SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6ch0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)		 6ch0 -
(-) 		4 / 5 ASP C 220
HIS C 266
HIS C 118
HIS C 123
 CO  C 301 (-2.1A)
CO  C 301 ( 3.3A)
CO  C 302 (-3.3A)
CO  C 301 (-3.3A)
 1.22A 1ei6A-6ch0C:
undetectable		 1ei6A-6ch0C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA141_0
(LYSOZYME C)		 6ch0 -
(-) 		4 / 6 ASP C 162
GLY C 125
PRO C  70
SER C  72
 None
 0.93A 1n4fA-6ch0C:
undetectable		 1n4fA-6ch0C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA888_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 6ch0 -
(-) 		4 / 6 PRO C 210
LYS C   9
GLU C  59
GLU C 187
 None
 1.45A 1qhyA-6ch0C:
undetectable		 1qhyA-6ch0C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2888_0
(AMINOMETHYLTRANSFERA
SE)		 6ch0 -
(-) 		5 / 10 LEU C  63
LEU C  54
ILE C 111
GLU C 102
LEU C 104
 None
 1.02A 1wopA-6ch0C:
undetectable		 1wopA-6ch0C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_A_CLUA808_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 6ch0 -
(-) 		4 / 7 ALA C 199
TYR C 239
TYR C 158
HIS C 120
 None
None
None
CO  C 302 ( 3.1A)
 1.45A 2pncA-6ch0C:
undetectable		 2pncA-6ch0C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_B_CLUB809_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 6ch0 -
(-) 		4 / 6 ALA C 199
TYR C 239
TYR C 158
HIS C 120
 None
None
None
CO  C 302 ( 3.1A)
 1.46A 2pncB-6ch0C:
undetectable		 2pncB-6ch0C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0J_B_BEZB500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 6ch0 -
(-) 		5 / 11 ASP C 122
HIS C 123
HIS C 198
ASP C 220
HIS C 266
 CO  C 301 ( 2.6A)
CO  C 301 (-3.3A)
CO  C 302 ( 3.4A)
CO  C 301 (-2.1A)
CO  C 301 ( 3.3A)
 0.53A 2q0jB-6ch0C:
13.4		 2q0jB-6ch0C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_A_SHHA700_1
(HISTONE DEACETYLASE
8)		 6ch0 -
(-) 		5 / 10 ASP C 122
HIS C 120
ASP C 220
HIS C 198
TYR C 223
 CO  C 301 ( 2.6A)
CO  C 302 ( 3.1A)
CO  C 301 (-2.1A)
CO  C 302 ( 3.4A)
GOL  C 306 (-4.6A)
 1.27A 4bz6A-6ch0C:
undetectable		 4bz6A-6ch0C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_D_SHHD700_1
(HISTONE DEACETYLASE
8)		 6ch0 -
(-) 		5 / 10 ASP C 122
HIS C 120
ASP C 220
HIS C 198
TYR C 223
 CO  C 301 ( 2.6A)
CO  C 302 ( 3.1A)
CO  C 301 (-2.1A)
CO  C 302 ( 3.4A)
GOL  C 306 (-4.6A)
 1.27A 4bz6D-6ch0C:
undetectable		 4bz6D-6ch0C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1D_B_X8ZB350_1
(BETA-LACTAMASE CLASS
B VIM-2)		 6ch0 -
(-) 		5 / 10 HIS C 118
HIS C 120
ASP C 122
HIS C 198
HIS C 266
 CO  C 302 (-3.3A)
CO  C 302 ( 3.1A)
CO  C 301 ( 2.6A)
CO  C 302 ( 3.4A)
CO  C 301 ( 3.3A)
 0.71A 4c1dB-6ch0C:
14.8		 4c1dB-6ch0C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1F_A_X8ZA300_1
(BETA-LACTAMASE IMP-1)		 6ch0 -
(-) 		5 / 11 HIS C 118
HIS C 120
ASP C 122
HIS C 198
HIS C 266
 CO  C 302 (-3.3A)
CO  C 302 ( 3.1A)
CO  C 301 ( 2.6A)
CO  C 302 ( 3.4A)
CO  C 301 ( 3.3A)
 0.76A 4c1fA-6ch0C:
15.7
4c1fB-6ch0C:
15.7		 4c1fA-6ch0C:
undetectable
4c1fB-6ch0C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1F_A_X8ZA300_1
(BETA-LACTAMASE IMP-1)		 6ch0 -
(-) 		5 / 11 TRP C  26
HIS C 118
HIS C 120
ASP C 122
HIS C 198
 None
CO  C 302 (-3.3A)
CO  C 302 ( 3.1A)
CO  C 301 ( 2.6A)
CO  C 302 ( 3.4A)
 1.38A 4c1fA-6ch0C:
15.7
4c1fB-6ch0C:
15.7		 4c1fA-6ch0C:
undetectable
4c1fB-6ch0C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1H_A_X8ZA305_1
(BETA-LACTAMASE 2)		 6ch0 -
(-) 		5 / 9 HIS C 118
HIS C 120
ASP C 122
HIS C 198
HIS C 266
 CO  C 302 (-3.3A)
CO  C 302 ( 3.1A)
