SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6cdz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AXW_A_MTXA732_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		6 / 12 ILE A  79
ASP A 169
LEU A 172
GLY A 173
PHE A 176
VAL A 262
 CB3  A 701 (-3.9A)
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
None
 1.15A 1axwA-6cdzA:
42.3		 1axwA-6cdzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AXW_A_MTXA732_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		7 / 12 ILE A  79
LEU A 143
ASP A 169
LEU A 172
GLY A 173
PHE A 176
TYR A 209
 CB3  A 701 (-3.9A)
None
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
UMP  A 702 ( 4.2A)
 0.99A 1axwA-6cdzA:
42.3		 1axwA-6cdzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AXW_A_MTXA732_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		6 / 12 LYS A  48
ILE A  79
ASP A 169
LEU A 172
GLY A 173
VAL A 262
 CB3  A 701 ( 4.8A)
CB3  A 701 (-3.9A)
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
None
 1.26A 1axwA-6cdzA:
42.3		 1axwA-6cdzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AXW_A_MTXA732_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		7 / 12 LYS A  48
ILE A  79
LEU A 143
ASP A 169
LEU A 172
GLY A 173
TYR A 209
 CB3  A 701 ( 4.8A)
CB3  A 701 (-3.9A)
None
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
UMP  A 702 ( 4.2A)
 0.78A 1axwA-6cdzA:
42.3		 1axwA-6cdzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AXW_B_MTXB733_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		6 / 11 ILE A  79
ASP A 169
LEU A 172
GLY A 173
PHE A 176
VAL A 262
 CB3  A 701 (-3.9A)
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
None
 1.04A 1axwB-6cdzA:
42.6		 1axwB-6cdzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AXW_B_MTXB733_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		7 / 11 ILE A  79
TRP A  80
ASP A 169
LEU A 172
GLY A 173
PHE A 176
TYR A 209
 CB3  A 701 (-3.9A)
None
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
UMP  A 702 ( 4.2A)
 0.92A 1axwB-6cdzA:
42.6		 1axwB-6cdzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AXW_B_MTXB733_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		6 / 11 LYS A  48
ILE A  79
ASP A 169
LEU A 172
GLY A 173
VAL A 262
 CB3  A 701 ( 4.8A)
CB3  A 701 (-3.9A)
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
None
 1.09A 1axwB-6cdzA:
42.6		 1axwB-6cdzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AXW_B_MTXB733_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		7 / 11 LYS A  48
ILE A  79
TRP A  80
ASP A 169
LEU A 172
GLY A 173
TYR A 209
 CB3  A 701 ( 4.8A)
CB3  A 701 (-3.9A)
None
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
UMP  A 702 ( 4.2A)
 0.77A 1axwB-6cdzA:
42.6		 1axwB-6cdzA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1B02_A_C2FA281_0
(PROTEIN (THYMIDYLATE
SYNTHASE))		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		6 / 11 ILE A  79
LEU A 143
ASP A 169
LEU A 172
GLY A 173
TYR A 209
 CB3  A 701 (-3.9A)
None
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
UMP  A 702 ( 4.2A)
 0.83A 1b02A-6cdzA:
34.2		 1b02A-6cdzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		5 / 12 ILE A 239
PHE A 247
LEU A 183
MET A 187
LEU A  59
 None
 1.14A 1dtlA-6cdzA:
undetectable		 1dtlA-6cdzA:
21.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_A_D16A414_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		7 / 12 GLU A  58
ILE A  79
ASP A 169
LEU A 172
GLY A 173
PHE A 176
TYR A 209
 CB3  A 701 ( 4.3A)
CB3  A 701 (-3.9A)
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
UMP  A 702 ( 4.2A)
 0.47A 1hvyA-6cdzA:
37.6		 1hvyA-6cdzA:
48.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_A_D16A414_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		5 / 12 GLU A  58
ILE A  79
TRP A  80
LEU A 172
PHE A 176
 CB3  A 701 ( 4.3A)
CB3  A 701 (-3.9A)
None
CB3  A 701 (-3.5A)
CB3  A 701 (-3.8A)
 0.70A 1hvyA-6cdzA:
37.6		 1hvyA-6cdzA:
48.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_B_D16B415_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		7 / 12 GLU A  58
ILE A  79
ASP A 169
LEU A 172
GLY A 173
PHE A 176
TYR A 209
 CB3  A 701 ( 4.3A)
CB3  A 701 (-3.9A)
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
UMP  A 702 ( 4.2A)
 0.50A 1hvyB-6cdzA:
37.5		 1hvyB-6cdzA:
48.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_B_D16B415_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		5 / 12 GLU A  58
ILE A  79
TRP A  80
LEU A 172
PHE A 176
 CB3  A 701 ( 4.3A)
CB3  A 701 (-3.9A)
None
CB3  A 701 (-3.5A)
CB3  A 701 (-3.8A)
 0.74A 1hvyB-6cdzA:
37.5		 1hvyB-6cdzA:
48.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_C_D16C416_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		7 / 11 GLU A  58
ILE A  79
ASP A 169
LEU A 172
GLY A 173
PHE A 176
TYR A 209
 CB3  A 701 ( 4.3A)
CB3  A 701 (-3.9A)
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
UMP  A 702 ( 4.2A)
 0.39A 1hvyC-6cdzA:
37.8		 1hvyC-6cdzA:
48.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_C_D16C416_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		5 / 11 GLU A  58
ILE A  79
TRP A  80
LEU A 172
PHE A 176
 CB3  A 701 ( 4.3A)
CB3  A 701 (-3.9A)
None
CB3  A 701 (-3.5A)
CB3  A 701 (-3.8A)
 0.61A 1hvyC-6cdzA:
37.8		 1hvyC-6cdzA:
48.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_D_D16D417_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		8 / 12 GLU A  58
ILE A  79
LEU A 143
ASP A 169
LEU A 172
GLY A 173
PHE A 176
TYR A 209
 CB3  A 701 ( 4.3A)
CB3  A 701 (-3.9A)
None
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
UMP  A 702 ( 4.2A)
 0.75A 1hvyD-6cdzA:
37.6		 1hvyD-6cdzA:
48.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_D_D16D417_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		6 / 12 GLU A  58
ILE A  79
TRP A  80
LEU A 143
LEU A 172
PHE A 176
 CB3  A 701 ( 4.3A)
CB3  A 701 (-3.9A)
None
None
CB3  A 701 (-3.5A)
CB3  A 701 (-3.8A)
 0.71A 1hvyD-6cdzA:
37.6		 1hvyD-6cdzA:
48.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I00_A_D16A315_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		8 / 9 GLU A  58
ILE A  79
TRP A  80
ASP A 169
LEU A 172
GLY A 173
PHE A 176
TYR A 209
 CB3  A 701 ( 4.3A)
CB3  A 701 (-3.9A)
None
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
UMP  A 702 ( 4.2A)
 0.55A 1i00A-6cdzA:
35.9		 1i00A-6cdzA:
48.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I00_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		7 / 9 ILE A  79
ASP A 169
LEU A 172
GLY A 173
PHE A 176
ASN A 177
TYR A 209
 CB3  A 701 (-3.9A)
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
UMP  A 702 ( 2.4A)
UMP  A 702 ( 4.2A)
 0.45A 1i00B-6cdzA:
22.7		 1i00B-6cdzA:
48.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JU6_A_LYAA317_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		6 / 11 ILE A  79
ASP A 169
LEU A 172
GLY A 173
PHE A 176
TYR A 209
 CB3  A 701 (-3.9A)
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
UMP  A 702 ( 4.2A)
 0.84A 1ju6A-6cdzA:
37.6		 1ju6A-6cdzA:
38.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JU6_B_LYAB315_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		6 / 9 LYS A  48
ILE A  79
ASP A 169
