SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6c8s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9H_A_RAPA108_1
(FKBP12.6)		 6c8s LOGANIC ACID
O-METHYLTRANSFERASE
(Catharanthus
roseus) 		5 / 12 ASP A  75
GLU A  93
VAL A  92
PHE A 133
ILE A 152
 SAH  A 401 ( 4.6A)
None
None
None
None
 0.99A 1c9hA-6c8sA:
undetectable		 1c9hA-6c8sA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQW_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN)		 6c8s LOGANIC ACID
O-METHYLTRANSFERASE
(Catharanthus
roseus) 		5 / 12 ILE A 261
VAL A 317
LEU A 337
LEU A 271
ILE A 184
 None
 1.09A 1kqwA-6c8sA:
undetectable		 1kqwA-6c8sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_B_ADNB1502_1
(CLASS B ACID
PHOSPHATASE)		 6c8s LOGANIC ACID
O-METHYLTRANSFERASE
(Catharanthus
roseus) 		4 / 7 PHE A 236
GLU A 190
TYR A 197
LYS A 195
 None
 1.18A 1rmtB-6c8sA:
undetectable		 1rmtB-6c8sA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_B_CQAB401_0
(HISTAMINE
N-METHYLTRANSFERASE)		 6c8s LOGANIC ACID
O-METHYLTRANSFERASE
(Catharanthus
roseus) 		4 / 7 GLY A 137
PHE A 112
ASP A 114
THR A  84
 None
None
SAH  A 401 (-2.8A)
None
 1.16A 2aouB-6c8sA:
17.3		 2aouB-6c8sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG4_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 6c8s LOGANIC ACID
O-METHYLTRANSFERASE
(Catharanthus
roseus) 		5 / 11 GLU A  93
VAL A  92
ILE A  73
PHE A 133
HIS A 156
 None
 1.16A 2dg4A-6c8sA:
undetectable		 2dg4A-6c8sA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EFJ_A_37TA502_1
(3,7-DIMETHYLXANTHINE
METHYLTRANSFERASE)		 6c8s LOGANIC ACID
O-METHYLTRANSFERASE
(Catharanthus
roseus) 		5 / 12 TYR A  31
TYR A 159
HIS A 162
TRP A 163
ILE A 320
 SAH  A 401 (-4.5A)
None
None
None
None
 0.44A 2efjA-6c8sA:
36.6		 2efjA-6c8sA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 6c8s LOGANIC ACID
O-METHYLTRANSFERASE
(Catharanthus
roseus) 		3 / 3 HIS A 275
HIS A 245
HIS A 185
 None
 0.66A 3ag4A-6c8sA:
undetectable		 3ag4A-6c8sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 6c8s LOGANIC ACID
O-METHYLTRANSFERASE
(Catharanthus
roseus) 		3 / 3 HIS A 275
HIS A 245
HIS A 185
 None
 0.70A 3ag4N-6c8sA:
undetectable		 3ag4N-6c8sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_1
(O-METHYLTRANSFERASE)		 6c8s LOGANIC ACID
O-METHYLTRANSFERASE
(Catharanthus
roseus) 		4 / 4 ASP A 114
SER A 141
PHE A 142
SER A 158
 SAH  A 401 (-2.8A)
SAH  A 401 (-3.1A)
SAH  A 401 (-3.3A)
SAH  A 401 (-3.6A)
 0.88A 3i5uA-6c8sA:
13.7		 3i5uA-6c8sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OPE_A_SAMA7_0
(PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 6c8s LOGANIC ACID
O-METHYLTRANSFERASE
(Catharanthus
roseus) 		5 / 12 LYS A  39
GLY A  40
ASN A  83
TYR A  31
GLN A 316
 None
None
SAH  A 401 (-3.8A)
SAH  A 401 (-4.5A)
None
 1.35A 3opeA-6c8sA:
undetectable		 3opeA-6c8sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OPE_B_SAMB8_0
(PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 6c8s LOGANIC ACID
O-METHYLTRANSFERASE
(Catharanthus
roseus) 		5 / 9 LYS A  39
GLY A  40
ASN A  83
