SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6cah'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1N5X_A_TEIA3006_1 (XANTHINE DEHYDROGENASE)	6cah	ABC TRANSPORTER ATP-BINDING/PERMEASE PROTEIN RV1747 (Mycobacterium tuberculosis)	5 / 12	LEU A 304 LEU A 254 ARG A 264 ALA A 282 ALA A 281	None	1.17A	1n5xA-6cahA: undetectable	1n5xA-6cahA: 4.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1N5X_B_TEIB4006_1 (XANTHINE DEHYDROGENASE)	6cah	ABC TRANSPORTER ATP-BINDING/PERMEASE PROTEIN RV1747 (Mycobacterium tuberculosis)	5 / 12	LEU A 304 LEU A 254 ARG A 264 ALA A 282 ALA A 281	None	1.16A	1n5xB-6cahA: undetectable	1n5xB-6cahA: 4.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2JC9_A_ADNA1497_1 (CYTOSOLIC PURINE 5'-NUCLEOTIDASE)	6cah	ABC TRANSPORTER ATP-BINDING/PERMEASE PROTEIN RV1747 (Mycobacterium tuberculosis)	4 / 7	ARG A 306 ASP A 296 THR A 291 ILE A 242	None	1.27A	2jc9A-6cahA: undetectable	2jc9A-6cahA: 9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LZV_A_017A200_2 (HIV-1 PROTEASE)	6cah	ABC TRANSPORTER ATP-BINDING/PERMEASE PROTEIN RV1747 (Mycobacterium tuberculosis)	5 / 11	ALA A 252 ASN A 266 GLY A 293 ILE A 295 VAL A 274	None	0.98A	3lzvB-6cahA: undetectable	3lzvB-6cahA: 26.00

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1N5X_A_TEIA3006_1","XANTHINE DEHYDROGENASE","6cah","ABC TRANSPORTER ATP-BINDING\/PERMEASE PROTEIN RV1747","Mycobacterium tuberculosis",5,"LEU A 304;LEU A 254;ARG A 264;ALA A 282;ALA A 281","None","1.17A","1n5xA-6cahA:undetectable","1n5xA-6cahA:4.96"],["1N5X_B_TEIB4006_1","XANTHINE DEHYDROGENASE","6cah","ABC TRANSPORTER ATP-BINDING\/PERMEASE PROTEIN RV1747","Mycobacterium tuberculosis",5,"LEU A 304;LEU A 254;ARG A 264;ALA A 282;ALA A 281","None","1.16A","1n5xB-6cahA:undetectable","1n5xB-6cahA:4.96"],["2JC9_A_ADNA1497_1","CYTOSOLIC PURINE 5'-NUCLEOTIDASE","6cah","ABC TRANSPORTER ATP-BINDING\/PERMEASE PROTEIN RV1747","Mycobacterium tuberculosis",4,"ARG A 306;ASP A 296;THR A 291;ILE A 242","None","1.27A","2jc9A-6cahA:undetectable","2jc9A-6cahA:9.89"],["3LZV_A_017A200_2","HIV-1 PROTEASE;HIV-1 PROTEASE","6cah","ABC TRANSPORTER ATP-BINDING\/PERMEASE PROTEIN RV1747","Mycobacterium tuberculosis",5,"ALA A 252;ASN A 266;GLY A 293;ILE A 295;VAL A 274","None","0.98A","3lzvB-6cahA:undetectable","3lzvB-6cahA:26.00"]]