SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6c9d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4001_1
(SERUM ALBUMIN)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
5 / 9 LEU A  76
LEU A 700
ARG A 698
GLY A 142
ALA A 139
None
1.24A 1e7aA-6c9dA:
undetectable
1e7aA-6c9dA:
8.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
7 / 12 GLY A  67
VAL A  74
ALA A  87
VAL A 120
ASN A 187
LEU A 189
ASP A 200
None
0.61A 1fmoE-6c9dA:
30.0
1fmoE-6c9dA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
7 / 12 VAL A  74
ALA A  87
GLU A 107
MET A 111
GLY A 142
LEU A 189
ALA A 199
None
0.99A 1iepA-6c9dA:
21.0
1iepA-6c9dA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
6 / 12 VAL A  74
ALA A  87
GLU A 107
MET A 111
GLY A 142
ALA A 199
None
0.91A 1iepB-6c9dA:
21.1
1iepB-6c9dA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUO_A_ADNA1_1
(AURORA-RELATED
KINASE 1)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
6 / 9 GLY A  67
VAL A  74
ALA A  87
TYR A 138
ALA A 139
LEU A 189
None
0.66A 1muoA-6c9dA:
10.4
1muoA-6c9dA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
7 / 12 VAL A  74
ALA A  87
GLU A 107
MET A 111
VAL A 120
GLY A 142
ALA A 199
None
0.92A 1opjB-6c9dA:
21.1
1opjB-6c9dA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDN_A_LEUA487_0
(L-AMINO ACID OXIDASE)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
4 / 7 ASN A 187
HIS A 180
PHE A 201
ILE A 166
None
1.30A 1tdnA-6c9dA:
undetectable
1tdnA-6c9dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2001_1
(SERUM ALBUMIN)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
4 / 8 SER A 776
ALA A 781
PHE A 782
ALA A 786
None
0.89A 2bxmA-6c9dA:
undetectable
2bxmA-6c9dA:
8.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
8 / 12 ILE A  66
VAL A  74
LYS A  89
VAL A 120
ASN A 187
LEU A 189
ALA A 199
ASP A 200
None
0.82A 2eufB-6c9dA:
27.5
2eufB-6c9dA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
7 / 11 GLY A  67
VAL A  74
ALA A  87
MET A 136
TYR A 138
ALA A 139
LEU A 189
None
0.66A 2evaA-6c9dA:
22.7
2evaA-6c9dA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
7 / 12 GLY A  67
VAL A  74
ALA A  87
ASP A 182
LYS A 184
ASN A 187
ASP A 200
None
0.78A 2fumA-6c9dA:
27.0
2fumA-6c9dA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
8 / 12 GLY A  67
VAL A  74
ALA A  87
MET A 136
TYR A 138
LYS A 184
ASN A 187
ASP A 200
None
0.79A 2fumB-6c9dA:
27.0
2fumB-6c9dA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_C_MIXC2539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
6 / 12 GLY A  67
VAL A  74
ALA A  87
MET A 136
TYR A 138
ASN A 187
None
0.59A 2fumC-6c9dA:
25.2
2fumC-6c9dA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
7 / 12 VAL A  74
ALA A  87
GLU A 107
MET A 111
GLY A 142
LEU A 189
ALA A 199
None
0.98A 2hyyA-6c9dA:
21.2
2hyyA-6c9dA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
7 / 12 VAL A  74
ALA A  87
GLU A 107
MET A 111
GLY A 142
LEU A 189
ALA A 199
None
0.97A 2hyyB-6c9dA:
21.3
2hyyB-6c9dA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_D_STID600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
6 / 12 VAL A  74
ALA A  87
GLU A 107
MET A 111
LEU A 189
ALA A 199
None
0.91A 2hyyD-6c9dA:
21.0
2hyyD-6c9dA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
8 / 12 VAL A  74
ALA A  87
LYS A  89
GLU A 107
MET A 111
TYR A 138
LEU A 189
ALA A 199
None
1.02A 2oiqA-6c9dA:
21.7
