SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6cau'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 6cau UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE
(Acinetobacter
baumannii) 		4 / 8 SER A  57
GLY A  32
CYH A  36
GLY A  29
 None
 0.71A 1f5lA-6cauA:
undetectable		 1f5lA-6cauA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1320_0
(CHLOROPEROXIDASE)		 6cau UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE
(Acinetobacter
baumannii) 		4 / 6 ALA A 300
ILE A 261
VAL A 277
PHE A 275
 None
 0.98A 2cizA-6cauA:
undetectable		 2cizA-6cauA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 6cau UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE
(Acinetobacter
baumannii) 		4 / 7 ILE A 174
ARG A 122
GLY A  37
MET A  35
 None
 1.07A 2pnjB-6cauA:
2.5		 2pnjB-6cauA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 6cau UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE
(Acinetobacter
baumannii) 		4 / 8 LEU A 188
ARG A 122
GLY A  37
MET A  35
 None
 0.78A 2po5A-6cauA:
undetectable		 2po5A-6cauA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO4_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 6cau UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE
(Acinetobacter
baumannii) 		5 / 12 LEU A 115
ILE A  38
ALA A 126
VAL A 127
THR A 152
 None
 1.39A 2qo4A-6cauA:
undetectable		 2qo4A-6cauA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_A_SALA404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 6cau UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE
(Acinetobacter
baumannii) 		4 / 7 ALA A 183
TYR A 187
ALA A 112
ARG A 111
 None
 1.02A 3twpA-6cauA:
3.6		 3twpA-6cauA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_B_SALB404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 6cau UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE
(Acinetobacter
baumannii) 		4 / 7 ALA A 183
TYR A 187
ALA A 112
ARG A 111
 None
 1.01A 3twpB-6cauA:
3.6		 3twpB-6cauA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_C_SALC404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 6cau UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE
(Acinetobacter
baumannii) 		4 / 7 ALA A 183
TYR A 187
ALA A 112
ARG A 111
 None
 1.01A 3twpC-6cauA:
3.8		 3twpC-6cauA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 6cau UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE
(Acinetobacter
baumannii) 		5 / 12 LEU A 229
ILE A 125
ALA A 302
THR A 136
VAL A 127
 None
 0.98A 4nkvA-6cauA:
undetectable		 4nkvA-6cauA:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 6cau UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE
(Acinetobacter
baumannii) 		5 / 12 LEU A 229
ILE A 125
ALA A 302
THR A 136
VAL A 127
 None
 0.98A 4nkvB-6cauA:
undetectable		 4nkvB-6cauA:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 6cau UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE
(Acinetobacter
baumannii) 		5 / 12 LEU A 229
ILE A 125
ALA A 302
THR A 136
VAL A 127
 None
 0.97A 4nkvD-6cauA:
undetectable		 4nkvD-6cauA:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 6cau UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE
(Acinetobacter
baumannii) 		5 / 11 VAL A 154
PHE A 324
GLY A 132
ASN A 296
GLU A 177
 None
None
ANP  A 501 (-3.1A)
None
MG  A 502 ( 2.7A)
 1.47A 4zvmA-6cauA:
2.5
4zvmB-6cauA:
2.1		 4zvmA-6cauA:
15.11
4zvmB-6cauA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HQA_A_ACRA705_2
(ALPHA-GLUCOSIDASE)		 6cau UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE
(Acinetobacter
baumannii) 		4 / 8 PHE A 220
GLU A 180
HIS A 131
THR A 252
 None
MG  A 503 ( 4.5A)
ANP  A 501 (-4.3A)
None
 1.02A 5hqaA-6cauA:
undetectable		 5hqaA-6cauA:
7.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH614_0
(NADH DEHYDROGENASE,
PUTATIVE)		 6cau UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE
(Acinetobacter
baumannii) 		4 / 6 ILE A 239
VAL A 250
TYR A 253
VAL A 232
 None
 0.99A 5jwaH-6cauA:
4.5		 5jwaH-6cauA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 6cau UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE
(Acinetobacter
baumannii) 		5 / 12 PHE A 220
ALA A 178
LEU A 188
PRO A 190
ILE A 194
 None
 1.19A 5ljcA-6cauA:
undetectable		 5ljcA-6cauA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MLM_A_STRA401_1
(-)		 6cau UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE
(Acinetobacter
baumannii) 		5 / 12 ILE A 261
MET A 143
ALA A 230
VAL A 306
ILE A 251
 None
 1.38A 5mlmA-6cauA:
5.5		 5mlmA-6cauA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0I_B_DAHB98_0
(MELC
TYROSINASE)		 6cau UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE
(Acinetobacter
baumannii) 		5 / 11 HIS A  26
ILE A  79
SER A  52
ASP A  92
PRO A  93
 None
 1.50A 5z0iA-6cauA:
undetectable
5z0iB-6cauA:
0.5		 5z0iA-6cauA:
19.39
5z0iB-6cauA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GZ9_A_TXCA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 6cau UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE
(Acinetobacter
baumannii) 		5 / 10 VAL A  41
ASN A  44
ALA A  43
GLN A  62
ASN A  66
 None
 1.19A 6gz9A-6cauA:
undetectable		 6gz9A-6cauA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_1
(TYROSINE-PROTEIN
KINASE ABL1)		 6cau UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE
(Acinetobacter
baumannii) 		4 / 5 LEU A  63
ILE A 106
MET A  35
GLY A  37
 None
 0.85A 6hd6A-6cauA:
undetectable		 6hd6A-6cauA:
27.47