SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6c8z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_CCSA381_0
(ESTROGEN RECEPTOR)		 6c8z ADP-DEPENDENT
PHOSPHOFRUCTOKINASE
(Methanosarcinale
s) 		4 / 5 HIS A 280
GLU A 282
ALA A 117
SER A 121
 None
 0.96A 1errA-6c8zA:
undetectable
1errB-6c8zA:
undetectable		 1errA-6c8zA:
undetectable
1errB-6c8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_1
(HIV-1 PROTEASE)		 6c8z ADP-DEPENDENT
PHOSPHOFRUCTOKINASE
(Methanosarcinale
s) 		5 / 9 ASP A 404
GLY A 128
ILE A 129
VAL A 390
ILE A 406
 None
 1.03A 1hxwA-6c8zA:
undetectable		 1hxwA-6c8zA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_A_ID2A1_0
(THYMIDINE KINASE)		 6c8z ADP-DEPENDENT
PHOSPHOFRUCTOKINASE
(Methanosarcinale
s) 		5 / 12 HIS A  40
TRP A 182
ILE A 184
ILE A 183
ALA A 111
 None
 1.17A 1ki7A-6c8zA:
undetectable		 1ki7A-6c8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 6c8z ADP-DEPENDENT
PHOSPHOFRUCTOKINASE
(Methanosarcinale
s) 		5 / 12 TYR A  10
ILE A 454
ALA A 392
GLY A 418
SER A 415
 None
 1.08A 1kiaA-6c8zA:
6.4		 1kiaA-6c8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 6c8z ADP-DEPENDENT
PHOSPHOFRUCTOKINASE
(Methanosarcinale
s) 		5 / 12 TYR A  10
ILE A 454
ALA A 392
GLY A 418
SER A 415
 None
 1.04A 1nbiA-6c8zA:
5.9		 1nbiA-6c8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 6c8z ADP-DEPENDENT
PHOSPHOFRUCTOKINASE
(Methanosarcinale
s) 		5 / 12 TYR A  10
ILE A 454
ALA A 392
GLY A 418
SER A 415
 None
 1.05A 1nbiB-6c8zA:
5.8		 1nbiB-6c8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA502_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 6c8z ADP-DEPENDENT
PHOSPHOFRUCTOKINASE
(Methanosarcinale
s) 		4 / 6 ASN A  32
ASN A  34
ILE A 119
GLY A 114
 None
 1.07A 1oniA-6c8zA:
undetectable
1oniB-6c8zA:
undetectable		 1oniA-6c8zA:
undetectable
1oniB-6c8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD508_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 6c8z ADP-DEPENDENT
PHOSPHOFRUCTOKINASE
(Methanosarcinale
s) 		4 / 6 ASN A  32
ASN A  34
ILE A 119
GLY A 114
 None
 1.13A 1oniD-6c8zA:
1.6
1oniF-6c8zA:
undetectable		 1oniD-6c8zA:
undetectable
1oniF-6c8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_B_DIFB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6c8z ADP-DEPENDENT
PHOSPHOFRUCTOKINASE
(Methanosarcinale
s) 		5 / 9 LEU A 326
TYR A 323
VAL A 314
GLY A 344
ALA A 345
 None
 1.17A 1pxxB-6c8zA:
undetectable		 1pxxB-6c8zA:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_D_DIFD3701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6c8z ADP-DEPENDENT
PHOSPHOFRUCTOKINASE
(Methanosarcinale
s) 		5 / 10 LEU A 326
TYR A 323
VAL A 314
GLY A 344
ALA A 345
 None
 1.15A 1pxxD-6c8zA:
undetectable		 1pxxD-6c8zA:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 6c8z ADP-DEPENDENT
PHOSPHOFRUCTOKINASE
(Methanosarcinale
s) 		5 / 10 ILE A 133
ALA A  30
LEU A 228
ILE A 277
ILE A 235
 None
 1.22A 1rb3A-6c8zA:
undetectable		 1rb3A-6c8zA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_F_BEZF5023_0
(CES1 PROTEIN)		 6c8z ADP-DEPENDENT
PHOSPHOFRUCTOKINASE
