SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6c93'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_A_ACAA90_1
(PLASMINOGEN)		 6c93 CYTOCHROME P450 4B1
(Oryctolagus
cuniculus) 		4 / 8 ASP A 313
TYR A 206
TYR A 207
THR A 316
 None
 1.01A 1ceaA-6c93A:
undetectable
1ceaB-6c93A:
undetectable		 1ceaA-6c93A:
17.20
1ceaB-6c93A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3003_1
(SERUM ALBUMIN)		 6c93 CYTOCHROME P450 4B1
(Oryctolagus
cuniculus) 		3 / 4 LYS A 459
ALA A 463
MET A 358
 None
 1.00A 1hk3A-6c93A:
undetectable		 1hk3A-6c93A:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_1
(GLYCINE
N-METHYLTRANSFERASE)		 6c93 CYTOCHROME P450 4B1
(Oryctolagus
cuniculus) 		4 / 6 TRP A 163
ASP A 174
ASN A 491
SER A 320
 None
 1.42A 1kiaC-6c93A:
undetectable		 1kiaC-6c93A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_SAMB1293_1
(GLYCINE
N-METHYLTRANSFERASE)		 6c93 CYTOCHROME P450 4B1
(Oryctolagus
cuniculus) 		4 / 5 TRP A 163
ASP A 174
ASN A 491
SER A 320
 None
 1.42A 1nbhB-6c93A:
undetectable		 1nbhB-6c93A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 6c93 CYTOCHROME P450 4B1
(Oryctolagus
cuniculus) 		5 / 12 GLN A 381
PHE A  83
LEU A  27
VAL A  80
ALA A 106
 None
 1.20A 2g70A-6c93A:
undetectable		 2g70A-6c93A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 6c93 CYTOCHROME P450 4B1
(Oryctolagus
cuniculus) 		5 / 12 GLN A 381
PHE A  83
LEU A  27
VAL A  80
ALA A 106
 None
 1.24A 2g70B-6c93A:
undetectable		 2g70B-6c93A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 6c93 CYTOCHROME P450 4B1
(Oryctolagus
cuniculus) 		5 / 12 PHE A 350
LEU A 464
ASP A 354
ALA A 454
VAL A 149
 None
None
None
HEM  A 600 (-3.4A)
None
 1.38A 2g70B-6c93A:
undetectable		 2g70B-6c93A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 6c93 CYTOCHROME P450 4B1
(Oryctolagus
cuniculus) 		5 / 12 PHE A 350
LEU A 464
ASP A 354
ALA A 454
VAL A 149
 None
None
None
HEM  A 600 (-3.4A)
None
 1.39A 2g72A-6c93A:
undetectable		 2g72A-6c93A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 6c93 CYTOCHROME P450 4B1
(Oryctolagus
cuniculus) 		5 / 12 GLN A 381
PHE A  83
LEU A  27
VAL A  80
ALA A 106
 None
 1.28A 2g72B-6c93A:
undetectable		 2g72B-6c93A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1351_1
(PROSTAGLANDIN
REDUCTASE 2)		 6c93 CYTOCHROME P450 4B1
(Oryctolagus
cuniculus) 		5 / 10 TYR A  94
ILE A  89
PHE A  41
LEU A 382
LEU A 394
 None
 1.23A 2w98A-6c93A:
undetectable		 2w98A-6c93A:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_1
(NEURAMINIDASE A)		 6c93 CYTOCHROME P450 4B1
(Oryctolagus
cuniculus) 		5 / 12 ILE A 117
ASP A 305
TYR A 206
LEU A 187
ARG A 488
 None
 1.15A 2ya7C-6c93A:
undetectable		 2ya7C-6c93A:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_A_ACRA5044_2
(GLUCOSYLTRANSFERASE-
SI)		 6c93 CYTOCHROME P450 4B1
(Oryctolagus
cuniculus) 		3 / 3 LEU A 199
TRP A 163
TYR A 207
 None
 0.84A 3aicA-6c93A:
undetectable		 3aicA-6c93A:
7.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_2
(GLUCOSYLTRANSFERASE-
SI)		 6c93 CYTOCHROME P450 4B1
(Oryctolagus
cuniculus) 		3 / 3 LEU A 199
TRP A 163
TYR A 207
 None
 0.85A 3aicB-6c93A:
undetectable		 3aicB-6c93A:
7.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_2
(GLUCOSYLTRANSFERASE-
SI)		 6c93 CYTOCHROME P450 4B1
(Oryctolagus
