SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6ci7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_B_SAMB105_0
(MET REPRESSOR)		 6ci7 YCAO
(Methanopyrus
kandleri) 		5 / 10 GLU A 132
ARG A 351
LEU A 142
ALA A 141
GLY A 139
 None
 1.44A 1cmcA-6ci7A:
undetectable
1cmcB-6ci7A:
undetectable		 1cmcA-6ci7A:
undetectable
1cmcB-6ci7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_B_IPHB802_0
(PHENOL HYDROXYLASE)		 6ci7 YCAO
(Methanopyrus
kandleri) 		5 / 10 GLY A  64
GLN A 255
VAL A  48
ILE A  50
ARG A  51
 ACP  A 500 ( 4.9A)
ACP  A 500 ( 4.9A)
None
None
None
 1.42A 1fohB-6ci7A:
undetectable		 1fohB-6ci7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_C_IPHC802_0
(PHENOL HYDROXYLASE)		 6ci7 YCAO
(Methanopyrus
kandleri) 		5 / 10 GLY A  64
GLN A 255
VAL A  48
ILE A  50
ARG A  51
 ACP  A 500 ( 4.9A)
ACP  A 500 ( 4.9A)
None
None
None
 1.42A 1fohC-6ci7A:
undetectable		 1fohC-6ci7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_D_IPHD802_0
(PHENOL HYDROXYLASE)		 6ci7 YCAO
(Methanopyrus
kandleri) 		5 / 10 GLY A  64
GLN A 255
VAL A  48
ILE A  50
ARG A  51
 ACP  A 500 ( 4.9A)
ACP  A 500 ( 4.9A)
None
None
None
 1.44A 1fohD-6ci7A:
undetectable		 1fohD-6ci7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M2Z_D_DEXD401_1
(GLUCOCORTICOID
RECEPTOR)		 6ci7 YCAO
(Methanopyrus
kandleri) 		5 / 12 MET A  78
GLY A  64
GLN A 255
THR A  20
ILE A  24
 ACP  A 500 (-4.6A)
ACP  A 500 ( 4.9A)
ACP  A 500 ( 4.9A)
ACP  A 500 ( 3.9A)
None
 0.93A 1m2zD-6ci7A:
undetectable		 1m2zD-6ci7A:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MIC_A_DVAA6_0
(GRAMICIDIN A)		 6ci7 YCAO
(Methanopyrus
kandleri) 		3 / 3 ALA A 130
VAL A 128
TRP A 102
 None
 0.90A 1micA-6ci7A:
undetectable
1micB-6ci7A:
undetectable		 1micA-6ci7A:
undetectable
1micB-6ci7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6L_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 6ci7 YCAO
(Methanopyrus
kandleri) 		4 / 6 VAL A 128
TRP A 137
PHE A 134
GLU A 132
 None
 1.30A 1p6lA-6ci7A:
undetectable
1p6lB-6ci7A:
undetectable		 1p6lA-6ci7A:
11.72
1p6lB-6ci7A:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		 6ci7 YCAO
(Methanopyrus
kandleri) 		5 / 12 MET A  78
GLY A  64
GLN A 255
THR A  20
ILE A  24
 ACP  A 500 (-4.6A)
ACP  A 500 ( 4.9A)
ACP  A 500 ( 4.9A)
ACP  A 500 ( 3.9A)
None
 1.03A 1p93A-6ci7A:
undetectable		 1p93A-6ci7A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_B_DEXB2999_1
(GLUCOCORTICOID
RECEPTOR)		 6ci7 YCAO
(Methanopyrus
kandleri) 		5 / 12 MET A  78
GLY A  64
GLN A 255
THR A  20
ILE A  24
 ACP  A 500 (-4.6A)
ACP  A 500 ( 4.9A)
ACP  A 500 ( 4.9A)
ACP  A 500 ( 3.9A)
None
 1.08A 1p93B-6ci7A:
undetectable		 1p93B-6ci7A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_D_DEXD4999_1
(GLUCOCORTICOID
RECEPTOR)		 6ci7 YCAO
(Methanopyrus
kandleri) 		5 / 12 MET A  78
GLY A  64
GLN A 255
THR A  20
ILE A  24
 ACP  A 500 (-4.6A)
ACP  A 500 ( 4.9A)
ACP  A 500 ( 4.9A)
ACP  A 500 ( 3.9A)
None
 0.92A 1p93D-6ci7A:
undetectable		 1p93D-6ci7A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2001_1
(SERUM ALBUMIN)		 6ci7 YCAO
(Methanopyrus
kandleri) 		5 / 11 VAL A 220
GLY A 237
ALA A 222
LEU A 207
ARG A 195
 None
 1.19A 2bxgA-6ci7A:
undetectable		 2bxgA-6ci7A:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 6ci7 YCAO
(Methanopyrus
kandleri) 		5 / 12 ILE A  50
ALA A 254
GLY A 256
THR A 224
VAL A 233
 None
 1.08A 2okcA-6ci7A:
undetectable		 2okcA-6ci7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CWK_A_REAA300_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 6ci7 YCAO
(Methanopyrus
kandleri) 		5 / 12 LEU A 314
ALA A  14
PRO A  17
VAL A  74
THR A  20
 None
None
ACP  A 500 ( 4.6A)
None
ACP  A 500 ( 3.9A)
 1.27A 3cwkA-6ci7A:
undetectable		 3cwkA-6ci7A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FSU_A_C2FA995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 6ci7 YCAO
(Methanopyrus
kandleri) 		5 / 12 THR A  20
SER A 239
LEU A 314
THR A   3
ARG A 248
 ACP  A 500 ( 3.9A)
None
None
None
ACP  A 500 (-3.1A)
 1.43A 3fsuA-6ci7A:
undetectable		 3fsuA-6ci7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FSU_E_C2FE995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 6ci7 YCAO