(Methanosarcinale
s) 		4 / 6 GLY A 363
SER A 361
LEU A 422
ILE A 366
 None
 0.96A 1yajF-6c8zA:
undetectable		 1yajF-6c8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A7Q_A_CFBA328_2
(DEOXYCYTIDINE KINASE)		 6c8z ADP-DEPENDENT
PHOSPHOFRUCTOKINASE
(Methanosarcinale
s) 		4 / 4 ILE A  38
ASP A  45
LEU A 102
ARG A 206
 None
NI  A 504 (-2.5A)
None
None
 1.34A 2a7qA-6c8zA:
2.3		 2a7qA-6c8zA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC8_0
(ACTINOMYCIN D)		 6c8z ADP-DEPENDENT
PHOSPHOFRUCTOKINASE
(Methanosarcinale
s) 		3 / 3 PRO A 213
THR A  93
PRO A  92
 None
 0.83A 2d55C-6c8zA:
undetectable		 2d55C-6c8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_B_TOPB1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 6c8z ADP-DEPENDENT
PHOSPHOFRUCTOKINASE
(Methanosarcinale
s) 		5 / 11 ILE A 133
ALA A  30
LEU A 228
ILE A 231
ILE A 277
 None
 1.06A 2w9sB-6c8zA:
undetectable		 2w9sB-6c8zA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_A_ADNA1301_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 6c8z ADP-DEPENDENT
PHOSPHOFRUCTOKINASE
(Methanosarcinale
s) 		4 / 7 GLU A 282
ALA A  30
ASN A  32
ALA A 117
 None
 1.13A 2zgwA-6c8zA:
2.9		 2zgwA-6c8zA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_B_ADNB1302_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 6c8z ADP-DEPENDENT
PHOSPHOFRUCTOKINASE
(Methanosarcinale
s) 		4 / 6 GLU A 282
ALA A  30
ASN A  32
ALA A 117
 None
 1.17A 2zgwB-6c8zA:
4.7		 2zgwB-6c8zA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_1
(FIV PROTEASE)		 6c8z ADP-DEPENDENT
PHOSPHOFRUCTOKINASE
(Methanosarcinale
s) 		5 / 10 ALA A 125
ILE A 129
VAL A 132
ILE A 119
LEU A 153
 None
 0.95A 3ogqA-6c8zA:
undetectable		 3ogqA-6c8zA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL3_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 6c8z ADP-DEPENDENT
PHOSPHOFRUCTOKINASE
(Methanosarcinale
s) 		5 / 12 ILE A 133
ALA A  30
LEU A 228
ILE A 277
ILE A 235
 None
 1.23A 3ql3A-6c8zA:
undetectable		 3ql3A-6c8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_A_9PLA501_1
(CYTOCHROME P450 2E1)		 6c8z ADP-DEPENDENT
PHOSPHOFRUCTOKINASE
(Methanosarcinale
s) 		4 / 6 LEU A 403
PHE A 386
ALA A 387
LEU A 123
 None
 0.76A 3t3zA-6c8zA:
undetectable		 3t3zA-6c8zA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_B_9PLB501_1
(CYTOCHROME P450 2E1)		 6c8z ADP-DEPENDENT
PHOSPHOFRUCTOKINASE
(Methanosarcinale
s) 		4 / 6 LEU A 403
PHE A 386
ALA A 387
LEU A 123
 None
 0.76A 3t3zB-6c8zA:
undetectable		 3t3zB-6c8zA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_D_9PLD501_1
(CYTOCHROME P450 2E1)		 6c8z ADP-DEPENDENT
PHOSPHOFRUCTOKINASE
(Methanosarcinale
s) 		4 / 6 LEU A 403
PHE A 386
ALA A 387
LEU A 123
 None
 0.77A 3t3zD-6c8zA:
undetectable		 3t3zD-6c8zA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_A_ADNA353_1
(ADENOSINE KINASE)		 6c8z ADP-DEPENDENT
PHOSPHOFRUCTOKINASE
(Methanosarcinale
s) 		5 / 12 ASP A  36
GLY A 114
GLY A 115
GLY A 468
ASP A 471
 None
None
None
ADP  A 501 (-3.8A)
ADP  A 501 (-3.6A)
 0.76A 3uboA-6c8zA:
