SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6cf6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3004_1
(SERUM ALBUMIN)		 6cf6 TANKYRASE-1
(Mus
musculus) 		4 / 7 GLU A 560
VAL A 566
MET A 567
LEU A 519
 None
 0.75A 1hk3A-6cf6A:
undetectable		 1hk3A-6cf6A:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_A_NCAA1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 6cf6 TANKYRASE-1
(Mus
musculus) 		4 / 7 ARG A 440
SER A 404
SER A 437
GLU A 434
 None
 1.14A 2c8aA-6cf6A:
undetectable		 2c8aA-6cf6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_C_NCAC1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 6cf6 TANKYRASE-1
(Mus
musculus) 		4 / 6 ARG A 440
SER A 404
SER A 437
GLU A 434
 None
 1.14A 2c8aC-6cf6A:
undetectable		 2c8aC-6cf6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 6cf6 TANKYRASE-1
(Mus
musculus) 		4 / 8 LYS A 462
ASN A 458
HIS A 433
MET A 467
 None
 1.34A 3kp6A-6cf6A:
undetectable
3kp6B-6cf6A:
undetectable		 3kp6A-6cf6A:
19.46
3kp6B-6cf6A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 6cf6 TANKYRASE-1
(Mus
musculus) 		3 / 3 PHE A 618
SER A 614
GLN A 616
 None
 0.86A 3smtA-6cf6A:
undetectable		 3smtA-6cf6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_D_ESTD600_1
(ESTROGEN RECEPTOR
BETA)		 6cf6 TANKYRASE-1
(Mus
musculus) 		5 / 12 MET A 577
ALA A 558
LEU A 519
LEU A 538
HIS A 571
 None
 1.24A 4j24D-6cf6A:
undetectable		 4j24D-6cf6A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_D_017D101_2
(PROTEASE)		 6cf6 TANKYRASE-1
(Mus
musculus) 		5 / 9 LEU A 446
GLY A 451
ALA A 452
ASP A 453
THR A 411
 None
 1.17A 4njtD-6cf6A:
undetectable		 4njtD-6cf6A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_E_IPHE101_0
(INSULIN)		 6cf6 TANKYRASE-1
(Mus
musculus) 		5 / 11 ILE A 377
LEU A 366
HIS A 384
LEU A 382
ALA A 386
 None
 1.06A 4p65E-6cf6A:
undetectable
4p65F-6cf6A:
undetectable
4p65J-6cf6A:
undetectable
4p65L-6cf6A:
undetectable		 4p65E-6cf6A:
undetectable
4p65F-6cf6A:
undetectable
4p65J-6cf6A:
undetectable
4p65L-6cf6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_B_RPBB1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 6cf6 TANKYRASE-1
(Mus
musculus) 		5 / 11 HIS A 407
GLY A 406
TYR A 372
ALA A 370
TYR A 405
 None
 1.47A 4rv6B-6cf6A:
undetectable		 4rv6B-6cf6A:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_B_CHDB102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 6cf6 TANKYRASE-1
(Mus
musculus) 		5 / 11 LEU A 473
ARG A 474
LEU A 477
GLU A 434
LEU A 432
 None
 1.06A 4wg0B-6cf6A:
undetectable
4wg0C-6cf6A:
undetectable
4wg0D-6cf6A:
undetectable		 4wg0B-6cf6A:
undetectable
4wg0C-6cf6A:
undetectable
4wg0D-6cf6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_D_CHDD102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 6cf6 TANKYRASE-1
(Mus
musculus) 		5 / 11 LEU A 473
ARG A 474
LEU A 477
GLU A 434
LEU A 432
 None
 1.05A 4wg0D-6cf6A:
undetectable
4wg0E-6cf6A:
undetectable
4wg0F-6cf6A:
undetectable		 4wg0D-6cf6A:
undetectable
4wg0E-6cf6A:
undetectable
4wg0F-6cf6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_F_CHDF103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 6cf6 TANKYRASE-1
(Mus
musculus) 		5 / 11 LEU A 473
ARG A 474
LEU A 477
GLU A 434
LEU A 432
 None
 1.13A 4wg0F-6cf6A:
undetectable
4wg0G-6cf6A:
undetectable
4wg0H-6cf6A:
undetectable		 4wg0F-6cf6A:
undetectable
4wg0G-6cf6A:
undetectable
4wg0H-6cf6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA407_0
(FAD:PROTEIN FMN
TRANSFERASE)		 6cf6 TANKYRASE-1
(Mus
musculus) 		3 / 3 ASP A 425
GLY A 394
ASP A 392
 None
 0.57A 4xdtA-6cf6A:
undetectable		 4xdtA-6cf6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_A_ACTA701_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 6cf6 TANKYRASE-1
(Mus
musculus) 		3 / 3 LYS A 497
LYS A 482
SER A 485
 None
 1.30A 5odiA-6cf6A:
undetectable		 5odiA-6cf6A:
undetectable