SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6ccz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_A_FFOA1002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		9 / 12 LEU A 204
GLY A 207
HIS A 209
LEU A 210
VAL A 221
SER A 264
ALA A 265
ASN A 439
ARG A 454
 None
None
LLP  A 318 (-3.5A)
None
None
ACT  A 612 (-2.7A)
None
None
ACT  A 612 (-2.9A)
 0.63A 1dfoA-6cczA:
54.4		 1dfoA-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_A_FFOA1002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 12 LEU A 204
GLY A 208
SER A 264
ASN A 439
ARG A 454
 None
None
ACT  A 612 (-2.7A)
None
ACT  A 612 (-2.9A)
 1.06A 1dfoA-6cczA:
54.4		 1dfoA-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_A_FFOA1002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		4 / 5 GLU A 136
TYR A 134
PHE A 349
PRO A 350
 None
None
None
SEY  A 607 (-4.7A)
 1.46A 1dfoB-6cczA:
56.4		 1dfoB-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_A_FFOA1002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 5 GLU A 136
TYR A 143
TYR A 144
PHE A 349
PRO A 350
 None
None
None
None
SEY  A 607 (-4.7A)
 0.27A 1dfoB-6cczA:
56.4		 1dfoB-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_B_FFOB2002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		4 / 5 GLU A 136
TYR A 134
PHE A 349
PRO A 350
 None
None
None
SEY  A 607 (-4.7A)
 1.46A 1dfoA-6cczA:
54.4		 1dfoA-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_B_FFOB2002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 5 GLU A 136
TYR A 143
TYR A 144
PHE A 349
PRO A 350
 None
None
None
None
SEY  A 607 (-4.7A)
 0.26A 1dfoA-6cczA:
54.4		 1dfoA-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_B_FFOB2002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		9 / 12 LEU A 204
GLY A 207
HIS A 209
LEU A 210
VAL A 221
SER A 264
ALA A 265
ASN A 439
ARG A 454
 None
None
LLP  A 318 (-3.5A)
None
None
ACT  A 612 (-2.7A)
None
None
ACT  A 612 (-2.9A)
 0.64A 1dfoB-6cczA:
56.4		 1dfoB-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_B_FFOB2002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 12 LEU A 204
GLY A 208
SER A 264
ASN A 439
ARG A 454
 None
None
ACT  A 612 (-2.7A)
None
ACT  A 612 (-2.9A)
 1.06A 1dfoB-6cczA:
56.4		 1dfoB-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_C_FFOC3002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		9 / 12 LEU A 204
GLY A 207
HIS A 209
LEU A 210
VAL A 221
SER A 264
ALA A 265
ASN A 439
ARG A 454
 None
None
LLP  A 318 (-3.5A)
None
None
ACT  A 612 (-2.7A)
None
None
ACT  A 612 (-2.9A)
 0.63A 1dfoC-6cczA:
56.4		 1dfoC-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_C_FFOC3002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 12 LEU A 204
GLY A 208
SER A 264
ASN A 439
ARG A 454
 None
None
ACT  A 612 (-2.7A)
None
ACT  A 612 (-2.9A)
 1.06A 1dfoC-6cczA:
56.4		 1dfoC-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_C_FFOC3002_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		4 / 5 GLU A 136
TYR A 134
PHE A 349
PRO A 350
 None
None
None
SEY  A 607 (-4.7A)
 1.46A 1dfoD-6cczA:
54.4		 1dfoD-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_C_FFOC3002_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 5 GLU A 136
TYR A 143
TYR A 144
PHE A 349
PRO A 350
