SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6caj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEI_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 6caj TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA
(Homo
sapiens) 		4 / 8 ASP C 219
ILE C 234
GLU C 193
GLY C 200
 None
 0.84A 1meiA-6cajC:
undetectable		 1meiA-6cajC:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 6caj TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA
(Homo
sapiens) 		5 / 12 THR C 173
SER C 171
LEU C 245
VAL C 316
VAL C 267
 None
 1.29A 1q23B-6cajC:
undetectable		 1q23B-6cajC:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 6caj TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA
(Homo
sapiens) 		5 / 12 THR C 173
SER C 171
LEU C 245
VAL C 316
VAL C 267
 None
 1.29A 1q23C-6cajC:
undetectable		 1q23C-6cajC:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_F_FUAF704_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 6caj TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA
(Homo
sapiens) 		5 / 11 THR C 173
SER C 171
LEU C 245
VAL C 316
VAL C 267
 None
 1.35A 1q23F-6cajC:
undetectable		 1q23F-6cajC:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 6caj TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA
(Homo
sapiens) 		5 / 11 THR C 173
SER C 171
LEU C 245
VAL C 316
VAL C 267
 None
 1.31A 1q23I-6cajC:
undetectable		 1q23I-6cajC:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 6caj TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA
(Homo
sapiens) 		5 / 11 THR C 173
SER C 171
LEU C 245
VAL C 316
VAL C 267
 None
 1.34A 1q23J-6cajC:
undetectable		 1q23J-6cajC:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 6caj TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA
(Homo
sapiens) 		5 / 11 THR C 173
SER C 171
LEU C 245
VAL C 316
VAL C 267
 None
 1.31A 1q23L-6cajC:
undetectable		 1q23L-6cajC:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ1_A_HLTA2001_1
(FERRITIN LIGHT CHAIN)		 6caj TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA
(Homo
sapiens) 		4 / 4 LEU C 339
SER C 341
TYR C 344
LEU C 274
 None
 1.18A 1xz1A-6cajC:
undetectable		 1xz1A-6cajC:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		 6caj TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA
(Homo
sapiens) 		4 / 4 LEU C 339
SER C 341
TYR C 344
LEU C 274
 None
 1.19A 1xz3A-6cajC:
undetectable		 1xz3A-6cajC:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 6caj TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA
(Homo
sapiens) 		3 / 3 PHE C 187
ARG C 228
ASN C 230
 None
 0.90A 1xzxX-6cajC:
undetectable		 1xzxX-6cajC:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 6caj TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA
(Homo
sapiens) 		5 / 11 THR C 167
ALA C 255
GLY C 235
THR C 236
ALA C 247
 None
 1.14A 2f16H-6cajC:
undetectable
2f16I-6cajC:
undetectable		 2f16H-6cajC:
15.56
2f16I-6cajC:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 6caj TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA
(Homo
sapiens) 		5 / 11 THR C 167
ALA C 255
GLY C 235
THR C 236
ALA C 247
 None
 1.15A 2f16V-6cajC:
undetectable
2f16W-6cajC:
undetectable		 2f16V-6cajC:
15.56
2f16W-6cajC:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A164_1
(BETA-LACTOGLOBULIN)		 6caj TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA
(Homo
sapiens) 		4 / 5 ASP C 348
LEU C  86
LYS C  87
ARG C  62
 None
 1.20A 2gj5A-6cajC:
undetectable		 2gj5A-6cajC:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_2
(PROTEASE)		 6caj TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA
(Homo
sapiens) 		3 / 3 ARG C 228
VAL C 232
THR C 263
 None
 0.79A 2nmzA-6cajC:
undetectable		 2nmzA-6cajC:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_C_SNLC3001_1
(MINERALOCORTICOID
RECEPTOR)		 6caj TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA
(Homo
sapiens) 		5 / 12 GLN C 277
ARG C  83
MET C  34
LEU C  22
PHE C 313
 None
 1.31A 2oaxC-6cajC:
undetectable		 2oaxC-6cajC:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQT_A_AINA596_1
(LACTOPEROXIDASE)		 6caj TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA
(Homo
sapiens) 		4 / 6 ARG C 172
GLU C  32
PHE C 272
PRO C 270
 None
 1.29A 2qqtA-6cajC:
1.8		 2qqtA-6cajC:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 6caj TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA
(Homo
sapiens) 		4 / 7 ILE C  45
ARG C  66
MET C  68
THR C  69
 None
 1.08A 2zxwN-6cajC:
2.2
2zxwW-6cajC:
undetectable		 2zxwN-6cajC:
undetectable
2zxwW-6cajC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 6caj TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA
(Homo
sapiens) 		4 / 5 ILE C  45
ARG C  66
MET C  68
THR C  69
 None
 1.08A 3abkN-6cajC:
undetectable
3abkW-6cajC:
undetectable		 3abkN-6cajC:
undetectable
3abkW-6cajC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 6caj TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA
(Homo
sapiens) 		4 / 7 ILE C  45
ARG C  66
MET C  68
THR C  69
 None
 0.99A 3ablA-6cajC:
undetectable
3ablJ-6cajC:
undetectable		 3ablA-6cajC:
undetectable
3ablJ-6cajC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCL_A_AINA609_1
(LACTOPEROXIDASE)		 6caj TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA
(Homo
sapiens) 		4 / 6 ARG C 172
GLU C  32
PHE C 272
PRO C 270
 None
 1.23A 3gclA-6cajC:
0.6		 3gclA-6cajC:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_B_SAMB270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 6caj TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA
(Homo
sapiens) 		5 / 11 ALA C 241
ILE C 336
MET C 340
SER C 275
LEU C 274
 None
 0.97A 3gyqB-6cajC:
3.3		 3gyqB-6cajC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 6caj TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA
(Homo
sapiens) 		5 / 12 SER C 171
MET C 203
VAL C 229
ILE C 165
GLU C 163
 None
 1.40A 3jayA-6cajC:
undetectable		 3jayA-6cajC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 6caj TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA
(Homo
sapiens) 		5 / 12 SER C 171
MET C 203
VAL C 229
ILE C 165
GLU C 163
 None
 1.42A 3jb2A-6cajC:
undetectable		 3jb2A-6cajC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 6caj TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA
(Homo
sapiens) 		5 / 10 THR C  38
GLY C  40
GLU C  37
LEU C  42
ILE C 137
 None
 1.32A 3kvrB-6cajC:
undetectable		 3kvrB-6cajC:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 6caj TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA
(Homo
sapiens) 		5 / 11 THR C 167
ALA C 255
GLY C 235
THR C 236
ALA C 247
 None
 1.14A 3mg0V-6cajC:
undetectable
3mg0W-6cajC:
undetectable		 3mg0V-6cajC:
15.56
3mg0W-6cajC:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL6_A_NIMA614_1
(LACTOPEROXIDASE)		 6caj TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA
(Homo
sapiens) 		4 / 7 ARG C 172
GLU C  32
PHE C 272
PRO C 270
 None
 1.28A 3ql6A-6cajC:
undetectable		 3ql6A-6cajC:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R4X_A_PZAA598_0
(LACTOPEROXIDASE)		 6caj TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA
(Homo
sapiens) 		4 / 5 ARG C 172
GLU C  32
PHE C 272
PRO C 270
 None
 1.25A 3r4xA-6cajC:
2.2		 3r4xA-6cajC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_B_CLMB221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 6caj TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA
(Homo
sapiens) 		5 / 12 THR C 173
SER C 171
LEU C 245
VAL C 316
VAL C 267
 None
 1.41A 3u9fB-6cajC:
undetectable
3u9fC-6cajC:
undetectable		 3u9fB-6cajC:
undetectable
3u9fC-6cajC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 6caj TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA
(Homo
sapiens) 		5 / 10 THR C 173
SER C 171
LEU C 245
VAL C 316
VAL C 267
 None
 1.45A 3u9fE-6cajC:
undetectable		 3u9fE-6cajC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 6caj TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA
(Homo
sapiens) 		5 / 10 THR C 173
SER C 171
LEU C 245
VAL C 316
VAL C 267
 None
 1.40A 3u9fI-6cajC:
undetectable		 3u9fI-6cajC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_P_CLMP221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 6caj TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA
(Homo
sapiens) 		5 / 9 THR C 173
SER C 171
LEU C 245
VAL C 316
VAL C 267
 None
 1.43A 3u9fP-6cajC:
undetectable		 3u9fP-6cajC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_S_CLMS221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 6caj TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA
(Homo
sapiens) 		5 / 12 THR C 173
SER C 171
LEU C 245
VAL C 316
VAL C 267
 None
 1.33A 3u9fP-6cajC:
undetectable
3u9fS-6cajC:
undetectable		 3u9fP-6cajC:
undetectable
3u9fS-6cajC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_A_QDNA602_1
(CYTOCHROME P450 2D6)		 6caj TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA
(Homo
sapiens) 		5 / 11 LEU C 144
GLY C  40
LEU C  41
LEU C 140
PHE C  18
 None
 0.96A 4wnuA-6cajC:
1.4		 4wnuA-6cajC:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE0_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 6caj TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA
(Homo
sapiens) 		5 / 9 THR C 147
ILE C 151
GLY C 329
LEU C 339
LEU C 274
 None
 1.12A 4ze0A-6cajC:
undetectable		 4ze0A-6cajC:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_B_ACTB1321_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT)		 6caj TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA
(Homo
sapiens) 		3 / 3 THR C 218
ASP C 219
ALA C 220
 None
 0.00A 5g5gB-6cajC:
undetectable		 5g5gB-6cajC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKW_A_TESA601_1
(AROMATASE)		 6caj TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA
(Homo
sapiens) 		5 / 11 ILE C 165
ILE C 266
THR C 263
VAL C 225
LEU C 254
 None
None
None
C7B  C 401 (-4.3A)
None
 1.36A 5jkwA-6cajC:
undetectable		 5jkwA-6cajC:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 6caj TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA
(Homo
sapiens) 		4 / 8 ARG C 172
ARG C  36
GLU C 145
GLN C  44
 None
 1.24A 6fbvD-6cajC:
undetectable		 6fbvD-6cajC:
undetectable