2oiqA-6c9dA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
8 / 12 VAL A  74
LYS A  89
GLU A 107
MET A 111
TYR A 138
GLY A 142
LEU A 189
ALA A 199
None
1.10A 2oiqA-6c9dA:
21.7
2oiqA-6c9dA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PL0_A_STIA200_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
8 / 12 ALA A  87
LYS A  89
GLU A 107
MET A 111
VAL A 120
TYR A 138
LEU A 189
ALA A 199
None
1.24A 2pl0A-6c9dA:
21.0
2pl0A-6c9dA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6O_A_1N1A1892_1
(EPHRIN TYPE-A
RECEPTOR 4)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
7 / 12 LYS A  64
ILE A  66
ALA A  87
LYS A  89
GLU A 107
MET A 111
TYR A 138
None
0.68A 2y6oA-6c9dA:
22.1
2y6oA-6c9dA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6O_A_1N1A1892_1
(EPHRIN TYPE-A
RECEPTOR 4)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
7 / 12 LYS A  64
ILE A  66
ALA A  87
LYS A  89
MET A 111
TYR A 138
LEU A 189
None
0.91A 2y6oA-6c9dA:
22.1
2y6oA-6c9dA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_C_NILC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
5 / 12 ALA A  87
GLU A 107
MET A 111
HIS A 180
ALA A 199
None
0.87A 3cs9C-6c9dA:
21.0
3cs9C-6c9dA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
8 / 12 VAL A  74
ALA A  87
LYS A  89
MET A 111
VAL A 120
TYR A 138
LEU A 189
ALA A 199
None
0.75A 3g5dB-6c9dA:
23.0
3g5dB-6c9dA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GVU_A_STIA1001_1
(TYROSINE-PROTEIN
KINASE ABL2)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
7 / 12 VAL A  74
ALA A  87
GLU A 107
MET A 111
VAL A 120
LEU A 189
ALA A 199
None
0.88A 3gvuA-6c9dA:
21.8
3gvuA-6c9dA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_1
(TYROSINE-PROTEIN
KINASE ABL1)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
7 / 12 VAL A  74
ALA A  87
GLU A 107
MET A 111
GLY A 142
LEU A 189
ALA A 199
None
0.98A 3k5vA-6c9dA:
16.1
3k5vA-6c9dA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_1
(TYROSINE-PROTEIN
KINASE ABL1)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
7 / 12 VAL A  74
ALA A  87
GLU A 107
MET A 111
GLY A 142
LEU A 189
ALA A 199
None
0.97A 3k5vB-6c9dA:
20.8
3k5vB-6c9dA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
10 / 12 GLY A  67
VAL A  74
ALA A  87
LYS A  89
VAL A 120
MET A 136
TYR A 138
LEU A 189
ALA A 199
ASP A 200
None
1.04A 3lxkA-6c9dA:
24.5
3lxkA-6c9dA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
6 / 12 VAL A  74
ALA A  87
GLU A 107
MET A 111
LEU A 189
ALA A 199
None
0.94A 3ms9A-6c9dA:
20.8
3ms9A-6c9dA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
6 / 12 VAL A  74
ALA A  87
GLU A 107
MET A 111
LEU A 189
ALA A 199
None
0.95A 3mssA-6c9dA:
21.0
3mssA-6c9dA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
6 / 12 VAL A  74
ALA A  87
GLU A 107
MET A 111
LEU A 189
ALA A 199
None
0.93A 3mssC-6c9dA:
21.0
3mssC-6c9dA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_1
(TYROSINE-PROTEIN
KINASE ABL1)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
6 / 12 ALA A  87
GLU A 107
MET A 111
GLY A 142
LEU A 189
ALA A 199
None
1.00A 3mssD-6c9dA:
21.0
3mssD-6c9dA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_B_STIB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
8 / 12 VAL A  74
ALA A  87
LYS A  89
GLU A 107
MET A 111
TYR A 138
LEU A 189
ALA A 199
None
0.84A 3oezB-6c9dA:
22.0
3oezB-6c9dA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXZ_A_0LIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