 None
None
None
None
SEY  A 607 (-4.7A)
 0.27A 1dfoD-6cczA:
54.4		 1dfoD-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_D_FFOD4002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		4 / 5 GLU A 136
TYR A 134
PHE A 349
PRO A 350
 None
None
None
SEY  A 607 (-4.7A)
 1.46A 1dfoC-6cczA:
56.4		 1dfoC-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_D_FFOD4002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 5 GLU A 136
TYR A 143
TYR A 144
PHE A 349
PRO A 350
 None
None
None
None
SEY  A 607 (-4.7A)
 0.27A 1dfoC-6cczA:
56.4		 1dfoC-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_D_FFOD4002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		9 / 12 LEU A 204
GLY A 207
HIS A 209
LEU A 210
VAL A 221
SER A 264
ALA A 265
ASN A 439
ARG A 454
 None
None
LLP  A 318 (-3.5A)
None
None
ACT  A 612 (-2.7A)
None
None
ACT  A 612 (-2.9A)
 0.64A 1dfoD-6cczA:
54.4		 1dfoD-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_D_FFOD4002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 12 LEU A 204
GLY A 208
SER A 264
ASN A 439
ARG A 454
 None
None
ACT  A 612 (-2.7A)
None
ACT  A 612 (-2.9A)
 1.06A 1dfoD-6cczA:
54.4		 1dfoD-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 12 GLY A 207
SER A 264
ALA A 265
PRO A 450
ARG A 454
 None
ACT  A 612 (-2.7A)
None
None
ACT  A 612 (-2.9A)
 1.12A 1eqbA-6cczA:
54.1		 1eqbA-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		9 / 12 LEU A 204
GLY A 207
HIS A 209
LEU A 210
VAL A 221
SER A 264
ALA A 265
ASN A 439
ARG A 454
 None
None
LLP  A 318 (-3.5A)
None
None
ACT  A 612 (-2.7A)
None
None
ACT  A 612 (-2.9A)
 0.62A 1eqbA-6cczA:
54.1		 1eqbA-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 12 LEU A 204
GLY A 208
SER A 264
ASN A 439
ARG A 454
 None
None
ACT  A 612 (-2.7A)
None
ACT  A 612 (-2.9A)
 1.07A 1eqbA-6cczA:
54.1		 1eqbA-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		3 / 3 GLU A 136
TYR A 143
PHE A 349
 None
 0.21A 1eqbB-6cczA:
56.2		 1eqbB-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_GLYA1292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 8 SER A 114
HIS A 209
SER A 264
HIS A 292
ARG A 454
 ACT  A 612 (-2.3A)
LLP  A 318 (-3.5A)
ACT  A 612 (-2.7A)
LLP  A 318 (-3.4A)
ACT  A 612 (-2.9A)
 0.62A 1eqbA-6cczA:
54.1
1eqbB-6cczA:
56.2		 1eqbA-6cczA:
undetectable
1eqbB-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		3 / 3 GLU A 136
TYR A 143
PHE A 349
 None
 0.20A 1eqbA-6cczA:
54.1		 1eqbA-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 12 GLY A 207
SER A 264
ALA A 265
PRO A 450
ARG A 454
 None
ACT  A 612 (-2.7A)
None
None
ACT  A 612 (-2.9A)
 1.12A 1eqbB-6cczA:
56.2		 1eqbB-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		9 / 12 LEU A 204
GLY A 207
HIS A 209
LEU A 210
VAL A 221
SER A 264
ALA A 265
ASN A 439
ARG A 454
 None
None
LLP  A 318 (-3.5A)
None
None
ACT  A 612 (-2.7A)
None
None
ACT  A 612 (-2.9A)
 0.62A 1eqbB-6cczA:
56.2		 1eqbB-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 12 LEU A 204
GLY A 208
SER A 264
ASN A 439
ARG A 454
 None
None
ACT  A 612 (-2.7A)
None
ACT  A 612 (-2.9A)
 1.07A 1eqbB-6cczA:
56.2		 1eqbB-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 8 SER A 114
HIS A 209
SER A 264
HIS A 292
ARG A 454
 ACT  A 612 (-2.3A)
