SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6c8v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_A_SALA506_1
(SALICYLATE
SYNTHETASE, IRP9)		 6c8v COENZYME PQQ
SYNTHESIS PROTEIN E
(Methylobacterium
extorquens) 		5 / 11 GLY A 101
THR A  99
LEU A 112
GLY A 104
GLU A  74
 None
 1.32A 2fn1A-6c8vA:
undetectable		 2fn1A-6c8vA:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1003_0
(ALDEHYDE
DEHYDROGENASE A)		 6c8v COENZYME PQQ
SYNTHESIS PROTEIN E
(Methylobacterium
extorquens) 		4 / 5 ILE A 233
LEU A 188
ASP A 178
ALA A 223
 None
 1.04A 2opxA-6c8vA:
undetectable		 2opxA-6c8vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 6c8v COENZYME PQQ
SYNTHESIS PROTEIN E
(Methylobacterium
extorquens) 		5 / 10 ALA A 107
ALA A 105
THR A  99
LEU A  97
VAL A 120
 None
 1.23A 2wuzA-6c8vA:
undetectable		 2wuzA-6c8vA:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 6c8v COENZYME PQQ
SYNTHESIS PROTEIN E
(Methylobacterium
extorquens) 		5 / 10 ALA A 107
ALA A 105
THR A  99
LEU A  97
VAL A 120
 None
 1.20A 2wuzB-6c8vA:
undetectable		 2wuzB-6c8vA:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_A_ADNA506_2
(ADENOSYLHOMOCYSTEINA
SE)		 6c8v COENZYME PQQ
SYNTHESIS PROTEIN E
(Methylobacterium
extorquens) 		3 / 3 GLN A 194
THR A 193
LEU A 256
 None
 0.53A 3ondA-6c8vA:
undetectable		 3ondA-6c8vA:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_B_ADNB507_2
(ADENOSYLHOMOCYSTEINA
SE)		 6c8v COENZYME PQQ
SYNTHESIS PROTEIN E
(Methylobacterium
extorquens) 		3 / 3 GLN A 194
THR A 193
LEU A 256
 None
 0.54A 3ondB-6c8vA:
undetectable		 3ondB-6c8vA:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RFA_B_SAMB406_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE N)		 6c8v COENZYME PQQ
SYNTHESIS PROTEIN E
(Methylobacterium
extorquens) 		5 / 12 GLU A  74
PRO A  75
SER A 100
SER A 123
VAL A 164
 None
 1.04A 3rfaB-6c8vA:
10.3		 3rfaB-6c8vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 6c8v COENZYME PQQ
SYNTHESIS PROTEIN E
(Methylobacterium
extorquens) 		4 / 6 GLU A 272
TYR A 281
HIS A 285
VAL A  56
 None
 1.24A 4a97I-6c8vA:
undetectable		 4a97I-6c8vA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_A_ADNA401_1
(APH(2'')-ID)		 6c8v COENZYME PQQ
SYNTHESIS PROTEIN E
(Methylobacterium
extorquens) 		5 / 10 ILE A 219
ILE A 233
LEU A 188
ILE A 177
ASP A 178
 None
 1.30A 4dtaA-6c8vA:
undetectable		 4dtaA-6c8vA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI504_0
(RNA POLYMERASE
3D-POL)		 6c8v COENZYME PQQ
SYNTHESIS PROTEIN E
(Methylobacterium
extorquens) 		3 / 3 VAL A 181
GLY A 184
LYS A 186
 None
 0.55A 4k50I-6c8vA:
undetectable		 4k50I-6c8vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_B_ACTB401_0
(UNCHARACTERIZED
PROTEIN)		 6c8v COENZYME PQQ
SYNTHESIS PROTEIN E
(Methylobacterium
extorquens) 		4 / 5 GLU A  74
LEU A  97
VAL A 120
PHE A 148
 None
 1.03A 4lb0B-6c8vA:
undetectable		 4lb0B-6c8vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 6c8v COENZYME PQQ
SYNTHESIS PROTEIN E
(Methylobacterium
extorquens) 		5 / 12 THR A 193
CYH A 323
ALA A 270
THR A 273
CYH A 268
 None
FES  A 501 (-2.7A)
FES  A 501 ( 4.5A)
None
FES  A 501 (-2.6A)
 1.28A 5d0xH-6c8vA:
undetectable
5d0xI-6c8vA:
undetectable		 5d0xH-6c8vA:
13.79
5d0xI-6c8vA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 6c8v COENZYME PQQ
SYNTHESIS PROTEIN E
(Methylobacterium
extorquens) 		5 / 12 THR A 193
CYH A 323
ALA A 270
THR A 273
CYH A 268
 None
FES  A 501 (-2.7A)
FES  A 501 ( 4.5A)
None
FES  A 501 (-2.6A)
 1.29A 5l5zH-6c8vA:
undetectable
5l5zI-6c8vA:
undetectable		 5l5zH-6c8vA:
13.79
5l5zI-6c8vA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 6c8v COENZYME PQQ
SYNTHESIS PROTEIN E
(Methylobacterium
extorquens) 		5 / 12 THR A 193
CYH A 323
ALA A 270
THR A 273
CYH A 268
 None
FES  A 501 (-2.7A)
FES  A 501 ( 4.5A)
None
FES  A 501 (-2.6A)
 1.29A 5l5zV-6c8vA:
undetectable
5l5zW-6c8vA:
undetectable		 5l5zV-6c8vA:
13.79
5l5zW-6c8vA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V1S_B_SAMB604_0
(RADICAL SAM)		 6c8v COENZYME PQQ
SYNTHESIS PROTEIN E
(Methylobacterium
extorquens) 		5 / 9 CYH A  28
GLU A  74
SER A 123
ASN A 162
VAL A 164
 None
 0.95A 5v1sB-6c8vA:
24.6		 5v1sB-6c8vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB303_1
(BIFUNCTIONAL PROTEIN
FOLD)		 6c8v COENZYME PQQ
SYNTHESIS PROTEIN E
(Methylobacterium
extorquens) 		4 / 5 TYR A 195
GLN A 194
GLY A 101
ILE A  98
 None
 1.45A 6debB-6c8vA:
undetectable		 6debB-6c8vA:
21.05