SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6cfz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXH_B_PACB1001_0
(PENICILLIN ACYLASE)		 6cfz DAD1,DAD1
DAM1
(Chaetomium
thermophilum;
Chaetomium
thermophilum) 		4 / 7 PHE F  35
PHE H  59
ALA F  32
ILE F  31
 None
 1.03A 1fxhA-6cfzF:
undetectable
1fxhB-6cfzF:
undetectable		 1fxhA-6cfzF:
undetectable
1fxhB-6cfzF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_A_NIOA604_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 6cfz DAD1,DAD1
DAD3
(Chaetomium
thermophilum) 		4 / 5 THR B  65
PHE F  59
GLU F  58
GLY F  56
 None
 1.35A 1icrA-6cfzB:
undetectable
1icrB-6cfzB:
undetectable		 1icrA-6cfzB:
16.67
1icrB-6cfzB:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_C_NIOC708_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 6cfz DAD1,DAD1
DAD3
(Chaetomium
thermophilum) 		4 / 5 THR B  65
PHE F  59
GLU F  58
GLY F  56
 None
 1.31A 1icvC-6cfzB:
undetectable
1icvD-6cfzB:
undetectable		 1icvC-6cfzB:
16.67
1icvD-6cfzB:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_1
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 6cfz ASK1
DAD2
HSK3
(Chaetomium
thermophilum;
Chaetomium
thermophilum;
Chaetomium
thermophilum) 		4 / 7 LEU A  50
ILE C  73
THR C  70
MET G  59
 None
 1.19A 1kglA-6cfzA:
undetectable		 1kglA-6cfzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 6cfz ASK1
DAD4
(Chaetomium
thermophilum) 		3 / 3 ARG A  59
ILE E  44
TRP A  62
 None
 0.95A 1nodB-6cfzA:
undetectable		 1nodB-6cfzA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QOM_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 6cfz ASK1
DAD4
(Chaetomium
thermophilum) 		3 / 3 ARG A  59
ILE E  44
TRP A  62
 None
 1.00A 1qomA-6cfzA:
undetectable		 1qomA-6cfzA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 6cfz ASK1
DAD4
HSK3
(Chaetomium
thermophilum;
Chaetomium
thermophilum;
Chaetomium
thermophilum) 		3 / 3 ASN E  43
TRP A  62
GLN G  55
 None
 1.09A 1xoqA-6cfzE:
undetectable		 1xoqA-6cfzE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 6cfz ASK1
DAD4
(Chaetomium
thermophilum) 		3 / 3 ARG A  59
ILE E  44
TRP A  62
 None
 0.92A 2nodB-6cfzA:
undetectable		 2nodB-6cfzA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 6cfz DAD1,DAD1
DAD3
DUO1
SPC34
(Chaetomium
thermophilum) 		5 / 11 ILE J  18
ALA D  79
LEU B  46
LEU F  49
ILE F  42
 None
 1.07A 2w9sA-6cfzJ:
undetectable		 2w9sA-6cfzJ:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_B_TOPB1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 6cfz DAD1,DAD1
DAD3
DUO1
SPC34
(Chaetomium
thermophilum) 		5 / 11 ILE J  18
ALA D  79
LEU B  46
LEU F  49
ILE F  42
 None
 1.06A 2w9sB-6cfzJ:
undetectable		 2w9sB-6cfzJ:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7I_B_H4BB2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 6cfz ASK1
DAD4
(Chaetomium
thermophilum) 		3 / 3 ARG A  59
ILE E  44
TRP A  62
 None
 1.02A 3e7iB-6cfzA:
undetectable		 3e7iB-6cfzA:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP3_B_AICB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 6cfz DAD2
(Chaetomium
thermophilum) 		3 / 3 ALA C  27
ARG C  31
LYS C  35
 None
 0.66A 3kp3B-6cfzC:
undetectable		 3kp3B-6cfzC:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_B_TPFB490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 6cfz DAD2
SPC19
SPC34
(Chaetomium
thermophilum) 		5 / 9 ALA I  62
ALA I  58
THR I  55
LEU J  42
MET C  89
 None
 1.39A 3l4dB-6cfzI:
undetectable		 3l4dB-6cfzI:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_C_TPFC490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 6cfz DAD2
SPC19
SPC34
(Chaetomium
thermophilum) 		5 / 9 ALA I  62
ALA I  58
THR I  55
LEU J  42
MET C  89
 None
 1.48A 3l4dC-6cfzI:
undetectable		 3l4dC-6cfzI:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 6cfz DAD2
SPC19
SPC34
(Chaetomium
thermophilum) 		4 / 6 LEU J  33
ALA C  90
THR I  55
THR J  40
 None
 1.13A 3mdrA-6cfzJ:
undetectable		 3mdrA-6cfzJ:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 6cfz ASK1
DAD4
(Chaetomium
thermophilum) 		3 / 3 ARG A  59
ILE E  44
TRP A  62
 None
 0.95A 3nw2A-6cfzA:
undetectable		 3nw2A-6cfzA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 6cfz ASK1
DAD4
(Chaetomium
thermophilum) 		3 / 3 ARG A  59
ILE E  44
TRP A  62
 None
 0.88A 3nw2B-6cfzA:
undetectable		 3nw2B-6cfzA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 6cfz DAD2
HSK3
(Chaetomium
thermophilum;
Chaetomium
thermophilum) 		5 / 12 LEU G  62
GLY G  68
GLY G  63
SER G  64
TRP C  80
 None
 1.22A 3ou7A-6cfzG:
undetectable		 3ou7A-6cfzG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 6cfz DAD2
HSK3
(Chaetomium
thermophilum;
Chaetomium
thermophilum) 		5 / 12 LEU G  62
GLY G  68
GLY G  63
SER G  64
TRP C  80
 None
 1.18A 3ou7D-6cfzG:
undetectable		 3ou7D-6cfzG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_1
(GLYCINE
N-METHYLTRANSFERASE)		 6cfz DAM1
(Chaetomium
thermophilum) 		3 / 3 LEU H  78
HIS H  75
MET H  74
 None
 0.84A 3thrD-6cfzH:
undetectable		 3thrD-6cfzH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 6cfz DAD1,DAD1
DUO1
(Chaetomium
thermophilum) 		4 / 4 ASN D  82
SER F  48
LEU F  49
THR D  85
 None
 1.49A 4an2A-6cfzD:
undetectable		 4an2A-6cfzD:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_B_STRB301_1
(STEROID RECEPTOR 2)		 6cfz DAM1
DUO1
(Chaetomium
thermophilum) 		5 / 12 LEU H  94
LEU H  97
ASN H  98
ALA H 101
THR D  99
 None
 1.19A 4fn9B-6cfzH:
undetectable		 4fn9B-6cfzH:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_2
(ANDROGEN RECEPTOR)		 6cfz ASK1
DAD2
HSK3
(Chaetomium
thermophilum) 		4 / 8 ASN C  41
LEU G  31
HIS G  30
ILE A  32
 None
 0.98A 4ok1A-6cfzC:
undetectable		 4ok1A-6cfzC:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_0
(HYDG PROTEIN)		 6cfz ASK1
DAD2
HSK3
SPC19
(Chaetomium
thermophilum;
Chaetomium
thermophilum;
Chaetomium
thermophilum;
Chaetomium
thermophilum) 		5 / 12 ASN G  41
LEU G  42
LEU I  15
LEU C  45
PHE A  36
 None
 1.44A 4rtbA-6cfzG:
undetectable		 4rtbA-6cfzG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_C_FUAC1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 6cfz ASK1
DAD2
(Chaetomium
thermophilum) 		3 / 3 VAL C  52
HIS A  40
VAL A  43
 None
 0.41A 5jmnC-6cfzC:
undetectable		 5jmnC-6cfzC:
5.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 6cfz ASK1
DAD2
HSK3
(Chaetomium
thermophilum;
Chaetomium
thermophilum;
Chaetomium
thermophilum) 		4 / 6 LEU A  50
ILE C  73
THR C  70
MET G  59
 None
 1.15A 5ljeA-6cfzA:
undetectable		 5ljeA-6cfzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUO_D_08HD501_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT GAMMA-2)		 6cfz SPC19
SPC34
(Chaetomium
thermophilum;
Chaetomium
thermophilum) 		4 / 8 PHE I  71
HIS J 117
VAL J 152
TYR J 153
 None
 0.97A 6huoC-6cfzI:
undetectable
6huoD-6cfzI:
undetectable		 6huoC-6cfzI:
18.95
6huoD-6cfzI:
22.47