SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6c90'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEI_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 6c90 EXOSOME RNA HELICASE
MTR4,EXOSOME RNA
HELICASE MTR4
(Homo
sapiens) 		4 / 8 SER A 513
SER A 514
ILE A 518
GLY A 548
 None
 0.95A 1meiA-6c90A:
undetectable		 1meiA-6c90A:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_D_FUAD705_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 6c90 EXOSOME RNA HELICASE
MTR4,EXOSOME RNA
HELICASE MTR4
(Homo
sapiens) 		5 / 12 TYR A 136
PHE A 138
PHE A 187
LEU A 282
VAL A 159
 None
ADP  A1101 (-3.9A)
None
None
None
 1.48A 1q23D-6c90A:
undetectable
1q23E-6c90A:
undetectable		 1q23D-6c90A:
15.53
1q23E-6c90A:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 6c90 EXOSOME RNA HELICASE
MTR4,EXOSOME RNA
HELICASE MTR4
(Homo
sapiens) 		5 / 11 TYR A 136
PHE A 138
PHE A 187
LEU A 282
VAL A 159
 None
ADP  A1101 (-3.9A)
None
None
None
 1.46A 1q23G-6c90A:
undetectable		 1q23G-6c90A:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_1
(RETINOIC ACID
RECEPTOR, BETA)		 6c90 EXOSOME RNA HELICASE
MTR4,EXOSOME RNA
HELICASE MTR4
(Homo
sapiens) 		5 / 12 LEU A 236
LEU A 232
ILE A 231
SER A 195
LEU A 273
 None
 1.25A 1xdkB-6c90A:
undetectable		 1xdkB-6c90A:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXK_A_IMNA2001_1
(SERUM ALBUMIN)		 6c90 EXOSOME RNA HELICASE
MTR4,EXOSOME RNA
HELICASE MTR4
(Homo
sapiens) 		4 / 8 LYS A 198
PHE A 187
ALA A 171
LEU A 282
 None
 1.01A 2bxkA-6c90A:
2.3		 2bxkA-6c90A:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD37_0
(GCN4 LEUCINE ZIPPER)		 6c90 EXOSOME RNA HELICASE
MTR4,EXOSOME RNA
HELICASE MTR4
(Homo
sapiens) 		3 / 3 LYS A 301
ARG A  98
VAL A  99
 None
 1.03A 2r2vC-6c90A:
undetectable
2r2vD-6c90A:
undetectable		 2r2vC-6c90A:
undetectable
2r2vD-6c90A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRH_A_NIOA200_1
(PROTEIN HP0721)		 6c90 EXOSOME RNA HELICASE
MTR4,EXOSOME RNA
HELICASE MTR4
(Homo
sapiens) 		4 / 7 GLY A 976
ILE A1030
THR A 906
ARG A1032
 None
 0.99A 2xrhA-6c90A:
undetectable		 2xrhA-6c90A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_2
(PHOSPHOLIPASE A2)		 6c90 EXOSOME RNA HELICASE
MTR4,EXOSOME RNA
HELICASE MTR4
(Homo
sapiens) 		4 / 6 VAL A 331
PHE A 321
ARG A 339
ARG A 312
 None
 1.05A 3bjwF-6c90A:
undetectable		 3bjwF-6c90A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX95_0
(PROTEIN S100-B)		 6c90 EXOSOME RNA HELICASE
MTR4,EXOSOME RNA
HELICASE MTR4
(Homo
sapiens) 		3 / 3 CYH A 911
PHE A 962
PHE A 912
 None
 0.89A 3cr5X-6c90A:
undetectable		 3cr5X-6c90A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9X_A_NIMA1_1
(LACTOTRANSFERRIN')		 6c90 EXOSOME RNA HELICASE
MTR4,EXOSOME RNA
HELICASE MTR4
(Homo
sapiens) 		4 / 4 GLU A1001
GLY A1026
THR A1028
GLU A1025
 None
 0.95A 3e9xA-6c90A:
undetectable		 3e9xA-6c90A:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_B_ACRB820_1
(ALPHA-AMYLASE, SUSG)		 6c90 EXOSOME RNA HELICASE
MTR4,EXOSOME RNA
HELICASE MTR4
(Homo
sapiens) 		4 / 7 GLU A 890
LEU A1019
LYS A1022
ASN A 898
 None
 1.27A 3k8mB-6c90A:
undetectable		 3k8mB-6c90A:
8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1507_0
(FERROCHELATASE,
MITOCHONDRIAL)		 6c90 EXOSOME RNA HELICASE
MTR4,EXOSOME RNA
HELICASE MTR4
(Homo
sapiens) 		3 / 3 ARG A 998
