SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6cc0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_D_TC9D1206_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 6cc0 LUXR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		4 / 7 TRP A 102
TYR A  66
GLU A  69
TYR A  71
 EWM  A 301 (-4.9A)
EWM  A 301 (-4.4A)
None
None
 1.29A 2xytD-6cc0A:
undetectable		 2xytD-6cc0A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_G_TC9G1206_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 6cc0 LUXR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		4 / 7 TRP A 102
TYR A  66
GLU A  69
TYR A  71
 EWM  A 301 (-4.9A)
EWM  A 301 (-4.4A)
None
None
 1.38A 2xytG-6cc0A:
undetectable		 2xytG-6cc0A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_H_TC9H1206_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 6cc0 LUXR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		4 / 7 TRP A 102
TYR A  66
GLU A  69
TYR A  71
 EWM  A 301 (-4.9A)
EWM  A 301 (-4.4A)
None
None
 1.45A 2xytH-6cc0A:
undetectable		 2xytH-6cc0A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 6cc0 LUXR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		4 / 5 GLN A 157
THR A 153
THR A  86
HIS A  80
 None
 1.40A 2zj0C-6cc0A:
undetectable		 2zj0C-6cc0A:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_A_ADNA438_2
(ADENOSYLHOMOCYSTEINA
SE)		 6cc0 LUXR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		4 / 4 GLN A 157
THR A 153
THR A  86
HIS A  80
 None
 1.37A 3g1uA-6cc0A:
undetectable		 3g1uA-6cc0A:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_C_ADNC438_2
(ADENOSYLHOMOCYSTEINA
SE)		 6cc0 LUXR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		4 / 5 GLN A 157
THR A 153
THR A  86
HIS A  80
 None
 1.39A 3g1uC-6cc0A:
undetectable		 3g1uC-6cc0A:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_A_RABA602_2
(ADENOSYLHOMOCYSTEINA
SE)		 6cc0 LUXR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		4 / 5 GLN A 157
THR A 153
THR A  86
HIS A  80
 None
 1.36A 3glqA-6cc0A:
undetectable		 3glqA-6cc0A:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_B_RABB602_2
(ADENOSYLHOMOCYSTEINA
SE)		 6cc0 LUXR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		4 / 5 GLN A 157
THR A 153
THR A  86
HIS A  80
 None
 1.39A 3glqB-6cc0A:
undetectable		 3glqB-6cc0A:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 6cc0 LUXR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		4 / 5 SER A  38
ARG A 111
GLY A  92
GLU A  93
 EWM  A 301 (-2.7A)
None
None
None
 1.07A 3k9fA-6cc0A:
undetectable
3k9fB-6cc0A:
undetectable
3k9fC-6cc0A:
undetectable		 3k9fA-6cc0A:
9.48
3k9fB-6cc0A:
9.48
3k9fC-6cc0A:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 6cc0 LUXR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		4 / 6 SER A  38
ARG A 111
GLY A  92
GLU A  93
 EWM  A 301 (-2.7A)
None
None
None
 1.07A 3k9fA-6cc0A:
undetectable
3k9fB-6cc0A:
undetectable
3k9fD-6cc0A:
undetectable		 3k9fA-6cc0A:
9.48
3k9fB-6cc0A:
9.48
3k9fD-6cc0A:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 6cc0 LUXR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		4 / 5 GLN A 157
THR A 153
THR A  86
HIS A  80
 None
 1.38A 3n58A-6cc0A:
undetectable		 3n58A-6cc0A:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 6cc0 LUXR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		4 / 7 ALA A 214
ALA A 230
LEU A 176
THR A 181
 None
 0.90A 4du2A-6cc0A:
undetectable		 4du2A-6cc0A:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 6cc0 LUXR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		4 / 7 ALA A 214
ALA A 230
LEU A 176
THR A 181
 None
 0.91A 4du2B-6cc0A:
undetectable		 4du2B-6cc0A:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLD_A_BRLA502_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 6cc0 LUXR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		5 / 12 PHE A  34
GLY A  30
CYH A  29
TYR A  58
LEU A 128
 None
None
None
EWM  A 301 (-4.3A)
None
 1.42A 4xldA-6cc0A:
undetectable		 4xldA-6cc0A:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z3O_F_MFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