LEU A 172
GLY A 173
TYR A 209
 CB3  A 701 ( 4.8A)
CB3  A 701 (-3.9A)
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
UMP  A 702 ( 4.2A)
 0.72A 1ju6B-6cdzA:
37.6		 1ju6B-6cdzA:
38.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JU6_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		6 / 10 ILE A  79
ASP A 169
LEU A 172
GLY A 173
PHE A 176
TYR A 209
 CB3  A 701 (-3.9A)
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
UMP  A 702 ( 4.2A)
 0.84A 1ju6C-6cdzA:
37.6		 1ju6C-6cdzA:
38.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JU6_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		6 / 11 LYS A  48
ILE A  79
ASP A 169
LEU A 172
GLY A 173
TYR A 209
 CB3  A 701 ( 4.8A)
CB3  A 701 (-3.9A)
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
UMP  A 702 ( 4.2A)
 0.72A 1ju6D-6cdzA:
37.6		 1ju6D-6cdzA:
38.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_A_LYAA315_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		6 / 10 ILE A  79
ASP A 169
LEU A 172
GLY A 173
PHE A 176
TYR A 209
 CB3  A 701 (-3.9A)
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
UMP  A 702 ( 4.2A)
 0.89A 1jujA-6cdzA:
37.5		 1jujA-6cdzA:
38.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_A_LYAA315_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		6 / 10 LYS A  48
ILE A  79
ASP A 169
LEU A 172
GLY A 173
TYR A 209
 CB3  A 701 ( 4.8A)
CB3  A 701 (-3.9A)
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
UMP  A 702 ( 4.2A)
 0.67A 1jujA-6cdzA:
37.5		 1jujA-6cdzA:
38.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_B_LYAB315_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		6 / 10 ILE A  79
ASP A 169
LEU A 172
GLY A 173
PHE A 176
TYR A 209
 CB3  A 701 (-3.9A)
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
UMP  A 702 ( 4.2A)
 0.89A 1jujB-6cdzA:
37.5		 1jujB-6cdzA:
38.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_B_LYAB315_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		6 / 10 LYS A  48
ILE A  79
ASP A 169
LEU A 172
GLY A 173
TYR A 209
 CB3  A 701 ( 4.8A)
CB3  A 701 (-3.9A)
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
UMP  A 702 ( 4.2A)
 0.67A 1jujB-6cdzA:
37.5		 1jujB-6cdzA:
38.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		6 / 10 ILE A  79
ASP A 169
LEU A 172
GLY A 173
PHE A 176
TYR A 209
 CB3  A 701 (-3.9A)
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
UMP  A 702 ( 4.2A)
 0.89A 1jujC-6cdzA:
37.4		 1jujC-6cdzA:
38.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		6 / 10 LYS A  48
ILE A  79
ASP A 169
LEU A 172
GLY A 173
TYR A 209
 CB3  A 701 ( 4.8A)
CB3  A 701 (-3.9A)
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
UMP  A 702 ( 4.2A)
 0.67A 1jujC-6cdzA:
37.4		 1jujC-6cdzA:
38.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		6 / 10 ILE A  79
ASP A 169
LEU A 172
GLY A 173
PHE A 176
TYR A 209
 CB3  A 701 (-3.9A)
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
UMP  A 702 ( 4.2A)
 0.89A 1jujD-6cdzA:
37.5		 1jujD-6cdzA:
38.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		6 / 10 LYS A  48
ILE A  79
ASP A 169
LEU A 172
GLY A 173
TYR A 209
 CB3  A 701 ( 4.8A)
CB3  A 701 (-3.9A)
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
UMP  A 702 ( 4.2A)
 0.67A 1jujD-6cdzA:
37.5		 1jujD-6cdzA:
38.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RTS_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		6 / 8 ILE A  79
ASP A 169
LEU A 172
GLY A 173
PHE A 176
TYR A 209
 CB3  A 701 (-3.9A)
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
UMP  A 702 ( 4.2A)
 0.46A 1rtsA-6cdzA:
36.7		 1rtsA-6cdzA:
39.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RTS_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		6 / 7 ILE A  79
ASP A 169
LEU A 172
GLY A 173
PHE A 176
TYR A 209
 CB3  A 701 (-3.9A)
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
UMP  A 702 ( 4.2A)
 0.33A 1rtsB-6cdzA:
37.3		 1rtsB-6cdzA:
39.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		7 / 12 SER A  54
ILE A  79
LEU A 143
LEU A 172
GLY A 173
PHE A 176
TYR A 209
 None
CB3  A 701 (-3.9A)
None
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
UMP  A 702 ( 4.2A)
 1.14A 1tlsA-6cdzA:
41.9		 1tlsA-6cdzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		6 / 12 SER A  54
ILE A  79
LEU A 172
GLY A 173
PHE A 176
VAL A 262
 None
CB3  A 701 (-3.9A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
None
 1.37A 1tlsA-6cdzA:
41.9		 1tlsA-6cdzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		7 / 12 SER A  54
ILE A  79
TRP A  80
LEU A 143
LEU A 172
GLY A 173
PHE A 176
 None
CB3  A 701 (-3.9A)
None
None
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
 1.11A 1tlsA-6cdzA:
41.9		 1tlsA-6cdzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_B_C2FB266_0
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		7 / 12 SER A  54
ILE A  79
LEU A 143
LEU A 172
GLY A 173
PHE A 176
TYR A 209
 None
CB3  A 701 (-3.9A)
None
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
UMP  A 702 ( 4.2A)
 1.08A 1tlsB-6cdzA:
42.0		 1tlsB-6cdzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_B_C2FB266_0
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		6 / 12 SER A  54
ILE A  79
LEU A 172
GLY A 173
PHE A 176
VAL A 262
 None
CB3  A 701 (-3.9A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
None
 1.23A 1tlsB-6cdzA:
42.0		 1tlsB-6cdzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_B_C2FB266_0
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		5 / 12 SER A  54
ILE A  79
TRP A  80
LEU A 143
PHE A 176
 None
CB3  A 701 (-3.9A)
None
None
CB3  A 701 (-3.8A)
 0.84A 1tlsB-6cdzA:
42.0		 1tlsB-6cdzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TSN_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		7 / 12 SER A  54
ILE A  79
LEU A 143
LEU A 172
GLY A 173
PHE A 176
TYR A 209
 None
CB3  A 701 (-3.9A)
None
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
UMP  A 702 ( 4.2A)
 1.09A 1tsnA-6cdzA:
41.9		 1tsnA-6cdzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TSN_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		6 / 12 SER A  54
ILE A  79
LEU A 172
GLY A 173
PHE A 176
VAL A 262
 None
CB3  A 701 (-3.9A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
None
 1.32A 1tsnA-6cdzA:
41.9		 1tsnA-6cdzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TSN_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		7 / 12 SER A  54
ILE A  79
TRP A  80
LEU A 143
LEU A 172
GLY A 173
PHE A 176
 None
CB3  A 701 (-3.9A)
None
None
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
 1.07A 1tsnA-6cdzA:
41.9		 1tsnA-6cdzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_IMNA2001_1
(SERUM ALBUMIN)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		5 / 10 ALA A 148
PHE A 150
ARG A  99
LEU A  63
LEU A 184
 None
 1.16A 2bxqA-6cdzA:
undetectable		 2bxqA-6cdzA:
9.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2KCE_A_D16A566_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		6 / 12 SER A  54
GLU A  58
LEU A 143
ASP A 169
GLY A 173
TYR A 209
 None
CB3  A 701 ( 4.3A)
None
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.3A)
UMP  A 702 ( 4.2A)
 0.79A 2kceA-6cdzA:
42.1		 2kceA-6cdzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2KCE_A_D16A566_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		6 / 12 SER A  54
LEU A 143
ASP A 169
GLY A 173
PHE A 176
TYR A 209
 None
None
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
UMP  A 702 ( 4.2A)
 1.23A 2kceA-6cdzA:
42.1		 2kceA-6cdzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2KCE_B_D16B568_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		6 / 12 SER A  54
ASP A 169
LEU A 172
GLY A 173
PHE A 176
TYR A 209
 None
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
UMP  A 702 ( 4.2A)
 0.58A 2kceB-6cdzA:
42.3		 2kceB-6cdzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2KCE_B_D16B568_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		6 / 12 SER A  54
ASP A 169
LEU A 172
GLY A 173
PHE A 176
VAL A 262
 None
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
None
 1.11A 2kceB-6cdzA:
42.3		 2kceB-6cdzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2KCE_B_D16B568_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		6 / 12 SER A  54
LEU A 143
ASP A 169
LEU A 172
GLY A 173
PHE A 176
 None
None
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
 0.85A 2kceB-6cdzA:
42.3		 2kceB-6cdzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2KCE_B_D16B568_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		5 / 12 SER A  54
TRP A  80
LEU A 143
LEU A 172
PHE A 176
 None
None
None
CB3  A 701 (-3.5A)
CB3  A 701 (-3.8A)
 0.83A 2kceB-6cdzA:
42.3		 2kceB-6cdzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		5 / 7 ILE A  79
ASP A 169
GLY A 173
PHE A 176
TYR A 209
 CB3  A 701 (-3.9A)
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
UMP  A 702 ( 4.2A)
 0.33A 2tsrA-6cdzA:
37.0		 2tsrA-6cdzA:
39.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		5 / 7 ILE A  79
LEU A 172
GLY A 173
PHE A 176
TYR A 209
 CB3  A 701 (-3.9A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
UMP  A 702 ( 4.2A)
 0.48A 2tsrA-6cdzA:
37.0		 2tsrA-6cdzA:
39.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_C_D16C509_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		7 / 10 GLU A  58
ILE A  79
ASP A 169
LEU A 172
GLY A 173
PHE A 176
TYR A 209
 CB3  A 701 ( 4.3A)
CB3  A 701 (-3.9A)
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
UMP  A 702 ( 4.2A)
 0.54A 2tsrC-6cdzA:
36.7		 2tsrC-6cdzA:
39.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_C_D16C509_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		5 / 10 GLU A  58
ILE A  79
TRP A  80
LEU A 172
PHE A 176
 CB3  A 701 ( 4.3A)
CB3  A 701 (-3.9A)
None
CB3  A 701 (-3.5A)
CB3  A 701 (-3.8A)
 0.78A 2tsrC-6cdzA:
36.7		 2tsrC-6cdzA:
39.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_D_D16D609_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		6 / 9 ILE A  79
ASP A 169
LEU A 172
GLY A 173
PHE A 176
TYR A 209
 CB3  A 701 (-3.9A)
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
UMP  A 702 ( 4.2A)
 0.46A 2tsrD-6cdzA:
23.5		 2tsrD-6cdzA:
39.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_D_D16D609_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		5 / 9 ILE A  79
TRP A  80
ASP A 169
LEU A 172
PHE A 176
 CB3  A 701 (-3.9A)
None
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.8A)
 0.81A 2tsrD-6cdzA:
23.5		 2tsrD-6cdzA:
39.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		4 / 5 LEU A 208
GLN A 219
THR A 216
THR A 206
 None
 1.20A 2zj0C-6cdzA:
undetectable		 2zj0C-6cdzA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_2
(ADENOSYLHOMOCYSTEINA
SE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		4 / 4 LEU A 208
GLN A 219
THR A 216
THR A 206
 None
 1.18A 2zj0D-6cdzA:
undetectable		 2zj0D-6cdzA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		6 / 12 SER A  54
GLU A  58
ASP A 169
LEU A 172
GLY A 173
TYR A 209
 None
CB3  A 701 ( 4.3A)
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
UMP  A 702 ( 4.2A)
 0.81A 3k2hA-6cdzA:
36.5		 3k2hA-6cdzA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		6 / 12 SER A  54
GLU A  58
ILE A  79
ASP A 169
GLY A 173
TYR A 209
 None
CB3  A 701 ( 4.3A)
CB3  A 701 (-3.9A)
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.3A)
UMP  A 702 ( 4.2A)
 0.74A 3k2hA-6cdzA:
36.5		 3k2hA-6cdzA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		6 / 12 SER A  54
GLU A  58
ILE A  79
LEU A 143
ASP A 169
GLY A 173
 None
CB3  A 701 ( 4.3A)
CB3  A 701 (-3.9A)
None
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.3A)
 0.84A 3k2hA-6cdzA:
36.5		 3k2hA-6cdzA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		5 / 12 SER A  54
GLU A  58
ILE A  79
TRP A  80
LEU A 143
 None
CB3  A 701 ( 4.3A)
CB3  A 701 (-3.9A)
None
None
 0.42A 3k2hA-6cdzA:
36.5		 3k2hA-6cdzA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		6 / 12 SER A  54
GLU A  58
LEU A 143
ASP A 169
LEU A 172
GLY A 173
 None
CB3  A 701 ( 4.3A)
None
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
 0.94A 3k2hA-6cdzA:
36.5		 3k2hA-6cdzA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		5 / 12 SER A  54
ILE A  79
GLY A 173
PHE A 176
TYR A 209
 None
CB3  A 701 (-3.9A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
UMP  A 702 ( 4.2A)
 1.06A 3k2hA-6cdzA:
36.5		 3k2hA-6cdzA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		5 / 12 SER A  54
ILE A  79
LEU A 143
GLY A 173
PHE A 176
 None
CB3  A 701 (-3.9A)
None
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
 1.09A 3k2hA-6cdzA:
36.5		 3k2hA-6cdzA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		5 / 12 SER A  54
ILE A  79
TRP A  80
LEU A 143
PHE A 176
 None
CB3  A 701 (-3.9A)
None
None
CB3  A 701 (-3.8A)
 0.80A 3k2hA-6cdzA:
36.5		 3k2hA-6cdzA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		5 / 12 SER A  54
LEU A 172
GLY A 173
PHE A 176
TYR A 209
 None
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
UMP  A 702 ( 4.2A)
 1.13A 3k2hA-6cdzA:
36.5		 3k2hA-6cdzA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		7 / 12 SER A  54
GLU A  58
ILE A  79
LEU A 143
ASP A 169
GLY A 173
TYR A 209
 None
CB3  A 701 ( 4.3A)
CB3  A 701 (-3.9A)
None
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.3A)
UMP  A 702 ( 4.2A)
 0.88A 3k2hB-6cdzA:
37.0		 3k2hB-6cdzA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		5 / 12 SER A  54
GLU A  58
ILE A  79
TRP A  80
LEU A 143
 None
CB3  A 701 ( 4.3A)
CB3  A 701 (-3.9A)
None
None
 0.42A 3k2hB-6cdzA:
37.0		 3k2hB-6cdzA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		7 / 12 SER A  54
GLU A  58
LEU A 143
ASP A 169
LEU A 172
GLY A 173
TYR A 209
 None
CB3  A 701 ( 4.3A)
None
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
UMP  A 702 ( 4.2A)
 0.93A 3k2hB-6cdzA:
37.0		 3k2hB-6cdzA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		7 / 12 SER A  54
ILE A  79
LEU A 143
ASP A 169
GLY A 173
PHE A 176
TYR A 209
 None
CB3  A 701 (-3.9A)
None
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
UMP  A 702 ( 4.2A)
 1.12A 3k2hB-6cdzA:
37.0		 3k2hB-6cdzA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		5 / 12 SER A  54
ILE A  79
TRP A  80
LEU A 143
PHE A 176
 None
CB3  A 701 (-3.9A)
None
None
CB3  A 701 (-3.8A)
 0.81A 3k2hB-6cdzA:
37.0		 3k2hB-6cdzA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		7 / 12 SER A  54
LEU A 143
ASP A 169
LEU A 172
GLY A 173
PHE A 176
TYR A 209
 None
None
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
UMP  A 702 ( 4.2A)
 1.16A 3k2hB-6cdzA:
37.0		 3k2hB-6cdzA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		7 / 12 SER A  54
GLU A  58
ILE A  79
ASP A 169
LEU A 172
GLY A 173
TYR A 209
 None
CB3  A 701 ( 4.3A)
CB3  A 701 (-3.9A)
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
UMP  A 702 ( 4.2A)
 0.58A 3nrrA-6cdzA:
undetectable		 3nrrA-6cdzA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		5 / 12 SER A  54
GLU A  58
ILE A  79
TRP A  80
LEU A 172
 None
CB3  A 701 ( 4.3A)
CB3  A 701 (-3.9A)
None
CB3  A 701 (-3.5A)
 0.75A 3nrrA-6cdzA:
undetectable		 3nrrA-6cdzA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		7 / 12 SER A  54
ILE A  79
ASP A 169
LEU A 172
GLY A 173
PHE A 176
TYR A 209
 None
CB3  A 701 (-3.9A)
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
UMP  A 702 ( 4.2A)
 0.94A 3nrrA-6cdzA:
undetectable		 3nrrA-6cdzA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		5 / 12 SER A  54
ILE A  79
TRP A  80
LEU A 172
PHE A 176
 None
CB3  A 701 (-3.9A)
None
CB3  A 701 (-3.5A)
CB3  A 701 (-3.8A)
 1.12A 3nrrA-6cdzA:
undetectable		 3nrrA-6cdzA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		7 / 12 SER A  54
GLU A  58
ILE A  79
ASP A 169
LEU A 172
GLY A 173
TYR A 209
 None
CB3  A 701 ( 4.3A)
CB3  A 701 (-3.9A)
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
UMP  A 702 ( 4.2A)
 0.57A 3nrrB-6cdzA:
undetectable		 3nrrB-6cdzA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		5 / 12 SER A  54
GLU A  58
ILE A  79
TRP A  80
LEU A 172
 None
CB3  A 701 ( 4.3A)
CB3  A 701 (-3.9A)
None
CB3  A 701 (-3.5A)
 0.76A 3nrrB-6cdzA:
undetectable		 3nrrB-6cdzA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		7 / 12 SER A  54
ILE A  79
ASP A 169
LEU A 172
GLY A 173
PHE A 176
TYR A 209
 None
CB3  A 701 (-3.9A)
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
UMP  A 702 ( 4.2A)
 0.94A 3nrrB-6cdzA:
undetectable		 3nrrB-6cdzA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		5 / 12 SER A  54
ILE A  79
TRP A  80
LEU A 172
PHE A 176
 None
CB3  A 701 (-3.9A)
None
CB3  A 701 (-3.5A)
CB3  A 701 (-3.8A)
 1.14A 3nrrB-6cdzA:
undetectable		 3nrrB-6cdzA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_D_FOZD316_0
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		5 / 12 HIS A 147
LEU A 172
GLY A 173
ASN A 177
TYR A 209
 UMP  A 702 (-4.3A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
UMP  A 702 ( 2.4A)
UMP  A 702 ( 4.2A)
 0.84A 3uwlD-6cdzA:
37.6		 3uwlD-6cdzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_D_FOZD316_0
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		6 / 12 TRP A  80
LEU A 143
HIS A 147
LEU A 172
GLY A 173
ASN A 177
 None
None
UMP  A 702 (-4.3A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
UMP  A 702 ( 2.4A)
 0.84A 3uwlD-6cdzA:
37.6		 3uwlD-6cdzA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		8 / 12 ILE A  79
ASP A 169
LEU A 172
GLY A 173
PHE A 176
ASN A 177
TYR A 209
LYS A 259
 CB3  A 701 (-3.9A)
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
UMP  A 702 ( 2.4A)
UMP  A 702 ( 4.2A)
None
 0.53A 4eb4A-6cdzA:
37.1		 4eb4A-6cdzA:
39.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		8 / 12 ILE A  79
ASP A 169
LEU A 172
GLY A 173
PHE A 176
ASN A 177
TYR A 209
LYS A 259
 CB3  A 701 (-3.9A)
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
UMP  A 702 ( 2.4A)
UMP  A 702 ( 4.2A)
None
 0.56A 4eb4B-6cdzA:
37.1		 4eb4B-6cdzA:
39.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		7 / 9 ILE A  79
ASP A 169
LEU A 172
GLY A 173
PHE A 176
ASN A 177
TYR A 209
 CB3  A 701 (-3.9A)
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
UMP  A 702 ( 2.4A)
UMP  A 702 ( 4.2A)
 0.50A 4eb4C-6cdzA:
36.3		 4eb4C-6cdzA:
39.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		8 / 10 ILE A  79
ASP A 169
LEU A 172
GLY A 173
PHE A 176
ASN A 177
TYR A 209
LYS A 259
 CB3  A 701 (-3.9A)
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
UMP  A 702 ( 2.4A)
UMP  A 702 ( 4.2A)
None
 0.81A 4eb4D-6cdzA:
37.0		 4eb4D-6cdzA:
39.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		7 / 10 ILE A  79
TRP A  80
ASP A 169
PHE A 176
ASN A 177
TYR A 209
LYS A 259
 CB3  A 701 (-3.9A)
None
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.8A)
UMP  A 702 ( 2.4A)
UMP  A 702 ( 4.2A)
None
 0.94A 4eb4D-6cdzA:
37.0		 4eb4D-6cdzA:
39.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_A_C2FA302_0
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		8 / 11 LYS A  48
SER A  54
ILE A  79
TRP A  80
LEU A 143
ASP A 169
GLY A 173
TYR A 209
 CB3  A 701 ( 4.8A)
None
CB3  A 701 (-3.9A)
None
None
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.3A)
UMP  A 702 ( 4.2A)
 0.63A 4fogA-6cdzA:
40.0		 4fogA-6cdzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_A_C2FA302_0
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		8 / 11 SER A  54
ILE A  79
TRP A  80
LEU A 143
ASP A 169
GLY A 173
PHE A 176
TYR A 209
 None
CB3  A 701 (-3.9A)
None
None
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
UMP  A 702 ( 4.2A)
 0.91A 4fogA-6cdzA:
40.0		 4fogA-6cdzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_C_C2FC302_0
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		6 / 11 SER A  54
ILE A  79
ASP A 169
GLY A 173
PHE A 176
VAL A 262
 None
CB3  A 701 (-3.9A)
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
None
 1.23A 4fogC-6cdzA:
40.8		 4fogC-6cdzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_C_C2FC302_0
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		8 / 11 SER A  54
ILE A  79
TRP A  80
TRP A  83
LEU A 143
ASP A 169
GLY A 173
TYR A 209
 None
CB3  A 701 (-3.9A)
None
None
None
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.3A)
UMP  A 702 ( 4.2A)
 0.86A 4fogC-6cdzA:
40.8		 4fogC-6cdzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_C_C2FC302_0
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		7 / 11 SER A  54
ILE A  79
TRP A  83
ASP A 169
GLY A 173
PHE A 176
TYR A 209
 None
CB3  A 701 (-3.9A)
None
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
UMP  A 702 ( 4.2A)
 1.04A 4fogC-6cdzA:
40.8		 4fogC-6cdzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_D_C2FD302_0
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		8 / 11 ILE A  79
TRP A  80
TRP A  83
ASP A 169
LEU A 172
GLY A 173
PHE A 176
TYR A 209
 CB3  A 701 (-3.9A)
None
None
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
UMP  A 702 ( 4.2A)
 1.02A 4fogD-6cdzA:
40.4		 4fogD-6cdzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_D_C2FD302_0
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		8 / 11 LYS A  48
ILE A  79
TRP A  80
TRP A  83
ASP A 169
LEU A 172
GLY A 173
TYR A 209
 CB3  A 701 ( 4.8A)
CB3  A 701 (-3.9A)
None
None
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
UMP  A 702 ( 4.2A)
 0.85A 4fogD-6cdzA:
40.4		 4fogD-6cdzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_D_C2FD302_0
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		8 / 11 LYS A  48
