SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6c9k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK6_A_LNLA1201_1
(NON-SPECIFIC LIPID
TRANSFER PROTEIN)		 6c9k DARP14 - SUBUNIT A
WITH DARPIN
(synthetic
construct) 		5 / 12 LEU A  34
ALA A 125
LEU A 146
ALA A 144
ILE A  79
 None
 1.07A 1fk6A-6c9kA:
undetectable		 1fk6A-6c9kA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)		 6c9k DARP14 - SUBUNIT A
WITH DARPIN
(synthetic
construct) 		5 / 11 ALA A 142
GLY A  71
GLU A  69
GLY A  78
ILE A  79
 None
 1.19A 1pg2A-6c9kA:
2.1		 1pg2A-6c9kA:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RV7_B_AB1B1001_1
(PROTEASE)		 6c9k DARP14 - SUBUNIT A
WITH DARPIN
(synthetic
construct) 		5 / 11 ALA A 287
THR A 298
VAL A 289
LEU A 250
VAL A 246
 None
 1.21A 1rv7A-6c9kA:
undetectable
1rv7B-6c9kA:
undetectable		 1rv7A-6c9kA:
21.43
1rv7B-6c9kA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 6c9k DARP14 - SUBUNIT A
WITH DARPIN
(synthetic
construct) 		4 / 6 GLY A 139
THR A 133
LEU A 130
GLU A  69
 None
 1.03A 3ps9A-6c9kA:
undetectable		 3ps9A-6c9kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_A_ECNA403_1
(FLAVOHEMOGLOBIN)		 6c9k DARP14 - SUBUNIT A
WITH DARPIN
(synthetic
construct) 		5 / 12 GLN A 176
ALA A 174
VAL A 215
LEU A 216
ILE A 245
 None
 1.13A 4g1bA-6c9kA:
undetectable		 4g1bA-6c9kA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA501_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 6c9k DARP14 - SUBUNIT A
WITH DARPIN
(synthetic
construct) 		5 / 12 ILE A 278
VAL A 213
ILE A 245
GLU A 214
GLU A 211
 None
 1.35A 4i41A-6c9kA:
undetectable		 4i41A-6c9kA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_2
(TUBULIN BETA-2B
CHAIN)		 6c9k DARP14 - SUBUNIT A
WITH DARPIN
(synthetic
construct) 		5 / 12 LEU A  87
ALA A 148
LEU A 146
ILE A  79
ILE A  66
 None
 1.09A 4o2bB-6c9kA:
undetectable		 4o2bB-6c9kA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_A_IPHA101_0
(INSULIN)		 6c9k DARP14 - SUBUNIT A
WITH DARPIN
(synthetic
construct) 		5 / 10 LEU A  37
LEU A 146
ALA A 122
LEU A  87
LEU A 153
 None
 1.26A 4p65A-6c9kA:
undetectable
4p65B-6c9kA:
undetectable
4p65F-6c9kA:
undetectable
4p65H-6c9kA:
undetectable		 4p65A-6c9kA:
undetectable
4p65B-6c9kA:
undetectable
4p65F-6c9kA:
undetectable
4p65H-6c9kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_I_IPHI101_0
(INSULIN)		 6c9k DARP14 - SUBUNIT A
WITH DARPIN
(synthetic
construct) 		6 / 12 VAL A 246
LEU A 234
LEU A 267
ILE A 278
LEU A 283
ALA A 287
 None
 1.24A 4p65B-6c9kA:
undetectable
4p65D-6c9kA:
undetectable
4p65I-6c9kA:
undetectable
4p65J-6c9kA:
undetectable		 4p65B-6c9kA:
undetectable
4p65D-6c9kA:
undetectable
4p65I-6c9kA:
undetectable
4p65J-6c9kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_C_QDNC602_1
(CYTOCHROME P450 2D6)		 6c9k DARP14 - SUBUNIT A
WITH DARPIN
(synthetic
construct) 		5 / 11 GLY A 187
LEU A 164
ALA A 113
ASP A 116
SER A 112
 None
 1.23A 4wnuC-6c9kA:
undetectable		 4wnuC-6c9kA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_B_SALB801_1
(PROTEIN POLYBROMO-1)		 6c9k DARP14 - SUBUNIT A
WITH DARPIN
(synthetic
construct) 		4 / 5 LEU A 146
ALA A  30
ASN A  31
ILE A  70
 None
 1.06A 4y03B-6c9kA:
undetectable		 4y03B-6c9kA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIO_B_LOCB502_1
(TUBULIN BETA CHAIN)		 6c9k DARP14 - SUBUNIT A
WITH DARPIN
(synthetic
construct) 		5 / 12 LEU A  87
ALA A 148
LEU A 146
ILE A  79
ILE A  66
 None
 1.06A 5mioB-6c9kA:
undetectable		 5mioB-6c9kA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 6c9k DARP14 - SUBUNIT A
WITH DARPIN
(synthetic
construct) 		5 / 10 LEU A 283
VAL A 279
VAL A 289
ILE A 302
LEU A 311
 None
 1.25A 6h1lA-6c9kA:
undetectable		 6h1lA-6c9kA:
undetectable