SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6cet'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_A_CHDA1150_0
(ALCOHOL
DEHYDROGENASE)		 6cet GATOR COMPLEX
PROTEIN DEPDC5
(Homo
sapiens) 		5 / 11 LEU D 220
LEU D 200
CYH D 368
VAL D 334
ILE D 175
 None
 1.19A 1ee2A-6cetD:
undetectable		 1ee2A-6cetD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 6cet GATOR COMPLEX
PROTEIN NPRL2
GATOR COMPLEX
PROTEIN NPRL3
(Homo
sapiens) 		3 / 3 GLN N 240
ILE N 206
HIS M 518
 None
 0.67A 1fm9A-6cetN:
undetectable		 1fm9A-6cetN:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_1
(HIV-1 PROTEASE)		 6cet GATOR COMPLEX
PROTEIN DEPDC5
(Homo
sapiens) 		5 / 10 LEU D 366
ALA D 195
ILE D 274
VAL D 334
ILE D 336
 None
 0.96A 1hsgA-6cetD:
undetectable		 1hsgA-6cetD:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_2
(HIV-1 PROTEASE)		 6cet GATOR COMPLEX
PROTEIN NPRL3
(Homo
sapiens) 		3 / 3 ARG M 422
THR M 388
VAL M 385
 None
 0.96A 1hxbA-6cetM:
undetectable		 1hxbA-6cetM:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 6cet GATOR COMPLEX
PROTEIN NPRL2
GATOR COMPLEX
PROTEIN NPRL3
(Homo
sapiens) 		3 / 3 GLN N 240
ILE N 206
HIS M 518
 None
 0.69A 1k74A-6cetN:
undetectable		 1k74A-6cetN:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		 6cet GATOR COMPLEX
PROTEIN NPRL3
(Homo
sapiens) 		4 / 5 ASP M 266
LEU M 261
LEU M 264
LEU M 262
 None
 1.16A 1np1A-6cetM:
undetectable		 1np1A-6cetM:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_A_HSMA401_1
(NITROPHORIN 1)		 6cet GATOR COMPLEX
PROTEIN NPRL3
(Homo
sapiens) 		4 / 4 ASP M 266
LEU M 261
LEU M 264
LEU M 262
 None
 1.16A 1u18A-6cetM:
undetectable		 1u18A-6cetM:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_C_STRC3001_1
(MINERALOCORTICOID
RECEPTOR)		 6cet GATOR COMPLEX
PROTEIN NPRL3
(Homo
sapiens) 		5 / 12 LEU M 298
LEU M 304
ALA M 305
MET M 180
LEU M 282
 None
 0.95A 1ya3C-6cetM:
undetectable		 1ya3C-6cetM:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_1
(CYTOCHROME P450 2C8)		 6cet GATOR COMPLEX
PROTEIN DEPDC5
(Homo
sapiens) 		5 / 12 SER D 213
SER D 168
THR D 329
SER D 166
ALA D 139
 None
 1.11A 2nniA-6cetD:
undetectable		 2nniA-6cetD:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_2
(PROTEASE RETROPEPSIN)		 6cet GATOR COMPLEX
PROTEIN NPRL3
(Homo
sapiens) 		3 / 3 ARG M 422
THR M 388
VAL M 385
 None
 0.80A 2q64A-6cetM:
undetectable		 2q64A-6cetM:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 6cet GATOR COMPLEX
PROTEIN NPRL3
(Homo
sapiens) 		3 / 3 ARG M 422
THR M 388
VAL M 385
 None
 0.95A 2qakA-6cetM:
undetectable		 2qakA-6cetM:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 6cet GATOR COMPLEX
PROTEIN NPRL3
(Homo
sapiens) 		4 / 7 GLY M 448
THR M 535
PHE M 544
PHE M 520
 None
 1.20A 2qx4A-6cetM:
undetectable
2qx4B-6cetM:
undetectable		 2qx4A-6cetM:
15.56
2qx4B-6cetM:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1357_1
(PROSTAGLANDIN
REDUCTASE 2)		 6cet GATOR COMPLEX
PROTEIN DEPDC5
(Homo