LLP  A 318 (-3.5A)
ACT  A 612 (-2.7A)
LLP  A 318 (-3.4A)
ACT  A 612 (-2.9A)
 0.61A 1eqbA-6cczA:
54.1
1eqbB-6cczA:
56.2		 1eqbA-6cczA:
undetectable
1eqbB-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 12 GLY A 207
SER A 264
ALA A 265
PRO A 450
ARG A 454
 None
ACT  A 612 (-2.7A)
None
None
ACT  A 612 (-2.9A)
 1.12A 1eqbC-6cczA:
56.1		 1eqbC-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		9 / 12 LEU A 204
GLY A 207
HIS A 209
LEU A 210
VAL A 221
SER A 264
ALA A 265
ASN A 439
ARG A 454
 None
None
LLP  A 318 (-3.5A)
None
None
ACT  A 612 (-2.7A)
None
None
ACT  A 612 (-2.9A)
 0.62A 1eqbC-6cczA:
56.1		 1eqbC-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 12 LEU A 204
GLY A 208
SER A 264
ASN A 439
ARG A 454
 None
None
ACT  A 612 (-2.7A)
None
ACT  A 612 (-2.9A)
 1.08A 1eqbC-6cczA:
56.1		 1eqbC-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		3 / 3 GLU A 136
TYR A 143
PHE A 349
 None
 0.21A 1eqbD-6cczA:
56.9		 1eqbD-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 8 SER A 114
HIS A 209
SER A 264
HIS A 292
ARG A 454
 ACT  A 612 (-2.3A)
LLP  A 318 (-3.5A)
ACT  A 612 (-2.7A)
LLP  A 318 (-3.4A)
ACT  A 612 (-2.9A)
 0.62A 1eqbC-6cczA:
56.1
1eqbD-6cczA:
56.9		 1eqbC-6cczA:
undetectable
1eqbD-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		3 / 3 GLU A 136
TYR A 143
PHE A 349
 None
 0.21A 1eqbC-6cczA:
56.1		 1eqbC-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 12 GLY A 207
SER A 264
ALA A 265
PRO A 450
ARG A 454
 None
ACT  A 612 (-2.7A)
None
None
ACT  A 612 (-2.9A)
 1.11A 1eqbD-6cczA:
56.9		 1eqbD-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		9 / 12 LEU A 204
GLY A 207
HIS A 209
LEU A 210
VAL A 221
SER A 264
ALA A 265
ASN A 439
ARG A 454
 None
None
LLP  A 318 (-3.5A)
None
None
ACT  A 612 (-2.7A)
None
None
ACT  A 612 (-2.9A)
 0.63A 1eqbD-6cczA:
56.9		 1eqbD-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 12 LEU A 204
GLY A 208
SER A 264
ASN A 439
ARG A 454
 None
None
ACT  A 612 (-2.7A)
None
ACT  A 612 (-2.9A)
 1.07A 1eqbD-6cczA:
56.9		 1eqbD-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 8 SER A 114
HIS A 209
SER A 264
HIS A 292
ARG A 454
 ACT  A 612 (-2.3A)
LLP  A 318 (-3.5A)
ACT  A 612 (-2.7A)
LLP  A 318 (-3.4A)
ACT  A 612 (-2.9A)
 0.62A 1eqbC-6cczA:
56.1
1eqbD-6cczA:
56.9		 1eqbC-6cczA:
undetectable
1eqbD-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q8H_A_TF4A438_1
([PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		4 / 6 LEU A 258
TYR A 189
ILE A 311
ILE A 260
 None
 0.82A 2q8hA-6cczA:
undetectable		 2q8hA-6cczA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_FFOA505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 6 GLU A 136
TYR A 143
TYR A 144
PHE A 349
PRO A 350
 None
None
None
None
SEY  A 607 (-4.7A)
 0.39A 2vmyA-6cczA:
57.3		 2vmyA-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_FFOA505_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		9 / 12 LEU A 204
GLY A 207
HIS A 209
LEU A 210
VAL A 221
SER A 264
ALA A 265
ASN A 439
ARG A 454
 None
None
LLP  A 318 (-3.5A)
None
None
ACT  A 612 (-2.7A)
None
None
ACT  A 612 (-2.9A)
 0.64A 2vmyB-6cczA:
57.4		 2vmyB-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_GLYA502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		4 / 7 SER A 114