TRP A  80
TRP A  83
LEU A 143
ASP A 169
LEU A 172
GLY A 173
TYR A 209
 CB3  A 701 ( 4.8A)
None
None
None
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
UMP  A 702 ( 4.2A)
 0.87A 4fogD-6cdzA:
40.4		 4fogD-6cdzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_D_C2FD302_0
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		6 / 11 LYS A  48
TRP A  83
LEU A 143
ASP A 169
GLY A 173
ALA A 263
 CB3  A 701 ( 4.8A)
None
None
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.4A)
 1.49A 4fogD-6cdzA:
40.4		 4fogD-6cdzA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_A_D16A301_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		7 / 12 SER A  54
GLU A  58
ILE A  79
TRP A  80
TRP A  83
LEU A 143
LEU A 172
 None
CB3  A 701 ( 4.3A)
CB3  A 701 (-3.9A)
None
None
None
CB3  A 701 (-3.5A)
 0.65A 4foxA-6cdzA:
40.2		 4foxA-6cdzA:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_A_D16A301_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		9 / 12 SER A  54
GLU A  58
ILE A  79
TRP A  83
LEU A 143
ASP A 169
LEU A 172
GLY A 173
TYR A 209
 None
CB3  A 701 ( 4.3A)
CB3  A 701 (-3.9A)
None
None
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
UMP  A 702 ( 4.2A)
 0.73A 4foxA-6cdzA:
40.2		 4foxA-6cdzA:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_A_D16A301_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		6 / 12 SER A  54
ILE A  79
TRP A  80
TRP A  83
LEU A 172
PHE A 176
 None
CB3  A 701 (-3.9A)
None
None
CB3  A 701 (-3.5A)
CB3  A 701 (-3.8A)
 0.99A 4foxA-6cdzA:
40.2		 4foxA-6cdzA:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_A_D16A301_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		8 / 12 SER A  54
ILE A  79
TRP A  83
ASP A 169
LEU A 172
GLY A 173
PHE A 176
TYR A 209
 None
CB3  A 701 (-3.9A)
None
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
UMP  A 702 ( 4.2A)
 0.92A 4foxA-6cdzA:
40.2		 4foxA-6cdzA:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_B_D16B302_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		8 / 12 SER A  54
GLU A  58
ILE A  79
LEU A 143
ASP A 169
LEU A 172
GLY A 173
TYR A 209
 None
CB3  A 701 ( 4.3A)
CB3  A 701 (-3.9A)
None
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
UMP  A 702 ( 4.2A)
 0.69A 4foxB-6cdzA:
40.1		 4foxB-6cdzA:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_B_D16B302_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		6 / 12 SER A  54
GLU A  58
ILE A  79
TRP A  80
LEU A 143
LEU A 172
 None
CB3  A 701 ( 4.3A)
CB3  A 701 (-3.9A)
None
None
CB3  A 701 (-3.5A)
 0.62A 4foxB-6cdzA:
40.1		 4foxB-6cdzA:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_B_D16B302_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		8 / 12 SER A  54
ILE A  79
LEU A 143
ASP A 169
LEU A 172
GLY A 173
PHE A 176
TYR A 209
 None
CB3  A 701 (-3.9A)
None
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
UMP  A 702 ( 4.2A)
 1.07A 4foxB-6cdzA:
40.1		 4foxB-6cdzA:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_B_D16B302_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		6 / 12 SER A  54
ILE A  79
TRP A  80
LEU A 143
LEU A 172
PHE A 176
 None
CB3  A 701 (-3.9A)
None
None
CB3  A 701 (-3.5A)
CB3  A 701 (-3.8A)
 1.06A 4foxB-6cdzA:
40.1		 4foxB-6cdzA:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_C_D16C301_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		6 / 11 SER A  54
GLU A  58
TRP A  80
TRP A  83
LEU A 143
LEU A 172
 None
CB3  A 701 ( 4.3A)
None
None
None
CB3  A 701 (-3.5A)
 0.67A 4foxC-6cdzA:
39.8		 4foxC-6cdzA:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_C_D16C301_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		8 / 11 SER A  54
GLU A  58
TRP A  83
LEU A 143
ASP A 169
LEU A 172
GLY A 173
TYR A 209
 None
CB3  A 701 ( 4.3A)
None
None
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
UMP  A 702 ( 4.2A)
 0.83A 4foxC-6cdzA:
39.8		 4foxC-6cdzA:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_C_D16C301_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		6 / 11 SER A  54
TRP A  80
TRP A  83
LEU A 143
LEU A 172
PHE A 176
 None
None
None
None
CB3  A 701 (-3.5A)
CB3  A 701 (-3.8A)
 1.02A 4foxC-6cdzA:
39.8		 4foxC-6cdzA:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_C_D16C301_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		8 / 11 SER A  54
TRP A  83
LEU A 143
ASP A 169
LEU A 172
GLY A 173
PHE A 176
TYR A 209
 None
None
None
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
UMP  A 702 ( 4.2A)
 1.12A 4foxC-6cdzA:
39.8		 4foxC-6cdzA:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_D_D16D301_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		7 / 12 SER A  54
GLU A  58
ILE A  79
ASP A 169
LEU A 172
GLY A 173
TYR A 209
 None
CB3  A 701 ( 4.3A)
CB3  A 701 (-3.9A)
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
UMP  A 702 ( 4.2A)
 0.68A 4foxD-6cdzA:
40.3		 4foxD-6cdzA:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_D_D16D301_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		7 / 12 SER A  54
GLU A  58
ILE A  79
ASP A 169
LEU A 172
GLY A 173
VAL A 262
 None
CB3  A 701 ( 4.3A)
CB3  A 701 (-3.9A)
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
None
 1.17A 4foxD-6cdzA:
40.3		 4foxD-6cdzA:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_D_D16D301_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		7 / 12 SER A  54
ILE A  79
ASP A 169
LEU A 172
GLY A 173
PHE A 176
TYR A 209
 None
CB3  A 701 (-3.9A)
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
UMP  A 702 ( 4.2A)
 0.96A 4foxD-6cdzA:
40.3		 4foxD-6cdzA:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_D_D16D301_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		7 / 12 SER A  54
ILE A  79
ASP A 169
LEU A 172
GLY A 173
PHE A 176
VAL A 262
 None
CB3  A 701 (-3.9A)
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
None
 1.29A 4foxD-6cdzA:
40.3		 4foxD-6cdzA:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_E_D16E301_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		7 / 12 LYS A  48
SER A  54
GLU A  58
ILE A  79
TRP A  80
TRP A  83
LEU A 172
 CB3  A 701 ( 4.8A)
None
CB3  A 701 ( 4.3A)
CB3  A 701 (-3.9A)
None
None
CB3  A 701 (-3.5A)
 0.69A 4foxE-6cdzA:
40.3		 4foxE-6cdzA:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_E_D16E301_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		9 / 12 LYS A  48
SER A  54
GLU A  58
ILE A  79
TRP A  83
ASP A 169
LEU A 172
GLY A 173
TYR A 209
 CB3  A 701 ( 4.8A)
None
CB3  A 701 ( 4.3A)
CB3  A 701 (-3.9A)
None
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
UMP  A 702 ( 4.2A)
 0.67A 4foxE-6cdzA:
40.3		 4foxE-6cdzA:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_E_D16E301_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		6 / 12 SER A  54
ILE A  79
TRP A  80
TRP A  83
LEU A 172
PHE A 176
 None
CB3  A 701 (-3.9A)
None
None
CB3  A 701 (-3.5A)
CB3  A 701 (-3.8A)
 1.03A 4foxE-6cdzA:
40.3		 4foxE-6cdzA:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_E_D16E301_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		8 / 12 SER A  54
ILE A  79
TRP A  83
ASP A 169
LEU A 172
GLY A 173
PHE A 176
TYR A 209
 None
CB3  A 701 (-3.9A)
None