sapiens) 		4 / 6 LYS D 411
LEU D 271
ASN D 197
ASP D 189
 None
 1.45A 2w98A-6cetD:
undetectable
2w98B-6cetD:
undetectable		 2w98A-6cetD:
11.20
2w98B-6cetD:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		 6cet GATOR COMPLEX
PROTEIN DEPDC5
(Homo
sapiens) 		3 / 3 GLU D1497
HIS D1375
GLU D1350
 None
 0.77A 2x45B-6cetD:
undetectable		 2x45B-6cetD:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		 6cet GATOR COMPLEX
PROTEIN DEPDC5
(Homo
sapiens) 		3 / 3 GLU D1497
HIS D1375
GLU D1350
 None
 0.74A 2x45C-6cetD:
undetectable		 2x45C-6cetD:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1000_1
(LYSR-TYPE REGULATORY
PROTEIN)		 6cet GATOR COMPLEX
PROTEIN DEPDC5
(Homo
sapiens) 		5 / 10 TYR D 172
GLY D 363
PHE D 317
PRO D 750
ILE D 362
 None
 1.24A 2y7pA-6cetD:
0.8		 2y7pA-6cetD:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDY_A_RBFA187_1
(LUMAZINE PROTEIN)		 6cet GATOR COMPLEX
PROTEIN NPRL3
(Homo
sapiens) 		5 / 12 THR M 483
ILE M 498
ASP M 303
GLN M 300
ALA M 299
 None
 1.19A 3ddyA-6cetM:
undetectable		 3ddyA-6cetM:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_1
(CARBONIC ANHYDRASE 2)		 6cet GATOR COMPLEX
PROTEIN DEPDC5
(Homo
sapiens) 		5 / 12 ALA D 169
VAL D 334
PHE D 199
VAL D 364
LEU D 747
 None
 1.33A 3hkuA-6cetD:
undetectable		 3hkuA-6cetD:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IW1_A_ASDA1223_1
(CYTOCHROME P450
CYP125)		 6cet GATOR COMPLEX
PROTEIN DEPDC5
(Homo
sapiens) 		5 / 12 GLN D 372
VAL D 377
MET D 369
VAL D 340
VAL D 367
 None
 1.15A 3iw1A-6cetD:
undetectable		 3iw1A-6cetD:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		 6cet GATOR COMPLEX
PROTEIN DEPDC5
(Homo
sapiens) 		3 / 3 PHE D 278
TYR D 191
LEU D 270
 None
 0.76A 3keeB-6cetD:
undetectable		 3keeB-6cetD:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD202_1
(PROTEIN S100-A4)		 6cet GATOR COMPLEX
PROTEIN DEPDC5
GATOR COMPLEX
PROTEIN NPRL2
(Homo
sapiens) 		5 / 11 GLU D 344
ASP D 395
SER D 301
PHE D 343
SER N 187
 None
 1.41A 3ko0C-6cetD:
undetectable
3ko0D-6cetD:
undetectable
3ko0E-6cetD:
undetectable
3ko0F-6cetD:
undetectable		 3ko0C-6cetD:
19.61
3ko0D-6cetD:
19.61
3ko0E-6cetD:
19.61
3ko0F-6cetD:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_G_TFPG202_1
(PROTEIN S100-A4)		 6cet GATOR COMPLEX
PROTEIN DEPDC5
GATOR COMPLEX
PROTEIN NPRL2
(Homo
sapiens) 		5 / 10 SER N 187
SER D 301
PHE D 343
GLU D 344
ASP D 395
 None
 1.36A 3ko0E-6cetN:
0.0
3ko0F-6cetN:
undetectable
3ko0G-6cetN:
0.0
3ko0H-6cetN:
undetectable		 3ko0E-6cetN:
21.36
3ko0F-6cetN:
21.36
3ko0G-6cetN:
21.36
3ko0H-6cetN:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_H_TFPH202_1
(PROTEIN S100-A4)		 6cet GATOR COMPLEX
PROTEIN DEPDC5
GATOR COMPLEX
PROTEIN NPRL2
(Homo
sapiens) 		5 / 12 GLU D 344
ASP D 395
SER D 301
PHE D 343
SER N 187
 None
 1.38A 3ko0G-6cetD:
undetectable
3ko0H-6cetD:
undetectable
3ko0I-6cetD:
undetectable
3ko0J-6cetD:
undetectable		 3ko0G-6cetD:
19.61
3ko0H-6cetD:
19.61
3ko0I-6cetD:
19.61