6 / 12 ALA A  87
GLU A 107
MET A 111
VAL A 120
HIS A 180
ALA A 199
None
0.81A 3oxzA-6c9dA:
21.1
3oxzA-6c9dA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_B_STIB4_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
7 / 12 VAL A  74
ALA A  87
GLU A 107
MET A 111
VAL A 120
LEU A 189
ALA A 199
None
0.85A 3pyyB-6c9dA:
16.3
3pyyB-6c9dA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_1
(CYCLIN-DEPENDENT
KINASE 8)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
7 / 12 VAL A  74
ALA A  87
GLU A 107
TYR A 138
ALA A 139
HIS A 180
ALA A 199
None
0.85A 3rgfA-6c9dA:
22.3
3rgfA-6c9dA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG9_B_KANB305_1
(APH(2'')-ID)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
4 / 8 SER A 219
ASP A 258
GLU A 186
GLU A 143
None
0.96A 3sg9B-6c9dA:
8.1
3sg9B-6c9dA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_B_ADNB251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
5 / 10 ARG A 774
VAL A 144
GLU A 143
GLU A 186
HIS A 180
None
1.47A 3u40B-6c9dA:
undetectable
3u40C-6c9dA:
undetectable
3u40B-6c9dA:
15.19
3u40C-6c9dA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_C_ADNC251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
5 / 12 HIS A 180
ARG A 774
VAL A 144
GLU A 143
GLU A 186
None
1.46A 3u40B-6c9dA:
undetectable
3u40C-6c9dA:
undetectable
3u40B-6c9dA:
15.19
3u40C-6c9dA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_D_ADND251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
5 / 11 ARG A 774
VAL A 144
GLU A 143
GLU A 186
HIS A 180
None
1.50A 3u40D-6c9dA:
undetectable
3u40E-6c9dA:
undetectable
3u40D-6c9dA:
15.19
3u40E-6c9dA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_F_ADNF251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
5 / 10 HIS A 180
ARG A 774
VAL A 144
GLU A 143
GLU A 186
None
1.46A 3u40A-6c9dA:
undetectable
3u40F-6c9dA:
undetectable
3u40A-6c9dA:
15.19
3u40F-6c9dA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_B_CLMB221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
5 / 12 THR A 778
SER A 779
PHE A 145
LEU A 265
VAL A 269
None
1.23A 3u9fB-6c9dA:
undetectable
3u9fC-6c9dA:
undetectable
3u9fB-6c9dA:
undetectable
3u9fC-6c9dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_H_CLMH221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
5 / 12 THR A 778
SER A 779
PHE A 145
LEU A 265
VAL A 269
None
1.28A 3u9fH-6c9dA:
undetectable
3u9fI-6c9dA:
undetectable
3u9fH-6c9dA:
undetectable
3u9fI-6c9dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_L_CLML221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
5 / 12 THR A 778
SER A 779
PHE A 145
LEU A 265
VAL A 269
None
1.19A 3u9fJ-6c9dA:
undetectable
3u9fL-6c9dA:
undetectable
3u9fJ-6c9dA:
undetectable
3u9fL-6c9dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
4 / 7 ALA A 781
ILE A 785
HIS A 744
GLY A 745
None
0.94A 3v4tH-6c9dA:
undetectable
3v4tH-6c9dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
4 / 5 ILE A 110
VAL A 120
LEU A 189
ASP A 200
None
1.22A 3wzdA-6c9dA:
21.0
3wzdA-6c9dA:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
4 / 5 LYS A  89
ILE A 110
VAL A 120
LEU A 189
None
1.00A 3wzdA-6c9dA:
21.0
3wzdA-6c9dA:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
5 / 9 ILE A 110
LEU A 114
ILE A 119
TYR A 138
ILE A 198
None
0.79A 3zosA-6c9dA:
21.2
3zosA-6c9dA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