TYR A  31
GLN A 316
 None
None
SAH  A 401 (-3.8A)
SAH  A 401 (-4.5A)
None
 1.37A 3opeB-6c8sA:
undetectable		 3opeB-6c8sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_A_XRAA233_2
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 6c8s LOGANIC ACID
O-METHYLTRANSFERASE
(Catharanthus
roseus) 		4 / 5 VAL A 365
PHE A 205
ILE A 226
PHE A 201
 None
 1.02A 3owxB-6c8sA:
2.8		 3owxB-6c8sA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 6c8s LOGANIC ACID
O-METHYLTRANSFERASE
(Catharanthus
roseus) 		4 / 5 PHE A 329
GLY A 182
ILE A 261
VAL A 256
 None
 0.88A 3wrkA-6c8sA:
undetectable		 3wrkA-6c8sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_F_ACTF701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 6c8s LOGANIC ACID
O-METHYLTRANSFERASE
(Catharanthus
roseus) 		4 / 4 PHE A  65
HIS A 153
GLY A 219
ILE A  64
 None
 1.44A 4k50E-6c8sA:
undetectable		 4k50E-6c8sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_M_ACTM503_0
(RNA POLYMERASE
3D-POL)		 6c8s LOGANIC ACID
O-METHYLTRANSFERASE
(Catharanthus
roseus) 		4 / 4 PHE A  65
HIS A 153
GLY A 219
ILE A  64
 None
 1.45A 4k50M-6c8sA:
undetectable		 4k50M-6c8sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_2
(GLUCOCORTICOID
RECEPTOR)		 6c8s LOGANIC ACID
O-METHYLTRANSFERASE
(Catharanthus
roseus) 		3 / 3 MET A  88
GLN A  38
TYR A 159
 None
 1.13A 4udcA-6c8sA:
undetectable		 4udcA-6c8sA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNM_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 6c8s LOGANIC ACID
O-METHYLTRANSFERASE
(Catharanthus
roseus) 		5 / 12 LYS A  39
GLY A  40
ASN A  83
TYR A  31
GLN A 316
 None
None
SAH  A 401 (-3.8A)
SAH  A 401 (-4.5A)
None
 1.37A 4ynmA-6c8sA:
undetectable		 4ynmA-6c8sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_A_SAMA3004_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 6c8s LOGANIC ACID
O-METHYLTRANSFERASE
(Catharanthus
roseus) 		5 / 12 LYS A  39
GLY A  40
ASN A  83
TYR A  31
GLN A 316
 None
None
SAH  A 401 (-3.8A)
SAH  A 401 (-4.5A)
None
 1.42A 4ypaA-6c8sA:
undetectable		 4ypaA-6c8sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 6c8s LOGANIC ACID
O-METHYLTRANSFERASE
(Catharanthus
roseus) 		5 / 12 LYS A  39
GLY A  40
ASN A  83
TYR A  31
GLN A 316
 None
None
SAH  A 401 (-3.8A)
SAH  A 401 (-4.5A)
None
 1.35A 4ypaB-6c8sA:
undetectable		 4ypaB-6c8sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_C_SAMC2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 6c8s LOGANIC ACID
O-METHYLTRANSFERASE
(Catharanthus
roseus) 		5 / 12 LYS A  39
GLY A  40
ASN A  83
TYR A  31
GLN A 316
 None
None
SAH  A 401 (-3.8A)
SAH  A 401 (-4.5A)
None
 1.41A 4ypaC-6c8sA:
undetectable		 4ypaC-6c8sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 6c8s LOGANIC ACID
O-METHYLTRANSFERASE
(Catharanthus
roseus) 		5 / 12 LYS A  39
GLY A  40
ASN A  83
TYR A  31
GLN A 316
 None
None
SAH  A 401 (-3.8A)
SAH  A 401 (-4.5A)
None
 1.42A 4ypeA-6c8sA:
undetectable		 4ypeA-6c8sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPU_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 6c8s LOGANIC ACID