CO  C 301 ( 2.6A)
CO  C 302 ( 3.4A)
CO  C 301 ( 3.3A)
 0.70A 4c1hA-6ch0C:
3.6		 4c1hA-6ch0C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EXS_B_X8ZB301_1
(BETA-LACTAMASE NDM-1)		 6ch0 -
(-) 		4 / 8 HIS C 120
ASP C 122
HIS C 198
HIS C 266
 CO  C 302 ( 3.1A)
CO  C 301 ( 2.6A)
CO  C 302 ( 3.4A)
CO  C 301 ( 3.3A)
 0.74A 4exsB-6ch0C:
14.1		 4exsB-6ch0C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J03_A_FVSA603_1
(BIFUNCTIONAL EPOXIDE
HYDROLASE 2)		 6ch0 -
(-) 		5 / 12 ASP C 220
TYR C 228
ILE C 216
LEU C 121
HIS C 118
 CO  C 301 (-2.1A)
None
None
None
CO  C 302 (-3.3A)
 1.27A 4j03A-6ch0C:
undetectable		 4j03A-6ch0C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_D_FOLD301_1
(FOLATE RECEPTOR
ALPHA)		 6ch0 -
(-) 		3 / 3 HIS C 123
TRP C  79
SER C 219
 CO  C 301 (-3.3A)
None
None
 1.20A 4lrhD-6ch0C:
undetectable		 4lrhD-6ch0C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		 6ch0 -
(-) 		5 / 11 ALA C 199
TYR C 239
SER C 196
GLY C 201
THR C 148
 None
 1.30A 4mmaA-6ch0C:
undetectable		 4mmaA-6ch0C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_A_WJZA304_0
(BETA-LACTAMASE NDM-1)		 6ch0 -
(-) 		4 / 8 HIS C 120
ASP C 122
HIS C 198
HIS C 266
 CO  C 302 ( 3.1A)
CO  C 301 ( 2.6A)
CO  C 302 ( 3.4A)
CO  C 301 ( 3.3A)
 0.79A 5a5zA-6ch0C:
14.3		 5a5zA-6ch0C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYA_A_X8ZA307_1
(METALLO-BETA-LACTAMA
SE)		 6ch0 -
(-) 		6 / 11 HIS C 118
HIS C 120
ASP C 122
HIS C 123
HIS C 198
HIS C 266
 CO  C 302 (-3.3A)
CO  C 302 ( 3.1A)
CO  C 301 ( 2.6A)
CO  C 301 (-3.3A)
CO  C 302 ( 3.4A)
CO  C 301 ( 3.3A)
 0.48A 5ayaA-6ch0C:
14.8		 5ayaA-6ch0C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYA_A_X8ZA307_1
(METALLO-BETA-LACTAMA
SE)		 6ch0 -
(-) 		6 / 11 HIS C 118
HIS C 120
ASP C 122
HIS C 123
SER C 219
HIS C 266
 CO  C 302 (-3.3A)
CO  C 302 ( 3.1A)
CO  C 301 ( 2.6A)
CO  C 301 (-3.3A)
None
CO  C 301 ( 3.3A)
 1.18A 5ayaA-6ch0C:
14.8		 5ayaA-6ch0C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEN_B_5OGB804_1
(HDAC6 PROTEIN)		 6ch0 -
(-) 		5 / 12 PRO C 235
ASP C 122
HIS C 120
ASP C 220
TYR C 223
 None
CO  C 301 ( 2.6A)
CO  C 302 ( 3.1A)
CO  C 301 (-2.1A)
GOL  C 306 (-4.6A)
 1.15A 5eenB-6ch0C:
undetectable		 5eenB-6ch0C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_B_REAB602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 6ch0 -
(-) 		5 / 9 ILE C 159
GLY C 125
THR C  66
GLN C 153
LEU C 119
 None
 1.38A 5fhzB-6ch0C:
undetectable		 5fhzB-6ch0C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 6ch0 -
(-) 		5 / 10 HIS C 118
HIS C 120
HIS C 123
HIS C 198
ASP C 220
 CO  C 302 (-3.3A)
CO  C 302 ( 3.1A)
CO  C 301 (-3.3A)
CO  C 302 ( 3.4A)
CO  C 301 (-2.1A)
 0.42A 5nzwA-6ch0C:
5.1		 5nzwA-6ch0C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJ8_A_9DCA303_0
(METALLO-BETA-LACTAMA
SE TYPE 2)		 6ch0 -
(-) 		5 / 8 MET C  22
HIS C 120
ASP C 122
HIS C 198
HIS C 266
 GOL  C 306 ( 4.2A)
CO  C 302 ( 3.1A)
CO  C 301 ( 2.6A)
CO  C 302 ( 3.4A)
CO  C 301 ( 3.3A)
 1.30A 5zj8A-6ch0C:
14.4		 5zj8A-6ch0C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_B_ADNB502_1
(-)		 6ch0 -
(-) 		5 / 12 ASP C 220
HIS C 118
LEU C 121
MET C  22
PHE C  48
 CO  C 301 (-2.1A)
CO  C 302 (-3.3A)
None
GOL  C 306 ( 4.2A)
None
 1.47A 6f3mB-6ch0C:
undetectable		 6f3mB-6ch0C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_D_ADND502_1
(-)		 6ch0 -
(-) 		5 / 12 ASP C 220
HIS C 118
LEU C 121
MET C  22
PHE C  48
 CO  C 301 (-2.1A)
CO  C 302 (-3.3A)
None
GOL  C 306 ( 4.2A)
None
 1.47A 6f3mD-6ch0C:
undetectable		 6f3mD-6ch0C:
undetectable