cuniculus) 		3 / 3 LEU A 199
TRP A 163
TYR A 207
 None
 0.84A 3aicE-6c93A:
undetectable		 3aicE-6c93A:
7.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_F_ACRF5044_2
(GLUCOSYLTRANSFERASE-
SI)		 6c93 CYTOCHROME P450 4B1
(Oryctolagus
cuniculus) 		3 / 3 LEU A 199
TRP A 163
TYR A 207
 None
 0.81A 3aicF-6c93A:
undetectable		 3aicF-6c93A:
7.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_G_ACRG5044_2
(GLUCOSYLTRANSFERASE-
SI)		 6c93 CYTOCHROME P450 4B1
(Oryctolagus
cuniculus) 		3 / 3 LEU A 199
TRP A 163
TYR A 207
 None
 0.82A 3aicG-6c93A:
undetectable		 3aicG-6c93A:
7.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX95_0
(PROTEIN S100-B)		 6c93 CYTOCHROME P450 4B1
(Oryctolagus
cuniculus) 		3 / 3 CYH A 465
PHE A 469
PHE A 471
 None
 1.07A 3cr5X-6c93A:
undetectable		 3cr5X-6c93A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_A_4PZA501_1
(CYTOCHROME P450 2E1)		 6c93 CYTOCHROME P450 4B1
(Oryctolagus
cuniculus) 		3 / 3 ALA A 310
THR A 314
CYH A 448
 HEM  A 600 ( 3.2A)
HEM  A 600 ( 3.7A)
HEM  A 600 (-2.1A)
 0.38A 3e4eA-6c93A:
33.4		 3e4eA-6c93A:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_B_4PZB501_1
(CYTOCHROME P450 2E1)		 6c93 CYTOCHROME P450 4B1
(Oryctolagus
cuniculus) 		3 / 3 ALA A 310
THR A 314
CYH A 448
 HEM  A 600 ( 3.2A)
HEM  A 600 ( 3.7A)
HEM  A 600 (-2.1A)
 0.31A 3e4eB-6c93A:
33.2		 3e4eB-6c93A:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_E_TOPE200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 6c93 CYTOCHROME P450 4B1
(Oryctolagus
cuniculus) 		5 / 10 ALA A 183
GLU A 457
VAL A 461
LEU A 323
THR A 186
 None
 1.14A 3fl9E-6c93A:
undetectable		 3fl9E-6c93A:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_2
(GLUCOCORTICOID
RECEPTOR)		 6c93 CYTOCHROME P450 4B1
(Oryctolagus
cuniculus) 		3 / 3 MET A 455
CYH A 448
PRO A 374
 None
HEM  A 600 (-2.1A)
HEM  A 600 (-4.0A)
 1.26A 3h52C-6c93A:
1.1		 3h52C-6c93A:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_2
(GLUCOCORTICOID
RECEPTOR)		 6c93 CYTOCHROME P450 4B1
(Oryctolagus
cuniculus) 		3 / 3 MET A 455
CYH A 448
PRO A 440
 None
HEM  A 600 (-2.1A)
None
 1.07A 3h52C-6c93A:
1.1		 3h52C-6c93A:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_2
(DIHYDROFOLATE
REDUCTASE)		 6c93 CYTOCHROME P450 4B1
(Oryctolagus
cuniculus) 		3 / 3 ARG A 220
ILE A 117
THR A 298
 None
 0.70A 3ia4D-6c93A:
undetectable		 3ia4D-6c93A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGL_A_RZXA257_1
(CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1)		 6c93 CYTOCHROME P450 4B1
(Oryctolagus
cuniculus) 		4 / 7 PHE A 388
VAL A  98
ILE A  89
SER A 398
 None
 0.96A 3pglA-6c93A:
undetectable		 3pglA-6c93A:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_C_9PLC501_1
(CYTOCHROME P450 2E1)		 6c93 CYTOCHROME P450 4B1
(Oryctolagus
cuniculus) 		4 / 5 PHE A 113
PHE A 309
ALA A 310
THR A 314
 None
None
HEM  A 600 ( 3.2A)
HEM  A 600 ( 3.7A)
 1.05A 3t3zC-6c93A:
32.8		 3t3zC-6c93A:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB501_1
(HEMOLYTIC LECTIN
CEL-III)		 6c93 CYTOCHROME P450 4B1
(Oryctolagus
cuniculus) 		4 / 5 ASP A 196
SER A 197
GLY A 198
ASP A 154
 None
 1.22A 3w9tB-6c93A:
undetectable		 3w9tB-6c93A:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1003_1
(HEMOLYTIC LECTIN
CEL-III)		 6c93 CYTOCHROME P450 4B1
