEU A 881
VAL A 889
ALA A 906
GLU A 925
VAL A 938
PHE A 958
LEU A1010
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
None
None
None
ADP  A1201 (-4.5A)
 0.81A 6hd6B-6c7yA:
27.9		 6hd6B-6c7yA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_0
(TYROSINE-PROTEIN
KINASE ABL1)		 6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		7 / 12 LEU A 881
VAL A 889
ALA A 906
LYS A 908
GLU A 925
VAL A 938
PHE A 958
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
None
None
 0.53A 6hd6B-6c7yA:
27.9		 6hd6B-6c7yA:
27.78