SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6ces'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_A_AICA5001_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 6ces RAS-RELATED
GTP-BINDING PROTEIN
A
RAS-RELATED
GTP-BINDING PROTEIN
C
(Homo
sapiens) 		4 / 8 ARG A  34
GLN A 237
HIS C 223
TYR C 216
 None
 1.06A 1nx9A-6cesA:
undetectable		 1nx9A-6cesA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_B_AICB5002_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 6ces RAS-RELATED
GTP-BINDING PROTEIN
A
RAS-RELATED
GTP-BINDING PROTEIN
C
(Homo
sapiens) 		4 / 8 ARG A  34
GLN A 237
HIS C 223
TYR C 216
 None
 1.06A 1nx9B-6cesA:
undetectable		 1nx9B-6cesA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_C_AICC5003_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 6ces RAS-RELATED
GTP-BINDING PROTEIN
A
RAS-RELATED
GTP-BINDING PROTEIN
C
(Homo
sapiens) 		4 / 8 ARG A  34
GLN A 237
HIS C 223
TYR C 216
 None
 1.05A 1nx9C-6cesA:
undetectable		 1nx9C-6cesA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_D_AICD5004_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 6ces RAS-RELATED
GTP-BINDING PROTEIN
A
RAS-RELATED
GTP-BINDING PROTEIN
C
(Homo
sapiens) 		4 / 8 ARG A  34
GLN A 237
HIS C 223
TYR C 216
 None
 1.06A 1nx9D-6cesA:
undetectable		 1nx9D-6cesA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P9G_A_ACTA42_0
(EAFP 2)		 6ces RAS-RELATED
GTP-BINDING PROTEIN
A
(Homo
sapiens) 		3 / 3 CYH A 157
ARG A 149
CYH A 159
 None
 1.43A 1p9gA-6cesA:
undetectable		 1p9gA-6cesA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_2
(DIPEPTIDYL PEPTIDASE
IV)		 6ces RAS-RELATED
GTP-BINDING PROTEIN
A
(Homo
sapiens) 		3 / 3 PHE A  74
TYR A  90
TYR A 106
 None
 1.03A 1x70B-6cesA:
undetectable		 1x70B-6cesA:
6.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 6ces RAS-RELATED
GTP-BINDING PROTEIN
A
(Homo
sapiens) 		3 / 3 ALA A 172
THR A 162
PHE A 123
 None
 0.73A 2c6nB-6cesA:
undetectable		 2c6nB-6cesA:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		 6ces RAS-RELATED
GTP-BINDING PROTEIN
C
(Homo
sapiens) 		5 / 11 PHE C 134
ILE C 195
ALA C 199
MET C 171
GLU C 174
 None
 1.18A 2v0mA-6cesC:
undetectable		 2v0mA-6cesC:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UPR_A_1KXA277_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 6ces RAS-RELATED
GTP-BINDING PROTEIN
C
(Homo
sapiens) 		5 / 10 TYR C 142
ILE C 141
VAL C 143
ASP C 145
ILE C  77
 None
 1.41A 3uprA-6cesC:
undetectable		 3uprA-6cesC:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UPR_C_1KXC277_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 6ces RAS-RELATED
GTP-BINDING PROTEIN
C
(Homo
sapiens) 		5 / 10 TYR C 142
ILE C 141
VAL C 143
ASP C 145
ILE C  77
 None
 1.40A 3uprC-6cesC:
undetectable		 3uprC-6cesC:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_C_QMRC1214_1
(CAPITELLA TELETA
ACHBP)		 6ces RAS-RELATED
GTP-BINDING PROTEIN
A
(Homo
sapiens) 		4 / 8 VAL A  87
CYH A 109
ILE A  89
ILE A 122
 None
 1.01A 4afgD-6cesA:
undetectable
4afgE-6cesA:
undetectable		 4afgD-6cesA:
17.86
4afgE-6cesA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AT0_A_ACTA1490_0
(3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E)		 6ces RAS-RELATED
GTP-BINDING PROTEIN
C
(Homo
sapiens) 		3 / 3 GLU C 209
TYR C 165
SER C 162
 None
 0.98A 4at0A-6cesC:
undetectable		 4at0A-6cesC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CDT_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6ces RAS-RELATED
GTP-BINDING PROTEIN
A
(Homo
sapiens) 		4 / 7 MET A 252
VAL A 274
PHE A 259
GLU A 253
 None
 1.29A 4cdtA-6cesA:
undetectable
4cdtB-6cesA:
0.2		 4cdtA-6cesA:
12.26
4cdtB-6cesA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTT_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6ces RAS-RELATED
GTP-BINDING PROTEIN
A
(Homo
sapiens) 		4 / 7 MET A 252
VAL A 274
PHE A 259
GLU A 253
 None
 1.33A 4cttA-6cesA:
undetectable
4cttB-6cesA:
undetectable		 4cttA-6cesA:
12.26
4cttB-6cesA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCK_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6ces RAS-RELATED
GTP-BINDING PROTEIN
A
(Homo
sapiens) 		4 / 7 MET A 252
VAL A 274
PHE A 259
GLU A 253
 None
 1.31A 4kckA-6cesA:
undetectable
4kckB-6cesA:
undetectable		 4kckA-6cesA:
12.26
4kckB-6cesA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPN_A_H4BA760_1
(NEURONAL NITRIC
OXIDE SYNTHASE)		 6ces RAS-RELATED
GTP-BINDING PROTEIN
A
(Homo
sapiens) 		4 / 7 MET A 252
VAL A 274
PHE A 259
GLU A 253
 None
 1.33A 4upnA-6cesA:
undetectable
4upnB-6cesA:
undetectable		 4upnA-6cesA:
12.26
4upnB-6cesA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA605_1
(CHITINASE)		 6ces RAS-RELATED
GTP-BINDING PROTEIN
A
(Homo
sapiens) 		3 / 3 TRP A 165
ILE A  26
SER A  22
 GNP  A 500 (-4.6A)
None
GNP  A 500 (-4.4A)
 0.92A 5gqbA-6cesA:
3.7		 5gqbA-6cesA:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_I_IPHI101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 6ces RAS-RELATED
GTP-BINDING PROTEIN
C
(Homo
sapiens) 		4 / 6 VAL C 161
HIS C 158
LEU C 157
LEU C 203
 None
 1.12A 5hrqB-6cesC:
undetectable
5hrqI-6cesC:
undetectable
5hrqJ-6cesC:
undetectable		 5hrqB-6cesC:
undetectable
5hrqI-6cesC:
undetectable
5hrqJ-6cesC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZX_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 6ces RAS-RELATED
GTP-BINDING PROTEIN
C
(Homo
sapiens) 		5 / 8 ASN C 111
PHE C 112
ARG C  63
THR C 137
GLY C 138
 None
 1.00A 5nzxA-6cesC:
undetectable		 5nzxA-6cesC:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 6ces RAS-RELATED
GTP-BINDING PROTEIN
C
(Homo
sapiens) 		4 / 7 ASN C 111
PHE C 112
THR C 137
GLY C 138
 None
 0.99A 5nzyA-6cesC:
undetectable		 5nzyA-6cesC:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U98_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 6ces RAS-RELATED
GTP-BINDING PROTEIN
C
(Homo
sapiens) 		5 / 10 TYR C 142
ILE C 141
VAL C 143
ASP C 145
ILE C  77
 None
 1.40A 5u98A-6cesC:
undetectable		 5u98A-6cesC:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U98_D_1KXD301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 6ces RAS-RELATED
GTP-BINDING PROTEIN
C
(Homo
sapiens) 		5 / 10 TYR C 142
ILE C 141
VAL C 143
ASP C 145
ILE C  77
 None
 1.41A 5u98D-6cesC:
undetectable		 5u98D-6cesC:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNU_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6ces RAS-RELATED
GTP-BINDING PROTEIN
A
(Homo
sapiens) 		4 / 7 MET A 252
VAL A 274
PHE A 259
GLU A 253
 None
 1.23A 5unuA-6cesA:
undetectable
5unuB-6cesA:
undetectable		 5unuA-6cesA:
12.26
5unuB-6cesA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNW_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6ces RAS-RELATED
GTP-BINDING PROTEIN
A
(Homo
sapiens) 		4 / 7 PHE A 259
GLU A 253
MET A 252
VAL A 274
 None
 1.28A 5unwA-6cesA:
undetectable
5unwB-6cesA:
undetectable		 5unwA-6cesA:
12.26
5unwB-6cesA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNX_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6ces RAS-RELATED
GTP-BINDING PROTEIN
A
(Homo
sapiens) 		4 / 7 MET A 252
VAL A 274
PHE A 259
GLU A 253
 None
 1.36A 5unxA-6cesA:
0.8
5unxB-6cesA:
undetectable		 5unxA-6cesA:
12.26
5unxB-6cesA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNY_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6ces RAS-RELATED
GTP-BINDING PROTEIN
A
(Homo
sapiens) 		4 / 7 MET A 252
VAL A 274
PHE A 259
GLU A 253
 None
 1.22A 5unyA-6cesA:
undetectable
5unyB-6cesA:
undetectable		 5unyA-6cesA:
12.26
5unyB-6cesA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO3_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6ces RAS-RELATED
GTP-BINDING PROTEIN
A
(Homo
sapiens) 		4 / 7 MET A 252
VAL A 274
PHE A 259
GLU A 253
 None
 1.29A 5uo3A-6cesA:
undetectable
5uo3B-6cesA:
undetectable		 5uo3A-6cesA:
12.26
5uo3B-6cesA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO3_B_H4BB803_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6ces RAS-RELATED
GTP-BINDING PROTEIN
A
(Homo
sapiens) 		4 / 7 PHE A 259
GLU A 253
MET A 252
VAL A 274
 None
 1.32A 5uo3A-6cesA:
undetectable
5uo3B-6cesA:
undetectable		 5uo3A-6cesA:
12.26
5uo3B-6cesA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUS_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6ces RAS-RELATED
GTP-BINDING PROTEIN
A
(Homo
sapiens) 		4 / 7 MET A 252
VAL A 274
PHE A 259
GLU A 253
 None
 1.36A 5vusA-6cesA:
undetectable
5vusB-6cesA:
undetectable		 5vusA-6cesA:
12.26
5vusB-6cesA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUY_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6ces RAS-RELATED
GTP-BINDING PROTEIN
A
(Homo
sapiens) 		4 / 7 MET A 252
VAL A 274
PHE A 259
GLU A 253
 None
 1.26A 5vuyA-6cesA:
undetectable
5vuyB-6cesA:
undetectable		 5vuyA-6cesA:
12.26
5vuyB-6cesA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV1_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6ces RAS-RELATED
GTP-BINDING PROTEIN
A
(Homo
sapiens) 		4 / 7 MET A 252
VAL A 274
PHE A 259
GLU A 253
 None
 1.27A 6av1A-6cesA:
0.2
6av1B-6cesA:
undetectable		 6av1A-6cesA:
25.27
6av1B-6cesA:
25.27