SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6cfw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1B02_A_C2FA281_0
(PROTEIN (THYMIDYLATE
SYNTHASE))		 6cfw MBH SUBUNIT
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT C
(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		5 / 11 ALA G  93
THR G  97
ILE G  27
LEU D  40
ALA D  45
 None
 1.15A 1b02A-6cfwG:
undetectable		 1b02A-6cfwG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB8_0
(GRAMICIDIN A)		 6cfw MEMBRANE-BOUND
HYDROGENASE SUBUNIT
ALPHA
(Pyrococcus
furiosus) 		3 / 3 VAL L 327
VAL L 337
TRP L 339
 None
 0.68A 1bdwA-6cfwL:
undetectable
1bdwB-6cfwL:
undetectable		 1bdwA-6cfwL:
undetectable
1bdwB-6cfwL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZF_A_TMQA170_1
(DIHYDROFOLATE
REDUCTASE)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT D
(Pyrococcus
furiosus) 		6 / 12 LEU H 442
ALA H 394
LEU H 357
PHE H 445
LEU H 376
ALA H 441
 None
 1.11A 1bzfA-6cfwH:
undetectable		 1bzfA-6cfwH:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4001_1
(SERUM ALBUMIN)		 6cfw MBH13 NADH
DEHYDROGENASE
SUBUNIT
(Pyrococcus
furiosus) 		5 / 9 LEU M 227
ILE M 230
PHE M  68
VAL M 118
GLY M 117
 None
 0.89A 1e7aB-6cfwM:
undetectable		 1e7aB-6cfwM:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4004_1
(SERUM ALBUMIN)		 6cfw MBH13 NADH
DEHYDROGENASE
SUBUNIT
(Pyrococcus
furiosus) 		4 / 4 VAL M 273
PHE M 239
SER M 243
VAL M 246
 None
 1.11A 1e7cA-6cfwM:
2.3		 1e7cA-6cfwM:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 6cfw MBH SUBUNIT
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT C
(Pyrococcus
furiosus) 		5 / 12 ILE G  40
LEU E  10
LEU G  20
ALA G  19
ILE G  36
 None
 1.25A 1g5yB-6cfwG:
undetectable		 1g5yB-6cfwG:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT D
(Pyrococcus
furiosus) 		5 / 12 ILE H   7
LEU F  82
ALA F  85
LEU H  12
ILE H   8
 None
 1.30A 1g5yB-6cfwH:
2.3		 1g5yB-6cfwH:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GM7_B_PNNB1577_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 6cfw MBH SUBUNIT
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT C
(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		4 / 8 SER G  46
ALA G   3
PHE E  29
ILE G   2
 None
 1.03A 1gm7A-6cfwG:
undetectable
1gm7B-6cfwG:
undetectable		 1gm7A-6cfwG:
undetectable
1gm7B-6cfwG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT F
MBH SUBUNIT
(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		3 / 3 GLN D  19
TYR B  52
ARG B  54
 None
 0.64A 1gtbA-6cfwD:
undetectable		 1gtbA-6cfwD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_H_BEZH1162_0
(PEROXIREDOXIN 5)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT E
(Pyrococcus
furiosus) 		5 / 9 THR A 119
PRO A 120
GLY A 121
LEU A 112
THR A 124
 None
 1.30A 1h4oH-6cfwA:
undetectable		 1h4oH-6cfwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		 6cfw MBH SUBUNIT
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT F
(Pyrococcus
furiosus) 		5 / 11 ALA B  33
LEU B  21
LEU D  52
SER D  50
ALA D  47
 None
 0.99A 1h9zA-6cfwB:
4.2		 1h9zA-6cfwB:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		 6cfw MBH SUBUNIT
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT F
(Pyrococcus
furiosus) 		5 / 11 ALA B  33
LEU B  21
LEU D  52
SER D  50
ALA D  47
 None
 0.97A 1ha2A-6cfwB:
4.7		 1ha2A-6cfwB:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JB0_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT C
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT D
(Pyrococcus
furiosus) 		5 / 11 MET H 170
PHE H 171
SER H 174
ALA G  32
LEU G  29
 None
 1.45A 1jb0B-6cfwH:
2.5		 1jb0B-6cfwH:
7.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTX_A_CVIA200_0
(HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR IN QACA
5'REGION)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT F
MBH SUBUNIT
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT C
(Pyrococcus
furiosus;
Pyrococcus
furiosus;
Pyrococcus
furiosus) 		5 / 12 TYR B  64
ILE B  41
GLU D  56
ILE G  45
ALA D  62
 None
 1.05A 1jtxA-6cfwB:
undetectable		 1jtxA-6cfwB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTX_A_CVIA200_0
(HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR IN QACA
5'REGION)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT F
MBH SUBUNIT
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT C
(Pyrococcus
furiosus;
Pyrococcus
furiosus;
Pyrococcus
furiosus) 		5 / 12 TYR B  64
ILE B  41
ILE B  44
ILE G  45
ALA D  62
 None
 1.28A 1jtxA-6cfwB:
undetectable		 1jtxA-6cfwB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK2_A_ACAA91_1
(TISSUE-TYPE
PLASMINOGEN
ACTIVATOR)		 6cfw MEMBRANE-BOUND
HYDROGENASE SUBUNIT
ALPHA
(Pyrococcus
furiosus) 		4 / 8 VAL L 150
ASP L 140
HIS L 109
LEU L 113
 None
 1.07A 1pk2A-6cfwL:
undetectable		 1pk2A-6cfwL:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_A_IPHA6012_0
(PHENOL
2-MONOOXYGENASE)		 6cfw MBH SUBUNIT
PROBABLE
MEMBRANE-BOUND
HYDROGENASE SUBUNIT
MBHJ
MBH13 NADH
DEHYDROGENASE
SUBUNIT
(Pyrococcus
furiosus;
Pyrococcus
furiosus;
Pyrococcus
furiosus) 		5 / 10 GLY I  39
GLN J  89
VAL I  38
ILE M  59
GLY I  41
 None
 1.28A 1pn0A-6cfwI:
undetectable		 1pn0A-6cfwI:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 6cfw MBH SUBUNIT
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT C
(Pyrococcus
furiosus) 		5 / 10 SER G  91
LEU E  79
VAL F 129
PHE F  39
VAL G  87
 None
 1.33A 1q23E-6cfwG:
undetectable		 1q23E-6cfwG:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_F_FUAF704_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 6cfw MBH SUBUNIT
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT C
(Pyrococcus
furiosus) 		5 / 11 SER G  91
LEU E  79
VAL F 129
PHE F  39
VAL G  87
 None
 1.30A 1q23F-6cfwG:
undetectable		 1q23F-6cfwG:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_B_C2FB802_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 6cfw MEMBRANE-BOUND
HYDROGENASE SUBUNIT
BETA
MEMBRANE-BOUND
HYDROGENASE SUBUNIT
ALPHA
(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		5 / 12 GLU L  85
GLY K  28
SER K  58
ILE K  59
ILE L 313
 None
 1.10A 1q8jB-6cfwL:
undetectable		 1q8jB-6cfwL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QWC_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 6cfw MBH13 NADH
DEHYDROGENASE
SUBUNIT
PROBABLE
MEMBRANE-BOUND
HYDROGENASE SUBUNIT
MBHJ
(Pyrococcus
furiosus) 		3 / 3 ARG M  29
VAL J  57
TRP J  26
 None
 1.26A 1qwcA-6cfwM:
1.5		 1qwcA-6cfwM:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B
(Pyrococcus
furiosus) 		5 / 12 ILE F  27
GLN F  40
THR F  44
ALA F  46
GLY F 126
 None
 1.10A 1rjdB-6cfwF:
undetectable		 1rjdB-6cfwF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B
(Pyrococcus
furiosus) 		5 / 12 ILE F  27
GLN F  40
THR F  44
ALA F  46
GLY F 126
 None
 1.10A 1rjdC-6cfwF:
undetectable		 1rjdC-6cfwF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_D_URFD2021_1
(URIDINE
PHOSPHORYLASE)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT F
(Pyrococcus
furiosus) 		4 / 7 GLY F   6
GLN B  80
ILE F   8
VAL F   9
 None
 1.05A 1rxcD-6cfwF:
undetectable		 1rxcD-6cfwF:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_F_URFF2001_1
(URIDINE
PHOSPHORYLASE)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT F
(Pyrococcus
furiosus) 		4 / 7 GLY F   6
GLN B  80
ILE F   8
VAL F   9
 None
 1.00A 1rxcF-6cfwF:
undetectable		 1rxcF-6cfwF:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_L_URFL2071_1
(URIDINE
PHOSPHORYLASE)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT F
(Pyrococcus
furiosus) 		4 / 7 GLY F   6
GLN B  80
ILE F   8
VAL F   9
 None
 1.01A 1rxcL-6cfwF:
undetectable		 1rxcL-6cfwF:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDT_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 6cfw MBH SUBUNIT
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT D
(Pyrococcus
furiosus) 		5 / 10 GLY H 221
GLY H 220
ILE I 107
VAL H 267
ILE H 263
 None
 0.93A 1sdtA-6cfwH:
undetectable		 1sdtA-6cfwH:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_A_DVAA6_0
(MINI-GRAMICIDIN A)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT E
(Pyrococcus
furiosus) 		3 / 3 ALA A  69
VAL A  71
TRP A  74
 None
 0.92A 1tkqA-6cfwA:
undetectable		 1tkqA-6cfwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_A_SAMA302_0
(HYPOTHETICAL PROTEIN
PH0226)		 6cfw PROBABLE
MEMBRANE-BOUND
HYDROGENASE SUBUNIT
MBHJ
MEMBRANE-BOUND
HYDROGENASE SUBUNIT
ALPHA
MBH13 NADH
DEHYDROGENASE