LYS A 192
ARG A 999
 None
MLI  A1105 (-3.7A)
MLI  A1105 (-3.9A)
 1.48A 3w1wA-6c90A:
3.6
3w1wB-6c90A:
3.8		 3w1wA-6c90A:
undetectable
3w1wB-6c90A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 6c90 EXOSOME RNA HELICASE
MTR4,EXOSOME RNA
HELICASE MTR4
(Homo
sapiens) 		4 / 8 GLY A 263
VAL A 264
ILE A 270
PHE A 281
 None
 0.92A 4fglD-6c90A:
undetectable		 4fglD-6c90A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G8Z_X_TOPX301_1
(DIHYDROFOLATE
REDUCTASE)		 6c90 EXOSOME RNA HELICASE
MTR4,EXOSOME RNA
HELICASE MTR4
(Homo
sapiens) 		5 / 10 ILE A 296
LEU A 559
PHE A 281
PRO A 190
ILE A 270
 None
 1.14A 4g8zX-6c90A:
undetectable		 4g8zX-6c90A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 6c90 EXOSOME RNA HELICASE
MTR4,EXOSOME RNA
HELICASE MTR4
(Homo
sapiens) 		4 / 7 ASN A 572
GLU A 268
GLU A 885
ARG A 854
 None
None
None
MLI  A1104 (-2.9A)
 1.02A 4mi4B-6c90A:
undetectable
4mi4C-6c90A:
undetectable		 4mi4B-6c90A:
17.99
4mi4C-6c90A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 6c90 EXOSOME RNA HELICASE
MTR4,EXOSOME RNA
HELICASE MTR4
(Homo
sapiens) 		4 / 8 ASN A 572
GLU A 268
GLU A 885
ARG A 854
 None
None
None
MLI  A1104 (-2.9A)
 1.01A 4mj8B-6c90A:
undetectable
4mj8C-6c90A:
undetectable		 4mj8B-6c90A:
18.18
4mj8C-6c90A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 6c90 EXOSOME RNA HELICASE
MTR4,EXOSOME RNA
HELICASE MTR4
ZINC FINGER CCHC
DOMAIN-CONTAINING
PROTEIN 8
(Homo
sapiens) 		4 / 5 TYR B 685
ARG B 689
GLU A 201
VAL A 169
 None
 1.36A 4nkvB-6c90B:
undetectable		 4nkvB-6c90B:
8.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_1
(UNCHARACTERIZED
PROTEIN)		 6c90 EXOSOME RNA HELICASE
MTR4,EXOSOME RNA
HELICASE MTR4
ZINC FINGER CCHC
DOMAIN-CONTAINING
PROTEIN 8
(Homo
sapiens;
Homo
sapiens) 		3 / 3 ARG B 689
GLU A 201
TYR B 685
 None
 1.01A 4r29D-6c90B:
undetectable		 4r29D-6c90B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 6c90 EXOSOME RNA HELICASE
MTR4,EXOSOME RNA
HELICASE MTR4
(Homo
sapiens) 		4 / 4 ASN A 196
VAL A 216
THR A 228
ILE A 231
 None
 1.10A 4retA-6c90A:
2.1		 4retA-6c90A:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 6c90 EXOSOME RNA HELICASE
MTR4,EXOSOME RNA
HELICASE MTR4
(Homo
sapiens) 		4 / 4 ASN A 196
VAL A 216
THR A 228
ILE A 231
 None
 1.10A 4retC-6c90A:
2.0		 4retC-6c90A:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWZ_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 6c90 EXOSOME RNA HELICASE
MTR4,EXOSOME RNA
HELICASE MTR4
(Homo
sapiens) 		3 / 3 MET A 935
GLN A 934
ARG A 933
 None
 1.11A 5ewzB-6c90A:
2.2		 5ewzB-6c90A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 6c90 EXOSOME RNA HELICASE
MTR4,EXOSOME RNA
HELICASE MTR4
(Homo
sapiens) 		3 / 3 ALA A 974
GLN A 904
THR A 906
 None
 0.71A 5n0oA-6c90A:
1.8		 5n0oA-6c90A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_B_OAQB302_0
(SULFOTRANSFERASE)		 6c90 EXOSOME RNA HELICASE
MTR4,EXOSOME RNA
HELICASE MTR4
(Homo
sapiens) 		5 / 12 ILE A 186
LEU A 211
SER A 195
LEU A 236
THR A 269
 None
 1.18A 5tiwB-6c90A:
undetectable		 5tiwB-6c90A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB307_0
(WELO5)		 6c90 EXOSOME RNA HELICASE
MTR4,EXOSOME RNA
HELICASE MTR4
(Homo
sapiens) 		3 / 3 GLU A 294
HIS A 298
VAL A  99
 None
 0.36A 5trqB-6c90A:
undetectable		 5trqB-6c90A:
undetectable