5 / 9 ILE A 110
MET A 111
ILE A 119
TYR A 138
ILE A 198
None
0.97A 3zosA-6c9dA:
21.2
3zosA-6c9dA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
5 / 9 ILE A 110
LEU A 114
ILE A 119
TYR A 138
ILE A 198
None
0.80A 3zosB-6c9dA:
21.2
3zosB-6c9dA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
5 / 9 ILE A 110
MET A 111
ILE A 119
TYR A 138
ILE A 198
None
0.98A 3zosB-6c9dA:
21.2
3zosB-6c9dA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_A_STIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
8 / 12 VAL A  74
ALA A  87
GLU A 107
ILE A 110
MET A 111
TYR A 138
LEU A 189
ALA A 199
None
1.36A 4bkjA-6c9dA:
21.0
4bkjA-6c9dA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
7 / 12 VAL A  74
ALA A  87
GLU A 107
ILE A 110
MET A 111
LEU A 189
ALA A 199
None
1.14A 4bkjB-6c9dA:
21.1
4bkjB-6c9dA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_B_STIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
4 / 5 LYS A  89
LEU A 114
TYR A 138
ARG A 181
None
1.14A 4bkjB-6c9dA:
21.1
4bkjB-6c9dA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
4 / 5 VAL A  74
ILE A 119
TYR A 138
ILE A 198
None
0.49A 4c8bA-6c9dA:
22.1
4c8bA-6c9dA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
7 / 12 ALA A  87
LYS A  89
GLU A 107
ILE A 119
HIS A 180
LEU A 189
ALA A 199
None
0.73A 4c8bB-6c9dA:
22.2
4c8bB-6c9dA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
7 / 10 GLY A  67
GLY A  69
VAL A  74
ALA A  87
TYR A 138
ALA A 139
LEU A 189
None
0.73A 4ckjA-6c9dA:
26.1
4ckjA-6c9dA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CSV_A_STIA1265_1
(SRC-ABL TYROSINE
KINASE ANCESTOR)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
9 / 12 VAL A  74
ALA A  87
GLU A 107
ILE A 110
MET A 111
VAL A 120
TYR A 138
LEU A 189
ALA A 199
None
1.04A 4csvA-6c9dA:
22.4
4csvA-6c9dA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
6 / 11 VAL A  74
ALA A  87
LYS A  89
GLU A 186
LEU A 189
ASP A 200
None
1.01A 4iaaA-6c9dA:
28.2
4iaaA-6c9dA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
4 / 5 MET A 712
LEU A 795
ARG A 722
PRO A 697
None
1.46A 4kmmB-6c9dA:
undetectable
4kmmB-6c9dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
6 / 8 ILE A  66
VAL A  74
ALA A  87
ASN A 187
LEU A 189
ASP A 200
None
0.86A 4ogrA-6c9dA:
27.2
4ogrA-6c9dA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_I_ADNI401_1
(CYCLIN-DEPENDENT
KINASE 9)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
6 / 9 ILE A  66
VAL A  74
ALA A  87
ASN A 187
LEU A 189
ASP A 200
None
0.89A 4ogrI-6c9dA:
27.0
4ogrI-6c9dA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
7 / 12 GLY A  67
VAL A  74
ALA A  87
LYS A  89
VAL A 120
LEU A 189
ALA A 199
None
0.53A 4otiA-6c9dA:
23.5
4otiA-6c9dA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
7 / 12 VAL A  74
LYS A  89
VAL A 120
TYR A 138
LEU A 189
ALA A 199
ASP A 200
None
1.04A 4otwA-6c9dA:
21.1
4otwA-6c9dA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
7 / 12 VAL A  74
VAL A 120
TYR A 138
GLY A 142
LEU A 189
ALA A 199
ASP A 200
None
0.88A 4otwA-6c9dA:
21.1
4otwA-6c9dA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMN_A_DB8A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
6 / 12 ALA A  87
GLU A 107
TYR A 138
LEU A 189
ALA A 199
ASP A 200
None
0.54A 4qmnA-6c9dA:
29.3
4qmnA-6c9dA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMS_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