HIS A 209
HIS A 292
ARG A 454
 ACT  A 612 (-2.3A)
LLP  A 318 (-3.5A)
LLP  A 318 (-3.4A)
ACT  A 612 (-2.9A)
 0.63A 2vmyA-6cczA:
57.3
2vmyB-6cczA:
57.4		 2vmyA-6cczA:
undetectable
2vmyB-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_FFOB505_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		4 / 4 GLU A 136
TYR A 143
TYR A 144
PHE A 349
 None
 0.32A 2vmyB-6cczA:
57.4		 2vmyB-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 8 SER A 114
HIS A 209
SER A 264
HIS A 292
ARG A 454
 ACT  A 612 (-2.3A)
LLP  A 318 (-3.5A)
ACT  A 612 (-2.7A)
LLP  A 318 (-3.4A)
ACT  A 612 (-2.9A)
 0.58A 2vmyA-6cczA:
57.3
2vmyB-6cczA:
57.4		 2vmyA-6cczA:
undetectable
2vmyB-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_D_TOPD1158_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 10 ILE A 530
ALA A 525
LEU A 109
PHE A 117
THR A 526
 None
None
None
None
SEY  A 610 ( 3.7A)
 1.13A 2w9sD-6cczA:
undetectable		 2w9sD-6cczA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_F_TOPF1159_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 10 ILE A 530
ALA A 525
LEU A 109
PHE A 117
THR A 526
 None
None
None
None
SEY  A 610 ( 3.7A)
 1.14A 2w9sF-6cczA:
undetectable		 2w9sF-6cczA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		4 / 4 TYR A 399
LEU A 401
LEU A 394
HIS A 478
 None
 1.39A 2x7hB-6cczA:
4.8		 2x7hB-6cczA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_A_VD3A2001_1
(VITAMIN D
HYDROXYLASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 12 ILE A 455
LEU A 390
ILE A 473
ALA A 474
LEU A 429
 None
 1.15A 3a50A-6cczA:
undetectable		 3a50A-6cczA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1200_1
(SERUM ALBUMIN)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		4 / 5 ILE A 420
TYR A 399
ARG A 482
GLY A 480
 None
 1.15A 3b9mA-6cczA:
3.3		 3b9mA-6cczA:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB501_2
(PHOSPHOLIPASE A2)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 11 VAL A 449
GLY A 422
ILE A 453
PRO A 417
SER A 418
 None
 1.26A 3bjwB-6cczA:
undetectable		 3bjwB-6cczA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH504_3
(PHOSPHOLIPASE A2)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 11 VAL A 449
GLY A 422
ILE A 453
PRO A 417
SER A 418
 None
 1.28A 3bjwH-6cczA:
1.0		 3bjwH-6cczA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_0
(CATECHOL
O-METHYLTRANSFERASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 12 GLY A 208
TYR A 266
ILE A 260
SER A 211
HIS A 209
 None
None
None
LLP  A 318 ( 3.8A)
LLP  A 318 (-3.5A)
 1.14A 3bwmA-6cczA:
3.8		 3bwmA-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_0
(COMT PROTEIN)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 12 GLY A 208
TYR A 266
ILE A 260
SER A 211
HIS A 209
 None
None
None
LLP  A 318 ( 3.8A)
LLP  A 318 (-3.5A)
 1.14A 3bwyA-6cczA:
4.1		 3bwyA-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		4 / 7 GLN A 382
GLY A 466
GLU A 469
ALA A 389
 None
 0.87A 3fpjB-6cczA:
3.9		 3fpjB-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_B_MTXB164_1
(DIHYDROFOLATE
REDUCTASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 12 ILE A 112
ALA A 459
LEU A 109
ILE A 477
LEU A 429
 None
 1.24A 3ia4B-6cczA:
undetectable		 3ia4B-6cczA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_A_SAMA465_0
(RRNA METHYLASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 12 GLY A 207
GLY A 208
VAL A 413
ASP A 414
LEU A 436
 None
 0.99A 3m6vA-6cczA:
3.1		 3m6vA-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6W_A_SAMA465_0
(RRNA METHYLASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 12 GLY A 207
GLY A 208
VAL A 413
ASP A 414
LEU A 436
 None
 1.01A 3m6wA-6cczA:
2.9		 3m6wA-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_D_AC2D601_1
(DEOXYCYTIDINE KINASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		4 / 8 GLU A 471
TYR A 528
ARG A 393
ASP A 475
 None
 1.15A 3mjrD-6cczA:
undetectable		 3mjrD-6cczA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_A_GLYA510_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		4 / 6 GLU A 110
ILE A 112
PHE A 117
ALA A 459
 None
 0.76A 3pgyA-6cczA:
53.1
3pgyB-6cczA:
54.1		 3pgyA-6cczA:
undetectable
3pgyB-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 11 ILE A 453
ALA A 423
ASP A 421
ILE A 483
LEU A 429
 None
 1.10A 3qg2B-6cczA:
undetectable		 3qg2B-6cczA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA451_1
(CYTOCHROME P450
164A2)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 10 LEU A 296
ALA A 291
THR A 314
VAL A 312
VAL A 309
 None
LLP  A 318 (-3.3A)
FMT  A 613 ( 4.6A)
None
None
 1.45A 3r9cA-6cczA:
undetectable		 3r9cA-6cczA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S79_A_ASDA601_1
(CYTOCHROME P450 19A1)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 12 ILE A 455
ILE A 473
ALA A 474
VAL A 481
LEU A 429
 None
 1.14A 3s79A-6cczA:
undetectable		 3s79A-6cczA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_1
(HIV-1 PROTEASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 9 ARG A 454
LEU A 410
ASN A 408
VAL A 383
GLY A 295
 ACT  A 612 (-2.9A)
None
SEY  A 605 (-4.4A)
None
None
 1.14A 3spkA-6cczA:
undetectable		 3spkA-6cczA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_2
(ADENOSINE KINASE,
PUTATIVE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		4 / 5 LEU A 162
ALA A 164
MET A 327
PHE A 165
 None
 1.05A 3uq6A-6cczA:
undetectable		 3uq6A-6cczA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		4 / 5 LEU A 162
ALA A 164
MET A 327
PHE A 165
 None
 1.16A 3vasB-6cczA:
3.6		 3vasB-6cczA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		4 / 5 LEU A 162
ALA A 164
MET A 327
PHE A 165
 None
 1.04A 4dc3B-6cczA:
undetectable		 4dc3B-6cczA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		4 / 6 ALA A 371
GLY A 322
PRO A 323
LEU A 368
 None
 1.00A 4dubA-6cczA:
undetectable		 4dubA-6cczA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		4 / 8 SER A 319
ASN A 116
GLY A 322
CYH A 367
 FMT  A 613 (-4.5A)
LLP  A 318 ( 3.9A)
None
None
 0.83A 4fo4B-6cczA:
undetectable		 4fo4B-6cczA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_2
(ADENOSINE KINASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		4 / 4 LEU A 202
SER A 264
LEU A 204
LEU A 235
 None
ACT  A 612 (-2.7A)
None
None
 1.10A 4n09A-6cczA:
2.8		 4n09A-6cczA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_2
(ADENOSINE KINASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		4 / 5 LEU A 202
SER A 264