SUBUNIT
(Pyrococcus
furiosus;
Pyrococcus
furiosus;
Pyrococcus
furiosus) 		5 / 12 TYR M 125
ALA M 215
GLY M 217
SER J  62
HIS L  16
 None
 1.19A 1ve3A-6cfwM:
undetectable		 1ve3A-6cfwM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_1
(RETINOIC ACID
RECEPTOR, BETA)		 6cfw MBH SUBUNIT
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT F
(Pyrococcus
furiosus) 		5 / 12 ALA B  13
LEU B  37
LEU B  40
ILE B  41
LEU D  52
 None
 1.12A 1xdkB-6cfwB:
undetectable		 1xdkB-6cfwB:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_1
(RETINOIC ACID
RECEPTOR, BETA)		 6cfw MBH SUBUNIT
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT F
(Pyrococcus
furiosus) 		5 / 12 ALA B  13
LEU B  37
LEU B  40
ILE B  44
LEU D  52
 None
 1.10A 1xdkB-6cfwB:
undetectable		 1xdkB-6cfwB:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 6cfw MEMBRANE-BOUND
HYDROGENASE SUBUNIT
ALPHA
(Pyrococcus
furiosus) 		4 / 5 ILE L 371
ARG L 342
LEU L 349
ASN L 348
 None
 0.94A 1y0xX-6cfwL:
undetectable		 1y0xX-6cfwL:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT D
(Pyrococcus
furiosus) 		4 / 7 PRO H 466
LEU H 359
GLY H 362
PRO H 459
 None
 0.86A 1ya4B-6cfwH:
0.1		 1ya4B-6cfwH:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT D
(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		5 / 12 ILE H  20
GLY F  75
LEU H  12
LEU F  79
ILE H 121
 None
 1.16A 1zq9A-6cfwH:
undetectable		 1zq9A-6cfwH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT D
(Pyrococcus
furiosus) 		4 / 7 LEU H 124
GLY H 128
THR H 132
ILE H  76
 None
 0.81A 2bdmA-6cfwH:
undetectable		 2bdmA-6cfwH:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BLA_A_CP6A302_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT C
(Pyrococcus
furiosus) 		5 / 11 ALA G   9
SER G  82
ILE G  83
ILE G  45
THR G   8
 None
 1.20A 2blaA-6cfwG:
undetectable		 2blaA-6cfwG:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2002_1
(SERUM ALBUMIN)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT E
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT F
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT G
(Pyrococcus
furiosus) 		5 / 10 ALA C  98
ALA C  95
LEU A 123
LEU C  35
VAL B  32
 None
 1.24A 2bxeA-6cfwC:
3.8		 2bxeA-6cfwC:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_C_SPMC1434_1
(NITROALKANE OXIDASE)		 6cfw MEMBRANE-BOUND
HYDROGENASE SUBUNIT
ALPHA
MEMBRANE-BOUND
HYDROGENASE SUBUNIT
BETA
(Pyrococcus
furiosus) 		5 / 12 GLN L  49
MET K 120
LEU K 136
VAL L  48
LEU L  45
 None
 1.22A 2c12C-6cfwL:
undetectable		 2c12C-6cfwL:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_F_SPMF1433_1
(NITROALKANE OXIDASE)		 6cfw MEMBRANE-BOUND
HYDROGENASE SUBUNIT
ALPHA
MEMBRANE-BOUND
HYDROGENASE SUBUNIT
BETA
(Pyrococcus
furiosus) 		5 / 11 GLN L  49
MET K 120
LEU K 136
VAL L  48
LEU L  45
 None
 1.28A 2c12F-6cfwL:
1.4		 2c12F-6cfwL:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CPP_A_CAMA422_0
(CYTOCHROME P450-CAM)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT C
(Pyrococcus
furiosus) 		4 / 7 THR G  97
LEU G  33
VAL G  30
VAL G 109
 None
 0.91A 2cppA-6cfwG:
undetectable		 2cppA-6cfwG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 6cfw MBH SUBUNIT
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B
(Pyrococcus
furiosus) 		5 / 8 GLY D  75
GLY F  47
THR F  44
ALA F  43
ALA F  46
 None
 1.10A 2ej3A-6cfwD:
undetectable		 2ej3A-6cfwD:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_B_GBNB914_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 6cfw MBH SUBUNIT
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B
(Pyrococcus
furiosus) 		5 / 10 GLY D  75
GLY F  47
THR F  44
ALA F  43
ALA F  46
 None
 1.07A 2ej3B-6cfwD:
undetectable		 2ej3B-6cfwD:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H79_A_T3A1_1
(THRA PROTEIN)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT D
(Pyrococcus
furiosus) 		5 / 12 ILE H 284
ILE H 285
ALA H 288
ALA H 343
LEU H 324
 None
 1.10A 2h79A-6cfwH:
undetectable		 2h79A-6cfwH:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6cfw MBH13 NADH
DEHYDROGENASE
SUBUNIT
(Pyrococcus
furiosus) 		4 / 6 LEU M 315
VAL M 276
VAL M 248
MET M 152
 None
 1.19A 2hyyB-6cfwM:
undetectable		 2hyyB-6cfwM:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JC9_A_ADNA1497_1
(CYTOSOLIC PURINE
5'-NUCLEOTIDASE)		 6cfw MEMBRANE-BOUND
HYDROGENASE SUBUNIT
ALPHA
(Pyrococcus
furiosus) 		4 / 7 ASP L 372
THR L 345
ILE L 352
PHE L  25
 None
NFU  L 401 (-3.7A)
None
None
 1.06A 2jc9A-6cfwL:
2.5		 2jc9A-6cfwL:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_2
(ESTROGEN RECEPTOR)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT F
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT G
(Pyrococcus
furiosus) 		4 / 4 LEU B  73
THR B  72
ILE F   8
HIS C  92
 None
 1.14A 2jfaB-6cfwB:
undetectable		 2jfaB-6cfwB:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_B_D16B568_1
(THYMIDYLATE SYNTHASE)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT D
(Pyrococcus
furiosus) 		5 / 12 LEU H 199
LEU H 186
GLY H 183
VAL H 210
ALA H 211
 None
 1.22A 2kceB-6cfwH:
undetectable		 2kceB-6cfwH:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA501_1
(CYTOCHROME P450 2C8)		 6cfw MBH SUBUNIT
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT C
(Pyrococcus
furiosus) 		5 / 11 GLY E  85
ILE G  94
SER G  91
ALA D  84
THR D  88
 None
 1.06A 2nnhA-6cfwE:
undetectable		 2nnhA-6cfwE:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_E_MTXE621_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 6cfw MBH SUBUNIT
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT C
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT D
(Pyrococcus
furiosus) 		6 / 12 LEU E  17
LEU H 182
PHE H 179
SER H 178
ILE G  17
LEU H 175
 None
 1.43A 2oipE-6cfwE:
undetectable		 2oipE-6cfwE:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_B_ACTB141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 6cfw PROBABLE
MEMBRANE-BOUND
HYDROGENASE SUBUNIT
MBHJ
MEMBRANE-BOUND
HYDROGENASE SUBUNIT
ALPHA
NADH-PLASTOQUINONE
OXIDOREDUCTASE
SUBUNIT
(Pyrococcus
furiosus;
Pyrococcus
furiosus;
Pyrococcus
furiosus) 		3 / 3 PRO J 133
ASN L 148
ARG N  36
 SF4  J 201 ( 3.8A)
None
None
 0.99A 2qeuB-6cfwJ:
undetectable		 2qeuB-6cfwJ:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT C
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT E
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT G
(Pyrococcus
furiosus) 		4 / 7 SER C  76
THR G  63
ILE C  54
GLY A  20
 None
 0.95A 2v0mB-6cfwC:
undetectable		 2v0mB-6cfwC:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLK_B_SPMB1302_1
(ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL 10)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT D
(Pyrococcus
furiosus) 		4 / 4 ALA H 154
TYR H 150
ALA H 165
TYR H 169
 None
 1.24A 2wlkA-6cfwH:
2.5
2wlkB-6cfwH:
2.2		 2wlkA-6cfwH:
16.72
2wlkB-6cfwH:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_B_CTCB1385_0
(TETX2 PROTEIN)		 6cfw MEMBRANE-BOUND
HYDROGENASE SUBUNIT
BETA
MEMBRANE-BOUND
HYDROGENASE SUBUNIT
ALPHA
(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		4 / 8 ARG L  54
GLY L  47
PRO K 146
GLY K 153
 None
 0.93A 2y6rB-6cfwL:
undetectable		 2y6rB-6cfwL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_A_RBFA191_1
(LUMAZINE PROTEIN)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT E
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT G
(Pyrococcus
furiosus) 		5 / 12 VAL A 136
LEU A 123
ALA C  91
THR C  39
ASN A 114
 None
 1.21A 3a35A-6cfwA:
undetectable		 3a35A-6cfwA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_B_RBFB191_1
(LUMAZINE PROTEIN)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT E
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT G
(Pyrococcus
furiosus) 		5 / 12 VAL A 136
LEU A 123
ALA C  91
THR C  39
ASN A 114
 None
 1.20A 3a35B-6cfwA:
undetectable		 3a35B-6cfwA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3B_A_RBFA191_1
(LUMAZINE PROTEIN)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT E
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT G
(Pyrococcus
furiosus) 		5 / 12 VAL A 136
LEU A 123
ALA C  91
THR C  39
ASN A 114
 None
 1.18A 3a3bA-6cfwA:
undetectable		 3a3bA-6cfwA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A65_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 6cfw MBH SUBUNIT
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT F
(Pyrococcus
furiosus) 		5 / 12 ALA D  74
VAL B  34
TYR B  64
SER B  68