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
UMP  A 702 ( 4.2A)
 1.00A 4foxE-6cdzA:
40.3		 4foxE-6cdzA:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_F_D16F301_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		5 / 11 GLU A  58
ILE A  79
TRP A  80
TRP A  83
LEU A 143
 CB3  A 701 ( 4.3A)
CB3  A 701 (-3.9A)
None
None
None
 0.61A 4foxF-6cdzA:
40.0		 4foxF-6cdzA:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_F_D16F301_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		7 / 11 GLU A  58
ILE A  79
TRP A  83
LEU A 143
ASP A 169
GLY A 173
TYR A 209
 CB3  A 701 ( 4.3A)
CB3  A 701 (-3.9A)
None
None
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.3A)
UMP  A 702 ( 4.2A)
 0.91A 4foxF-6cdzA:
40.0		 4foxF-6cdzA:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_F_D16F301_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		6 / 11 ILE A  79
TRP A  83
ASP A 169
GLY A 173
PHE A 176
TYR A 209
 CB3  A 701 (-3.9A)
None
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
UMP  A 702 ( 4.2A)
 1.01A 4foxF-6cdzA:
40.0		 4foxF-6cdzA:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_G_D16G301_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		8 / 12 SER A  54
GLU A  58
ILE A  79
LEU A 143
ASP A 169
LEU A 172
GLY A 173
TYR A 209
 None
CB3  A 701 ( 4.3A)
CB3  A 701 (-3.9A)
None
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
UMP  A 702 ( 4.2A)
 0.79A 4foxG-6cdzA:
39.9		 4foxG-6cdzA:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_G_D16G301_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		6 / 12 SER A  54
GLU A  58
ILE A  79
TRP A  80
LEU A 143
LEU A 172
 None
CB3  A 701 ( 4.3A)
CB3  A 701 (-3.9A)
None
None
CB3  A 701 (-3.5A)
 0.68A 4foxG-6cdzA:
39.9		 4foxG-6cdzA:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_G_D16G301_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		7 / 12 SER A  54
ILE A  79
ASP A 169
LEU A 172
GLY A 173
PHE A 176
TYR A 209
 None
CB3  A 701 (-3.9A)
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
UMP  A 702 ( 4.2A)
 0.96A 4foxG-6cdzA:
39.9		 4foxG-6cdzA:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_G_D16G301_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		5 / 12 SER A  54
ILE A  79
TRP A  80
LEU A 172
PHE A 176
 None
CB3  A 701 (-3.9A)
None
CB3  A 701 (-3.5A)
CB3  A 701 (-3.8A)
 1.06A 4foxG-6cdzA:
39.9		 4foxG-6cdzA:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_H_D16H301_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		6 / 11 SER A  54
GLU A  58
ILE A  79
ASP A 169
GLY A 173
TYR A 209
 None
CB3  A 701 ( 4.3A)
CB3  A 701 (-3.9A)
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.3A)
UMP  A 702 ( 4.2A)
 0.62A 4foxH-6cdzA:
39.7		 4foxH-6cdzA:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_H_D16H301_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		6 / 11 SER A  54
ILE A  79
ASP A 169
GLY A 173
PHE A 176
TYR A 209
 None
CB3  A 701 (-3.9A)
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
UMP  A 702 ( 4.2A)
 0.87A 4foxH-6cdzA:
39.7		 4foxH-6cdzA:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		6 / 12 GLU A  58
ILE A  79
ASP A 169
LEU A 172
GLY A 173
TYR A 209
 CB3  A 701 ( 4.3A)
CB3  A 701 (-3.9A)
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
UMP  A 702 ( 4.2A)
 0.82A 4fqsA-6cdzA:
40.3		 4fqsA-6cdzA:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		6 / 12 GLU A  58
ILE A  79
ASP A 169
LEU A 172
GLY A 173
VAL A 262
 CB3  A 701 ( 4.3A)
CB3  A 701 (-3.9A)
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
None
 1.32A 4fqsA-6cdzA:
40.3		 4fqsA-6cdzA:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		5 / 12 GLU A  58
ILE A  79
TRP A  80
LEU A 172
GLY A 173
 CB3  A 701 ( 4.3A)
CB3  A 701 (-3.9A)
None
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
 0.91A 4fqsA-6cdzA:
40.3		 4fqsA-6cdzA:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		6 / 12 ILE A  79
ASP A 169
LEU A 172
GLY A 173
PHE A 176
TYR A 209
 CB3  A 701 (-3.9A)
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
UMP  A 702 ( 4.2A)
 1.00A 4fqsA-6cdzA:
40.3		 4fqsA-6cdzA:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		6 / 12 ILE A  79
ASP A 169
LEU A 172
GLY A 173
PHE A 176
VAL A 262
 CB3  A 701 (-3.9A)
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
None
 1.34A 4fqsA-6cdzA:
40.3		 4fqsA-6cdzA:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		6 / 12 GLU A  58
ILE A  79
ASP A 169
LEU A 172
GLY A 173
TYR A 209
 CB3  A 701 ( 4.3A)
CB3  A 701 (-3.9A)
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
UMP  A 702 ( 4.2A)
 0.84A 4fqsB-6cdzA:
40.2		 4fqsB-6cdzA:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		6 / 12 GLU A  58
ILE A  79
ASP A 169
LEU A 172
GLY A 173
VAL A 262
 CB3  A 701 ( 4.3A)
CB3  A 701 (-3.9A)
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
None
 1.31A 4fqsB-6cdzA:
40.2		 4fqsB-6cdzA:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		5 / 12 GLU A  58
ILE A  79
TRP A  80
LEU A 172
GLY A 173
 CB3  A 701 ( 4.3A)
CB3  A 701 (-3.9A)
None
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
 0.91A 4fqsB-6cdzA:
40.2		 4fqsB-6cdzA:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		5 / 12 ILE A  79
LEU A 172
GLY A 173
PHE A 176
TYR A 209
 CB3  A 701 (-3.9A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
UMP  A 702 ( 4.2A)
 1.07A 4fqsB-6cdzA:
40.2		 4fqsB-6cdzA:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IQQ_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		6 / 7 ILE A  79
ASP A 169
LEU A 172
GLY A 173
PHE A 176
TYR A 209
 CB3  A 701 (-3.9A)
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
UMP  A 702 ( 4.2A)
 0.56A 4iqqB-6cdzA:
35.2		 4iqqB-6cdzA:
39.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IQQ_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		6 / 7 ILE A  79
ASP A 169
LEU A 172
GLY A 173
PHE A 176
TYR A 209
 CB3  A 701 (-3.9A)
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
UMP  A 702 ( 4.2A)
 0.62A 4iqqC-6cdzA:
35.6		 4iqqC-6cdzA:
39.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQ4_B_IMNB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		5 / 10 HIS A  51
VAL A  77
ILE A  79
TYR A 252
LEU A  44
 None
None
CB3  A 701 (-3.9A)
None
None
 1.49A 4jq4B-6cdzA:
undetectable		 4jq4B-6cdzA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_A_C2FA402_0
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		6 / 11 ILE A  79
LEU A 143
ASP A 169
LEU A 172
GLY A 173
TYR A 209
 CB3  A 701 (-3.9A)
None
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
UMP  A 702 ( 4.2A)
 0.97A 5fctA-6cdzA:
37.6		 5fctA-6cdzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_0
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		6 / 12 LYS A  48
ILE A  79
LEU A 143
CYH A 146
LEU A 172
TYR A 209
 CB3  A 701 ( 4.8A)
CB3  A 701 (-3.9A)
None
UMP  A 702 (-3.4A)
CB3  A 701 (-3.5A)
UMP  A 702 ( 4.2A)
 1.06A 5fctB-6cdzA:
37.7		 5fctB-6cdzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_B_D16B401_1
(ORF70)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		6 / 7 ILE A  79
ASP A 169
LEU A 172
GLY A 173
PHE A 176
TYR A 209
 CB3  A 701 (-3.9A)