19.3		 3uboA-6c8zA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A83_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 6c8z ADP-DEPENDENT
PHOSPHOFRUCTOKINASE
(Methanosarcinale
s) 		5 / 12 PRO A 137
PRO A 156
LEU A 165
ILE A 231
ALA A  30
 None
 1.37A 4a83A-6c8zA:
undetectable		 4a83A-6c8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGA_A_ACTA1131_0
(LYSOZYME C)		 6c8z ADP-DEPENDENT
PHOSPHOFRUCTOKINASE
(Methanosarcinale
s) 		3 / 3 ASN A  34
ASP A  36
ASN A 181
 None
 0.79A 4agaA-6c8zA:
undetectable		 4agaA-6c8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		 6c8z ADP-DEPENDENT
PHOSPHOFRUCTOKINASE
(Methanosarcinale
s) 		5 / 12 ASP A  36
GLY A 114
GLY A 115
GLY A 468
ASP A 471
 None
None
None
ADP  A 501 (-3.8A)
ADP  A 501 (-3.6A)
 0.89A 4dc3B-6c8zA:
18.2		 4dc3B-6c8zA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_1
(PROLINE--TRNA LIGASE)		 6c8z ADP-DEPENDENT
PHOSPHOFRUCTOKINASE
(Methanosarcinale
s) 		3 / 3 GLU A 343
THR A 447
HIS A 450
 None
 0.86A 4q15B-6c8zA:
undetectable		 4q15B-6c8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		 6c8z ADP-DEPENDENT
PHOSPHOFRUCTOKINASE
(Methanosarcinale
s) 		5 / 12 ARG A  67
ILE A  81
ASP A  74
ALA A  77
ILE A  62
 None
 1.27A 4uroC-6c8zA:
undetectable		 4uroC-6c8zA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_2_BEZ2801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 6c8z ADP-DEPENDENT
PHOSPHOFRUCTOKINASE
(Methanosarcinale
s) 		4 / 4 LEU A  79
ARG A  84
ILE A  80
ILE A  62
 None
 1.32A 5dzk2-6c8zA:
undetectable
5dzkM-6c8zA:
undetectable
5dzkN-6c8zA:
undetectable		 5dzk2-6c8zA:
undetectable
5dzkM-6c8zA:
undetectable
5dzkN-6c8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)		 6c8z ADP-DEPENDENT
PHOSPHOFRUCTOKINASE
(Methanosarcinale
s) 		5 / 11 ILE A 299
TYR A 243
ILE A 218
ILE A 235
ILE A 231
 None
 1.05A 5hw8A-6c8zA:
undetectable
5hw8D-6c8zA:
undetectable		 5hw8A-6c8zA:
19.51
5hw8D-6c8zA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6c8z ADP-DEPENDENT
PHOSPHOFRUCTOKINASE
(Methanosarcinale
s) 		5 / 12 VAL A 266
LEU A 482
GLY A 237
ALA A 238
LEU A 240
 None
 1.16A 5iktB-6c8zA:
undetectable		 5iktB-6c8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_B_PFLB407_1
(PROTON-GATED ION
CHANNEL)		 6c8z ADP-DEPENDENT
PHOSPHOFRUCTOKINASE
(Methanosarcinale
s) 		4 / 7 TYR A 256
ILE A 291
ILE A 246
ILE A 299
 None
 0.91A 5murB-6c8zA:
undetectable		 5murB-6c8zA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 6c8z ADP-DEPENDENT
PHOSPHOFRUCTOKINASE
(Methanosarcinale
s) 		5 / 12 ILE A 469
GLY A 470
ALA A 391
ALA A 395
VAL A 459
 ADP  A 501 (-3.5A)
ADP  A 501 (-3.4A)
ADP  A 501 ( 4.5A)
ADP  A 501 ( 3.9A)
ADP  A 501 ( 3.9A)
 1.04A 5n0oB-6c8zA:
undetectable		 5n0oB-6c8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 6c8z ADP-DEPENDENT
PHOSPHOFRUCTOKINASE
(Methanosarcinale
s) 		5 / 12 ILE A 469
GLY A 470
ALA A 391
ALA A 395
VAL A 459
 ADP  A 501 (-3.5A)
ADP  A 501 (-3.4A)
ADP  A 501 ( 4.5A)
ADP  A 501 ( 3.9A)
ADP  A 501 ( 3.9A)
 1.01A 5n0tB-6c8zA:
2.2		 5n0tB-6c8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGJ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 6c8z ADP-DEPENDENT