(Oryctolagus
cuniculus) 		4 / 5 ASP A 196
SER A 197
GLY A 198
ASP A 154
 None
 1.23A 3w9tC-6c93A:
undetectable		 3w9tC-6c93A:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD501_1
(HEMOLYTIC LECTIN
CEL-III)		 6c93 CYTOCHROME P450 4B1
(Oryctolagus
cuniculus) 		4 / 5 ASP A 196
SER A 197
GLY A 198
ASP A 154
 None
 1.23A 3w9tD-6c93A:
undetectable		 3w9tD-6c93A:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		 6c93 CYTOCHROME P450 4B1
(Oryctolagus
cuniculus) 		3 / 3 ARG A 259
TYR A 206
ASN A 200
 None
 0.90A 4ffwB-6c93A:
undetectable		 4ffwB-6c93A:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 6c93 CYTOCHROME P450 4B1
(Oryctolagus
cuniculus) 		5 / 10 PHE A 113
GLY A 311
THR A 314
VAL A 375
VAL A 486
 None
HEM  A 600 (-3.5A)
HEM  A 600 ( 3.7A)
HEM  A 600 (-4.4A)
None
 1.18A 4jx1B-6c93A:
30.1		 4jx1B-6c93A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QE6_A_JN3A1001_1
(BILE ACID RECEPTOR)		 6c93 CYTOCHROME P450 4B1
(Oryctolagus
cuniculus) 		5 / 12 ALA A 406
HIS A 408
ILE A  89
TYR A 379
TYR A  99
 None
 1.37A 4qe6A-6c93A:
undetectable		 4qe6A-6c93A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 6c93 CYTOCHROME P450 4B1
(Oryctolagus
cuniculus) 		4 / 8 HIS A 181
LEU A 184
GLY A 180
SER A 177
 None
 0.96A 5m8rC-6c93A:
undetectable		 5m8rC-6c93A:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB603_0
(ACETYLCHOLINESTERASE)		 6c93 CYTOCHROME P450 4B1
(Oryctolagus
cuniculus) 		4 / 7 TYR A 110
GLN A 218
ASP A 222
HIS A 227
 HEM  A 600 (-4.4A)
None
None
None
 1.35A 5ov9B-6c93A:
undetectable		 5ov9B-6c93A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 6c93 CYTOCHROME P450 4B1
(Oryctolagus
cuniculus) 		5 / 12 ILE A  56
ASP A  63
LEU A  62
GLY A  60
ALA A 406
 None
 1.21A 5x5qB-6c93A:
undetectable		 5x5qB-6c93A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 6c93 CYTOCHROME P450 4B1
(Oryctolagus
cuniculus) 		3 / 3 MET A 308
ASP A 203
ARG A 257
 None
 0.83A 5z6jA-6c93A:
undetectable		 5z6jA-6c93A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 6c93 CYTOCHROME P450 4B1
(Oryctolagus
cuniculus) 		3 / 3 MET A 308
ASP A 203
ARG A 257
 None
 0.80A 5z6kA-6c93A:
undetectable		 5z6kA-6c93A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AF6_A_GLYA507_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 6c93 CYTOCHROME P450 4B1
(Oryctolagus
cuniculus) 		3 / 3 TYR A 360
HIS A 332
MET A 326
 None
 1.23A 6af6A-6c93A:
2.1		 6af6A-6c93A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AY6_A_VORA501_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 6c93 CYTOCHROME P450 4B1
(Oryctolagus
cuniculus) 		5 / 9 TYR A 110
ALA A 310
THR A 314
CYH A 448
LEU A 485
 HEM  A 600 (-4.4A)
HEM  A 600 ( 3.2A)
HEM  A 600 ( 3.7A)
HEM  A 600 (-2.1A)
OCT  A 601 ( 4.9A)
 0.86A 6ay6A-6c93A:
36.6		 6ay6A-6c93A:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 6c93 CYTOCHROME P450 4B1
(Oryctolagus
cuniculus) 		5 / 12 SER A 320
THR A 316
VAL A 179
TRP A 163
LEU A 478
 None
 1.34A 6djzB-6c93A:
undetectable		 6djzB-6c93A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_D_ADND502_2
(-)		 6c93 CYTOCHROME P450 4B1
(Oryctolagus
cuniculus) 		4 / 5 ILE A 449
THR A 137
THR A 306
LEU A 124
 HEM  A 600 ( 4.3A)
None
HEM  A 600 ( 4.9A)
None
 1.11A 6f3mD-6c93A:
undetectable		 6f3mD-6c93A:
12.07