SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6chk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_B_EAAB224_1
(GLUTATHIONE
TRANSFERASE)		 6chk TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Lactobacillus
paracasei) 		5 / 12 LEU A 323
LEU A 156
VAL A 144
LEU A  77
ALA A  80
 None
 0.93A 1gseB-6chkA:
3.1		 1gseB-6chkA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_2
(TRANSTHYRETIN)		 6chk TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Lactobacillus
paracasei) 		4 / 8 LEU A 323
THR A 154
LEU A 158
VAL A 142
 None
None
CL  A 403 (-4.6A)
None
 0.95A 1sn5C-6chkA:
undetectable		 1sn5C-6chkA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1N_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 6chk TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Lactobacillus
paracasei) 		5 / 11 THR A 247
LEU A 260
VAL A 256
GLY A 230
VAL A 182
 None
 1.29A 2a1nA-6chkA:
undetectable		 2a1nA-6chkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 6chk TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Lactobacillus
paracasei) 		5 / 10 THR A 247
LEU A 260
VAL A 256
GLY A 230
VAL A 182
 None
 1.25A 2cp4A-6chkA:
undetectable		 2cp4A-6chkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JC9_A_ADNA1497_1
(CYTOSOLIC PURINE
5'-NUCLEOTIDASE)		 6chk TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Lactobacillus
paracasei) 		4 / 7 ARG A 196
ASP A 147
ASN A  71
PHE A  73
 TRS  A 401 (-2.7A)
None
TRS  A 401 (-3.0A)
None
 1.27A 2jc9A-6chkA:
undetectable		 2jc9A-6chkA:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD36_0
(GCN4 LEUCINE ZIPPER)		 6chk TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Lactobacillus
paracasei) 		3 / 3 SER A 195
TYR A 161
HIS A 160
 None
None
CL  A 403 (-4.7A)
 0.72A 2r2vD-6chkA:
undetectable		 2r2vD-6chkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 6chk TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Lactobacillus
paracasei) 		5 / 12 LEU A 289
GLY A 275
VAL A 182
ALA A 272
LEU A 233
 None
 1.12A 3dh0B-6chkA:
undetectable		 3dh0B-6chkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_C_ACTC800_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 6chk TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Lactobacillus
paracasei) 		3 / 3 ASP A 214
ARG A 178
ALA A 212
 None
 0.69A 3mbgC-6chkA:
undetectable		 3mbgC-6chkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDI_A_SAMA601_0
(METHYLTRANSFERASE)		 6chk TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Lactobacillus
paracasei) 		5 / 12 PHE A  73
ILE A  81
PHE A  78
PHE A  74
ALA A 301
 None
 1.38A 3ndiA-6chkA:
2.6		 3ndiA-6chkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_A_ADNA506_2
(ADENOSYLHOMOCYSTEINA
SE)		 6chk TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Lactobacillus
paracasei) 		3 / 3 GLN A  96
THR A  97
LEU A  77
 None
 0.60A 3ondA-6chkA:
4.1		 3ondA-6chkA:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_B_ADNB507_2
(ADENOSYLHOMOCYSTEINA
SE)		 6chk TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Lactobacillus
paracasei) 		3 / 3 GLN A  96
THR A  97
LEU A  77
 None
 0.61A 3ondB-6chkA:
4.0		 3ondB-6chkA:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_B_STRB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 6chk TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Lactobacillus
paracasei) 		4 / 6 VAL A  92
VAL A  64
ILE A 120
LEU A 308
 None
 0.86A 4l1wB-6chkA:
undetectable		 4l1wB-6chkA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 6chk TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Lactobacillus
paracasei) 		5 / 9 THR A 247
LEU A 260
VAL A 256
GLY A 230
VAL A 182
 None
 1.23A 5cp4A-6chkA:
undetectable		 5cp4A-6chkA:
undetectable