SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6cbl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RBP_A_RTLA183_0
(PLASMA
RETINOL-BINDING
PROTEIN PRECURSOR)		 6cbl NEAMINE TRANSAMINASE
NEON
(Streptomyces
fradiae) 		5 / 12 ALA A 110
PHE A 101
ALA A 107
ALA A 111
VAL A 200
 None
 1.31A 1rbpA-6cblA:
undetectable		 1rbpA-6cblA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 6cbl NEAMINE TRANSAMINASE
NEON
(Streptomyces
fradiae) 		4 / 8 GLY A 104
THR A 105
ALA A 106
ALA A 107
 DOW  A 501 (-3.3A)
DOW  A 501 (-3.6A)
None
None
 0.58A 2ej3A-6cblA:
undetectable		 2ej3A-6cblA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KOT_B_ANWB99_0
(PROTEIN S100-A13)		 6cbl NEAMINE TRANSAMINASE
NEON
(Streptomyces
fradiae) 		4 / 8 MET A 233
ALA A 234
VAL A  60
THR A 264
 None
 0.76A 2kotB-6cblA:
undetectable		 2kotB-6cblA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		 6cbl NEAMINE TRANSAMINASE
NEON
(Streptomyces
fradiae) 		4 / 8 SER A 217
THR A 218
PRO A 224
THR A 314
 None
 0.87A 2v0zO-6cblA:
undetectable		 2v0zO-6cblA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_1
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT)		 6cbl NEAMINE TRANSAMINASE
NEON
(Streptomyces
fradiae) 		5 / 10 VAL A 242
VAL A 226
GLY A 243
VAL A  97
GLY A  95
 None
 1.27A 3ls4H-6cblA:
undetectable		 3ls4H-6cblA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA452_1
(CYTOCHROME P450
164A2)		 6cbl NEAMINE TRANSAMINASE
NEON
(Streptomyces
fradiae) 		5 / 12 ALA A 271
LEU A 273
LEU A  89
ALA A 269
LEU A 266
 None
 0.83A 3r9cA-6cblA:
undetectable		 3r9cA-6cblA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_S_CLMS221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 6cbl NEAMINE TRANSAMINASE
NEON
(Streptomyces
fradiae) 		5 / 12 PHE A 316
PHE A  44
LEU A 329
VAL A 307
VAL A 367
 None
 1.34A 3u9fP-6cblA:
undetectable
3u9fS-6cblA:
undetectable		 3u9fP-6cblA:
undetectable
3u9fS-6cblA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_A_PQNA846_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 6cbl NEAMINE TRANSAMINASE
NEON
(Streptomyces
fradiae) 		5 / 10 PHE A 292
ARG A 294
LEU A 293
GLY A 289
ALA A 384
 None
 1.25A 4fe1A-6cblA:
undetectable
4fe1J-6cblA:
undetectable		 4fe1A-6cblA:
8.14
4fe1J-6cblA:
30.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L3G_F_ACTF401_0
(METHYLAMINE
DEHYDROGENASE HEAVY
CHAIN)		 6cbl NEAMINE TRANSAMINASE
NEON
(Streptomyces
fradiae) 		3 / 3 ARG A 116
LEU A 113
GLU A 117
 None
 0.72A 4l3gF-6cblA:
undetectable		 4l3gF-6cblA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 6cbl NEAMINE TRANSAMINASE
NEON
(Streptomyces
fradiae) 		4 / 6 PHE A 318
ILE A 309
ARG A 297
VAL A 348
 None
 1.23A 4mk4B-6cblA:
undetectable		 4mk4B-6cblA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 6cbl NEAMINE TRANSAMINASE
NEON
(Streptomyces
fradiae) 		4 / 5 TYR A 212
PRO A 177
LEU A 221
TYR A 187
 None
 1.48A 4w5qA-6cblA:
undetectable		 4w5qA-6cblA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 6cbl NEAMINE TRANSAMINASE
NEON
(Streptomyces
fradiae) 		4 / 8 PHE A 154
ALA A 127
LEU A 160
LEU A 159
 None
 1.05A 5dzkd-6cblA:
undetectable
5dzkr-6cblA:
undetectable		 5dzkd-6cblA:
undetectable
5dzkr-6cblA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 6cbl NEAMINE TRANSAMINASE
NEON
(Streptomyces
fradiae) 		4 / 8 PHE A 154
ALA A 127
LEU A 160
LEU A 159
 None
 1.20A 5dzkF-6cblA:
undetectable
5dzkT-6cblA:
undetectable		 5dzkF-6cblA:
undetectable
5dzkT-6cblA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 6cbl NEAMINE TRANSAMINASE
NEON
(Streptomyces
fradiae) 		3 / 3 SER A 217
HIS A 179
TYR A 187
 None
 0.94A 5y2tA-6cblA:
undetectable		 5y2tA-6cblA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7M_B_68HB405_0
(BETA-1 ADRENERGIC
RECEPTOR)		 6cbl NEAMINE TRANSAMINASE
NEON
(Streptomyces
fradiae) 		5 / 12 ASP A 204
VAL A 206
VAL A 228
SER A 103
SER A 240
 DOW  A 501 (-2.7A)
DOW  A 501 (-4.0A)
None
DOW  A 501 ( 4.0A)
None
 1.33A 6h7mB-6cblA:
undetectable		 6h7mB-6cblA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IEY_A_CLMA401_0
(ESTERASE)		 6cbl NEAMINE TRANSAMINASE
NEON
(Streptomyces
fradiae) 		5 / 11 ILE A 265
ASP A  72
ALA A  67
GLY A  73
SER A  79
 None
 1.29A 6ieyA-6cblA:
undetectable
6ieyB-6cblA:
undetectable		 6ieyA-6cblA:
undetectable
6ieyB-6cblA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_B_FFOB403_0
(THYMIDYLATE SYNTHASE)		 6cbl NEAMINE TRANSAMINASE
NEON
(Streptomyces
fradiae) 		5 / 10 PHE A 153
LEU A 113
LEU A 123
GLY A 149
ASN A 146
 None
 1.38A 6r2eB-6cblA:
undetectable		 6r2eB-6cblA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_C_FFOC404_0
(THYMIDYLATE SYNTHASE)		 6cbl NEAMINE TRANSAMINASE
NEON
(Streptomyces
fradiae) 		5 / 10 PHE A 153
LEU A 113
LEU A 123
GLY A 149
ASN A 146
 None
 1.45A 6r2eC-6cblA:
undetectable		 6r2eC-6cblA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_D_FFOD403_0
(THYMIDYLATE SYNTHASE)		 6cbl NEAMINE TRANSAMINASE
NEON
(Streptomyces
fradiae) 		5 / 10 PHE A 153
LEU A 113
LEU A 123
GLY A 149
ASN A 146
 None
 1.39A 6r2eD-6cblA:
undetectable		 6r2eD-6cblA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_G_FFOG403_0
(THYMIDYLATE SYNTHASE)		 6cbl NEAMINE TRANSAMINASE
NEON
(Streptomyces
fradiae) 		5 / 11 PHE A 153
LEU A 113
LEU A 123
GLY A 149
ASN A 146
 None
 1.35A 6r2eG-6cblA:
undetectable		 6r2eG-6cblA:
undetectable