SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6c8a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A27_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 6c8a INOSITOL
POLYPHOSPHATE
MULTIKINASE
(Homo
sapiens) 		5 / 12 VAL A 178
GLY A 199
LEU A 202
TYR A 168
VAL A 409
 None
 1.41A 1a27A-6c8aA:
undetectable		 1a27A-6c8aA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_A_DESA129_1
(TRANSTHYRETIN)		 6c8a INOSITOL
POLYPHOSPHATE
MULTIKINASE
(Homo
sapiens) 		4 / 4 LYS A  75
LEU A  77
LEU A 126
SER A 118
 None
 1.42A 1tt6A-6c8aA:
undetectable		 1tt6A-6c8aA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_A_9CRA131_1
(TRANSTHYRETIN)		 6c8a INOSITOL
POLYPHOSPHATE
MULTIKINASE
(Homo
sapiens) 		4 / 6 LYS A  75
LEU A  77
LEU A 126
SER A 118
 None
 1.28A 1tyrA-6c8aA:
undetectable		 1tyrA-6c8aA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_D_DESD128_1
(TRANSTHYRETIN)		 6c8a INOSITOL
POLYPHOSPHATE
MULTIKINASE
(Homo
sapiens) 		4 / 4 LYS A  75
LEU A  77
LEU A 126
SER A 118
 None
 1.43A 1tz8D-6c8aA:
1.1		 1tz8D-6c8aA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGG_A_CHDA211_0
(CMER)		 6c8a INOSITOL
POLYPHOSPHATE
MULTIKINASE
(Homo
sapiens) 		4 / 7 PHE A 386
PHE A  89
PHE A 240
TYR A 109
 None
 1.45A 3hggA-6c8aA:
undetectable		 3hggA-6c8aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J7Z_A_ERYA9000_0
(23S RRNA
50S RIBOSOMAL
PROTEIN L22
ERMCL NASCENT CHAIN)		 6c8a INOSITOL
POLYPHOSPHATE
MULTIKINASE
(Homo
sapiens) 		3 / 3 LYS A 136
ILE A 236
PHE A 240
 None
 0.86A 3j7zS-6c8aA:
undetectable
3j7za-6c8aA:
undetectable		 3j7zS-6c8aA:
undetectable
3j7za-6c8aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 6c8a INOSITOL
POLYPHOSPHATE
MULTIKINASE
(Homo
sapiens) 		4 / 8 ILE A 233
ARG A 382
PRO A 140
VAL A 133
 None
 1.30A 4f4dB-6c8aA:
undetectable		 4f4dB-6c8aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA302_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 6c8a INOSITOL
POLYPHOSPHATE
MULTIKINASE
(Homo
sapiens) 		4 / 5 HIS A 216
TYR A 198
GLY A 210
SER A 212
 None
 1.24A 4fu8A-6c8aA:
undetectable		 4fu8A-6c8aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CR0_A_ACTA506_0
((S)-6-HYDROXYNICOTIN
E OXIDASE)		 6c8a INOSITOL
POLYPHOSPHATE
MULTIKINASE
(Homo
sapiens) 		4 / 4 ALA A 250
HIS A 388
TYR A 152
LYS A 160
 None
 1.28A 6cr0A-6c8aA:
0.0		 6cr0A-6c8aA:
undetectable