SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6c9e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_1
(POL PROTEIN)		 6c9e CYSTEINE DESULFURASE
(Legionella
pneumophila) 		5 / 11 ILE A 126
ASP A 208
GLY A 209
ALA A 210
GLY A 101
 None
LLP  A 234 ( 2.6A)
None
LLP  A 234 ( 3.3A)
LLP  A 234 ( 4.3A)
 1.09A 2fxdA-6c9eA:
undetectable		 2fxdA-6c9eA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_B_TOPB1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 6c9e CYSTEINE DESULFURASE
(Legionella
pneumophila) 		5 / 11 ALA A 384
ILE A 355
SER A 389
ILE A 388
PHE A 345
 None
 0.98A 2w9sB-6c9eA:
undetectable		 2w9sB-6c9eA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLG_A_ASCA130_0
(CYTOCHROME C')		 6c9e CYSTEINE DESULFURASE
(Legionella
pneumophila) 		4 / 5 ALA A 115
GLY A 146
CYH A 142
LYS A 143
 None
 1.47A 2ylgA-6c9eA:
undetectable		 2ylgA-6c9eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_B_LOCB700_2
(TUBULIN BETA-2B
CHAIN)		 6c9e CYSTEINE DESULFURASE
(Legionella
pneumophila) 		5 / 11 LYS A 168
LEU A 169
ASN A 170
ALA A 203
VAL A 205
 None
 1.08A 3e22B-6c9eA:
undetectable		 3e22B-6c9eA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_D_LOCD700_2
(TUBULIN BETA-2B
CHAIN)		 6c9e CYSTEINE DESULFURASE
(Legionella
pneumophila) 		5 / 11 LYS A 168
LEU A 169
ASN A 170
ALA A 203
VAL A 205
 None
 1.06A 3e22D-6c9eA:
undetectable		 3e22D-6c9eA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 6c9e CYSTEINE DESULFURASE
(Legionella
pneumophila) 		5 / 12 GLY A 209
HIS A 233
LEU A 294
VAL A  84
ILE A  88
 None
LLP  A 234 ( 3.7A)
None
None
None
 1.17A 3g9eA-6c9eA:
undetectable		 3g9eA-6c9eA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 6c9e CYSTEINE DESULFURASE
(Legionella
pneumophila) 		5 / 12 GLY A 246
HIS A 199
LEU A 223
VAL A 218
ILE A  88
 None
 1.23A 3g9eA-6c9eA:
undetectable		 3g9eA-6c9eA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)		 6c9e CYSTEINE DESULFURASE
(Legionella
pneumophila) 		3 / 3 PHE A  87
TYR A 180
TYR A 228
 None
 1.06A 4ffwA-6c9eA:
undetectable		 4ffwA-6c9eA:
7.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 6c9e CYSTEINE DESULFURASE
(Legionella
pneumophila) 		3 / 3 GLN A  42
THR A  41
THR A  40
 None
LLP  A 234 ( 3.4A)
None
 0.76A 4fu9A-6c9eA:
undetectable		 4fu9A-6c9eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUF_A_ACTA310_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 6c9e CYSTEINE DESULFURASE
(Legionella
pneumophila) 		3 / 3 GLN A  42
THR A  41
THR A  40
 None
LLP  A 234 ( 3.4A)
None
 0.78A 4fufA-6c9eA:
undetectable		 4fufA-6c9eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 6c9e CYSTEINE DESULFURASE
(Legionella
pneumophila) 		4 / 6 LEU A 223
ILE A 195
LEU A 207
TYR A 180
 None
 0.95A 4w5nA-6c9eA:
undetectable		 4w5nA-6c9eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_2
(TUBULIN BETA CHAIN)		 6c9e CYSTEINE DESULFURASE
(Legionella
pneumophila) 		5 / 12 LYS A 168
LEU A 169
ASN A 170
ALA A 203
VAL A 205
 None
 1.17A 4x1iB-6c9eA:
undetectable		 4x1iB-6c9eA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_2
(TUBULIN BETA CHAIN)		 6c9e CYSTEINE DESULFURASE
(Legionella
pneumophila) 		5 / 11 LYS A 168
LEU A 169
ASN A 170
ALA A 203
VAL A 205
 None
 1.18A 4x20D-6c9eA:
undetectable		 4x20D-6c9eA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		 6c9e CYSTEINE DESULFURASE
(Legionella
pneumophila) 		5 / 8 ALA A  39
HIS A 131
ASN A 183
ARG A 367
ARG A 387
 EDO  A 503 (-3.5A)
LLP  A 234 ( 3.5A)
EDO  A 503 (-3.8A)
EDO  A 503 (-4.4A)
EDO  A 503 (-2.9A)
 0.58A 5db5A-6c9eA:
32.7
5db5B-6c9eA:
61.1		 5db5A-6c9eA:
undetectable
5db5B-6c9eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLI_A_ASCA202_0
(CYTOCHROME C')		 6c9e CYSTEINE DESULFURASE
(Legionella
pneumophila) 		4 / 5 ALA A 115
GLY A 146
CYH A 142
LYS A 143
 None
 1.47A 5jliA-6c9eA:
undetectable		 5jliA-6c9eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 6c9e CYSTEINE DESULFURASE
(Legionella
pneumophila) 		3 / 3 THR A 385
SER A 344
ASP A  36
 None
 0.73A 5kvaB-6c9eA:
undetectable		 5kvaB-6c9eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 6c9e CYSTEINE DESULFURASE
(Legionella
pneumophila) 		3 / 3 TYR A 228
ALA A 181
TYR A 180
 None
 0.86A 5uunB-6c9eA:
undetectable		 5uunB-6c9eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_0
(SERUM ALBUMIN)		 6c9e CYSTEINE DESULFURASE
(Legionella
pneumophila) 		5 / 12 ILE A 350
LEU A 317
GLY A 329
LEU A 406
PHE A  35
 None
 1.15A 6a7pA-6c9eA:
undetectable		 6a7pA-6c9eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BC9_A_ETSA302_2
(CARBONIC ANHYDRASE 2)		 6c9e CYSTEINE DESULFURASE
(Legionella
pneumophila) 		4 / 5 HIS A 370
HIS A 128
LEU A 149
VAL A 151
 ZN  A 501 ( 4.9A)
None
None
None
 0.66A 6bc9A-6c9eA:
undetectable		 6bc9A-6c9eA:
26.19