3ko0J-6cetD:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM201_1
(PROTEIN S100-A4)		 6cet GATOR COMPLEX
PROTEIN DEPDC5
(Homo
sapiens) 		4 / 7 GLY D1090
CYH D1370
GLY D1254
PHE D1255
 None
 0.95A 3ko0M-6cetD:
undetectable
3ko0P-6cetD:
undetectable		 3ko0M-6cetD:
19.61
3ko0P-6cetD:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO202_1
(PROTEIN S100-A4)		 6cet GATOR COMPLEX
PROTEIN DEPDC5
GATOR COMPLEX
PROTEIN NPRL2
(Homo
sapiens) 		5 / 11 SER D 301
PHE D 343
GLU D 344
ASP D 395
SER N 187
 None
 1.36A 3ko0O-6cetD:
undetectable
3ko0P-6cetD:
undetectable
3ko0Q-6cetD:
undetectable
3ko0R-6cetD:
undetectable		 3ko0O-6cetD:
19.61
3ko0P-6cetD:
19.61
3ko0Q-6cetD:
19.61
3ko0R-6cetD:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_B_CAMB423_0
(CYTOCHROME P450)		 6cet GATOR COMPLEX
PROTEIN NPRL2
(Homo
sapiens) 		5 / 11 TYR N  43
THR N  24
LEU N  50
VAL N  88
ASP N  38
 None
 1.30A 3lxiB-6cetN:
undetectable		 3lxiB-6cetN:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_B_P77B203_1
(PROTEIN S100-A4)		 6cet GATOR COMPLEX
PROTEIN DEPDC5
GATOR COMPLEX
PROTEIN NPRL2
(Homo
sapiens) 		5 / 9 SER N 187
SER D 301
PHE D 343
GLU D 344
ASP D 395
 None
 1.41A 3m0wA-6cetN:
undetectable
3m0wB-6cetN:
undetectable
3m0wC-6cetN:
undetectable
3m0wD-6cetN:
undetectable		 3m0wA-6cetN:
19.00
3m0wB-6cetN:
19.00
3m0wC-6cetN:
19.00
3m0wD-6cetN:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_C_ACTC502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 6cet GATOR COMPLEX
PROTEIN DEPDC5
(Homo
sapiens) 		3 / 3 PRO D1086
ASP D1084
GLU D1196
 None
 0.88A 3v4tC-6cetD:
1.1		 3v4tC-6cetD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG306_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 6cet GATOR COMPLEX
PROTEIN NPRL3
GATOR COMPLEX
PROTEIN NPRL2
(Homo
sapiens;
Homo
sapiens) 		3 / 3 ARG M 515
ARG N 204
ASP N 173
 None
 0.92A 3wipG-6cetM:
undetectable
3wipH-6cetM:
undetectable		 3wipG-6cetM:
undetectable
3wipH-6cetM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_B_CAMB1420_0
(CYTOCHROME P450)		 6cet GATOR COMPLEX
PROTEIN NPRL2
(Homo
sapiens) 		5 / 10 TYR N  43
THR N  24
LEU N  50
VAL N  88
ASP N  38
 None
 1.32A 4c9nB-6cetN:
undetectable		 4c9nB-6cetN:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_B_CAMB423_0
(CYTOCHROME P450)		 6cet GATOR COMPLEX
PROTEIN NPRL2
(Homo
sapiens) 		5 / 10 TYR N  43
THR N  24
LEU N  50
VAL N  88
ASP N  38
 None
 1.35A 4c9pB-6cetN:
undetectable		 4c9pB-6cetN:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 6cet GATOR COMPLEX
PROTEIN DEPDC5
(Homo
sapiens) 		4 / 8 ASP D 318
SER D 313
SER D 333
ASP D 359
 None
 1.19A 4kttC-6cetD:
undetectable		 4kttC-6cetD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)		 6cet GATOR COMPLEX
PROTEIN NPRL3
GATOR COMPLEX
PROTEIN NPRL2
(Homo
sapiens;
Homo
sapiens) 		4 / 7 VAL N 281
GLN M 405
LEU N 278
GLU N 367
 None
 1.04A 4zphA-6cetN:
undetectable
4zphB-6cetN:
undetectable		 4zphA-6cetN:
undetectable
