SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6chj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZ4_A_BEZA784_0
(MALT REGULATORY
PROTEIN)		 6chj DIACYLGLYCEROL
O-ACYLTRANSFERASE
(Marinobacter
hydrocarbonoclas
ticus) 		4 / 6 TRP A 390
LEU A 152
LEU A 388
PRO A 387
 None
 1.34A 1hz4A-6chjA:
undetectable		 1hz4A-6chjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA799_1
(ADENOSINE KINASE)		 6chj DIACYLGLYCEROL
O-ACYLTRANSFERASE
(Marinobacter
hydrocarbonoclas
ticus) 		5 / 10 GLY A 323
VAL A 319
ALA A 268
ALA A 271
ILE A 329
 None
 1.10A 1likA-6chjA:
undetectable		 1likA-6chjA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_B_T44B602_1
(TRANSTHYRETIN)		 6chj DIACYLGLYCEROL
O-ACYLTRANSFERASE
(Marinobacter
hydrocarbonoclas
ticus) 		4 / 7 LEU A  87
GLU A  85
ALA A 129
LEU A  26
 None
 1.07A 1sn0B-6chjA:
undetectable
1sn0D-6chjA:
undetectable		 1sn0B-6chjA:
20.30
1sn0D-6chjA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_B_THHB4001_0
(AMINOMETHYLTRANSFERA
SE)		 6chj DIACYLGLYCEROL
O-ACYLTRANSFERASE
(Marinobacter
hydrocarbonoclas
ticus) 		5 / 12 THR A 413
ILE A 378
VAL A 293
CYH A 270
LEU A 231
 None
 1.31A 1wsvB-6chjA:
undetectable		 1wsvB-6chjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_A_9CRA201_1
(RXR-LIKE PROTEIN)		 6chj DIACYLGLYCEROL
O-ACYLTRANSFERASE
(Marinobacter
hydrocarbonoclas
ticus) 		5 / 12 CYH A 270
ALA A 272
ALA A 273
VAL A 421
LEU A 425
 None
 0.77A 1xiuA-6chjA:
undetectable		 1xiuA-6chjA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZQ_A_PCFA954_0
(CATECHOL
1,2-DIOXYGENASE)		 6chj DIACYLGLYCEROL
O-ACYLTRANSFERASE
(Marinobacter
hydrocarbonoclas
ticus) 		5 / 9 LEU A  10
HIS A 362
ALA A 360
LEU A 356
LEU A 208
 None
 1.42A 2azqA-6chjA:
undetectable		 2azqA-6chjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_NCAA493_0
(CHORISMATE SYNTHASE)		 6chj DIACYLGLYCEROL
O-ACYLTRANSFERASE
(Marinobacter
hydrocarbonoclas
ticus) 		5 / 11 ALA A 271
ILE A 378
ILE A 329
ALA A 291
VAL A 376
 None
 1.18A 2qhfA-6chjA:
undetectable		 2qhfA-6chjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_GLYA502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6chj DIACYLGLYCEROL
O-ACYLTRANSFERASE
(Marinobacter
hydrocarbonoclas
ticus) 		4 / 7 HIS A 106
HIS A 118
LYS A 133
ARG A  83
 None
None
None
CL  A 501 ( 4.7A)
 1.37A 2vmyA-6chjA:
undetectable
2vmyB-6chjA:
undetectable		 2vmyA-6chjA:
undetectable
2vmyB-6chjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6chj DIACYLGLYCEROL
O-ACYLTRANSFERASE
(Marinobacter
hydrocarbonoclas
ticus) 		4 / 8 HIS A 106
HIS A 118
LYS A 133
ARG A  83
 None
None
None
CL  A 501 ( 4.7A)
 1.35A 2vmyA-6chjA:
undetectable
2vmyB-6chjA:
undetectable		 2vmyA-6chjA:
undetectable
2vmyB-6chjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 6chj DIACYLGLYCEROL
O-ACYLTRANSFERASE
(Marinobacter
hydrocarbonoclas
ticus) 		5 / 12 PHE A 374
PHE A  11
VAL A  23
ILE A 403
THR A 413
 None
 1.16A 3em0B-6chjA:
undetectable		 3em0B-6chjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 6chj DIACYLGLYCEROL
O-ACYLTRANSFERASE
(Marinobacter
hydrocarbonoclas
ticus) 		5 / 12 VAL A 266
CYH A 270
ALA A 272
ALA A 273
VAL A 421
 None
 0.62A 3fc6C-6chjA:
undetectable		 3fc6C-6chjA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_B_BEZB264_0
(ECHA1_1)		 6chj DIACYLGLYCEROL
O-ACYLTRANSFERASE
(Marinobacter
hydrocarbonoclas
ticus) 		4 / 7 ILE A 378
LEU A 315
ALA A 273
ALA A 272
 None
 0.80A 3r9tB-6chjA:
undetectable		 3r9tB-6chjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 6chj DIACYLGLYCEROL
O-ACYLTRANSFERASE
(Marinobacter
hydrocarbonoclas
ticus) 		4 / 8 LEU A  97
VAL A 401
TYR A 399
LEU A 439
 None
 1.01A 3v81C-6chjA:
2.6		 3v81C-6chjA:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA501_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 6chj DIACYLGLYCEROL
O-ACYLTRANSFERASE
(Marinobacter
hydrocarbonoclas
ticus) 		5 / 12 ILE A 235
THR A 236
VAL A 401
ASP A 404
ILE A 426
 None
 1.25A 4i41A-6chjA:
undetectable		 4i41A-6chjA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_B_STRB503_1
(CYTOCHROME P450
MONOOXYGENASE)		 6chj DIACYLGLYCEROL
O-ACYLTRANSFERASE
(Marinobacter
hydrocarbonoclas
ticus) 		5 / 10 PHE A 292
ALA A 357
ALA A 359
ALA A 360
LEU A  10
 None
 1.18A 4j6cB-6chjA:
undetectable		 4j6cB-6chjA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_A_TESA503_1
(CYTOCHROME P450
MONOOXYGENASE)		 6chj DIACYLGLYCEROL
O-ACYLTRANSFERASE
(Marinobacter
hydrocarbonoclas
ticus) 		5 / 12 PHE A 292
ALA A 357
ALA A 359
ALA A 360
LEU A  10
 None
 1.10A 4j6dA-6chjA:
undetectable		 4j6dA-6chjA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_B_TESB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 6chj DIACYLGLYCEROL
O-ACYLTRANSFERASE
(Marinobacter
hydrocarbonoclas
ticus) 		5 / 12 PHE A 292
ALA A 357
ALA A 359
ALA A 360
LEU A  10
 None
 1.10A 4j6dB-6chjA:
undetectable		 4j6dB-6chjA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_A_ASDA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 6chj DIACYLGLYCEROL
O-ACYLTRANSFERASE
(Marinobacter
hydrocarbonoclas
ticus) 		5 / 12 PHE A 292
ALA A 357
ALA A 359
ALA A 360
LEU A  10
 None
 1.12A 4jbtA-6chjA:
undetectable		 4jbtA-6chjA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_B_ASDB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 6chj DIACYLGLYCEROL
O-ACYLTRANSFERASE
(Marinobacter
hydrocarbonoclas
ticus) 		5 / 11 PHE A 292
ALA A 357
ALA A 359
ALA A 360
LEU A  10
 None
 1.11A 4jbtB-6chjA:
undetectable		 4jbtB-6chjA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA407_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 6chj DIACYLGLYCEROL
O-ACYLTRANSFERASE
(Marinobacter
hydrocarbonoclas
ticus) 		3 / 3 GLU A 116
ARG A  83
HIS A 118
 CL  A 502 (-3.8A)
CL  A 501 ( 4.7A)
None
 0.73A 4kf9A-6chjA:
undetectable		 4kf9A-6chjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_2
(ANCESTRAL STEROID
RECEPTOR 2)		 6chj DIACYLGLYCEROL
O-ACYLTRANSFERASE
(Marinobacter
