SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6cgb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AVP_A_MV2A313_1
(PANTOTHENATE KINASE)		 6cgb CADHERIN-11,
CADHERIN-6 CHIMERA
(Mus
musculus) 		4 / 7 VAL A  96
ASP A 101
TYR A  71
ILE A  47
 None
CA  A 302 (-2.9A)
None
None
 1.03A 3avpA-6cgbA:
undetectable		 3avpA-6cgbA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		 6cgb CADHERIN-11,
CADHERIN-6 CHIMERA
(Mus
musculus) 		4 / 7 ASP A 134
ASP A  98
GLN A  97
GLU A  66
 CA  A 303 ( 3.3A)
CA  A 301 (-3.2A)
None
CA  A 301 ( 2.3A)
 1.08A 3l2vA-6cgbA:
undetectable		 3l2vA-6cgbA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		 6cgb CADHERIN-11,
CADHERIN-6 CHIMERA
(Mus
musculus) 		4 / 8 ASP A 134
ASP A  98
GLN A  97
GLU A  66
 CA  A 303 ( 3.3A)
CA  A 301 (-3.2A)
None
CA  A 301 ( 2.3A)
 1.11A 3oyaA-6cgbA:
undetectable		 3oyaA-6cgbA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_A_RBVA601_1
(RNA POLYMERASE)		 6cgb CADHERIN-11,
CADHERIN-6 CHIMERA
(Mus
musculus) 		5 / 9 ASN A  56
TYR A  37
GLY A  55
ASP A  51
ASP A  52
 None
 1.29A 3sfuA-6cgbA:
undetectable		 3sfuA-6cgbA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		 6cgb CADHERIN-11,
CADHERIN-6 CHIMERA
(Mus
musculus) 		4 / 6 GLU A 103
ASP A 134
ASP A  98
GLU A  11
 None
CA  A 303 ( 3.3A)
CA  A 301 (-3.2A)
CA  A 301 ( 2.9A)
 1.35A 4ntxA-6cgbA:
undetectable
4ntxC-6cgbA:
undetectable		 4ntxA-6cgbA:
9.56
4ntxC-6cgbA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA302_0
(THAUMATIN-1)		 6cgb CADHERIN-11,
CADHERIN-6 CHIMERA
(Mus
musculus) 		3 / 3 ARG A  68
GLN A  70
GLU A  42
 None
 0.75A 4tvtA-6cgbA:
undetectable		 4tvtA-6cgbA:
undetectable