SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6caa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 6caa ELECTROGENIC SODIUM
BICARBONATE
COTRANSPORTER 1
(Homo
sapiens) 		4 / 6 ILE A 481
THR A 438
PHE A 865
PHE A 552
 None
 1.33A 3elzB-6caaA:
undetectable		 3elzB-6caaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPC_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 6caa ELECTROGENIC SODIUM
BICARBONATE
COTRANSPORTER 1
(Homo
sapiens) 		5 / 11 ASP A 754
VAL A 802
ILE A 805
ASN A 763
ILE A 761
 None
 1.26A 3kpcA-6caaA:
undetectable		 3kpcA-6caaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6caa ELECTROGENIC SODIUM
BICARBONATE
COTRANSPORTER 1
(Homo
sapiens) 		5 / 12 LEU A 861
ILE A 688
SER A 663
LEU A 434
THR A 442
 None
 1.19A 3nrrA-6caaA:
undetectable		 3nrrA-6caaA:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6caa ELECTROGENIC SODIUM
BICARBONATE
COTRANSPORTER 1
(Homo
sapiens) 		5 / 12 LEU A 861
ILE A 688
SER A 663
LEU A 434
THR A 442
 None
 1.20A 3nrrB-6caaA:
undetectable		 3nrrB-6caaA:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_0
(MNMC2)		 6caa ELECTROGENIC SODIUM
BICARBONATE
COTRANSPORTER 1
(Homo
sapiens) 		5 / 12 GLY A 836
LEU A 482
GLY A 468
ALA A 428
LEU A 811
 None
 1.11A 3vywC-6caaA:
undetectable		 3vywC-6caaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_TESA1000_1
(ANDROGEN RECEPTOR)		 6caa ELECTROGENIC SODIUM
BICARBONATE
COTRANSPORTER 1
(Homo
sapiens) 		5 / 12 LEU A 923
LEU A 920
LEU A 917
GLN A 913
VAL A 940
 None
 1.41A 3zqtA-6caaA:
undetectable		 3zqtA-6caaA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 6caa ELECTROGENIC SODIUM
BICARBONATE
COTRANSPORTER 1
(Homo
sapiens) 		4 / 8 PHE A 865
TYR A 862
VAL A 864
ILE A 692
 None
 1.04A 4a97C-6caaA:
undetectable		 4a97C-6caaA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 6caa ELECTROGENIC SODIUM
BICARBONATE
COTRANSPORTER 1
(Homo
sapiens) 		4 / 7 PHE A 865
TYR A 862
VAL A 864
ILE A 692
 None
 1.09A 4a97H-6caaA:
0.7		 4a97H-6caaA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_2
(CYP51 VARIANT1)		 6caa ELECTROGENIC SODIUM
BICARBONATE
COTRANSPORTER 1
(Homo
sapiens) 		3 / 3 PRO A 795
LEU A 482
SER A 460
 None
 0.77A 5fsaB-6caaA:
undetectable		 5fsaB-6caaA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 6caa ELECTROGENIC SODIUM
BICARBONATE
COTRANSPORTER 1
(Homo
sapiens) 		4 / 7 ILE A 513
GLY A 514
PHE A 932
PHE A 752
 None
 1.14A 5hieA-6caaA:
undetectable		 5hieA-6caaA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_A_RFPA502_1
(RIFAMPIN
MONOOXYGENASE)		 6caa ELECTROGENIC SODIUM
BICARBONATE
COTRANSPORTER 1
(Homo
sapiens) 		5 / 12 HIS A 807
VAL A 762
PHE A 417
THR A 837
GLY A 836
 None
 1.23A 6brdA-6caaA:
undetectable		 6brdA-6caaA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_0
(NS3 PROTEASE)		 6caa ELECTROGENIC SODIUM
BICARBONATE
COTRANSPORTER 1
(Homo
sapiens) 		5 / 12 GLY A 468
VAL A 798
GLY A 844
PHE A 461
ALA A 440
 None
 1.21A 6c2mB-6caaA:
undetectable		 6c2mB-6caaA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 6caa ELECTROGENIC SODIUM
BICARBONATE
COTRANSPORTER 1
(Homo
sapiens) 		5 / 12 PRO A 712
ILE A 852
TYR A 433
THR A 438
ILE A 441
 None
 1.36A 6j20A-6caaA:
1.3		 6j20A-6caaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JI6_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME)		 6caa ELECTROGENIC SODIUM
BICARBONATE
COTRANSPORTER 1
(Homo
sapiens) 		4 / 5 GLY A 444
LEU A 447
SER A 484
TYR A 797
 None
 1.01A 6ji6A-6caaA:
undetectable		 6ji6A-6caaA:
undetectable