PHOSPHOFRUCTOKINASE
(Methanosarcinale
s) 		3 / 3 VAL A 209
VAL A  91
GLN A  68
 None
 0.51A 5qgjA-6c8zA:
undetectable		 5qgjA-6c8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGM_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 6c8z ADP-DEPENDENT
PHOSPHOFRUCTOKINASE
(Methanosarcinale
s) 		3 / 3 VAL A 209
VAL A  91
GLN A  68
 None
 0.54A 5qgmA-6c8zA:
undetectable		 5qgmA-6c8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGN_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 6c8z ADP-DEPENDENT
PHOSPHOFRUCTOKINASE
(Methanosarcinale
s) 		3 / 3 VAL A 209
VAL A  91
GLN A  68
 None
 0.50A 5qgnA-6c8zA:
undetectable		 5qgnA-6c8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGY_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 6c8z ADP-DEPENDENT
PHOSPHOFRUCTOKINASE
(Methanosarcinale
s) 		3 / 3 VAL A 209
VAL A  91
GLN A  68
 None
 0.51A 5qgyA-6c8zA:
undetectable		 5qgyA-6c8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGZ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 6c8z ADP-DEPENDENT
PHOSPHOFRUCTOKINASE
(Methanosarcinale
s) 		3 / 3 VAL A 209
VAL A  91
GLN A  68
 None
 0.51A 5qgzA-6c8zA:
undetectable		 5qgzA-6c8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH0_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 6c8z ADP-DEPENDENT
PHOSPHOFRUCTOKINASE
(Methanosarcinale
s) 		3 / 3 VAL A 209
VAL A  91
GLN A  68
 None
 0.52A 5qh0A-6c8zA:
undetectable		 5qh0A-6c8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH2_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 6c8z ADP-DEPENDENT
PHOSPHOFRUCTOKINASE
(Methanosarcinale
s) 		3 / 3 VAL A 209
VAL A  91
GLN A  68
 None
 0.52A 5qh2A-6c8zA:
undetectable		 5qh2A-6c8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH3_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 6c8z ADP-DEPENDENT
PHOSPHOFRUCTOKINASE
(Methanosarcinale
s) 		3 / 3 VAL A 209
VAL A  91
GLN A  68
 None
 0.52A 5qh3A-6c8zA:
undetectable		 5qh3A-6c8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH5_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 6c8z ADP-DEPENDENT
PHOSPHOFRUCTOKINASE
(Methanosarcinale
s) 		3 / 3 VAL A 209
VAL A  91
GLN A  68
 None
 0.50A 5qh5A-6c8zA:
undetectable		 5qh5A-6c8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH6_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 6c8z ADP-DEPENDENT
PHOSPHOFRUCTOKINASE
(Methanosarcinale
s) 		3 / 3 VAL A 209
VAL A  91
GLN A  68
 None
 0.52A 5qh6A-6c8zA:
undetectable		 5qh6A-6c8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH7_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 6c8z ADP-DEPENDENT
PHOSPHOFRUCTOKINASE
(Methanosarcinale
s) 		3 / 3 VAL A 209
VAL A  91
GLN A  68
 None
 0.51A 5qh7A-6c8zA:
undetectable		 5qh7A-6c8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHA_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 6c8z ADP-DEPENDENT
PHOSPHOFRUCTOKINASE
(Methanosarcinale
s) 		3 / 3 VAL A 209
VAL A  91
GLN A  68
 None
 0.53A 5qhaA-6c8zA:
undetectable		 5qhaA-6c8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHH_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 6c8z ADP-DEPENDENT
PHOSPHOFRUCTOKINASE
(Methanosarcinale
s) 		3 / 3 VAL A 209
VAL A  91
GLN A  68
 None
 0.52A 5qhhA-6c8zA:
undetectable		 5qhhA-6c8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 6c8z ADP-DEPENDENT
PHOSPHOFRUCTOKINASE
(Methanosarcinale
s) 		4 / 9 TYR A 259
LYS A 262
ILE A 267
LEU A 270
 None
 0.82A 5vkqB-6c8zA:
undetectable
5vkqC-6c8zA:
undetectable		 5vkqB-6c8zA:
undetectable
5vkqC-6c8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 6c8z ADP-DEPENDENT
PHOSPHOFRUCTOKINASE
(Methanosarcinale
s) 		5 / 12 GLY A 242
ASP A 471
GLY A 114
SER A  33
ILE A 119
 None
ADP  A 501 (-3.6A)
None
None
None
 0.92A 5vooA-6c8zA:
undetectable		 5vooA-6c8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 6c8z ADP-DEPENDENT
PHOSPHOFRUCTOKINASE
(Methanosarcinale
s) 		5 / 12 GLY A 242
ASP A 471
GLY A 114
SER A  33
ILE A 119
 None
ADP  A 501 (-3.6A)
None
None
None
 0.92A 5vooC-6c8zA:
2.3		 5vooC-6c8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 6c8z ADP-DEPENDENT
PHOSPHOFRUCTOKINASE
(Methanosarcinale
s) 		5 / 12 GLY A 242
ASP A 471
GLY A 114
SER A  33
ILE A 119
 None
ADP  A 501 (-3.6A)
None
None
None
 0.97A 5vooD-6c8zA:
2.6		 5vooD-6c8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 6c8z ADP-DEPENDENT
PHOSPHOFRUCTOKINASE
(Methanosarcinale
s) 		5 / 12 GLY A 242
ASP A 471
GLY A 114
SER A  33
ILE A 119
 None
ADP  A 501 (-3.6A)
None
None
None
 0.92A 5vooE-6c8zA:
2.4		 5vooE-6c8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 6c8z ADP-DEPENDENT
PHOSPHOFRUCTOKINASE
(Methanosarcinale
s) 		5 / 12 GLY A 242
ASP A 471
GLY A 114
SER A  33
ILE A 119
 None
ADP  A 501 (-3.6A)
None
None
None
 0.97A 5vooF-6c8zA:
2.4		 5vooF-6c8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 6c8z ADP-DEPENDENT
PHOSPHOFRUCTOKINASE
(Methanosarcinale
s) 		6 / 12 GLY A 242
ASP A 471
GLY A 114
SER A  33
ASN A  34
ILE A 119
 None
ADP  A 501 (-3.6A)
None
None
None
None
 0.87A 5vopA-6c8zA:
2.6		 5vopA-6c8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 6c8z ADP-DEPENDENT
PHOSPHOFRUCTOKINASE
(Methanosarcinale
s) 		6 / 12 GLY A 242
ASP A 471
GLY A 114
SER A  33
ASN A  34
ILE A 119
 None
ADP  A 501 (-3.6A)
None
None
None
None
 0.89A 5vopB-6c8zA:
undetectable		 5vopB-6c8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_B_DAHB60_1
(PUTATIVE CYTOCHROME
C)		 6c8z ADP-DEPENDENT
PHOSPHOFRUCTOKINASE
(Methanosarcinale
s) 		4 / 5 HIS A 155
MET A 220
ASN A 173
LEU A 224
 None
 1.45A 5xdhB-6c8zA:
undetectable		 5xdhB-6c8zA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_D_DAHD60_1
(PUTATIVE CYTOCHROME
C)		 6c8z ADP-DEPENDENT
PHOSPHOFRUCTOKINASE
(Methanosarcinale
s) 		4 / 5 HIS A 155
MET A 220
ASN A 173
LEU A 224
 None
 1.19A 5xdhD-6c8zA:
undetectable		 5xdhD-6c8zA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_A_ACTA404_0
(L-LYSINE
3-HYDROXYLASE)		 6c8z ADP-DEPENDENT
PHOSPHOFRUCTOKINASE
(Methanosarcinale
s) 		4 / 6 ILE A 347
TYR A 323
LEU A 321
ARG A 301
 None
 1.14A 6f6jA-6c8zA:
undetectable		 6f6jA-6c8zA:
undetectable