LEU A 204
LEU A 235
 None
ACT  A 612 (-2.7A)
None
None
 1.08A 4n09D-6cczA:
undetectable		 4n09D-6cczA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_A_FK5A205_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 10 ASP A 475
LEU A 390
LEU A 111
ILE A 434
LEU A 109
 None
 0.94A 4odoA-6cczA:
undetectable		 4odoA-6cczA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 10 ASP A 475
LEU A 390
LEU A 111
ILE A 434
LEU A 109
 None
 0.93A 4odoB-6cczA:
undetectable		 4odoB-6cczA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_C_FK5C204_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 10 ASP A 475
LEU A 390
LEU A 111
ILE A 434
LEU A 109
 None
 0.90A 4odoC-6cczA:
undetectable		 4odoC-6cczA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 11 ASP A 475
LEU A 390
LEU A 111
ILE A 434
LEU A 109
 None
 0.99A 4odrA-6cczA:
undetectable
4odrB-6cczA:
undetectable		 4odrA-6cczA:
16.24
4odrB-6cczA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 11 HIS A 209
SER A 211
THR A 313
THR A 314
THR A 315
 LLP  A 318 (-3.5A)
LLP  A 318 ( 3.8A)
None
FMT  A 613 ( 4.6A)
FMT  A 613 (-3.6A)
 1.43A 4qvlV-6cczA:
undetectable
4qvlb-6cczA:
undetectable		 4qvlV-6cczA:
16.59
4qvlb-6cczA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 11 HIS A 209
SER A 211
THR A 313
THR A 314
THR A 315
 LLP  A 318 (-3.5A)
LLP  A 318 ( 3.8A)
None
FMT  A 613 ( 4.6A)
FMT  A 613 (-3.6A)
 1.43A 4qvlH-6cczA:
undetectable
4qvlN-6cczA:
undetectable		 4qvlH-6cczA:
16.59
4qvlN-6cczA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 11 HIS A 209
SER A 211
THR A 313
THR A 314
THR A 315
 LLP  A 318 (-3.5A)
LLP  A 318 ( 3.8A)
None
FMT  A 613 ( 4.6A)
FMT  A 613 (-3.6A)
 1.41A 4qvwV-6cczA:
undetectable
4qvwb-6cczA:
undetectable		 4qvwV-6cczA:
16.59
4qvwb-6cczA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 11 HIS A 209
SER A 211
THR A 313
THR A 314
THR A 315
 LLP  A 318 (-3.5A)
LLP  A 318 ( 3.8A)
None
FMT  A 613 ( 4.6A)
FMT  A 613 (-3.6A)
 1.41A 4qvwH-6cczA:
undetectable
4qvwN-6cczA:
undetectable		 4qvwH-6cczA:
16.59
4qvwN-6cczA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 11 HIS A 209
SER A 211
THR A 313
THR A 314
THR A 315
 LLP  A 318 (-3.5A)
LLP  A 318 ( 3.8A)
None
FMT  A 613 ( 4.6A)
FMT  A 613 (-3.6A)
 1.42A 4qvyH-6cczA:
undetectable
4qvyN-6cczA:
undetectable		 4qvyH-6cczA:
16.59
4qvyN-6cczA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 11 HIS A 209
SER A 211
THR A 313
THR A 314
THR A 315
 LLP  A 318 (-3.5A)
LLP  A 318 ( 3.8A)
None
FMT  A 613 ( 4.6A)
FMT  A 613 (-3.6A)
 1.40A 4qw1V-6cczA:
undetectable
4qw1b-6cczA:
undetectable		 4qw1V-6cczA:
16.59
4qw1b-6cczA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 11 HIS A 209
SER A 211
THR A 313
THR A 314
THR A 315
 LLP  A 318 (-3.5A)
LLP  A 318 ( 3.8A)
None
FMT  A 613 ( 4.6A)
FMT  A 613 (-3.6A)
 1.40A 4qw1H-6cczA:
undetectable
4qw1N-6cczA:
undetectable		 4qw1H-6cczA:
16.59
4qw1N-6cczA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_F_CHDF103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 11 LEU A 401
ARG A 268
LEU A 394
GLU A 471
LEU A 390
 None
 1.13A 4wg0F-6cczA:
undetectable
4wg0G-6cczA:
undetectable
4wg0H-6cczA:
undetectable		 4wg0F-6cczA:
undetectable
4wg0G-6cczA:
undetectable