GLY D  73
 None
 1.49A 3a65A-6cfwD:
undetectable		 3a65A-6cfwD:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 6cfw MBH SUBUNIT
(Pyrococcus
furiosus) 		4 / 5 ILE E  59
TYR E  67
ARG E  68
THR E  42
 None
 1.48A 3abkN-6cfwE:
undetectable
3abkW-6cfwE:
undetectable		 3abkN-6cfwE:
undetectable
3abkW-6cfwE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_2
(PHOSPHOLIPASE A2)		 6cfw MBH13 NADH
DEHYDROGENASE
SUBUNIT
NADH-PLASTOQUINONE
OXIDOREDUCTASE
SUBUNIT
(Pyrococcus
furiosus) 		4 / 5 ILE M  39
PRO N  22
PHE N  23
PRO N  24
 None
 1.33A 3bjwC-6cfwM:
undetectable		 3bjwC-6cfwM:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_0
(COMT PROTEIN)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT F
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT G
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT C
(Pyrococcus
furiosus;
Pyrococcus
furiosus;
Pyrococcus
furiosus) 		5 / 12 GLU G  66
GLY G  64
TYR G  62
ILE B  56
GLN C  71
 None
 1.45A 3bwyA-6cfwG:
undetectable		 3bwyA-6cfwG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_A_BEZA261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B
(Pyrococcus
furiosus) 		4 / 8 HIS F  32
GLY F  31
ASN F 122
PHE F 105
 None
 1.37A 3ccfA-6cfwF:
undetectable		 3ccfA-6cfwF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFL_A_5CHA693_1
(LACTOTRANSFERRIN)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT E
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT G
(Pyrococcus
furiosus) 		4 / 4 THR C  33
VAL A  83
GLY A  90
THR A  89
 None
 1.09A 3cflA-6cfwC:
undetectable		 3cflA-6cfwC:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_B_TMQB612_1
(DHFR-TS)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT D
(Pyrococcus
furiosus) 		5 / 12 ALA H  33
ILE H 119
SER H 245
PRO H 243
ILE H 103
 None
 0.94A 3clbB-6cfwH:
undetectable		 3clbB-6cfwH:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 6cfw MBH SUBUNIT
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT C
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT D
(Pyrococcus
furiosus;
Pyrococcus
furiosus;
Pyrococcus
furiosus) 		4 / 4 ILE H 163
THR D  88
LYS D  87
TYR G 104
 None
 1.29A 3elzA-6cfwH:
0.0		 3elzA-6cfwH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 6cfw PROBABLE
MEMBRANE-BOUND
HYDROGENASE SUBUNIT
MBHJ
NADH-PLASTOQUINONE
OXIDOREDUCTASE
SUBUNIT
(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		4 / 6 ILE N 111
THR J 104
PHE J 128
TYR N 106
 None
 1.31A 3elzB-6cfwN:
undetectable		 3elzB-6cfwN:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 6cfw PROBABLE
MEMBRANE-BOUND
HYDROGENASE SUBUNIT
MBHJ
(Pyrococcus
furiosus) 		4 / 6 VAL J  27
ILE J 139
ILE J  68
LEU J  69
 None
 0.45A 3hegA-6cfwJ:
undetectable		 3hegA-6cfwJ:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_D_MTXD615_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 6cfw MBH SUBUNIT
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT C
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT D
(Pyrococcus
furiosus) 		6 / 12 LEU E  17
LEU H 182
PHE H 179
SER H 178
ILE G  17
LEU H 175
 None
 1.46A 3hj3D-6cfwE:
undetectable		 3hj3D-6cfwE:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 6cfw PROBABLE
MEMBRANE-BOUND
HYDROGENASE SUBUNIT
MBHJ
NADH-PLASTOQUINONE
OXIDOREDUCTASE
SUBUNIT
(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		5 / 12 PRO N  24
GLY J 142
SER N 102
ASP J 126
ILE J  95
 None
 1.28A 3iv6C-6cfwN:
undetectable		 3iv6C-6cfwN:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 6cfw MEMBRANE-BOUND
HYDROGENASE SUBUNIT
ALPHA
(Pyrococcus
furiosus) 		3 / 3 ARG L 201
ASP L 263
ASP L 202
 None
 0.88A 3jayA-6cfwL:
undetectable		 3jayA-6cfwL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 6cfw MEMBRANE-BOUND
HYDROGENASE SUBUNIT
ALPHA
(Pyrococcus
furiosus) 		3 / 3 ARG L 201
ASP L 263
ASP L 202
 None
 0.77A 3jb2A-6cfwL:
undetectable		 3jb2A-6cfwL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT D
(Pyrococcus
furiosus) 		5 / 12 ILE H 285
GLY H 325
ALA H 339
ALA H 330
VAL H 329
 None
 1.10A 3jb3A-6cfwH:
undetectable		 3jb3A-6cfwH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 6cfw MEMBRANE-BOUND
HYDROGENASE SUBUNIT
ALPHA
(Pyrococcus
furiosus) 		3 / 3 ARG L 201
ASP L 263
ASP L 202
 None
 0.84A 3jb3A-6cfwL:
undetectable		 3jb3A-6cfwL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECLA600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 6cfw MBH SUBUNIT
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT D
(Pyrococcus
furiosus) 		4 / 8 LEU H 112
GLY E  85
ALA H 151
ILE H 246
 None
 0.84A 3jusA-6cfwH:
undetectable		 3jusA-6cfwH:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 6cfw MBH SUBUNIT
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT D
(Pyrococcus
furiosus) 		4 / 8 LEU H 112
GLY E  85
ALA H 151
ILE H 246
 None
 0.84A 3jusA-6cfwH:
undetectable		 3jusA-6cfwH:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT F
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT G
(Pyrococcus
furiosus) 		3 / 3 ARG B  20
THR B  72
THR C  42
 None
 0.54A 3k2hB-6cfwB:
undetectable		 3k2hB-6cfwB:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 6cfw MBH13 NADH
DEHYDROGENASE
SUBUNIT
(Pyrococcus
furiosus) 		4 / 6 LEU M 315
VAL M 276
VAL M 248
MET M 152
 None
 1.18A 3k5vA-6cfwM:
undetectable		 3k5vA-6cfwM:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3008_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 6cfw MEMBRANE-BOUND
HYDROGENASE SUBUNIT
BETA
(Pyrococcus
furiosus) 		4 / 7 GLU K   5
VAL K  85
VAL K  22
ALA K   8
 None
 1.01A 3kp6B-6cfwK:
undetectable		 3kp6B-6cfwK:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_A_URFA254_1
(URIDINE
PHOSPHORYLASE)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT F
(Pyrococcus
furiosus) 		4 / 6 GLY F   6
GLN B  80
ILE F   8
VAL F   9
 None
 1.00A 3kvvA-6cfwF:
undetectable		 3kvvA-6cfwF:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_B_URFB254_1
(URIDINE
PHOSPHORYLASE)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT F
(Pyrococcus
furiosus) 		4 / 6 GLY F   6
GLN B  80
ILE F   8
VAL F   9
 None
 1.00A 3kvvB-6cfwF:
undetectable		 3kvvB-6cfwF:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_C_URFC254_1
(URIDINE
PHOSPHORYLASE)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT F
(Pyrococcus
furiosus) 		4 / 6 GLY F   6
GLN B  80
ILE F   8
VAL F   9
 None
 1.00A 3kvvC-6cfwF:
undetectable		 3kvvC-6cfwF:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_D_URFD254_1
(URIDINE
PHOSPHORYLASE)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT F
(Pyrococcus
furiosus) 		4 / 6 GLY F   6
GLN B  80
ILE F   8
VAL F   9
 None
 1.07A 3kvvD-6cfwF:
undetectable		 3kvvD-6cfwF:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_E_URFE254_1
(URIDINE
PHOSPHORYLASE)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT F
(Pyrococcus
furiosus) 		4 / 6 GLY F   6
GLN B  80
ILE F   8
VAL F   9
 None
 1.03A 3kvvE-6cfwF:
undetectable		 3kvvE-6cfwF:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_F_URFF254_1
(URIDINE
PHOSPHORYLASE)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT F
(Pyrococcus
furiosus) 		4 / 6 GLY F   6
GLN B  80
ILE F   8
VAL F   9
 None
 0.99A 3kvvF-6cfwF:
undetectable		 3kvvF-6cfwF:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_B_P77B204_1
(PROTEIN S100-A4)		 6cfw MEMBRANE-BOUND
HYDROGENASE SUBUNIT
BETA
PROBABLE
MEMBRANE-BOUND
HYDROGENASE SUBUNIT
MBHJ
(Pyrococcus
furiosus) 		4 / 6 MET K 120
GLU K 119
PHE K 140
PHE J 114
 None
 1.13A 3m0wB-6cfwK:
undetectable
3m0wJ-6cfwK:
undetectable		 3m0wB-6cfwK:
21.65
3m0wJ-6cfwK:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 6cfw MBH13 NADH
DEHYDROGENASE
SUBUNIT
(Pyrococcus
furiosus) 		4 / 7 VAL M 276
VAL M 248
ILE M 189
MET M 152
 None
 1.19A 3ms9B-6cfwM:
undetectable		 3ms9B-6cfwM:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_C_OBNC1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 6cfw MBH13 NADH
DEHYDROGENASE
SUBUNIT
PROBABLE
MEMBRANE-BOUND
HYDROGENASE SUBUNIT
MBHJ
(Pyrococcus
furiosus) 		5 / 11 PRO M  46
ASP M  49
LEU M  53
ALA J  66
ARG M  38
 None
 1.40A 3n23C-6cfwM:
undetectable		 3n23C-6cfwM:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_1
(CYTOCHROME P450 3A4)		 6cfw MBH SUBUNIT
MBH13 NADH
DEHYDROGENASE
SUBUNIT
(Pyrococcus
furiosus) 		5 / 12 LEU I  18
THR M  86
PHE I  14
ALA M  71
ILE M 230
 None
 0.99A 3nxuB-6cfwI:
undetectable		 3nxuB-6cfwI:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_1