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
UMP  A 702 ( 4.2A)
 0.54A 5h3aB-6cdzA:
36.6		 5h3aB-6cdzA:
19.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J7W_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		5 / 12 GLU A  58
ILE A  79
LEU A 143
LEU A 172
GLY A 173
 CB3  A 701 ( 4.3A)
CB3  A 701 (-3.9A)
None
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
 0.89A 5j7wC-6cdzA:
39.4		 5j7wC-6cdzA:
61.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J7W_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		7 / 12 GLU A  58
ILE A  79
LEU A 143
ASP A 169
LEU A 172
GLY A 173
TYR A 209
 CB3  A 701 ( 4.3A)
CB3  A 701 (-3.9A)
None
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
UMP  A 702 ( 4.2A)
 1.10A 5j7wD-6cdzA:
38.9		 5j7wD-6cdzA:
61.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J7W_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		6 / 12 GLU A  58
ILE A  79
TRP A  80
LEU A 143
LEU A 172
GLY A 173
 CB3  A 701 ( 4.3A)
CB3  A 701 (-3.9A)
None
None
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
 0.91A 5j7wD-6cdzA:
38.9		 5j7wD-6cdzA:
61.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NOO_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		6 / 7 ILE A  79
ASP A 169
LEU A 172
GLY A 173
PHE A 176
TYR A 209
 CB3  A 701 (-3.9A)
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
UMP  A 702 ( 4.2A)
 0.48A 5nooA-6cdzA:
36.0		 5nooA-6cdzA:
39.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NOO_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		6 / 7 ILE A  79
ASP A 169
LEU A 172
GLY A 173
PHE A 176
TYR A 209
 CB3  A 701 (-3.9A)
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
UMP  A 702 ( 4.2A)
 0.56A 5nooB-6cdzA:
35.6		 5nooB-6cdzA:
39.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NOO_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		5 / 6 ASP A 169
LEU A 172
GLY A 173
PHE A 176
TYR A 209
 CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
UMP  A 702 ( 4.2A)
 0.53A 5nooC-6cdzA:
35.3		 5nooC-6cdzA:
39.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		7 / 12 GLU A  58
ILE A  79
ASP A 169
LEU A 172
GLY A 173
PHE A 176
TYR A 209
 CB3  A 701 ( 4.3A)
CB3  A 701 (-3.9A)
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
UMP  A 702 ( 4.2A)
 0.40A 5x5qB-6cdzA:
37.9		 5x5qB-6cdzA:
49.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		6 / 12 GLU A  58
ILE A  79
TRP A  80
ASP A 169
LEU A 172
PHE A 176
 CB3  A 701 ( 4.3A)
CB3  A 701 (-3.9A)
None
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.8A)
 0.68A 5x5qB-6cdzA:
37.9		 5x5qB-6cdzA:
49.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		6 / 7 ILE A  79
ASP A 169
LEU A 172
GLY A 173
PHE A 176
TYR A 209
 CB3  A 701 (-3.9A)
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
UMP  A 702 ( 4.2A)
 0.42A 5x5qC-6cdzA:
36.6		 5x5qC-6cdzA:
49.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		6 / 8 ILE A  79
ASP A 169
LEU A 172
GLY A 173
PHE A 176
TYR A 209
 CB3  A 701 (-3.9A)
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
UMP  A 702 ( 4.2A)
 0.39A 5x5qD-6cdzA:
23.2		 5x5qD-6cdzA:
49.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		5 / 8 LYS A  48
ILE A  79
ASP A 169
LEU A 172
TYR A 209
 CB3  A 701 ( 4.8A)
CB3  A 701 (-3.9A)
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
UMP  A 702 ( 4.2A)
 1.27A 5x5qD-6cdzA:
23.2		 5x5qD-6cdzA:
49.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_F_D16F402_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		6 / 8 ILE A  79
ASP A 169
LEU A 172
GLY A 173
PHE A 176
TYR A 209
 CB3  A 701 (-3.9A)
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
UMP  A 702 ( 4.2A)
 0.42A 5x5qF-6cdzA:
36.6		 5x5qF-6cdzA:
49.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_A_MTXA402_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		6 / 12 ILE A  79
ASP A 169
GLY A 173
PHE A 176
ASN A 177
TYR A 209
 CB3  A 701 (-3.9A)
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
UMP  A 702 ( 2.4A)
UMP  A 702 ( 4.2A)
 0.30A 5x66A-6cdzA:
37.8
5x66B-6cdzA:
37.9		 5x66A-6cdzA:
49.41
5x66B-6cdzA:
49.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_A_MTXA402_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		6 / 12 ILE A  79
ASP A 169
LEU A 172
GLY A 173
ASN A 177
TYR A 209
 CB3  A 701 (-3.9A)
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
UMP  A 702 ( 2.4A)
UMP  A 702 ( 4.2A)
 0.67A 5x66A-6cdzA:
37.8
5x66B-6cdzA:
37.9		 5x66A-6cdzA:
49.41
5x66B-6cdzA:
49.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		7 / 9 ILE A  79
ASP A 169
LEU A 172
GLY A 173
PHE A 176
ASN A 177
TYR A 209
 CB3  A 701 (-3.9A)
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
UMP  A 702 ( 2.4A)
UMP  A 702 ( 4.2A)
 0.47A 5x66C-6cdzA:
38.0		 5x66C-6cdzA:
49.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		6 / 10 ILE A  79
ASP A 169
GLY A 173
PHE A 176
ASN A 177
TYR A 209
 CB3  A 701 (-3.9A)
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
UMP  A 702 ( 2.4A)
UMP  A 702 ( 4.2A)
 0.29A 5x66D-6cdzA:
38.1		 5x66D-6cdzA:
49.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_F_MTXF402_1
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		7 / 12 LYS A  48
ILE A  79
ASP A 169
LEU A 172
GLY A 173
PHE A 176
TYR A 209
 CB3  A 701 ( 4.8A)
CB3  A 701 (-3.9A)
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
UMP  A 702 ( 4.2A)
 0.54A 5x66F-6cdzA:
38.1		 5x66F-6cdzA:
49.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		4 / 5 HIS A 212
ASP A  20
GLY A  25
ASN A 211
 None
 1.34A 5x7pB-6cdzA:
undetectable		 5x7pB-6cdzA:
4.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		3 / 3 SER A 167
HIS A 207
TYR A 209
 UMP  A 702 (-2.4A)
UMP  A 702 (-4.0A)
UMP  A 702 ( 4.2A)
 1.05A 5y2tA-6cdzA:
undetectable		 5y2tA-6cdzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_B_FOZB403_0
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		6 / 12 ILE A  79
LEU A 172
GLY A 173
PHE A 176
ASN A 177
TYR A 209
 CB3  A 701 (-3.9A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
UMP  A 702 ( 2.4A)
UMP  A 702 ( 4.2A)
 1.08A 6qxsB-6cdzA:
37.5		 6qxsB-6cdzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_B_FOZB403_0
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		5 / 12 ILE A  79
TRP A  80
LEU A 172
GLY A 173
ASN A 177
 CB3  A 701 (-3.9A)
None
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
UMP  A 702 ( 2.4A)
 0.86A 6qxsB-6cdzA:
37.5		 6qxsB-6cdzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_B_FOZB403_0
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		5 / 12 TRP A  80
LEU A 143
LEU A 172
GLY A 173
ASN A 177
 None
None
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
UMP  A 702 ( 2.4A)
 0.92A 6qxsB-6cdzA:
37.5		 6qxsB-6cdzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		5 / 12 ILE A  79
ASP A 169
LEU A 172
GLY A 173
ASN A 177
 CB3  A 701 (-3.9A)
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
UMP  A 702 ( 2.4A)
 0.77A 6qxsD-6cdzA:
37.4		 6qxsD-6cdzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		5 / 12 ILE A  79
LEU A 143
LEU A 172
GLY A 173
ASN A 177
 CB3  A 701 (-3.9A)
None
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
