SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6chd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_B_CCSB47_0
(GLUTATHIONE
S-TRANSFERASE)		 6chd LYSINE--TRNA LIGASE
(Homo
sapiens) 		4 / 7 LEU A 258
GLY A 262
LEU A 264
TYR A 316
 None
 0.92A 1gtiB-6chdA:
undetectable		 1gtiB-6chdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_D_CCSD47_0
(GLUTATHIONE
S-TRANSFERASE)		 6chd LYSINE--TRNA LIGASE
(Homo
sapiens) 		4 / 7 LEU A 258
GLY A 262
LEU A 264
TYR A 316
 None
 0.92A 1gtiD-6chdA:
undetectable		 1gtiD-6chdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_E_CCSE47_0
(GLUTATHIONE
S-TRANSFERASE)		 6chd LYSINE--TRNA LIGASE
(Homo
sapiens) 		4 / 7 LEU A 258
GLY A 262
LEU A 264
TYR A 316
 None
 0.92A 1gtiE-6chdA:
undetectable		 1gtiE-6chdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_A_ADNA433_2
(ADENOSYLHOMOCYSTEINA
SE)		 6chd LYSINE--TRNA LIGASE
(Homo
sapiens) 		3 / 3 THR A 337
GLU A 494
HIS A 331
 KAA  A 601 (-4.4A)
KAA  A 601 (-3.0A)
KAA  A 601 (-4.2A)
 0.89A 1xwfA-6chdA:
undetectable		 1xwfA-6chdA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_B_ADNB433_2
(ADENOSYLHOMOCYSTEINA
SE)		 6chd LYSINE--TRNA LIGASE
(Homo
sapiens) 		3 / 3 THR A 337
GLU A 494
HIS A 331
 KAA  A 601 (-4.4A)
KAA  A 601 (-3.0A)
KAA  A 601 (-4.2A)
 0.90A 1xwfB-6chdA:
undetectable		 1xwfB-6chdA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_D_ADND433_2
(ADENOSYLHOMOCYSTEINA
SE)		 6chd LYSINE--TRNA LIGASE
(Homo
sapiens) 		3 / 3 THR A 337
GLU A 494
HIS A 331
 KAA  A 601 (-4.4A)
KAA  A 601 (-3.0A)
KAA  A 601 (-4.2A)
 0.87A 1xwfD-6chdA:
undetectable		 1xwfD-6chdA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_C_SNLC3001_1
(MINERALOCORTICOID
RECEPTOR)		 6chd LYSINE--TRNA LIGASE
(Homo
sapiens) 		5 / 12 LEU A 452
MET A 469
LEU A 482
LEU A 444
PHE A 489
 None
 1.43A 2oaxC-6chdA:
undetectable		 2oaxC-6chdA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		 6chd LYSINE--TRNA LIGASE
(Homo
sapiens) 		3 / 3 GLU A 317
HIS A 304
THR A 268
 None
 0.73A 3hkuA-6chdA:
undetectable		 3hkuA-6chdA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 6chd LYSINE--TRNA LIGASE
(Homo
sapiens) 		5 / 12 LEU A 452
MET A 469
LEU A 482
LEU A 444
PHE A 489
 None
 1.40A 3vhuA-6chdA:
undetectable		 3vhuA-6chdA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1005_1
(HEMOLYTIC LECTIN
CEL-III)		 6chd LYSINE--TRNA LIGASE
(Homo
sapiens) 		3 / 3 ASP A 560
GLY A 377
TYR A 373
 None
SO4  A 606 (-3.3A)
None
 0.80A 3w9tC-6chdA:
undetectable		 3w9tC-6chdA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG503_1
(HEMOLYTIC LECTIN
CEL-III)		 6chd LYSINE--TRNA LIGASE
(Homo
sapiens) 		3 / 3 ASP A 560
GLY A 377
TYR A 373
 None
SO4  A 606 (-3.3A)
None
 0.80A 3w9tG-6chdA:
undetectable		 3w9tG-6chdA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 6chd LYSINE--TRNA LIGASE