(CYTOCHROME P450 3A4)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT F
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT G
(Pyrococcus
furiosus) 		5 / 12 SER C  22
THR B  72
ILE B  16
ILE B  44
ALA B  43
 None
 1.15A 3nxuB-6cfwC:
undetectable		 3nxuB-6cfwC:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 6cfw MBH SUBUNIT
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT D
(Pyrococcus
furiosus;
Pyrococcus
furiosus;
Pyrococcus
furiosus) 		5 / 12 ALA F 139
GLY E  85
PHE E  80
ILE E  83
LEU H 118
 None
 1.11A 3o7wA-6cfwF:
undetectable		 3o7wA-6cfwF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B2000_1
(P38A)		 6cfw MEMBRANE-BOUND
HYDROGENASE SUBUNIT
ALPHA
(Pyrococcus
furiosus) 		5 / 10 ILE L 157
ILE L  98
ARG L  99
MET L 154
VAL L  80
 None
 1.38A 3ohtA-6cfwL:
1.7
3ohtB-6cfwL:
2.0		 3ohtA-6cfwL:
14.13
3ohtB-6cfwL:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 6cfw PROBABLE
MEMBRANE-BOUND
HYDROGENASE SUBUNIT
MBHJ
MBH13 NADH
DEHYDROGENASE
SUBUNIT
(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		5 / 12 TYR M 125
GLU M 211
ALA M 215
GLY J  61
SER J  62
 None
 1.44A 3ou6D-6cfwM:
undetectable		 3ou6D-6cfwM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_0
(16S RRNA METHYLASE)		 6cfw MBH SUBUNIT
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT C
(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		5 / 12 GLY D  73
ALA D  45
ALA D  42
LEU D  80
LEU G  31
 None
 1.02A 3p2kC-6cfwD:
undetectable		 3p2kC-6cfwD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PCQ_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT C
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT D
(Pyrococcus
furiosus) 		5 / 11 MET H 170
PHE H 171
SER H 174
ALA G  32
LEU G  29
 None
 1.45A 3pcqB-6cfwH:
undetectable		 3pcqB-6cfwH:
7.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_H_LFXH101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 6cfw MBH13 NADH
DEHYDROGENASE
SUBUNIT
(Pyrococcus
furiosus) 		4 / 5 SER M 123
GLY M 217
GLU M 234
GLU M 209
 None
 1.46A 3raeB-6cfwM:
undetectable
3raeD-6cfwM:
undetectable		 3raeB-6cfwM:
9.93
3raeD-6cfwM:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUN_A_CCSA165_0
(LYSOZYME)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT D
MBH13 NADH
DEHYDROGENASE
SUBUNIT
(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		3 / 3 ASN M  65
ALA M  64
LYS H 381
 None
 0.85A 3runA-6cfwM:
undetectable		 3runA-6cfwM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S68_A_SAMA228_1
(CATECHOL
O-METHYLTRANSFERASE)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT E
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT G
(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		5 / 12 ASN A  80
VAL A  77
ASN C  87
ALA C  82
PHE A  73
 None
 1.43A 3s68A-6cfwA:
undetectable		 3s68A-6cfwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP6_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT E
(Pyrococcus
furiosus) 		5 / 12 THR A  45
SER A  44
ILE F  45
VAL F 134
TYR F  70
 None
 1.45A 3sp6A-6cfwA:
undetectable		 3sp6A-6cfwA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUG_A_SUEA1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 6cfw MBH SUBUNIT
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT C
(Pyrococcus
furiosus) 		4 / 5 GLN D  19
PHE D  20
TYR G   6
LEU D  28
 None
 1.33A 3sugA-6cfwD:
undetectable		 3sugA-6cfwD:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_2
(HIV-1 PROTEASE)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT E
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT G
(Pyrococcus
furiosus) 		5 / 10 ALA A  84
ILE A  88
GLY A  90
ILE A  92
ALA C  24
 None
 1.03A 3t3cB-6cfwA:
undetectable		 3t3cB-6cfwA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_A_CYZA266_2
(GLUTAMATE RECEPTOR 2)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT E
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT G
(Pyrococcus
furiosus) 		4 / 5 PRO C  67
SER A  27
LYS A  22
GLY A  23
 None
 1.14A 3tkdB-6cfwC:
undetectable		 3tkdB-6cfwC:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_B_CYZB267_1
(GLUTAMATE RECEPTOR 2)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT E
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT G
(Pyrococcus
furiosus) 		4 / 5 PRO C  67
SER A  27
LYS A  22
GLY A  23
 None
 1.14A 3tkdA-6cfwC:
undetectable		 3tkdA-6cfwC:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U52_A_CUA515_0
(PHENOL HYDROXYLASE
COMPONENT PHL
PHENOL HYDROXYLASE
COMPONENT PHN)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT D
(Pyrococcus
furiosus) 		3 / 3 HIS H 350
HIS H 346
ILE H 320
 None
 0.78A 3u52A-6cfwH:
1.0
3u52C-6cfwH:
3.0		 3u52A-6cfwH:
undetectable
3u52C-6cfwH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		 6cfw MEMBRANE-BOUND
HYDROGENASE SUBUNIT
ALPHA
MEMBRANE-BOUND
HYDROGENASE SUBUNIT
BETA
(Pyrococcus
furiosus) 		5 / 12 ARG L  54
GLY L  47
PRO K 146
GLY K 153
GLU K 151
 None
 1.31A 3v3oB-6cfwL:
undetectable		 3v3oB-6cfwL:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT D
(Pyrococcus
furiosus) 		3 / 3 THR H  92
VAL H  88
GLU H 123
 None
 0.67A 3v4tA-6cfwH:
undetectable
3v4tD-6cfwH:
undetectable		 3v4tA-6cfwH:
undetectable
3v4tD-6cfwH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT E
(Pyrococcus
furiosus) 		5 / 12 LEU A  72
ALA A 162
GLN A 108
ARG A  55
THR A 119
 None
 1.48A 3vhuA-6cfwA:
undetectable		 3vhuA-6cfwA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_2
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 6cfw MEMBRANE-BOUND
HYDROGENASE SUBUNIT
ALPHA
PROBABLE
MEMBRANE-BOUND
HYDROGENASE SUBUNIT
MBHJ
(Pyrococcus
furiosus) 		4 / 4 PRO L 373
LEU L  19
HIS J  29
LEU J  70
 None
 1.48A 3vw7A-6cfwL:
0.7		 3vw7A-6cfwL:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_D_CAMD502_0
(CAMPHOR
5-MONOOXYGENASE)		 6cfw MBH13 NADH
DEHYDROGENASE
SUBUNIT
(Pyrococcus
furiosus) 		4 / 5 LEU M 137
GLY M 133
THR M 218
VAL M 118
 None
 1.09A 3wrkD-6cfwM:
1.2		 3wrkD-6cfwM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_D_DVAD8_0
(VAL-GRAMICIDIN A)		 6cfw MBH13 NADH
DEHYDROGENASE
SUBUNIT
(Pyrococcus
furiosus) 		3 / 3 TRP M 252
VAL M 248
TRP M 175
 None
 1.24A 3zq8C-6cfwM:
undetectable
3zq8D-6cfwM:
undetectable		 3zq8C-6cfwM:
undetectable
3zq8D-6cfwM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZTV_A_ADNA1600_1
(NAD NUCLEOTIDASE)		 6cfw MBH SUBUNIT
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B
(Pyrococcus
furiosus) 		5 / 9 GLY F  37
GLY F  38
PHE E  65
GLY F  36
ASP D  64
 None
 1.17A 3ztvA-6cfwF:
undetectable		 3ztvA-6cfwF:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		 6cfw MEMBRANE-BOUND
HYDROGENASE SUBUNIT
ALPHA
MEMBRANE-BOUND
HYDROGENASE SUBUNIT
BETA
(Pyrococcus
furiosus) 		5 / 11 ARG L  54
GLY L  47
PRO K 146
GLY K 153
GLU K 151
 None
 1.25A 4a6nA-6cfwL:
undetectable		 4a6nA-6cfwL:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_B_T1CB392_1
(TETX2 PROTEIN)		 6cfw MEMBRANE-BOUND
HYDROGENASE SUBUNIT
ALPHA
MEMBRANE-BOUND
HYDROGENASE SUBUNIT
BETA
(Pyrococcus
furiosus) 		5 / 11 ARG L  54
GLY L  47
PRO K 146
GLY K 153
GLU K 151
 None
 1.25A 4a6nB-6cfwL:
undetectable		 4a6nB-6cfwL:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 6cfw MBH13 NADH
DEHYDROGENASE
SUBUNIT
MEMBRANE-BOUND
HYDROGENASE SUBUNIT
ALPHA
(Pyrococcus
furiosus) 		4 / 6 ILE M 287
PHE M 204
TYR L 124
VAL L 366
 None
 1.10A 4a97I-6cfwM:
5.1		 4a97I-6cfwM:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 6cfw MBH SUBUNIT
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B
(Pyrococcus
furiosus) 		4 / 4 ASN F 122
SER F 107
LEU F 113
THR E  61
 None
 1.49A 4an2A-6cfwF:
undetectable		 4an2A-6cfwF:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CD2_A_FOLA207_0
(DIHYDROFOLATE
REDUCTASE)		 6cfw MEMBRANE-BOUND
HYDROGENASE SUBUNIT
ALPHA
(Pyrococcus
furiosus) 		5 / 12 ILE L 368
ALA L 353
PHE L  25
THR L 345
LEU L 375
 None
None
None
NFU  L 401 (-3.7A)
None
 1.26A 4cd2A-6cfwL:
undetectable		 4cd2A-6cfwL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_A_ADNA401_1
(APH(2'')-ID)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT C
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT D
(Pyrococcus
furiosus) 		5 / 10 ALA H 241
LYS H 168
ILE H 167
HIS G 103
ILE H 163
 None
 1.25A 4dtaA-6cfwH:
undetectable		 4dtaA-6cfwH:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_B_URFB1301_1
(URIDINE
PHOSPHORYLASE)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT F
(Pyrococcus