UMP  A 702 ( 2.4A)
 0.96A 6qxsD-6cdzA:
37.4		 6qxsD-6cdzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		5 / 12 ILE A  79
TRP A  80
LEU A 143
GLY A 173
ASN A 177
 CB3  A 701 (-3.9A)
None
None
CB3  A 701 (-3.3A)
UMP  A 702 ( 2.4A)
 0.83A 6qxsD-6cdzA:
37.4		 6qxsD-6cdzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_B_FOZB401_0
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		5 / 12 ILE A  79
HIS A 147
LEU A 172
GLY A 173
TYR A 209
 CB3  A 701 (-3.9A)
UMP  A 702 (-4.3A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
UMP  A 702 ( 4.2A)
 0.84A 6qyaB-6cdzA:
37.3		 6qyaB-6cdzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_D_FOZD401_0
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		5 / 12 ILE A  79
HIS A 147
GLY A 173
ASN A 177
TYR A 209
 CB3  A 701 (-3.9A)
UMP  A 702 (-4.3A)
CB3  A 701 (-3.3A)
UMP  A 702 ( 2.4A)
UMP  A 702 ( 4.2A)
 0.57A 6qyaD-6cdzA:
37.3		 6qyaD-6cdzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_D_FOZD401_0
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		5 / 12 ILE A  79
LEU A 172
GLY A 173
ASN A 177
TYR A 209
 CB3  A 701 (-3.9A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
UMP  A 702 ( 2.4A)
UMP  A 702 ( 4.2A)
 0.75A 6qyaD-6cdzA:
37.3		 6qyaD-6cdzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		7 / 12 ILE A  79
ASP A 169
LEU A 172
GLY A 173
PHE A 176
ASN A 177
TYR A 209
 CB3  A 701 (-3.9A)
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
UMP  A 702 ( 2.4A)
UMP  A 702 ( 4.2A)
 0.96A 6r2eA-6cdzA:
37.1		 6r2eA-6cdzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		6 / 12 ILE A  79
LEU A 143
LEU A 172
GLY A 173
PHE A 176
ASN A 177
 CB3  A 701 (-3.9A)
None
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
UMP  A 702 ( 2.4A)
 1.18A 6r2eA-6cdzA:
37.1		 6r2eA-6cdzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		6 / 12 ILE A  79
TRP A  80
LEU A 143
GLY A 173
PHE A 176
ASN A 177
 CB3  A 701 (-3.9A)
None
None
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
UMP  A 702 ( 2.4A)
 1.14A 6r2eA-6cdzA:
37.1		 6r2eA-6cdzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_B_FFOB403_0
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		5 / 10 ILE A  79
ASP A 169
LEU A 172
GLY A 173
ASN A 177
 CB3  A 701 (-3.9A)
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
UMP  A 702 ( 2.4A)
 0.86A 6r2eB-6cdzA:
37.2		 6r2eB-6cdzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_B_FFOB403_0
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		5 / 10 ILE A  79
LEU A 143
LEU A 172
GLY A 173
ASN A 177
 CB3  A 701 (-3.9A)
None
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
UMP  A 702 ( 2.4A)
 0.93A 6r2eB-6cdzA:
37.2		 6r2eB-6cdzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_C_FFOC404_0
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		5 / 10 ILE A  79
ASP A 169
LEU A 172
GLY A 173
ASN A 177
 CB3  A 701 (-3.9A)
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
UMP  A 702 ( 2.4A)
 0.70A 6r2eC-6cdzA:
37.1		 6r2eC-6cdzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_C_FFOC404_0
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		5 / 10 ILE A  79
LEU A 143
LEU A 172
GLY A 173
ASN A 177
 CB3  A 701 (-3.9A)
None
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
UMP  A 702 ( 2.4A)
 0.93A 6r2eC-6cdzA:
37.1		 6r2eC-6cdzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_D_FFOD403_0
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		6 / 10 ILE A  79
LEU A 143
ASP A 169
LEU A 172
GLY A 173
ASN A 177
 CB3  A 701 (-3.9A)
None
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
UMP  A 702 ( 2.4A)
 1.00A 6r2eD-6cdzA:
37.3		 6r2eD-6cdzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		6 / 12 ILE A  79
LEU A 143
LEU A 172
GLY A 173
PHE A 176
ASN A 177
 CB3  A 701 (-3.9A)
None
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
UMP  A 702 ( 2.4A)
 1.19A 6r2eE-6cdzA:
37.2		 6r2eE-6cdzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		5 / 12 ILE A  79
TRP A  80
LEU A 143
PHE A 176
ASN A 177
 CB3  A 701 (-3.9A)
None
None
CB3  A 701 (-3.8A)
UMP  A 702 ( 2.4A)
 1.02A 6r2eE-6cdzA:
37.2		 6r2eE-6cdzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		5 / 12 ILE A  79
TRP A  80
TYR A  94
LEU A 143
ASN A 177
 CB3  A 701 (-3.9A)
None
None
None
UMP  A 702 ( 2.4A)
 0.57A 6r2eE-6cdzA:
37.2		 6r2eE-6cdzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		6 / 12 ILE A  79
TYR A  94
LEU A 143
LEU A 172
GLY A 173
ASN A 177
 CB3  A 701 (-3.9A)
None
None
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
UMP  A 702 ( 2.4A)
 0.86A 6r2eE-6cdzA:
37.2		 6r2eE-6cdzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_F_FFOF403_0
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		5 / 11 ILE A  79
ASP A 169
LEU A 172
GLY A 173
ASN A 177
 CB3  A 701 (-3.9A)
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
UMP  A 702 ( 2.4A)
 0.78A 6r2eF-6cdzA:
37.1		 6r2eF-6cdzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_F_FFOF403_0
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		5 / 11 ILE A  79
LEU A 143
LEU A 172
GLY A 173
ASN A 177
 CB3  A 701 (-3.9A)
None
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
UMP  A 702 ( 2.4A)
 0.95A 6r2eF-6cdzA:
37.1		 6r2eF-6cdzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_G_FFOG403_0
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		6 / 11 ILE A  79
ASP A 169
LEU A 172
GLY A 173
PHE A 176
ASN A 177
 CB3  A 701 (-3.9A)
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
UMP  A 702 ( 2.4A)
 1.04A 6r2eG-6cdzA:
37.2		 6r2eG-6cdzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_G_FFOG403_0
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		6 / 11 ILE A  79
LEU A 143
LEU A 172
GLY A 173
PHE A 176
ASN A 177
 CB3  A 701 (-3.9A)
None
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
CB3  A 701 (-3.8A)
UMP  A 702 ( 2.4A)
 1.20A 6r2eG-6cdzA:
37.2		 6r2eG-6cdzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_H_FFOH403_0
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		5 / 12 ILE A  79
ASP A 169
LEU A 172
GLY A 173
ASN A 177
 CB3  A 701 (-3.9A)
CB3  A 701 ( 3.6A)
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
UMP  A 702 ( 2.4A)
 0.76A 6r2eH-6cdzA:
37.1		 6r2eH-6cdzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_H_FFOH403_0
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		5 / 12 ILE A  79
TRP A  80
TYR A  94
LEU A 143
ASN A 177
 CB3  A 701 (-3.9A)
None
None
None
UMP  A 702 ( 2.4A)
 0.71A 6r2eH-6cdzA:
37.1		 6r2eH-6cdzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_H_FFOH403_0
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		6 / 12 ILE A  79
TYR A  94
LEU A 143
LEU A 172
GLY A 173
ASN A 177
 CB3  A 701 (-3.9A)
None
None
CB3  A 701 (-3.5A)
CB3  A 701 (-3.3A)
UMP  A 702 ( 2.4A)
 0.97A 6r2eH-6cdzA:
37.1		 6r2eH-6cdzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_H_FFOH403_0
(THYMIDYLATE SYNTHASE)		 6cdz THYMIDYLATE SYNTHASE
(Escherichia
coli) 		5 / 12 TYR A  94
LEU A 143
GLY A 173
ASN A 177
ALA A 263
 None
None
CB3  A 701 (-3.3A)
UMP  A 702 ( 2.4A)
CB3  A 701 (-3.4A)
 1.27A 6r2eH-6cdzA:
37.1		 6r2eH-6cdzA:
undetectable