hydrocarbonoclas
ticus) 		4 / 8 ALA A 313
MET A 333
VAL A 421
PHE A 423
 None
 0.86A 4ltwA-6chjA:
undetectable		 4ltwA-6chjA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 6chj DIACYLGLYCEROL
O-ACYLTRANSFERASE
(Marinobacter
hydrocarbonoclas
ticus) 		4 / 6 GLU A 422
THR A 415
THR A 132
LEU A 395
 None
 1.10A 4pgfA-6chjA:
undetectable		 4pgfA-6chjA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 6chj DIACYLGLYCEROL
O-ACYLTRANSFERASE
(Marinobacter
hydrocarbonoclas
ticus) 		4 / 8 LEU A  97
VAL A 401
TYR A 399
LEU A 439
 None
 0.93A 4pwdC-6chjA:
3.6		 4pwdC-6chjA:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MLM_A_STRA401_1
(-)		 6chj DIACYLGLYCEROL
O-ACYLTRANSFERASE
(Marinobacter
hydrocarbonoclas
ticus) 		5 / 12 PHE A 423
ASN A 263
ALA A 313
ILE A 378
PRO A 294
 None
 1.26A 5mlmA-6chjA:
undetectable		 5mlmA-6chjA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_B_SAMB501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 6chj DIACYLGLYCEROL
O-ACYLTRANSFERASE
(Marinobacter
hydrocarbonoclas
ticus) 		5 / 12 ILE A 426
SER A 105
LEU A  97
LEU A  96
LEU A  26
 None
 1.17A 5nfjB-6chjA:
undetectable		 5nfjB-6chjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UL4_A_SAMA803_0
(OXSB PROTEIN)		 6chj DIACYLGLYCEROL
O-ACYLTRANSFERASE
(Marinobacter
hydrocarbonoclas
ticus) 		5 / 12 PHE A  11
GLY A 141
ILE A 403
GLU A  15
LEU A  12
 None
 1.08A 5ul4A-6chjA:
undetectable		 5ul4A-6chjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_D_SALD201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 6chj DIACYLGLYCEROL
O-ACYLTRANSFERASE
(Marinobacter
hydrocarbonoclas
ticus) 		4 / 5 PRO A 400
GLY A 424
TYR A 399
VAL A 421
 None
 1.22A 5x80C-6chjA:
undetectable
5x80D-6chjA:
undetectable		 5x80C-6chjA:
18.35
5x80D-6chjA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YVN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 6chj DIACYLGLYCEROL
O-ACYLTRANSFERASE
(Marinobacter
hydrocarbonoclas
ticus) 		4 / 6 LEU A  14
GLN A  19
LEU A 408
LEU A 363
 None
 1.10A 5yvnA-6chjA:
undetectable		 5yvnA-6chjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11801_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
EL18)		 6chj DIACYLGLYCEROL
O-ACYLTRANSFERASE
(Marinobacter
hydrocarbonoclas
ticus) 		4 / 4 ARG A 240
ARG A 429
GLY A 237
ARG A  17
 None
 1.39A 6az3P-6chjA:
undetectable		 6az3P-6chjA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_C_ZOLC401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 6chj DIACYLGLYCEROL
O-ACYLTRANSFERASE
(Marinobacter
hydrocarbonoclas
ticus) 		4 / 5 ASP A 406
ARG A 407
GLN A  18
LYS A  16
 None
 1.37A 6g31C-6chjA:
undetectable		 6g31C-6chjA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JI6_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME)		 6chj DIACYLGLYCEROL
O-ACYLTRANSFERASE
(Marinobacter
hydrocarbonoclas
ticus) 		4 / 5 GLY A 397
LEU A  28
SER A 245
GLN A 420
 None
 1.13A 6ji6A-6chjA:
undetectable		 6ji6A-6chjA:
undetectable