furiosus) 		4 / 7 GLY F   6
GLN B  80
ILE F   8
VAL F   9
 None
 1.02A 4e1vB-6cfwF:
undetectable		 4e1vB-6cfwF:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_F_URFF1301_1
(URIDINE
PHOSPHORYLASE)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT F
(Pyrococcus
furiosus) 		4 / 6 GLY F   6
GLN B  80
ILE F   8
VAL F   9
 None
 1.04A 4e1vF-6cfwF:
undetectable		 4e1vF-6cfwF:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_G_URFG1301_1
(URIDINE
PHOSPHORYLASE)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT F
(Pyrococcus
furiosus) 		4 / 8 GLY F   6
GLN B  80
ILE F   8
VAL F   9
 None
 0.97A 4e1vG-6cfwF:
undetectable		 4e1vG-6cfwF:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT E
(Pyrococcus
furiosus) 		5 / 10 PHE F  56
ILE A  48
LEU F  51
GLY F  49
PHE F  52
 None
 1.43A 4eb4D-6cfwF:
undetectable		 4eb4D-6cfwF:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 6cfw MBH13 NADH
DEHYDROGENASE
SUBUNIT
(Pyrococcus
furiosus) 		4 / 8 ILE M 134
PRO M  72
VAL M 118
MET M  67
 None
 1.31A 4f4dB-6cfwM:
undetectable		 4f4dB-6cfwM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H2F_A_ADNA601_1
(5'-NUCLEOTIDASE)		 6cfw MBH SUBUNIT
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B
(Pyrococcus
furiosus) 		5 / 9 GLY F  37
GLY F  38
PHE E  65
GLY F  36
ASP D  64
 None
 1.20A 4h2fA-6cfwF:
undetectable		 4h2fA-6cfwF:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H2G_A_ADNA603_1
(5'-NUCLEOTIDASE)		 6cfw MBH SUBUNIT
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B
(Pyrococcus
furiosus) 		5 / 9 GLY F  37
GLY F  38
PHE E  65
GLY F  36
ASP D  64
 None
 1.25A 4h2gA-6cfwF:
undetectable		 4h2gA-6cfwF:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_A_SAMA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT F
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT G
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B
(Pyrococcus
furiosus;
Pyrococcus
furiosus;
Pyrococcus
furiosus) 		5 / 12 VAL C  78
TYR F  26
ILE B  62
ARG B  54
HIS C  75
 None
 0.93A 4iv0A-6cfwC:
undetectable		 4iv0A-6cfwC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_C_ESTC600_1
(ESTROGEN RECEPTOR
BETA)		 6cfw MBH SUBUNIT
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT C
(Pyrococcus
furiosus) 		5 / 12 LEU G  21
LEU I 101
ILE G  36
ILE G  13
LEU G  15
 None
 1.24A 4j24C-6cfwG:
undetectable		 4j24C-6cfwG:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KT0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT C
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT D
(Pyrococcus
furiosus) 		5 / 11 PHE F 117
LEU F 118
GLY F 116
ILE G  74
LEU H 194
 None
 1.08A 4kt0A-6cfwF:
undetectable
4kt0J-6cfwF:
undetectable		 4kt0A-6cfwF:
7.33
4kt0J-6cfwF:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4B_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 6cfw MBH SUBUNIT
MBH SUBUNIT
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT C
(Pyrococcus
furiosus;
Pyrococcus
furiosus;
Pyrococcus
furiosus) 		4 / 8 LEU E  79
VAL G  84
VAL D  76
VAL D  72
 None
 0.94A 4l4bA-6cfwE:
undetectable		 4l4bA-6cfwE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MFL_B_GCSB502_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24
TEICOPLANIN
PSEUDOAGLYCONE)		 6cfw MBH13 NADH
DEHYDROGENASE
SUBUNIT
(Pyrococcus
furiosus) 		4 / 6 MET M 144
TRP M 195
ALA M 247
PHE M 103
 None
 1.13A 4mflA-6cfwM:
undetectable		 4mflA-6cfwM:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MFQ_B_GCSB503_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24
TEICOPLANIN
PSEUDOAGLYCONE)		 6cfw MBH13 NADH
DEHYDROGENASE
SUBUNIT
(Pyrococcus
furiosus) 		4 / 6 MET M 144
TRP M 195
ALA M 247
PHE M 103
 None
 1.07A 4mfqA-6cfwM:
undetectable		 4mfqA-6cfwM:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJQ_A_27RA401_1
(DNA POLYMERASE III
SUBUNIT BETA)		 6cfw MBH SUBUNIT
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT F
(Pyrococcus
furiosus) 		4 / 5 ARG B  54
TYR B  57
PRO D  63
VAL E  60
 None
 1.41A 4mjqA-6cfwB:
undetectable		 4mjqA-6cfwB:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM6_A_29EA603_1
(TRANSPORTER)		 6cfw MBH SUBUNIT
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B
(Pyrococcus
furiosus) 		5 / 12 PHE E  65
PHE F  81
VAL F  80
GLY F  77
THR E  72
 None
 1.07A 4mm6A-6cfwE:
undetectable		 4mm6A-6cfwE:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT F
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT G
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B
(Pyrococcus
furiosus;
Pyrococcus
furiosus;
Pyrococcus
furiosus) 		5 / 12 VAL C  78
TYR F  26
ILE B  62
ARG B  54
HIS C  75
 None
 0.93A 4mwzB-6cfwC:
undetectable		 4mwzB-6cfwC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_2
(ADENOSINE KINASE)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT F
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT G
(Pyrococcus
furiosus) 		4 / 4 LEU B  66
SER B  68
LEU C  83
LEU F  16
 None
 1.04A 4n09A-6cfwB:
undetectable		 4n09A-6cfwB:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_2
(ADENOSINE KINASE)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT F
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT G
(Pyrococcus
furiosus) 		4 / 5 LEU B  66
SER B  68
LEU C  83
LEU F  16
 None
 1.05A 4n09B-6cfwB:
undetectable		 4n09B-6cfwB:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_2
(ADENOSINE KINASE)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT F
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT G
(Pyrococcus
furiosus) 		4 / 5 LEU B  66
SER B  68
LEU C  83
LEU F  16
 None
 1.03A 4n09D-6cfwB:
undetectable		 4n09D-6cfwB:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT D
(Pyrococcus
furiosus) 		5 / 12 ALA H 343
GLY H 325
GLY H 327
ILE H 219
LEU H 223
 None
 0.89A 4n48B-6cfwH:
undetectable		 4n48B-6cfwH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT D
(Pyrococcus
furiosus) 		5 / 12 ALA H 343
GLY H 325
GLY H 327
ILE H 219
LEU H 223
 None
 0.89A 4n49A-6cfwH:
undetectable		 4n49A-6cfwH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NPT_A_017A401_1
(PROTEASE)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT D
(Pyrococcus
furiosus) 		5 / 9 ALA H 264
GLY H 258
ILE H 129
THR H 347
ILE H 344
 None
 1.09A 4nptA-6cfwH:
undetectable		 4nptA-6cfwH:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B
(Pyrococcus
furiosus) 		5 / 12 GLY F  41
GLY F  38
GLY F  37
LEU F 123
GLY F 126
 None
 0.90A 4o33A-6cfwF:
undetectable		 4o33A-6cfwF:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_2
(ANDROGEN RECEPTOR)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT D
(Pyrococcus
furiosus) 		4 / 8 LEU H 223
MET H 328
LEU H 324
ILE H 257
 None
 1.05A 4ok1A-6cfwH:
undetectable		 4ok1A-6cfwH:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKT_A_198A1001_1
(ANDROGEN RECEPTOR)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT D
(Pyrococcus
furiosus) 		5 / 12 LEU H 223
LEU H 222
GLY H 259
VAL H 267
ILE H 320
 None
 1.36A 4oktA-6cfwH:
undetectable		 4oktA-6cfwH:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD5_A_GEOA501_1
(NUPC FAMILY PROTEIN)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B
(Pyrococcus
furiosus) 		5 / 12 GLY F  47
ALA F  46
VAL F 134
TYR F  70
ILE F  17
 None
 1.24A 4pd5A-6cfwF:
undetectable		 4pd5A-6cfwF:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT D
(Pyrococcus
furiosus) 		3 / 3 PRO H 466
MET H 467
TYR H 101
 None
 1.05A 4qa0A-6cfwH:
undetectable		 4qa0A-6cfwH:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT F
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT G
(Pyrococcus
furiosus) 		5 / 11 THR C  86
THR C  43
THR C  42
GLY C  90
THR B  72
 None
 1.31A 4qvlV-6cfwC:
undetectable
4qvlb-6cfwC:
undetectable		 4qvlV-6cfwC:
15.95
4qvlb-6cfwC:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT F
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT G
(Pyrococcus
furiosus) 		5 / 11 THR C  86
THR C  43
THR C  42
GLY C  90
THR B  72
 None
 1.31A 4qvlH-6cfwC:
undetectable
4qvlN-6cfwC:
undetectable		 4qvlH-6cfwC:
15.95
4qvlN-6cfwC:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B
(Pyrococcus
furiosus) 		5 / 9 ALA F  43
THR F  44
ALA F  46
GLY F  37
GLY F  38
 None
 1.07A 4qvmK-6cfwF:
undetectable
4qvmL-6cfwF:
undetectable		 4qvmK-6cfwF:
17.82
4qvmL-6cfwF:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT F
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT G
(Pyrococcus
furiosus) 		5 / 11 THR C  86
THR C  43
THR C  42