4wg0H-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_K_CHDK103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 11 GLU A 471
LEU A 390
LEU A 394
LEU A 401
ARG A 268
 None
 1.06A 4wg0I-6cczA:
undetectable
4wg0J-6cczA:
undetectable
4wg0K-6cczA:
undetectable		 4wg0I-6cczA:
undetectable
4wg0J-6cczA:
undetectable
4wg0K-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 12 GLY A 208
TYR A 266
ILE A 260
SER A 211
HIS A 209
 None
None
None
LLP  A 318 ( 3.8A)
LLP  A 318 (-3.5A)
 1.13A 4xudA-6cczA:
4.3		 4xudA-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_B_SAMB303_0
(CATECHOL
O-METHYLTRANSFERASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 12 GLY A 208
TYR A 266
ILE A 260
SER A 211
HIS A 209
 None
None
None
LLP  A 318 ( 3.8A)
LLP  A 318 (-3.5A)
 1.18A 4xueB-6cczA:
4.2		 4xueB-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CR1_A_T44A201_1
(TRANSTHYRETIN)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		4 / 5 LYS A 488
LEU A 485
ALA A 487
VAL A 503
 None
 1.14A 5cr1A-6cczA:
undetectable		 5cr1A-6cczA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 11 HIS A 209
SER A 211
THR A 313
THR A 314
THR A 315
 LLP  A 318 (-3.5A)
LLP  A 318 ( 3.8A)
None
FMT  A 613 ( 4.6A)
FMT  A 613 (-3.6A)
 1.43A 5d0xV-6cczA:
undetectable
5d0xb-6cczA:
undetectable		 5d0xV-6cczA:
16.59
5d0xb-6cczA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 11 HIS A 209
SER A 211
THR A 313
THR A 314
THR A 315
 LLP  A 318 (-3.5A)
LLP  A 318 ( 3.8A)
None
FMT  A 613 ( 4.6A)
FMT  A 613 (-3.6A)
 1.43A 5d0xH-6cczA:
undetectable
5d0xN-6cczA:
undetectable		 5d0xH-6cczA:
16.59
5d0xN-6cczA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		4 / 6 PHE A 329
VAL A 312
ILE A 297
ASP A 304
 None
 1.08A 5iwuA-6cczA:
undetectable		 5iwuA-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKV_A_ASDA602_1
(AROMATASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 12 ILE A 455
ILE A 473
ALA A 474
VAL A 481
LEU A 429
 None
 1.16A 5jkvA-6cczA:
undetectable		 5jkvA-6cczA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSA_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 12 GLY A 208
TYR A 266
ILE A 260
SER A 211
HIS A 209
 None
None
None
LLP  A 318 ( 3.8A)
LLP  A 318 (-3.5A)
 1.17A 5lsaA-6cczA:
4.2		 5lsaA-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_A_08JA602_1
(CYTOCHROME P450 3A4)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		4 / 7 LEU A 286
ALA A 261
ILE A 199
LEU A 258
 None
 0.98A 5te8A-6cczA:
undetectable		 5te8A-6cczA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WQP_A_NCAA302_0
(PROBABLE
DEHYDROGENASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		4 / 8 SER A 211
TYR A 189
HIS A 209
MET A 287
 LLP  A 318 ( 3.8A)
None
LLP  A 318 (-3.5A)
None
 1.24A 5wqpA-6cczA:
undetectable		 5wqpA-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW2_A_ACTA511_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		3 / 3 ARG A 220
ILE A 226
SER A 225
 None
 0.82A 5zw2A-6cczA:
undetectable		 5zw2A-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_B_REAB601_1
(RETINOIC ACID
RECEPTOR)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 10 LEU A 401
SER A 403
LEU A 235
GLY A 456
GLY A 207
 None
 1.22A 6eu9B-6cczA:
undetectable		 6eu9B-6cczA:
18.60