SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6c87'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQW_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN)		 6c87 RAB GDP DISSOCIATION
INHIBITOR ALPHA
(Naegleria
fowleri) 		5 / 12 PHE A 432
THR A  97
VAL A  96
LEU A  87
ILE A 420
 None
 1.25A 1kqwA-6c87A:
undetectable		 1kqwA-6c87A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OT7_B_IU5B1002_1
(BILE ACID RECEPTOR)		 6c87 RAB GDP DISSOCIATION
INHIBITOR ALPHA
(Naegleria
fowleri) 		5 / 12 LEU A 376
ARG A 331
ILE A 335
PHE A 324
TYR A 112
 None
 1.24A 1ot7B-6c87A:
undetectable		 1ot7B-6c87A:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H79_A_T3A1_1
(THRA PROTEIN)		 6c87 RAB GDP DISSOCIATION
INHIBITOR ALPHA
(Naegleria
fowleri) 		5 / 12 ALA A 191
ALA A 204
LEU A 144
ILE A 172
PHE A 185
 None
 0.95A 2h79A-6c87A:
undetectable		 2h79A-6c87A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P02_A_SAMA2_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-2)		 6c87 RAB GDP DISSOCIATION
INHIBITOR ALPHA
(Naegleria
fowleri) 		4 / 8 HIS A 188
ASP A 334
SER A 415
ASP A 195
 None
 1.14A 2p02A-6c87A:
undetectable		 2p02A-6c87A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)		 6c87 RAB GDP DISSOCIATION
INHIBITOR ALPHA
(Naegleria
fowleri) 		5 / 12 LEU A 236
LEU A 243
GLY A  21
LEU A  87
VAL A 284
 None
 1.44A 2w8yA-6c87A:
undetectable		 2w8yA-6c87A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 6c87 RAB GDP DISSOCIATION
INHIBITOR ALPHA
(Naegleria
fowleri) 		4 / 8 THR A 410
ASP A 408
TYR A 193
SER A 415
 None
 1.15A 2xz5C-6c87A:
undetectable
2xz5D-6c87A:
undetectable		 2xz5C-6c87A:
undetectable
2xz5D-6c87A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWS_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 6c87 RAB GDP DISSOCIATION
INHIBITOR ALPHA
(Naegleria
fowleri) 		5 / 12 ALA A 191
ALA A 204
LEU A 144
ILE A 172
PHE A 185
 None
 1.03A 3gwsX-6c87A:
undetectable		 3gwsX-6c87A:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK2_X_LDPX433_1
(6-HYDROXY-L-NICOTINE
OXIDASE)		 6c87 RAB GDP DISSOCIATION
INHIBITOR ALPHA
(Naegleria
fowleri) 		4 / 7 TYR A 385
MET A  51
LEU A  48
LEU A  76
 None
 1.28A 3nk2X-6c87A:
14.8		 3nk2X-6c87A:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1003_1
(HEMOLYTIC LECTIN
CEL-III)		 6c87 RAB GDP DISSOCIATION
INHIBITOR ALPHA
(Naegleria
fowleri) 		4 / 4 ASP A 286
GLU A  42
GLY A  41
TYR A 289
 None
 1.27A 3w9tA-6c87A:
0.0		 3w9tA-6c87A:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB507_1
(HEMOLYTIC LECTIN
CEL-III)		 6c87 RAB GDP DISSOCIATION
INHIBITOR ALPHA
(Naegleria
fowleri) 		4 / 4 ASP A 286
GLU A  42
GLY A  41
TYR A 289
 None
 1.26A 3w9tB-6c87A:
0.0		 3w9tB-6c87A:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD507_1
(HEMOLYTIC LECTIN
CEL-III)		 6c87 RAB GDP DISSOCIATION
INHIBITOR ALPHA
(Naegleria
fowleri) 		4 / 5 ASP A 286
GLU A  42
GLY A  41
TYR A 289
 None
 1.26A 3w9tD-6c87A:
undetectable		 3w9tD-6c87A:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 6c87 RAB GDP DISSOCIATION
INHIBITOR ALPHA
(Naegleria
fowleri) 		4 / 8 HIS A 188
ASP A 334
SER A 415
ASP A 195
 None
 1.21A 4kttA-6c87A:
undetectable		 4kttA-6c87A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 6c87 RAB GDP DISSOCIATION
INHIBITOR ALPHA
(Naegleria
fowleri) 		4 / 8 HIS A 188
ASP A 334
SER A 415
ASP A 195
 None
 1.18A 4ndnA-6c87A:
undetectable		 4ndnA-6c87A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 6c87 RAB GDP DISSOCIATION
INHIBITOR ALPHA
(Naegleria
fowleri) 		4 / 7 HIS A 188
ASP A 334
SER A 415
ASP A 195
 None
 1.18A 4ndnC-6c87A:
undetectable		 4ndnC-6c87A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODJ_A_SAMA500_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 6c87 RAB GDP DISSOCIATION
INHIBITOR ALPHA
(Naegleria
fowleri) 		4 / 7 HIS A 188
ASP A 334
SER A 415
ASP A 195
 None
 1.25A 4odjA-6c87A:
undetectable		 4odjA-6c87A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_ADNA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 6c87 RAB GDP DISSOCIATION
INHIBITOR ALPHA
(Naegleria
fowleri) 		4 / 8 HIS A 188
ASP A 334
SER A 415
ASP A 195
 None
 1.18A 5a1iA-6c87A:
undetectable		 5a1iA-6c87A:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 6c87 RAB GDP DISSOCIATION
INHIBITOR ALPHA
(Naegleria
fowleri) 		4 / 7 HIS A 188
ASP A 334
SER A 415
ASP A 195
 None
 1.18A 5a1iA-6c87A:
undetectable		 5a1iA-6c87A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_A_HISA402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 6c87 RAB GDP DISSOCIATION
INHIBITOR ALPHA
(Naegleria
fowleri) 		5 / 10 THR A 182
VAL A 145
VAL A 178
ALA A 141
LEU A 148
 None
 1.11A 6czmA-6c87A:
2.2
6czmC-6c87A:
1.8		 6czmA-6c87A:
undetectable
6czmC-6c87A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 6c87 RAB GDP DISSOCIATION
INHIBITOR ALPHA
(Naegleria
fowleri) 		4 / 8 HIS A 188
ASP A 334
SER A 415
ASP A 195
 None
 1.18A 6fbnB-6c87A:
undetectable		 6fbnB-6c87A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBO_A_ADNA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 6c87 RAB GDP DISSOCIATION
INHIBITOR ALPHA
(Naegleria
fowleri) 		4 / 8 HIS A 188
ASP A 334
SER A 415
ASP A 195
 None
 1.20A 6fboA-6c87A:
undetectable		 6fboA-6c87A:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCB_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 6c87 RAB GDP DISSOCIATION
INHIBITOR ALPHA
(Naegleria
fowleri) 		4 / 8 HIS A 188
ASP A 334
SER A 415
ASP A 195
 None
 1.20A 6fcbA-6c87A:
undetectable		 6fcbA-6c87A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCD_A_ADNA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 6c87 RAB GDP DISSOCIATION
INHIBITOR ALPHA
(Naegleria
fowleri) 		4 / 8 HIS A 188
ASP A 334
SER A 415
ASP A 195
 None
 1.21A 6fcdA-6c87A:
undetectable		 6fcdA-6c87A:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G6R_A_SAMA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 6c87 RAB GDP DISSOCIATION
INHIBITOR ALPHA
(Naegleria
fowleri) 		4 / 7 HIS A 188
ASP A 334
SER A 415
ASP A 195
 None
 1.18A 6g6rA-6c87A:
undetectable		 6g6rA-6c87A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_A_LLLA301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 6c87 RAB GDP DISSOCIATION
INHIBITOR ALPHA
(Naegleria
fowleri) 		4 / 6 ASP A 419
GLU A  16
ASP A 286
GLU A  42
 None
 1.31A 6mn5A-6c87A:
undetectable		 6mn5A-6c87A:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_B_LLLB301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 6c87 RAB GDP DISSOCIATION
INHIBITOR ALPHA
(Naegleria
fowleri) 		4 / 7 ASP A 419
GLU A  16
ASP A 286
GLU A  42
 None
 1.30A 6mn5B-6c87A:
undetectable		 6mn5B-6c87A:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_C_LLLC301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 6c87 RAB GDP DISSOCIATION
INHIBITOR ALPHA
(Naegleria
fowleri) 		4 / 6 ASP A 419
GLU A  16
ASP A 286
GLU A  42
 None
 1.50A 6mn5C-6c87A:
undetectable		 6mn5C-6c87A:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_D_LLLD301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 6c87 RAB GDP DISSOCIATION
INHIBITOR ALPHA
(Naegleria
fowleri) 		4 / 6 ASP A 419
GLU A  16
ASP A 286
GLU A  42
 None
 1.39A 6mn5D-6c87A:
undetectable		 6mn5D-6c87A:
24.14