(Homo
sapiens) 		4 / 5 VAL A 358
ILE A 394
MET A 351
ILE A 462
 None
 0.68A 4c8bA-6chdA:
undetectable		 4c8bA-6chdA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_SAMA301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 6chd LYSINE--TRNA LIGASE
(Homo
sapiens) 		5 / 12 ARG A 241
GLY A 130
LEU A 206
SER A 207
VAL A 101
 None
 0.93A 4htfA-6chdA:
undetectable		 4htfA-6chdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_B_SAMB301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 6chd LYSINE--TRNA LIGASE
(Homo
sapiens) 		5 / 12 ARG A 241
GLY A 130
LEU A 206
SER A 207
VAL A 101
 None
 0.94A 4htfB-6chdA:
undetectable		 4htfB-6chdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K87_A_ADNA602_1
(PROLINE--TRNA LIGASE)		 6chd LYSINE--TRNA LIGASE
(Homo
sapiens) 		4 / 8 ARG A 323
PHE A 335
GLY A 548
THR A 337
 KAA  A 601 (-2.5A)
KAA  A 601 (-3.3A)
KAA  A 601 (-3.7A)
KAA  A 601 (-4.4A)
 0.97A 4k87A-6chdA:
11.2		 4k87A-6chdA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_B_SAMB301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 6chd LYSINE--TRNA LIGASE
(Homo
sapiens) 		5 / 12 GLN A 515
GLU A 301
GLY A 277
ASN A 272
TYR A 303
 None
KAA  A 601 (-3.0A)
KAA  A 601 (-4.7A)
None
None
 1.32A 4pclB-6chdA:
undetectable		 4pclB-6chdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 6chd LYSINE--TRNA LIGASE
(Homo
sapiens) 		4 / 6 ILE A 353
PHE A 486
THR A 500
ARG A 393
 None
 1.17A 4xe5A-6chdA:
undetectable		 4xe5A-6chdA:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W8A_A_SAMA300_0
(AUTOINDUCER SYNTHASE)		 6chd LYSINE--TRNA LIGASE
(Homo
sapiens) 		5 / 12 LEU A 569
SER A 248
ILE A 246
GLU A 566
THR A 559
 None
 1.35A 5w8aA-6chdA:
undetectable		 5w8aA-6chdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XPR_A_K86A1201_1
(ENDOTHELIN B
RECEPTOR,ENDOLYSIN,E
NDOTHELIN B RECEPTOR)		 6chd LYSINE--TRNA LIGASE
(Homo
sapiens) 		5 / 12 GLN A 515
VAL A 279
LEU A 472
ILE A 468
ALA A 441
 None
 1.33A 5xprA-6chdA:
undetectable		 5xprA-6chdA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 6chd LYSINE--TRNA LIGASE
(Homo
sapiens) 		8 / 10 ARG A 323
GLU A 325
HIS A 331
PHE A 335
GLU A 494
GLY A 550
ARG A 553
ILE A 564
 KAA  A 601 (-2.5A)
KAA  A 601 (-3.9A)
KAA  A 601 (-4.2A)
KAA  A 601 (-3.3A)
KAA  A 601 (-3.0A)
KAA  A 601 (-3.2A)
KAA  A 601 (-3.8A)
None
 0.52A 6bniA-6chdA:
51.7		 6bniA-6chdA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 6chd LYSINE--TRNA LIGASE
(Homo
sapiens) 		8 / 10 ARG A 323
GLU A 325
HIS A 331
PHE A 335
GLU A 494
GLY A 550
ARG A 553
ILE A 564
 KAA  A 601 (-2.5A)
KAA  A 601 (-3.9A)
KAA  A 601 (-4.2A)
KAA  A 601 (-3.3A)
KAA  A 601 (-3.0A)
KAA  A 601 (-3.2A)
KAA  A 601 (-3.8A)
None
 0.47A 6bniB-6chdA:
52.4		 6bniB-6chdA:
18.82