SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6cfd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Y_B_MK1B524_1
(PROTEIN (PROTEASE))		 6cfd ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Enterococcus
faecium) 		5 / 11 ALA A 155
VAL A 164
GLY A 184
THR A 169
ILE A 165
 None
 0.94A 1c6yA-6cfdA:
undetectable		 1c6yA-6cfdA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6cfd ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Enterococcus
faecium) 		5 / 10 ILE A  45
ALA A  73
SER A  66
ILE A  64
ILE A  44
 None
 1.20A 1j3jA-6cfdA:
undetectable		 1j3jA-6cfdA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_G_SAMG199_0
(METHIONINE REPRESSOR)		 6cfd ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Enterococcus
faecium) 		5 / 10 GLU A 188
GLU A 178
ALA A 177
ALA A 114
PHE A 113
 None
None
None
None
EZA  A 402 ( 4.6A)
 1.17A 1mjqG-6cfdA:
undetectable
1mjqH-6cfdA:
undetectable		 1mjqG-6cfdA:
undetectable
1mjqH-6cfdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_B_THRB402_0
(ASPARTOKINASE)		 6cfd ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Enterococcus
faecium) 		5 / 9 ILE A 120
ILE A  64
GLY A  94
ALA A  96
THR A  90
 None
 1.34A 2dtjA-6cfdA:
undetectable
2dtjB-6cfdA:
undetectable		 2dtjA-6cfdA:
undetectable
2dtjB-6cfdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_1
(PROTEASE)		 6cfd ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Enterococcus
faecium) 		4 / 8 ASP A  52
ALA A  86
ASP A  87
ASP A  59
 None
 0.56A 3el0A-6cfdA:
undetectable		 3el0A-6cfdA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB262_1
(GLUTAMATE RECEPTOR 2)		 6cfd ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Enterococcus
faecium) 		5 / 10 ILE A  77
SER A  70
GLY A  74
LEU A  32
SER A  66
 None
 1.35A 3ik6B-6cfdA:
undetectable
3ik6E-6cfdA:
undetectable		 3ik6B-6cfdA:
15.29
3ik6E-6cfdA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 6cfd ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Enterococcus
faecium) 		5 / 12 ALA A 106
ILE A  44
ILE A  45
LEU A  48
GLY A  74
 None
 0.66A 3rukB-6cfdA:
undetectable		 3rukB-6cfdA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_1
(HIV-1 PROTEASE)		 6cfd ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Enterococcus
faecium) 		4 / 7 ASP A  52
ALA A  86
ASP A  87
ASP A  59
 None
 0.55A 3t3cA-6cfdA:
undetectable		 3t3cA-6cfdA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_B_017B101_1
(PROTEASE)		 6cfd ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Enterococcus
faecium) 		5 / 11 ALA A 155
VAL A 164
GLY A 184
THR A 169
ILE A 165
 None
 0.96A 4njtA-6cfdA:
undetectable		 4njtA-6cfdA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_D_017D101_1
(PROTEASE)		 6cfd ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Enterococcus
faecium) 		5 / 11 ALA A 155
VAL A 164
GLY A 184
THR A 169
ILE A 165
 None
 0.85A 4njtC-6cfdA:
undetectable		 4njtC-6cfdA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_A_TPVA500_2
(PROTEASE)		 6cfd ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Enterococcus
faecium) 		5 / 10 ALA A 155
VAL A 164
GLY A 184
THR A 169
ILE A 165
 None
 1.01A 4njuB-6cfdA:
undetectable		 4njuB-6cfdA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_C_TPVC500_2
(PROTEASE)		 6cfd ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Enterococcus
faecium) 		5 / 10 ALA A 155
VAL A 164
GLY A 184
THR A 169
ILE A 165
 None
 1.02A 4njuD-6cfdA:
undetectable		 4njuD-6cfdA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 6cfd ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Enterococcus
faecium) 		5 / 12 ALA A 106
ILE A  44
ILE A  45
LEU A  48
GLY A  74
 None
 0.68A 4nkvB-6cfdA:
undetectable		 4nkvB-6cfdA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_B_478B101_1
(HIV-1 PROTEASE)		 6cfd ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Enterococcus
faecium) 		5 / 11 ALA A 155
VAL A 164
GLY A 184
THR A 169
ILE A 165
 None
 0.97A 4rvjA-6cfdA:
undetectable		 4rvjA-6cfdA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_D_478D101_1
(HIV-1 PROTEASE)		 6cfd ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Enterococcus
faecium) 		5 / 11 ALA A 155
VAL A 164
GLY A 184
THR A 169
ILE A 165
 None
 0.96A 4rvjC-6cfdA:
undetectable		 4rvjC-6cfdA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VM8_B_SAMB301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 6cfd ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Enterococcus
faecium) 		5 / 10 MET A  99
GLY A  34
ILE A  44
THR A  37
ALA A  73
 MPD  A 401 (-4.2A)
None
None
None
None
 0.94A 5vm8B-6cfdA:
undetectable		 5vm8B-6cfdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7P_A_SAMA501_0
(OXAC)		 6cfd ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Enterococcus
faecium) 		5 / 12 ALA A 106
GLY A 107
PHE A 102
LEU A 150
ASP A  79
 None
None
None
MPD  A 401 (-4.4A)
None
 1.15A 5w7pA-6cfdA:
undetectable		 5w7pA-6cfdA:
undetectable