SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6c8q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_2
(ESTROGEN RECEPTOR)		 6c8q NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Enterococcus
faecalis) 		4 / 6 LEU A 185
LEU A 200
LEU A  35
LEU A  41
 None
 0.84A 1errA-6c8qA:
undetectable		 1errA-6c8qA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2001_1
(SERUM ALBUMIN)		 6c8q NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Enterococcus
faecalis) 		5 / 12 ILE A   8
PHE A 186
VAL A  14
GLY A  13
LEU A 239
 None
 1.21A 2bxeB-6c8qA:
undetectable		 2bxeB-6c8qA:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DM6_A_IMNA1401_1
(NADP-DEPENDENT
LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE)		 6c8q NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Enterococcus
faecalis) 		5 / 10 ALA A 234
ILE A   8
PRO A  16
GLU A 240
ILE A   9
 None
 0.99A 2dm6A-6c8qA:
undetectable
2dm6B-6c8qA:
undetectable		 2dm6A-6c8qA:
15.61
2dm6B-6c8qA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UY4_A_PAUA302_0
(PANTOTHENATE
SYNTHETASE)		 6c8q NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Enterococcus
faecalis) 		4 / 8 ARG A 143
VAL A 116
VAL A 120
ASP A 111
 None
 1.11A 3uy4A-6c8qA:
4.1		 3uy4A-6c8qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 6c8q NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Enterococcus
faecalis) 		4 / 7 ASP A  53
ASP A 162
ASP A 236
GLU A 166
 None
 1.12A 4feuB-6c8qA:
undetectable		 4feuB-6c8qA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 6c8q NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Enterococcus
faecalis) 		4 / 8 ASP A  53
ASP A 162
ASP A 236
GLU A 166
 None
 1.10A 4feuD-6c8qA:
undetectable		 4feuD-6c8qA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 6c8q NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Enterococcus
faecalis) 		4 / 8 ASP A  53
ASP A 162
ASP A 236
GLU A 166
 None
 1.09A 4feuF-6c8qA:
undetectable		 4feuF-6c8qA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 6c8q NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Enterococcus
faecalis) 		4 / 7 ASP A  53
ASP A 162
ASP A 236
GLU A 166
 None
 1.14A 4fevB-6c8qA:
undetectable		 4fevB-6c8qA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 6c8q NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Enterococcus
faecalis) 		4 / 7 ASP A  53
ASP A 162
ASP A 236
GLU A 166
 None
 1.14A 4fevD-6c8qA:
undetectable		 4fevD-6c8qA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 6c8q NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Enterococcus
faecalis) 		4 / 7 ASP A  53
ASP A 162
ASP A 236
GLU A 166
 None
 1.13A 4fevF-6c8qA:
undetectable		 4fevF-6c8qA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 6c8q NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Enterococcus
faecalis) 		4 / 7 ASP A  53
ASP A 162
ASP A 236
GLU A 166
 None
 1.13A 4fewB-6c8qA:
undetectable		 4fewB-6c8qA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 6c8q NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Enterococcus
faecalis) 		4 / 8 ASP A  53
ASP A 162
ASP A 236
GLU A 166
 None
 1.15A 4fewD-6c8qA:
undetectable		 4fewD-6c8qA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 6c8q NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Enterococcus
faecalis) 		4 / 8 ASP A  53
ASP A 162
ASP A 236
GLU A 166
 None
 1.14A 4fewF-6c8qA:
undetectable		 4fewF-6c8qA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEX_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 6c8q NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Enterococcus
faecalis) 		4 / 7 ASP A  53
ASP A 162
ASP A 236
GLU A 166
 None
 1.17A 4fexB-6c8qA:
undetectable		 4fexB-6c8qA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 6c8q NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Enterococcus
faecalis) 		4 / 8 ASP A  53
ASP A 162
ASP A 236
GLU A 166
 None
 1.15A 4gkhB-6c8qA:
undetectable		 4gkhB-6c8qA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 6c8q NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Enterococcus
faecalis) 		4 / 8 ASP A  53
ASP A 162
ASP A 236
GLU A 166
 None
 1.13A 4gkhD-6c8qA:
undetectable		 4gkhD-6c8qA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 6c8q NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Enterococcus
faecalis) 		4 / 8 ASP A  53
ASP A 162
ASP A 236
GLU A 166
 None
 1.17A 4gkhF-6c8qA:
undetectable		 4gkhF-6c8qA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 6c8q NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Enterococcus
faecalis) 		4 / 7 ASP A  53
ASP A 162
ASP A 236
GLU A 166
 None
 1.15A 4gkhG-6c8qA:
undetectable		 4gkhG-6c8qA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_J_KANJ301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 6c8q NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Enterococcus
faecalis) 		4 / 6 ASP A  53
ASP A 162
ASP A 236
GLU A 166
 None
 1.13A 4gkhJ-6c8qA:
undetectable		 4gkhJ-6c8qA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_K_KANK301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 6c8q NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Enterococcus
faecalis) 		4 / 8 ASP A  53
ASP A 162
ASP A 236
GLU A 166
 None
 1.13A 4gkhC-6c8qA:
undetectable
4gkhK-6c8qA:
undetectable		 4gkhC-6c8qA:
15.27
4gkhK-6c8qA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 6c8q NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Enterococcus
faecalis) 		4 / 8 ASP A  53
ASP A 162
ASP A 236
GLU A 166
 None
 1.16A 4gkiA-6c8qA:
undetectable		 4gkiA-6c8qA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_C_KANC301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 6c8q NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Enterococcus
faecalis) 		4 / 8 ASP A  53
ASP A 162
ASP A 236
GLU A 166
 None
 1.15A 4gkiC-6c8qA:
undetectable		 4gkiC-6c8qA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 6c8q NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Enterococcus
faecalis) 		4 / 8 ASP A  53
ASP A 162
ASP A 236
GLU A 166
 None
 1.15A 4gkiE-6c8qA:
undetectable
4gkiG-6c8qA:
undetectable		 4gkiE-6c8qA:
15.27
4gkiG-6c8qA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 6c8q NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Enterococcus
faecalis) 		3 / 3 ALA A 202
GLN A  52
THR A  55
 None
 0.69A 5n0oA-6c8qA:
undetectable		 5n0oA-6c8qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_B_OQRB302_0
(SULFOTRANSFERASE)		 6c8q NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Enterococcus
faecalis) 		5 / 10 ILE A 182
LEU A  60
LEU A 188
PHE A  30
GLU A  23
 None
 1.37A 5tixB-6c8qA:
undetectable		 5tixB-6c8qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_0
(PROTEASE)		 6c8q NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Enterococcus
faecalis) 		5 / 12 GLY A 152
ALA A 151
ILE A  82
ILE A 145
VAL A 158
 None
 0.88A 6dh0A-6c8qA:
undetectable		 6dh0A-6c8qA:
20.43