O-METHYLTRANSFERASE
(Catharanthus
roseus) 		5 / 12 LYS A  39
GLY A  40
ASN A  83
TYR A  31
GLN A 316
 None
None
SAH  A 401 (-3.8A)
SAH  A 401 (-4.5A)
None
 1.49A 4ypuA-6c8sA:
undetectable		 4ypuA-6c8sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPU_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 6c8s LOGANIC ACID
O-METHYLTRANSFERASE
(Catharanthus
roseus) 		5 / 11 LYS A  39
GLY A  40
ASN A  83
TYR A  31
GLN A 316
 None
None
SAH  A 401 (-3.8A)
SAH  A 401 (-4.5A)
None
 1.41A 4ypuB-6c8sA:
undetectable		 4ypuB-6c8sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 6c8s LOGANIC ACID
O-METHYLTRANSFERASE
(Catharanthus
roseus) 		4 / 7 ALA A  87
THR A  84
VAL A 110
HIS A 156
 None
 1.16A 5ecnA-6c8sA:
undetectable		 5ecnA-6c8sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HKG_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1B)		 6c8s LOGANIC ACID
O-METHYLTRANSFERASE
(Catharanthus
roseus) 		5 / 12 ASP A  75
GLU A  93
VAL A  92
PHE A 133
ILE A 152
 SAH  A 401 ( 4.6A)
None
None
None
None
 1.00A 5hkgA-6c8sA:
undetectable		 5hkgA-6c8sA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HKG_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1B)		 6c8s LOGANIC ACID
O-METHYLTRANSFERASE
(Catharanthus
roseus) 		5 / 12 GLU A  93
VAL A  92
ILE A  73
PHE A 133
HIS A 156
 None
 1.18A 5hkgA-6c8sA:
undetectable		 5hkgA-6c8sA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGW_A_CTYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 6c8s LOGANIC ACID
O-METHYLTRANSFERASE
(Catharanthus
roseus) 		5 / 12 GLY A  77
ASP A 361
ILE A 320
TYR A  31
MET A  22
 SAH  A 401 (-3.5A)
None
None
SAH  A 401 (-4.5A)
SAH  A 401 (-3.7A)
 1.15A 5igwA-6c8sA:
undetectable		 5igwA-6c8sA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB307_0
(WELO5)		 6c8s LOGANIC ACID
O-METHYLTRANSFERASE
(Catharanthus
roseus) 		3 / 3 GLU A 190
HIS A 192
VAL A 193
 None
 0.86A 5trqB-6c8sA:
undetectable		 5trqB-6c8sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V21_A_SAMA1804_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2)		 6c8s LOGANIC ACID
O-METHYLTRANSFERASE
(Catharanthus
roseus) 		5 / 12 LYS A  39
GLY A  40
ASN A  83
TYR A  31
GLN A 316
 None
None
SAH  A 401 (-3.8A)
SAH  A 401 (-4.5A)
None
 1.40A 5v21A-6c8sA:
undetectable		 5v21A-6c8sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 6c8s LOGANIC ACID
O-METHYLTRANSFERASE
(Catharanthus
roseus) 		3 / 3 HIS A 275
HIS A 245
HIS A 185
 None
 0.73A 5w97a-6c8sA:
undetectable		 5w97a-6c8sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6INE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 6c8s LOGANIC ACID
O-METHYLTRANSFERASE
(Catharanthus
roseus) 		5 / 12 LYS A  39
GLY A  40
ASN A  83
TYR A  31
GLN A 316
 None
None
SAH  A 401 (-3.8A)
SAH  A 401 (-4.5A)
None
 1.31A 6ineA-6c8sA:
undetectable		 6ineA-6c8sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 6c8s LOGANIC ACID
O-METHYLTRANSFERASE
(Catharanthus
roseus) 		3 / 3 HIS A 275
HIS A 245
HIS A 185
 None
 0.72A 6nmfN-6c8sA:
undetectable		 6nmfN-6c8sA:
undetectable