SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6c9b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		 6c9b PLP-DEPENDENT
L-ARGININE
HYDROXYLASE MPPP
(Streptomyces
wadayamensis) 		4 / 4 HIS A 138
LEU A 187
LEU A 185
LEU A 147
 None
 1.14A 1a4lD-6c9bA:
undetectable		 1a4lD-6c9bA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_B_803B311_1
(ANTIGEN CD11A (P180))		 6c9b PLP-DEPENDENT
L-ARGININE
HYDROXYLASE MPPP
(Streptomyces
wadayamensis) 		4 / 7 VAL A 372
LEU A 292
VAL A 298
LEU A 326
 None
 0.87A 1cqpA-6c9bA:
undetectable
1cqpB-6c9bA:
undetectable		 1cqpA-6c9bA:
16.47
1cqpB-6c9bA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 6c9b PLP-DEPENDENT
L-ARGININE
HYDROXYLASE MPPP
(Streptomyces
wadayamensis) 		5 / 5 LEU A 241
VAL A 184
CYH A 211
ALA A 175
CYH A 178
 None
 1.44A 1mz9D-6c9bA:
undetectable		 1mz9D-6c9bA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_0
(VP39)		 6c9b PLP-DEPENDENT
L-ARGININE
HYDROXYLASE MPPP
(Streptomyces
wadayamensis) 		5 / 12 ILE A 353
GLY A 163
VAL A 288
VAL A 312
ALA A 313
 None
 1.01A 1vptA-6c9bA:
2.6		 1vptA-6c9bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 6c9b PLP-DEPENDENT
L-ARGININE
HYDROXYLASE MPPP
(Streptomyces
wadayamensis) 		5 / 12 LEU A 274
LEU A  71
GLU A 217
ALA A 198
ALA A 197
 None
 1.12A 2br4F-6c9bA:
3.2		 2br4F-6c9bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 6c9b PLP-DEPENDENT
L-ARGININE
HYDROXYLASE MPPP
(Streptomyces
wadayamensis) 		5 / 12 ILE A 216
SER A  91
VAL A 214
PHE A 154
LEU A 122
 None
LLP  A 221 ( 2.6A)
None
None
None
 1.24A 2ft9A-6c9bA:
undetectable		 2ft9A-6c9bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_A_IBPA1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 6c9b PLP-DEPENDENT
L-ARGININE
HYDROXYLASE MPPP
(Streptomyces
wadayamensis) 		4 / 7 LEU A 373
VAL A 298
GLY A 297
GLY A 294
 None
 0.69A 2wd9A-6c9bA:
2.5		 2wd9A-6c9bA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_B_IBPB1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 6c9b PLP-DEPENDENT
L-ARGININE
HYDROXYLASE MPPP
(Streptomyces
wadayamensis) 		4 / 8 LEU A 373
VAL A 298
GLY A 297
GLY A 294
 None
 0.70A 2wd9B-6c9bA:
undetectable		 2wd9B-6c9bA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 6c9b PLP-DEPENDENT
L-ARGININE
HYDROXYLASE MPPP
(Streptomyces
wadayamensis) 		5 / 12 LEU A 129
LEU A 110
ILE A 118
THR A 156
ASP A 120
 None
None
None
LLP  A 221 ( 3.5A)
None
 1.01A 3gcsA-6c9bA:
undetectable		 3gcsA-6c9bA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB513_1
(HEMOLYTIC LECTIN
CEL-III)		 6c9b PLP-DEPENDENT
L-ARGININE
HYDROXYLASE MPPP
(Streptomyces
wadayamensis) 		4 / 6 THR A 114
ASN A 159
ASP A 188
ILE A 216
 None
None
LLP  A 221 ( 2.8A)
None
 1.16A 3w9tB-6c9bA:
undetectable		 3w9tB-6c9bA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		 6c9b PLP-DEPENDENT
L-ARGININE
HYDROXYLASE MPPP
(Streptomyces
wadayamensis) 		5 / 12 VAL A 298
GLY A 319
VAL A 322
VAL A 295
LEU A 369
 None
 0.97A 4m2vA-6c9bA:
undetectable		 4m2vA-6c9bA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_ACTA202_0
(RETINOL-BINDING
PROTEIN 2)		 6c9b PLP-DEPENDENT
L-ARGININE
HYDROXYLASE MPPP
(Streptomyces
wadayamensis) 		4 / 6 GLU A 217
THR A 189
LEU A 187
GLN A  74
 None
 1.32A 4qztA-6c9bA:
undetectable		 4qztA-6c9bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA303_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 6c9b PLP-DEPENDENT
L-ARGININE
HYDROXYLASE MPPP
(Streptomyces
wadayamensis) 		4 / 4 LEU A 326
VAL A 322
GLU A 325
ARG A 317
 None
 1.29A 4ww7A-6c9bA:
undetectable		 4ww7A-6c9bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPM_A_BO2A801_1
(LON PROTEASE)		 6c9b PLP-DEPENDENT
L-ARGININE
HYDROXYLASE MPPP
(Streptomyces
wadayamensis) 		5 / 12 ALA A 119
LEU A 110
THR A 156
PRO A 344
ALA A 342
 None
None
LLP  A 221 ( 3.5A)
None
None
 1.10A 4ypmA-6c9bA:
undetectable		 4ypmA-6c9bA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AQF_A_ADNA1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 6c9b PLP-DEPENDENT
L-ARGININE
HYDROXYLASE MPPP
(Streptomyces
wadayamensis) 		5 / 10 GLY A 231
GLU A 217
SER A 266
GLY A 220
ILE A 262
 None
None
None
LLP  A 221 ( 2.4A)
None
 1.03A 5aqfA-6c9bA:
undetectable		 5aqfA-6c9bA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AQY_A_ADNA1389_1
(HEAT SHOCK 70 KDA
PROTEIN 1A)		 6c9b PLP-DEPENDENT
L-ARGININE
HYDROXYLASE MPPP
(Streptomyces
wadayamensis) 		5 / 10 GLY A 231
GLU A 217
SER A 266
GLY A 220
ILE A 262
 None
None
None
LLP  A 221 ( 2.4A)
None
 0.97A 5aqyA-6c9bA:
undetectable		 5aqyA-6c9bA:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGG_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 6c9b PLP-DEPENDENT
L-ARGININE
HYDROXYLASE MPPP
(Streptomyces
wadayamensis) 		4 / 4 VAL A  84
VAL A 234
TYR A  77
GLN A  74
 None
 1.42A 5qggA-6c9bA:
undetectable		 5qggA-6c9bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGO_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 6c9b PLP-DEPENDENT
L-ARGININE
HYDROXYLASE MPPP
(Streptomyces
wadayamensis) 		4 / 4 VAL A  84
VAL A 234
TYR A  77
GLN A  74
 None
 1.37A 5qgoA-6c9bA:
undetectable		 5qgoA-6c9bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FK2_A_SORA302_0
(GALECTIN-3)		 6c9b PLP-DEPENDENT
L-ARGININE
HYDROXYLASE MPPP
(Streptomyces
wadayamensis) 		4 / 4 ARG A  55
GLU A  51
GLU A  63
ARG A 263
 None
 1.27A 6fk2A-6c9bA:
undetectable		 6fk2A-6c9bA:
undetectable