GLY C  90
THR B  72
 None
 1.29A 4qvwV-6cfwC:
undetectable
4qvwb-6cfwC:
undetectable		 4qvwV-6cfwC:
15.95
4qvwb-6cfwC:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B
(Pyrococcus
furiosus) 		5 / 11 ALA F  43
THR F  44
ALA F  46
GLY F  37
GLY F  38
 None
 1.06A 4qvwK-6cfwF:
undetectable
4qvwL-6cfwF:
undetectable		 4qvwK-6cfwF:
17.82
4qvwL-6cfwF:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT F
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT G
(Pyrococcus
furiosus) 		5 / 11 THR C  86
THR C  43
THR C  42
GLY C  90
THR B  72
 None
 1.28A 4qvwH-6cfwC:
undetectable
4qvwN-6cfwC:
undetectable		 4qvwH-6cfwC:
15.95
4qvwN-6cfwC:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B
(Pyrococcus
furiosus) 		5 / 11 ALA F  43
THR F  44
ALA F  46
GLY F  37
GLY F  38
 None
 1.06A 4qvwY-6cfwF:
undetectable
4qvwZ-6cfwF:
undetectable		 4qvwY-6cfwF:
17.82
4qvwZ-6cfwF:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT F
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT G
(Pyrococcus
furiosus) 		5 / 11 THR C  86
THR C  43
THR C  42
GLY C  90
THR B  72
 None
 1.30A 4qw0V-6cfwC:
undetectable
4qw0b-6cfwC:
undetectable		 4qw0V-6cfwC:
15.95
4qw0b-6cfwC:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT F
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT G
(Pyrococcus
furiosus) 		5 / 11 THR C  86
THR C  43
THR C  42
GLY C  90
THR B  72
 None
 1.30A 4qw0H-6cfwC:
undetectable
4qw0N-6cfwC:
undetectable		 4qw0H-6cfwC:
15.95
4qw0N-6cfwC:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT F
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT G
(Pyrococcus
furiosus) 		5 / 11 THR C  86
THR C  43
THR C  42
GLY C  90
THR B  72
 None
 1.30A 4qw3V-6cfwC:
undetectable
4qw3b-6cfwC:
undetectable		 4qw3V-6cfwC:
15.95
4qw3b-6cfwC:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B
(Pyrococcus
furiosus) 		5 / 10 ALA F  43
THR F  44
ALA F  46
GLY F  37
GLY F  38
 None
 1.06A 4qw3K-6cfwF:
undetectable
4qw3L-6cfwF:
undetectable		 4qw3K-6cfwF:
17.82
4qw3L-6cfwF:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT F
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT G
(Pyrococcus
furiosus) 		5 / 11 THR C  86
THR C  43
THR C  42
GLY C  90
THR B  72
 None
 1.30A 4qw3H-6cfwC:
undetectable
4qw3N-6cfwC:
undetectable		 4qw3H-6cfwC:
15.95
4qw3N-6cfwC:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B
(Pyrococcus
furiosus) 		5 / 10 ALA F  43
THR F  44
ALA F  46
GLY F  37
GLY F  38
 None
 1.06A 4qw3Y-6cfwF:
undetectable
4qw3Z-6cfwF:
undetectable		 4qw3Y-6cfwF:
17.82
4qw3Z-6cfwF:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT E
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT F
(Pyrococcus
furiosus) 		5 / 9 ILE F  17
LEU A  17
VAL B  63
LEU B  66
ILE B  62
 None
 1.34A 4r38C-6cfwF:
undetectable		 4r38C-6cfwF:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_1
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 6cfw PROBABLE
MEMBRANE-BOUND
HYDROGENASE SUBUNIT
MBHJ
MEMBRANE-BOUND
HYDROGENASE SUBUNIT
ALPHA
(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		3 / 3 GLU L 143
TYR J  50
GLU J 137
 None
 0.70A 4ryaA-6cfwL:
undetectable		 4ryaA-6cfwL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA303_0
(THAUMATIN-1)		 6cfw MBH SUBUNIT
(Pyrococcus
furiosus) 		4 / 7 LEU D  53
GLU D  69
SER D  50
VAL D  77
 None
 1.21A 4tvtA-6cfwD:
undetectable		 4tvtA-6cfwD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA503_1
(PENTALENIC ACID
SYNTHASE)		 6cfw MBH SUBUNIT
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT D
(Pyrococcus
furiosus) 		4 / 7 LEU H 217
ALA E  20
LEU H 186
LEU H 187
 None
 0.81A 4ubsA-6cfwH:
1.4		 4ubsA-6cfwH:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 6cfw PROBABLE
MEMBRANE-BOUND
HYDROGENASE SUBUNIT
MBHJ
(Pyrococcus
furiosus) 		4 / 7 CYH J  38
ILE J  40
PRO J 134
ILE J 139
 SF4  J 201 (-3.0A)
None
None
None
 1.04A 4w5oA-6cfwJ:
undetectable		 4w5oA-6cfwJ:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_B_MZMB303_1
(ALPHA-CARBONIC
ANHYDRASE)		 6cfw MBH13 NADH
DEHYDROGENASE
SUBUNIT
(Pyrococcus
furiosus) 		5 / 10 ASP M  99
VAL M 102
LEU M  82
THR M  78
ALA M  81
 None
 1.25A 4yhaB-6cfwM:
undetectable		 4yhaB-6cfwM:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_F_TR6F101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 6cfw MEMBRANE-BOUND
HYDROGENASE SUBUNIT
ALPHA
(Pyrococcus
furiosus) 		4 / 5 GLY L 329
ARG L 328
GLY L 312
GLU L 311
 None
 1.26A 4z2eB-6cfwL:
2.2
4z2eC-6cfwL:
undetectable		 4z2eB-6cfwL:
10.82
4z2eC-6cfwL:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 6cfw PROBABLE
MEMBRANE-BOUND
HYDROGENASE SUBUNIT
MBHJ
(Pyrococcus
furiosus) 		4 / 7 CYH J  38
ILE J  40
PRO J 134
ILE J 139
 SF4  J 201 (-3.0A)
None
None
None
 1.04A 4z4eA-6cfwJ:
3.5		 4z4eA-6cfwJ:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 6cfw PROBABLE
MEMBRANE-BOUND
HYDROGENASE SUBUNIT
MBHJ
(Pyrococcus
furiosus) 		4 / 7 CYH J  38
ILE J  40
PRO J 134
ILE J 139
 SF4  J 201 (-3.0A)
None
None
None
 1.03A 4z4gA-6cfwJ:
2.2		 4z4gA-6cfwJ:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT F
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT G
(Pyrococcus
furiosus) 		5 / 12 LEU B  47
ILE B   2
GLY C  12
THR C  16
THR B  39
 None
 1.10A 4ze2A-6cfwB:
undetectable		 4ze2A-6cfwB:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT D
(Pyrococcus
furiosus) 		4 / 5 ALA H 242
ARG H 371
ALA H 165
GLU H 161
 None
 1.43A 5a06C-6cfwH:
undetectable
5a06D-6cfwH:
undetectable		 5a06C-6cfwH:
undetectable
5a06D-6cfwH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT D
(Pyrococcus
furiosus) 		4 / 5 ALA H 242
ARG H 371
ALA H 238
GLU H 161
 None
 1.44A 5a06C-6cfwH:
undetectable
5a06D-6cfwH:
undetectable		 5a06C-6cfwH:
undetectable
5a06D-6cfwH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_E_SAME301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT D
(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		5 / 12 GLY F  75
GLY F  78
GLY F 124
LEU F 127
GLU H 113
 None
 1.18A 5c0oE-6cfwF:
undetectable		 5c0oE-6cfwF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT F
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT G
(Pyrococcus
furiosus) 		5 / 11 THR C  86
THR C  43
THR C  42
GLY C  90
THR B  72
 None
 1.31A 5cz7H-6cfwC:
undetectable
5cz7N-6cfwC:
undetectable		 5cz7H-6cfwC:
15.95
5cz7N-6cfwC:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZY_A_SAMA603_0
(LEGIONELLA EFFECTOR
LEGAS4)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT D
(Pyrococcus
furiosus) 		5 / 12 LEU H 187
GLY H 183
TYR H 139
TYR H 191
LEU H 199
 None
 1.24A 5czyA-6cfwH:
undetectable		 5czyA-6cfwH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT F
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT G
(Pyrococcus
furiosus) 		5 / 11 THR C  86
THR C  43
THR C  42
GLY C  90
THR B  72
 None
 1.29A 5d0xV-6cfwC:
undetectable
5d0xb-6cfwC:
undetectable		 5d0xV-6cfwC:
15.95
5d0xb-6cfwC:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B
(Pyrococcus
furiosus) 		5 / 9 ALA F  43
THR F  44
ALA F  46
GLY F  37
GLY F  38
 None
 1.07A 5d0xK-6cfwF:
undetectable
5d0xL-6cfwF:
undetectable		 5d0xK-6cfwF:
17.82
5d0xL-6cfwF:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B
(Pyrococcus
furiosus) 		5 / 9 ALA F  43
THR F  44
ALA F  46
GLY F  37
GLY F  38
 None
 1.07A 5d0xY-6cfwF:
undetectable
5d0xZ-6cfwF:
undetectable		 5d0xY-6cfwF:
17.82
5d0xZ-6cfwF:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHG_C_SAMC4001_0
(RNA-DIRECTED RNA
POLYMERASE NS5)		 6cfw PROBABLE
MEMBRANE-BOUND
HYDROGENASE SUBUNIT
MBHJ
MEMBRANE-BOUND
HYDROGENASE SUBUNIT
ALPHA
(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		5 / 12 GLY J  37
GLY J  73
GLU L  21
VAL L 150
ILE J  40
 SF4  J 201 ( 4.6A)
None
None
None
None
 0.92A 5ehgC-6cfwJ:
undetectable		 5ehgC-6cfwJ:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT F
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT G
(Pyrococcus
furiosus) 		5 / 12 LEU B  47
ILE B   2
GLY C  12
THR C  16
THR B  39
 None
 1.04A 5eskA-6cfwB:
undetectable		 5eskA-6cfwB:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT D
(Pyrococcus
furiosus) 		5 / 12 GLY H 342
GLY H 323
ILE H 320
ILE H 338
LEU H 496
 None
 1.14A 5fa8A-6cfwH:
undetectable		 5fa8A-6cfwH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6cfw MBH13 NADH
DEHYDROGENASE
SUBUNIT
PROBABLE
MEMBRANE-BOUND
HYDROGENASE SUBUNIT
MBHJ
(Pyrococcus
furiosus) 		3 / 3 ARG M  29
VAL J  57
TRP J  26
 None
 1.26A 5fvoA-6cfwM:
1.3		 5fvoA-6cfwM:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 6cfw MEMBRANE-BOUND
HYDROGENASE SUBUNIT
ALPHA
(Pyrococcus
furiosus) 		5 / 9 GLY L 119
ALA L 369
VAL L 118
GLU L  20
ILE L 122
 None
 1.09A 5i3cA-6cfwL:
undetectable		 5i3cA-6cfwL:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_B_AC2B301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 6cfw MEMBRANE-BOUND
HYDROGENASE SUBUNIT
ALPHA
(Pyrococcus
furiosus) 		5 / 10 GLY L 119
ALA L 369
VAL L 118
GLU L  20
ILE L 122
 None
 1.14A 5i3cB-6cfwL:
undetectable		 5i3cB-6cfwL:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_C_AC2C301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 6cfw MEMBRANE-BOUND
HYDROGENASE SUBUNIT
ALPHA
(Pyrococcus
furiosus) 		5 / 11 GLY L 119
ALA L 369
VAL L 118
GLU L  20
ILE L 122
 None
 1.11A 5i3cC-6cfwL:
undetectable		 5i3cC-6cfwL:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 6cfw MBH13 NADH
DEHYDROGENASE
SUBUNIT
MEMBRANE-BOUND
HYDROGENASE SUBUNIT
ALPHA
(Pyrococcus
furiosus) 		5 / 9 ARG L 199
ALA M 296
GLN M 295
PRO M 208
LEU M 136
 None
 1.34A 5i73A-6cfwL:
1.9		 5i73A-6cfwL:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_2
(CDL2.3B)		 6cfw MBH SUBUNIT
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT C
(Pyrococcus
furiosus) 		5 / 9 ILE G  45
VAL D  22
LEU D  23
ILE D  26
TYR G   6
 None
 1.41A 5iepA-6cfwG:
undetectable		 5iepA-6cfwG:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_2
(CDL2.3B)		 6cfw MBH13 NADH
DEHYDROGENASE
SUBUNIT
MEMBRANE-BOUND
HYDROGENASE SUBUNIT
ALPHA
NADH-PLASTOQUINONE
OXIDOREDUCTASE
SUBUNIT
(Pyrococcus
furiosus) 		5 / 9 MET M  35
VAL N  10
LEU N   6
ILE M 287
LEU L 115
 None
 1.45A 5iepA-6cfwM:
undetectable		 5iepA-6cfwM:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_A_GBMA801_1
(PROLINE--TRNA LIGASE)		 6cfw MBH SUBUNIT
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT D
(Pyrococcus
furiosus) 		5 / 12 LEU I 111
THR H 279
ILE H 283
GLY H 281
ILE H 284
 None
 1.26A 5ifuA-6cfwI:
undetectable		 5ifuA-6cfwI:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB603_1
(PHIAB6 TAILSPIKE)		 6cfw MEMBRANE-BOUND
HYDROGENASE SUBUNIT
ALPHA
(Pyrococcus
furiosus) 		3 / 3 VAL L 365
GLU L  21
GLU L  20
 None
 0.92A 5jsdB-6cfwL:
undetectable
5jsdC-6cfwL:
undetectable		 5jsdB-6cfwL:
7.76
5jsdC-6cfwL:
7.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMD_C_6UBC1304_1
(ION TRANSPORT
PROTEIN)		 6cfw MBH SUBUNIT
MBH13 NADH
DEHYDROGENASE
SUBUNIT
(Pyrococcus
furiosus) 		4 / 5 TYR M  14
ILE M 236
LEU I  18
GLY I  17
 None
 0.88A 5kmdC-6cfwM:
undetectable
5kmdD-6cfwM:
undetectable		 5kmdC-6cfwM:
16.49
5kmdD-6cfwM:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT D
(Pyrococcus
furiosus) 		5 / 12 PHE H  96
SER H  95
GLY H  44
VAL H  91
LEU H  89
 None
 1.20A 5kocB-6cfwH:
undetectable		 5kocB-6cfwH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_2
(PROTEASE E35D-DRV)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT D
(Pyrococcus
furiosus) 		4 / 7 GLY H 342
ALA H 341
GLY H 327
ILE H 326
 None
 0.61A 5kqyB-6cfwH:
undetectable		 5kqyB-6cfwH:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_1
(PROTEASE PR5-DRV)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B
(Pyrococcus
furiosus) 		5 / 10 LEU F 133
ALA F  48
GLY F  24
ILE F  27
VAL F 129
 None
 1.02A 5kr1A-6cfwF:
undetectable		 5kr1A-6cfwF:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_J_Z80J401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 6cfw PROBABLE
MEMBRANE-BOUND
HYDROGENASE SUBUNIT
MBHJ
(Pyrococcus
furiosus) 		5 / 12 ILE J  68
ILE J  97
VAL J  27
ASN J  31
ILE J  42
 None
 1.19A 5lg3J-6cfwJ:
undetectable		 5lg3J-6cfwJ:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFP_A_8W5A804_2
(GLUCOCORTICOID
RECEPTOR)		 6cfw MEMBRANE-BOUND
HYDROGENASE SUBUNIT
ALPHA
(Pyrococcus
furiosus) 		4 / 4 LEU L 283
MET L 175
ILE L  98
LEU L 105
 None
 1.33A 5nfpA-6cfwL:
undetectable		 5nfpA-6cfwL:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NY7_A_NCAA303_0
(AMIDASE)		 6cfw MEMBRANE-BOUND
HYDROGENASE SUBUNIT
ALPHA
(Pyrococcus
furiosus) 		4 / 6 ARG L 231
GLY L 103
GLU L 104
SER L 275
 None
 1.11A 5ny7A-6cfwL:
undetectable		 5ny7A-6cfwL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_B_TESB502_1
(-)		 6cfw MBH SUBUNIT
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT C
(Pyrococcus
furiosus) 		5 / 12 LEU G  20
VAL G  30
LEU G  33
LEU I  93
ALA G  93
 None
 1.03A 5og9B-6cfwG:
undetectable		 5og9B-6cfwG:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_1_PQN1842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT C
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT D
(Pyrococcus
furiosus) 		5 / 10 PHE F 117
LEU F 118
GLY F 116
ILE G  74
LEU H 194
 None
 1.09A 5oy01-6cfwF:
2.2
5oy07-6cfwF:
undetectable		 5oy01-6cfwF:
20.00
5oy07-6cfwF:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_1_PQN1842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT C
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT D
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT F
(Pyrococcus
furiosus) 		5 / 10 SER H 174
ALA G  93
LEU G  90
GLY G  86
ILE B  75
 None
 1.24A 5oy01-6cfwH:
undetectable
5oy07-6cfwH:
undetectable		 5oy01-6cfwH:
16.09
5oy07-6cfwH:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA405_0
(THIOREDOXIN
REDUCTASE)		 6cfw MBH13 NADH
DEHYDROGENASE
SUBUNIT
(Pyrococcus
furiosus) 		3 / 3 GLY M 159
LEU M 158
HIS M 172
 None
 0.64A 5u63A-6cfwM:
undetectable		 5u63A-6cfwM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_B_ACTB405_0
(THIOREDOXIN
REDUCTASE)		 6cfw MBH13 NADH
DEHYDROGENASE
SUBUNIT
(Pyrococcus
furiosus) 		3 / 3 GLY M 159
LEU M 158
HIS M 172
 None
 0.69A 5u63B-6cfwM:
undetectable		 5u63B-6cfwM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_1
(CYTOCHROME P450 3A4)		 6cfw MEMBRANE-BOUND
HYDROGENASE SUBUNIT
ALPHA
PROBABLE
MEMBRANE-BOUND
HYDROGENASE SUBUNIT
MBHJ
(Pyrococcus
furiosus) 		5 / 12 ILE L  70
ILE J  40
ALA J  44
THR J  47
ALA L 134
 NFU  L 401 ( 4.8A)
None
None
None
None
 0.95A 5vceA-6cfwL:
undetectable		 5vceA-6cfwL:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_1
(CYTOCHROME P450 3A4)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT E
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT F
(Pyrococcus
furiosus) 		5 / 12 PHE F  23
ILE B  62
ILE B  58
ALA B  55
ALA A  19
 None
 1.07A 5vceA-6cfwF:
undetectable		 5vceA-6cfwF:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_A_SAMA601_0
(NS5
METHYLTRANSFERASE)		 6cfw PROBABLE
MEMBRANE-BOUND
HYDROGENASE SUBUNIT
MBHJ
MEMBRANE-BOUND
HYDROGENASE SUBUNIT
ALPHA
(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		5 / 12 GLY J  37
GLY J  33
VAL L 150
ASP J  39
ILE J  40
 SF4  J 201 ( 4.6A)
None
None
None
None
 0.98A 5wz1A-6cfwJ:
undetectable		 5wz1A-6cfwJ:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_C_SAMC601_0
(NS5
METHYLTRANSFERASE)		 6cfw PROBABLE
MEMBRANE-BOUND
HYDROGENASE SUBUNIT
MBHJ
MEMBRANE-BOUND
HYDROGENASE SUBUNIT
ALPHA
(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		5 / 12 GLY J  37
GLY J  33
VAL L 150
ASP J  39
ILE J  40
 SF4  J 201 ( 4.6A)
None
None
None
None
 1.01A 5wz1C-6cfwJ:
undetectable		 5wz1C-6cfwJ:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_D_SAMD601_0
(NS5
METHYLTRANSFERASE)		 6cfw PROBABLE
MEMBRANE-BOUND
HYDROGENASE SUBUNIT
MBHJ
MEMBRANE-BOUND
HYDROGENASE SUBUNIT
ALPHA
(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		5 / 12 GLY J  37
GLY J  33
VAL L 150
ASP J  39
ILE J  40
 SF4  J 201 ( 4.6A)
None
None
None
None
 1.01A 5wz1D-6cfwJ:
undetectable		 5wz1D-6cfwJ:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_E_SAME601_0
(NS5
METHYLTRANSFERASE)		 6cfw PROBABLE
MEMBRANE-BOUND
HYDROGENASE SUBUNIT
MBHJ
MEMBRANE-BOUND
HYDROGENASE SUBUNIT
ALPHA
(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		5 / 12 GLY J  37
GLY J  33
VAL L 150
ASP J  39
ILE J  40
 SF4  J 201 ( 4.6A)
None
None
None
None
 1.01A 5wz1E-6cfwJ:
undetectable		 5wz1E-6cfwJ:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_F_SAMF601_0
(NS5
METHYLTRANSFERASE)		 6cfw PROBABLE
MEMBRANE-BOUND
HYDROGENASE SUBUNIT
MBHJ
MEMBRANE-BOUND
HYDROGENASE SUBUNIT
ALPHA
(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		5 / 12 GLY J  37
GLY J  33
VAL L 150
ASP J  39
ILE J  40
 SF4  J 201 ( 4.6A)
None
None
None
None
 1.01A 5wz1F-6cfwJ:
undetectable		 5wz1F-6cfwJ:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_G_SAMG601_0
(NS5
METHYLTRANSFERASE)		 6cfw PROBABLE
MEMBRANE-BOUND
