SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6cfs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_B_CQAB401_0
(HISTAMINE
N-METHYLTRANSFERASE)		 6cfs PHOSPHOMANNOMUTASE 1
(Homo
sapiens) 		4 / 7 GLY A  49
PHE A  18
ASP A  19
THR A 246
 None
None
MG  A 301 (-2.4A)
None
 1.17A 2aouB-6cfsA:
undetectable		 2aouB-6cfsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_C_SAMC604_1
(HYPOTHETICAL PROTEIN)		 6cfs PHOSPHOMANNOMUTASE 1
(Homo
sapiens) 		4 / 4 GLY A  88
GLU A  71
ASP A  67
TYR A  56
 None
 1.47A 2yvlC-6cfsA:
undetectable		 2yvlC-6cfsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_B_C2FB300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 6cfs PHOSPHOMANNOMUTASE 1
(Homo
sapiens) 		5 / 12 ASP A 226
LEU A  17
GLY A  52
SER A  54
GLN A  62
 MG  A 301 ( 4.3A)
None
None
None
None
 1.22A 4djfB-6cfsA:
undetectable		 4djfB-6cfsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_B_C2FB300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 6cfs PHOSPHOMANNOMUTASE 1
(Homo
sapiens) 		5 / 12 ILE A 229
LEU A  17
GLY A  52
SER A  54
GLN A  62
 None
 1.29A 4djfB-6cfsA:
undetectable		 4djfB-6cfsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_A_ADNA1002_1
(MYOSIN HEAVY CHAIN
KINASE A)		 6cfs PHOSPHOMANNOMUTASE 1
(Homo
sapiens) 		5 / 11 GLY A 224
VAL A  51
LEU A  24
LEU A  17
THR A  23
 None
 1.17A 4zmeA-6cfsA:
undetectable		 4zmeA-6cfsA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2Q_A_ACTA1728_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9)		 6cfs PHOSPHOMANNOMUTASE 1
(Homo
sapiens) 		3 / 3 ASN A 137
SER A 139
ARG A 150
 None
 0.92A 5b2qA-6cfsA:
undetectable		 5b2qA-6cfsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 6cfs PHOSPHOMANNOMUTASE 1
(Homo
sapiens) 		4 / 7 GLY A 126
THR A 127
PHE A 128
SER A 188
 None
 0.65A 6jnhA-6cfsA:
4.1		 6jnhA-6cfsA:
undetectable