4zphB-6cetN:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_A_ACTA202_0
(NITROGEN REGULATORY
PROTEIN P-II)		 6cet GATOR COMPLEX
PROTEIN DEPDC5
(Homo
sapiens) 		4 / 4 VAL D 987
GLY D 985
ARG D 988
VAL D 990
 None
 1.25A 5d4nA-6cetD:
undetectable
5d4nB-6cetD:
3.5		 5d4nA-6cetD:
undetectable
5d4nB-6cetD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 6cet GATOR COMPLEX
PROTEIN NPRL2
(Homo
sapiens) 		3 / 3 ALA N 223
ASN N 226
LEU N 227
 None
 0.40A 5i1nB-6cetN:
undetectable		 5i1nB-6cetN:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 6cet GATOR COMPLEX
PROTEIN NPRL2
(Homo
sapiens) 		3 / 3 ALA N 223
ASN N 226
LEU N 227
 None
 0.36A 5i1oC-6cetN:
undetectable		 5i1oC-6cetN:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 6cet GATOR COMPLEX
PROTEIN NPRL2
(Homo
sapiens) 		3 / 3 ALA N 223
ASN N 226
LEU N 227
 None
 0.36A 5i1pA-6cetN:
undetectable		 5i1pA-6cetN:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 6cet GATOR COMPLEX
PROTEIN DEPDC5
(Homo
sapiens) 		3 / 3 GLY D 188
ASP D 189
ASN D 197
 None
 0.59A 5jglA-6cetD:
undetectable		 5jglA-6cetD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M78_A_SALA304_1
(CARBONIC ANHYDRASE 2)		 6cet GATOR COMPLEX
PROTEIN DEPDC5
GATOR COMPLEX
PROTEIN NPRL2
(Homo
sapiens) 		4 / 7 VAL D 340
LEU N 191
THR N 192
THR N 193
 None
 0.86A 5m78A-6cetD:
undetectable		 5m78A-6cetD:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_2
(WTFP-TAG,GP41)		 6cet GATOR COMPLEX
PROTEIN DEPDC5
(Homo
sapiens) 		3 / 3 LEU D1415
LEU D1416
TRP D1405
 None
 0.91A 5nwuA-6cetD:
undetectable		 5nwuA-6cetD:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA307_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 6cet GATOR COMPLEX
PROTEIN DEPDC5
(Homo
sapiens) 		4 / 5 ASP D 297
GLU D 344
ARG D 223
THR D 300
 None
 1.41A 5uxcA-6cetD:
undetectable		 5uxcA-6cetD:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_A_NCAA402_0
(NADPH DEHYDROGENASE
3)		 6cet GATOR COMPLEX
PROTEIN DEPDC5
(Homo
sapiens) 		4 / 8 THR D 353
ASN D 398
PHE D 380
PRO D 400
 None
 1.34A 5v4vA-6cetD:
undetectable		 5v4vA-6cetD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_1
(CYTOCHROME P450 3A4)		 6cet GATOR COMPLEX
PROTEIN DEPDC5
(Homo
sapiens) 		5 / 12 ILE D 803
PHE D1286
THR D1355
ALA D 795
GLU D 979
 None
 1.20A 5vcgA-6cetD:
undetectable		 5vcgA-6cetD:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_1
(CYTOCHROME P450 3A4)		 6cet GATOR COMPLEX
PROTEIN DEPDC5
(Homo
sapiens) 		5 / 12 PHE D 802
PHE D1286
THR D1355
ALA D 795
GLU D 979
 None
 1.27A 5vcgA-6cetD:
undetectable		 5vcgA-6cetD:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 6cet GATOR COMPLEX
PROTEIN NPRL2
GATOR COMPLEX
PROTEIN NPRL3
(Homo
sapiens) 		3 / 3 GLN N 240
ILE N 206
HIS M 518
 None
 0.56A 5z12B-6cetN:
undetectable		 5z12B-6cetN:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 6cet GATOR COMPLEX
PROTEIN DEPDC5
(Homo
sapiens) 		3 / 3 ARG D  80
LEU D  79
PHE D  77
 None
 0.76A 6nknP-6cetD:
undetectable		 6nknP-6cetD:
undetectable