HYDROGENASE SUBUNIT
MBHJ
MEMBRANE-BOUND
HYDROGENASE SUBUNIT
ALPHA
(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		5 / 12 GLY J  37
GLY J  33
VAL L 150
ASP J  39
ILE J  40
 SF4  J 201 ( 4.6A)
None
None
None
None
 0.99A 5wz1G-6cfwJ:
undetectable		 5wz1G-6cfwJ:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_H_SAMH601_0
(NS5
METHYLTRANSFERASE)		 6cfw PROBABLE
MEMBRANE-BOUND
HYDROGENASE SUBUNIT
MBHJ
MEMBRANE-BOUND
HYDROGENASE SUBUNIT
ALPHA
(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		5 / 12 GLY J  37
GLY J  33
VAL L 150
ASP J  39
ILE J  40
 SF4  J 201 ( 4.6A)
None
None
None
None
 1.01A 5wz1H-6cfwJ:
undetectable		 5wz1H-6cfwJ:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT E
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT G
(Pyrococcus
furiosus) 		5 / 9 ILE C  47
LEU A 118
ASN C  87
MET A  76
ALA A  79
 None
 1.34A 5x66C-6cfwC:
undetectable		 5x66C-6cfwC:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT D
MBH SUBUNIT
(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		5 / 12 ARG I 114
ILE I 110
ILE H 263
LEU H 223
ILE H 286
 None
 1.00A 5y2tB-6cfwI:
undetectable		 5y2tB-6cfwI:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_C_CHDC401_0
(BILE SALT HYDROLASE)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT E
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B
(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		4 / 8 ILE F  45
PHE F  19
LEU A  13
ALA A  10
 None
 0.72A 5y7pC-6cfwF:
undetectable		 5y7pC-6cfwF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_E_CHDE401_0
(BILE SALT HYDROLASE)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT E
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B
(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		4 / 8 ILE F  45
PHE F  19
LEU A  13
ALA A  10
 None
 0.82A 5y7pE-6cfwF:
undetectable		 5y7pE-6cfwF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 6cfw MBH SUBUNIT
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT D
MBH SUBUNIT
(Pyrococcus
furiosus;
Pyrococcus
furiosus;
Pyrococcus
furiosus) 		3 / 3 MET H 233
ASP I  88
ARG E   3
 None
 0.98A 5z6jA-6cfwH:
undetectable		 5z6jA-6cfwH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT C
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT D
MBH SUBUNIT
(Pyrococcus
furiosus;
Pyrococcus
furiosus;
Pyrococcus
furiosus) 		3 / 3 MET H 298
ASP I  88
ARG G 113
 None
 1.05A 5z6jA-6cfwH:
undetectable		 5z6jA-6cfwH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 6cfw MBH SUBUNIT
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT D
MBH SUBUNIT
(Pyrococcus
furiosus;
Pyrococcus
furiosus;
Pyrococcus
furiosus) 		3 / 3 MET H 233
ASP I  88
ARG E   3
 None
 0.88A 5z6kA-6cfwH:
undetectable		 5z6kA-6cfwH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT C
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT D
MBH SUBUNIT
(Pyrococcus
furiosus;
Pyrococcus
furiosus;
Pyrococcus
furiosus) 		3 / 3 MET H 298
ASP I  88
ARG G 113
 None
 1.18A 5z6kA-6cfwH:
undetectable		 5z6kA-6cfwH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC607_0
(ALPHA-AMYLASE)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B
(Pyrococcus
furiosus) 		4 / 6 GLY F  41
GLY F  36
PRO F  35
GLY F  31
 None
 0.68A 6ag0C-6cfwF:
undetectable		 6ag0C-6cfwF:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 6cfw MEMBRANE-BOUND
HYDROGENASE SUBUNIT
BETA
MEMBRANE-BOUND
HYDROGENASE SUBUNIT
ALPHA
(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		5 / 12 THR K  24
VAL K   7
LYS K  10
SER K  86
GLU L 234
 None
 1.27A 6bzoC-6cfwK:
undetectable		 6bzoC-6cfwK:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CB4_A_BEZA501_0
(CANAVALIN)		 6cfw MBH13 NADH
DEHYDROGENASE
SUBUNIT
NADH-PLASTOQUINONE
OXIDOREDUCTASE
SUBUNIT
(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		4 / 8 LEU M  31
VAL N  10
LEU N  14
ILE N  11
 None
 0.75A 6cb4A-6cfwM:
undetectable		 6cb4A-6cfwM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT D
(Pyrococcus
furiosus) 		4 / 7 ALA H 436
THR H 435
TYR H 438
VAL H 300
 None
 0.92A 6cduA-6cfwH:
undetectable
6cduE-6cfwH:
2.6		 6cduA-6cfwH:
undetectable
6cduE-6cfwH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_H_EY4H500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT D
(Pyrococcus
furiosus) 		4 / 7 VAL H 300
ALA H 436
THR H 435
TYR H 438
 None
 0.96A 6cduH-6cfwH:
2.6
6cduI-6cfwH:
2.9		 6cduH-6cfwH:
undetectable
6cduI-6cfwH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 6cfw MBH SUBUNIT
MBH SUBUNIT
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT C
(Pyrococcus
furiosus;
Pyrococcus
furiosus;
Pyrococcus
furiosus) 		4 / 8 LEU E  79
VAL G  84
VAL D  76
VAL D  72
 None
 0.95A 6cp4A-6cfwE:
undetectable		 6cp4A-6cfwE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_A_HISA402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 6cfw MBH SUBUNIT
MBH SUBUNIT
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT C
(Pyrococcus
furiosus;
Pyrococcus
furiosus;
Pyrococcus
furiosus;
Pyrococcus
furiosus) 		6 / 10 GLY G  86
CYH G  88
VAL F 129
VAL D  72
ALA F  43
LEU E  79
 None
 1.42A 6czmA-6cfwG:
undetectable
6czmC-6cfwG:
undetectable		 6czmA-6cfwG:
undetectable
6czmC-6cfwG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_E_HISE402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 6cfw MBH SUBUNIT
MBH SUBUNIT
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT C
(Pyrococcus
furiosus;
Pyrococcus
furiosus;
Pyrococcus
furiosus;
Pyrococcus
furiosus) 		5 / 9 VAL F 129
VAL D  72
LEU E  79
GLY G  86
CYH G  88
 None
 1.34A 6czmD-6cfwF:
undetectable
6czmE-6cfwF:
undetectable		 6czmD-6cfwF:
undetectable
6czmE-6cfwF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_B_ACTB804_0
(UNCHARACTERIZED
PROTEIN)		 6cfw PROBABLE
MEMBRANE-BOUND
HYDROGENASE SUBUNIT
MBHJ
NADH-PLASTOQUINONE
OXIDOREDUCTASE
SUBUNIT
(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		4 / 4 HIS J 141
VAL J 127
LEU J 145
ALA N 101
 None
 1.30A 6d8pB-6cfwJ:
3.9		 6d8pB-6cfwJ:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 6cfw MBH SUBUNIT
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT D
(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		5 / 12 TYR E  70
LEU H  61
ILE H   8
THR H  40
VAL H  43
 None
 1.26A 6djzB-6cfwE:
undetectable		 6djzB-6cfwE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT D
MBH13 NADH
DEHYDROGENASE
SUBUNIT
(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		5 / 11 VAL M 116
SER M 120
LEU H 391
ALA M  71
PHE M  66
 None
 1.36A 6dryA-6cfwM:
2.5		 6dryA-6cfwM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E5Z_A_CCSA106_0
(PROTEIN/NUCLEIC ACID
DEGLYCASE DJ-1)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B
(Pyrococcus
furiosus) 		5 / 10 GLY F  21
ILE F  27
ALA F  25
THR F  29
GLY F  41
 None
 1.13A 6e5zA-6cfwF:
undetectable		 6e5zA-6cfwF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_D_READ601_1
(RETINOIC ACID
RECEPTOR)		 6cfw MBH SUBUNIT
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT C
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT D
(Pyrococcus
furiosus) 		4 / 7 LEU H 118
GLY G  86
LEU G  92
GLY E  85
 None
 0.76A 6eu9D-6cfwH:
undetectable		 6eu9D-6cfwH:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_1
(-)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT E
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT G
(Pyrococcus
furiosus) 		5 / 12 VAL A  97
HIS C  36
ASN A 140
PRO A 142
GLY A 144
 None
 1.49A 6gnfA-6cfwA:
undetectable		 6gnfA-6cfwA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT E
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT G
(Pyrococcus
furiosus) 		5 / 12 VAL A  97
HIS C  36
ASN A 140
PRO A 142
GLY A 144
 None
 1.47A 6gnfC-6cfwA:
undetectable		 6gnfC-6cfwA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_N_PCFN606_0
(CYTOCHROME B)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT E
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT G
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B
(Pyrococcus
furiosus;
Pyrococcus
furiosus;
Pyrococcus
furiosus) 		5 / 12 PHE C  77
MET C  80
ALA C  79
PHE F  23
VAL A  16
 None
 1.43A 6hu9N-6cfwC:
undetectable		 6hu9N-6cfwC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT F
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B
(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		5 / 9 ILE F  17
ALA F  48
GLY F  49
LEU F  53
GLY B  71
 None
 1.17A 6nm4B-6cfwF:
undetectable		 6nm4B-6cfwF:
undetectable