6 / 11 ALA A  87
LYS A  89
GLU A 107
TYR A 138
LEU A 189
ASP A 200
None
0.79A 4qmsA-6c9dA:
21.7
4qmsA-6c9dA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
6 / 12 ILE A  66
GLY A  67
VAL A  74
ALA A  87
TYR A 138
LEU A 189
None
0.79A 4qmzA-6c9dA:
21.6
4qmzA-6c9dA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
5 / 12 ALA A  87
GLU A 107
MET A 111
ARG A 181
ALA A 199
None
0.75A 4qrcA-6c9dA:
22.4
4qrcA-6c9dA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_1
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
6 / 12 VAL A  74
ALA A  87
LYS A  89
GLU A 107
MET A 111
LEU A 189
None
0.65A 4r7iA-6c9dA:
21.2
4r7iA-6c9dA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
7 / 12 ALA A  87
GLU A 107
MET A 111
ALA A 139
HIS A 180
LEU A 189
ALA A 199
None
0.86A 4tyjA-6c9dA:
21.9
4tyjA-6c9dA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
7 / 12 ALA A  87
GLU A 107
MET A 111
CYH A 173
HIS A 180
LEU A 189
ALA A 199
None
1.40A 4tyjA-6c9dA:
21.9
4tyjA-6c9dA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
7 / 10 VAL A  74
GLU A 107
LEU A 114
ILE A 119
VAL A 120
TYR A 138
ILE A 198
None
0.83A 4u0iA-6c9dA:
21.3
4u0iA-6c9dA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
7 / 10 VAL A  74
LEU A 114
ILE A 119
VAL A 120
TYR A 138
ARG A 181
ILE A 198
None
0.82A 4u0iA-6c9dA:
21.3
4u0iA-6c9dA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
4 / 7 VAL A  74
LYS A  89
MET A 111
ALA A 139
None
0.78A 4uxqA-6c9dA:
21.6
4uxqA-6c9dA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
5 / 7 VAL A  74
MET A 111
ALA A 139
ARG A 181
ILE A 198
None
0.92A 4uxqA-6c9dA:
21.6
4uxqA-6c9dA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
6 / 12 ALA A  87
GLU A 107
MET A 111
ALA A 139
HIS A 180
ALA A 199
None
0.77A 4v01A-6c9dA:
21.2
4v01A-6c9dA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
6 / 9 VAL A  74
LYS A  89
TYR A 138
ARG A 181
LEU A 189
ILE A 198
None
0.88A 4v01A-6c9dA:
21.2
4v01A-6c9dA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
6 / 12 ALA A  87
GLU A 107
MET A 111
ALA A 139
HIS A 180
ALA A 199
None
0.76A 4v01B-6c9dA:
21.6
4v01B-6c9dA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
7 / 12 VAL A  74
ALA A  87
GLU A 107
ALA A 139
HIS A 180
ALA A 199
GLY A 202
None
1.33A 4v04A-6c9dA:
21.2
4v04A-6c9dA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
4 / 8 LYS A  89
TYR A 138
LEU A 189
ILE A 198
None
0.76A 4v04A-6c9dA:
21.2
4v04A-6c9dA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
5 / 8 MET A 111
TYR A 138
ARG A 181
LEU A 189
ILE A 198
None
1.02A 4v04A-6c9dA:
21.2
4v04A-6c9dA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
7 / 10 VAL A  74
LYS A  89
MET A 111
TYR A 138
ARG A 181
LEU A 189
ILE A 198
None
0.97A 4v04B-6c9dA:
21.9
4v04B-6c9dA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
6 / 12 ALA A  87
GLU A 107
ALA A 139
HIS A 180
ALA A 199
GLY A 202
None
1.39A 4v04B-6c9dA:
21.9
4v04B-6c9dA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLI_B_1N1B600_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
8 / 12 ALA A  87
LYS A  89
MET A 111
VAL A 120
TYR A 138
GLY A 142
LEU A 189
ALA A 199
None
0.94A 4xliB-6c9dA:
24.7
4xliB-6c9dA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BVW_A_1N1A1009_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
8 / 12 VAL A  74
ALA A  87
LYS A  89
GLU A 107
MET A 111
TYR A 138
LEU A 189
ALA A 199
None
0.94A 5bvwA-6c9dA:
20.9