E-SITE DNA)		 6cc0 LUXR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		4 / 5 ARG A 111
GLY A  92
GLU A  93
SER A  38
 None
None
None
EWM  A 301 (-2.7A)
 1.25A 4z3oA-6cc0A:
undetectable
4z3oB-6cc0A:
2.6		 4z3oA-6cc0A:
7.41
4z3oB-6cc0A:
7.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 6cc0 LUXR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		4 / 6 SER A  38
ARG A 111
GLY A  92
GLU A  93
 EWM  A 301 (-2.7A)
None
None
None
 1.02A 5btaA-6cc0A:
undetectable
5btaB-6cc0A:
undetectable
5btaC-6cc0A:
undetectable		 5btaA-6cc0A:
8.37
5btaB-6cc0A:
16.67
5btaC-6cc0A:
8.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 6cc0 LUXR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		4 / 6 SER A  38
ARG A 111
GLY A  92
GLU A  93
 EWM  A 301 (-2.7A)
None
None
None
 1.10A 5btcA-6cc0A:
undetectable
5btcC-6cc0A:
undetectable
5btcD-6cc0A:
undetectable		 5btcA-6cc0A:
8.37
5btcC-6cc0A:
8.37
5btcD-6cc0A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 6cc0 LUXR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		4 / 6 SER A  38
ARG A 111
GLY A  92
GLU A  93
 EWM  A 301 (-2.7A)
None
None
None
 1.05A 5btcA-6cc0A:
undetectable
5btcB-6cc0A:
undetectable
5btcC-6cc0A:
undetectable		 5btcA-6cc0A:
8.37
5btcB-6cc0A:
16.67
5btcC-6cc0A:
8.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 6cc0 LUXR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		4 / 7 SER A  38
ARG A 111
GLY A  92
GLU A  93
 EWM  A 301 (-2.7A)
None
None
None
 1.11A 5btfA-6cc0A:
undetectable
5btfC-6cc0A:
undetectable
5btfD-6cc0A:
undetectable		 5btfA-6cc0A:
8.37
5btfC-6cc0A:
8.37
5btfD-6cc0A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_E_MFXE2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 6cc0 LUXR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		4 / 5 SER A  38
ARG A 111
GLY A  92
GLU A  93
 EWM  A 301 (-2.7A)
None
None
None
 1.16A 5cdqA-6cc0A:
undetectable
5cdqB-6cc0A:
undetectable
5cdqC-6cc0A:
undetectable		 5cdqA-6cc0A:
9.96
5cdqB-6cc0A:
16.75
5cdqC-6cc0A:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_V_MFXV2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 6cc0 LUXR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		4 / 5 SER A  38
ARG A 111
GLY A  92
GLU A  93
 EWM  A 301 (-2.7A)
None
None
None
 1.16A 5cdqR-6cc0A:
undetectable
5cdqS-6cc0A:
undetectable
5cdqT-6cc0A:
undetectable		 5cdqR-6cc0A:
9.96
5cdqS-6cc0A:
16.75
5cdqT-6cc0A:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_B_SAMB501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 6cc0 LUXR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  12
ILE A  11
GLY A   7
LEU A 156
LEU A 128
 None
 1.13A 5nfjB-6cc0A:
undetectable		 5nfjB-6cc0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_C_SAMC501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 6cc0 LUXR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  12
ILE A  11
GLY A   7
LEU A 156
LEU A 128
 None
 1.11A 5nfjC-6cc0A:
undetectable		 5nfjC-6cc0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_A_ADNA505_2
(-)		 6cc0 LUXR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		4 / 4 GLN A 157
THR A 153
THR A  86
HIS A  80
 None
 1.41A 6f3nA-6cc0A:
undetectable		 6f3nA-6cc0A:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_C_ADNC505_2
(-)		 6cc0 LUXR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		4 / 4 GLN A 157
THR A 153
THR A  86
HIS A  80
 None
 1.42A 6f3nC-6cc0A:
undetectable		 6f3nC-6cc0A:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_D_ADND506_2
(-)		 6cc0 LUXR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		4 / 4 GLN A 157
THR A 153
THR A  86
HIS A  80
 None
 1.41A 6f3nD-6cc0A:
undetectable		 6f3nD-6cc0A:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I0Y_A_TRPA3001_0
(23S RIBOSOMAL RNA
TRYPTOPHANASE OPERON
LEADER PEPTIDE)		 6cc0 LUXR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		3 / 3 TRP A 102
ILE A  74
ASP A  75
 EWM  A 301 (-4.9A)
None
EWM  A 301 (-3.3A)
 0.79A 6i0y7-6cc0A:
undetectable		 6i0y7-6cc0A:
undetectable