5bvwA-6c9dA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BVW_A_1N1A1009_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
8 / 12 VAL A  74
ALA A  87
LYS A  89
MET A 111
TYR A 138
GLY A 142
LEU A 189
ALA A 199
None
1.03A 5bvwA-6c9dA:
20.9
5bvwA-6c9dA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
5 / 7 GLY A  67
GLY A  69
PHE A  71
VAL A  74
LYS A  89
None
0.71A 5izjA-6c9dA:
29.1
5izjA-6c9dA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
5 / 7 GLY A  67
GLY A  69
PHE A  71
VAL A  74
LYS A  89
None
0.69A 5j5xA-6c9dA:
30.1
5j5xA-6c9dA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
5 / 7 GLY A  67
GLY A  69
VAL A  74
LYS A  89
ASP A 200
None
0.51A 5j5xA-6c9dA:
30.1
5j5xA-6c9dA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
7 / 12 ILE A  66
GLY A  67
VAL A  74
ALA A  87
VAL A 120
LEU A 189
ALA A 199
None
0.91A 5l2iA-6c9dA:
7.8
5l2iA-6c9dA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
7 / 11 GLY A  67
VAL A  74
ALA A  87
VAL A 120
TYR A 138
ALA A 139
LEU A 189
None
0.40A 5lvnA-6c9dA:
26.4
5lvnA-6c9dA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_B_ADNB401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
5 / 9 ILE A  66
GLY A  67
VAL A  74
ALA A  87
MET A 136
None
0.38A 5lw1B-6c9dA:
24.1
5lw1B-6c9dA:
28.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
6 / 10 VAL A  74
ALA A  87
VAL A 120
MET A 136
TYR A 138
LEU A 189
None
0.81A 5n3hA-6c9dA:
30.4
5n3hA-6c9dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
4 / 8 ALA A  87
GLU A 107
LEU A 189
ASP A 200
None
0.52A 5owrA-6c9dA:
21.8
5owrA-6c9dA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_1
(AP2-ASSOCIATED
PROTEIN KINASE 1)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
7 / 12 LEU A  76
ALA A  87
GLU A 107
MET A 111
VAL A 120
GLY A 142
LEU A 189
None
0.65A 5te0A-6c9dA:
28.1
5te0A-6c9dA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNI_A_YMZA302_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
5 / 9 GLY A 141
TYR A 147
GLU A 143
ASP A 191
GLY A 192
None
1.19A 5zniA-6c9dA:
2.0
5zniA-6c9dA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_0
(TYROSINE-PROTEIN
KINASE ABL1)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
8 / 12 VAL A  74
ALA A  87
LYS A  89
GLU A 107
MET A 111
VAL A 120
LEU A 189
ALA A 199
None
0.99A 6hd4A-6c9dA:
21.0
6hd4A-6c9dA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_0
(TYROSINE-PROTEIN
KINASE ABL1)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
7 / 12 VAL A  74
ALA A  87
GLU A 107
MET A 111
VAL A 120
LEU A 189
ALA A 199
None
0.94A 6hd4B-6c9dA:
20.7
6hd4B-6c9dA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_0
(TYROSINE-PROTEIN
KINASE ABL1)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
7 / 12 VAL A  74
ALA A  87
LYS A  89
GLU A 107
MET A 111
VAL A 120
LEU A 189
None
0.95A 6hd4B-6c9dA:
20.7
6hd4B-6c9dA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_0
(TYROSINE-PROTEIN
KINASE ABL1)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
8 / 12 VAL A  74
ALA A  87
LYS A  89
GLU A 107
MET A 111
VAL A 120
LEU A 189
ALA A 199
None
1.00A 6hd6A-6c9dA:
16.1
6hd6A-6c9dA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_0
(TYROSINE-PROTEIN
KINASE ABL1)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo
sapiens)
7 / 12 VAL A  74
ALA A  87
LYS A  89
GLU A 107
MET A 111
VAL A 120
LEU A 189
None
1.00A 6hd6B-6c9dA:
20.8
6hd6B-6c9dA:
24.18