(Methanopyrus
kandleri) 		5 / 11 THR A  20
SER A 239
LEU A 314
THR A   3
ARG A 248
 ACP  A 500 ( 3.9A)
None
None
None
ACP  A 500 (-3.1A)
 1.39A 3fsuE-6ci7A:
undetectable		 3fsuE-6ci7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_A_IMNA701_1
(CYCLOOXYGENASE-2)		 6ci7 YCAO
(Methanopyrus
kandleri) 		5 / 12 SER A  40
LEU A 251
GLY A  66
ALA A  72
SER A  75
 None
None
None
None
ACP  A 500 (-3.0A)
 1.10A 4coxA-6ci7A:
undetectable		 4coxA-6ci7A:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_B_IMNB701_1
(CYCLOOXYGENASE-2)		 6ci7 YCAO
(Methanopyrus
kandleri) 		5 / 12 SER A  40
LEU A 251
GLY A  66
ALA A  72
SER A  75
 None
None
None
None
ACP  A 500 (-3.0A)
 1.11A 4coxB-6ci7A:
undetectable		 4coxB-6ci7A:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_D_IMND701_1
(CYCLOOXYGENASE-2)		 6ci7 YCAO
(Methanopyrus
kandleri) 		5 / 12 SER A  40
LEU A 251
GLY A  66
ALA A  72
SER A  75
 None
None
None
None
ACP  A 500 (-3.0A)
 1.11A 4coxD-6ci7A:
0.0		 4coxD-6ci7A:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 6ci7 YCAO
(Methanopyrus
kandleri) 		4 / 8 ASN A 147
ARG A 364
ASP A 170
ILE A 174
 None
 1.05A 4k0bA-6ci7A:
undetectable		 4k0bA-6ci7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_K_HCYK900_1
(GLUCOCORTICOID
RECEPTOR)		 6ci7 YCAO
(Methanopyrus
kandleri) 		5 / 12 MET A  78
GLY A  64
GLN A 255
THR A  20
ILE A  24
 ACP  A 500 (-4.6A)
ACP  A 500 ( 4.9A)
ACP  A 500 ( 4.9A)
ACP  A 500 ( 3.9A)
None
 1.02A 4p6xK-6ci7A:
undetectable		 4p6xK-6ci7A:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_J_CHDJ103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 6ci7 YCAO
(Methanopyrus
kandleri) 		5 / 11 LEU A 164
ARG A 248
LEU A 321
GLU A 156
LEU A 317
 None
ACP  A 500 (-3.1A)
None
None
None
 1.15A 4wg0J-6ci7A:
undetectable
4wg0K-6ci7A:
undetectable
4wg0L-6ci7A:
undetectable		 4wg0J-6ci7A:
undetectable
4wg0K-6ci7A:
undetectable
4wg0L-6ci7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z3O_F_MFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
E-SITE DNA)		 6ci7 YCAO
(Methanopyrus
kandleri) 		4 / 5 ARG A 200
ARG A 204
GLY A 203
GLU A 225
 None
 1.08A 4z3oA-6ci7A:
undetectable
4z3oB-6ci7A:
undetectable		 4z3oA-6ci7A:
8.38
4z3oB-6ci7A:
8.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_B_1FLB1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 6ci7 YCAO
(Methanopyrus
kandleri) 		5 / 9 THR A 311
LEU A 317
PRO A 240
ILE A 160
LEU A 314
 None
 1.47A 5g48B-6ci7A:
undetectable		 5g48B-6ci7A:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_B_ADNB401_1
(ADENOSINE KINASE)		 6ci7 YCAO
(Methanopyrus
kandleri) 		5 / 12 GLY A 256
VAL A  43
ASP A  41
ALA A  63
ILE A  50
 None
 0.94A 5kb6B-6ci7A:
undetectable		 5kb6B-6ci7A:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MQT_A_STIA302_1
(DEOXYCYTIDINE KINASE)		 6ci7 YCAO
(Methanopyrus
kandleri) 		5 / 12 ILE A  92
VAL A 336
TYR A 127
GLU A 110
PHE A 134
 None
 1.41A 5mqtA-6ci7A:
undetectable		 5mqtA-6ci7A:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO8_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 6ci7 YCAO
(Methanopyrus
kandleri) 		4 / 6 TRP A 137
PHE A 134
GLU A 132
VAL A 128
 None
 1.25A 5uo8A-6ci7A:
undetectable
5uo8B-6ci7A:
undetectable		 5uo8A-6ci7A:
11.06
5uo8B-6ci7A:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVD_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 6ci7 YCAO
(Methanopyrus
kandleri) 		4 / 7 TRP A 137
PHE A 134
GLU A 132
VAL A 128
 None
 1.26A 5vvdA-6ci7A:
undetectable
5vvdB-6ci7A:
undetectable		 5vvdA-6ci7A:
11.06
5vvdB-6ci7A:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVD_C_H4BC502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 6ci7 YCAO
(Methanopyrus
kandleri) 		4 / 6 VAL A 128
TRP A 137
PHE A 134
GLU A 132
 None
 1.25A 5vvdC-6ci7A:
0.0
5vvdD-6ci7A:
undetectable		 5vvdC-6ci7A:
11.06
5vvdD-6ci7A:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_1
(CYTOCHROME P450 1A1)		 6ci7 YCAO
(Methanopyrus
kandleri) 		5 / 7 SER A 171
GLY A 237
ALA A 245
VAL A 187
LEU A 185
 None
 1.22A 6dwnB-6ci7A:
undetectable		 6dwnB-6ci7A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FK2_A_SORA302_0
(GALECTIN-3)		 6ci7 YCAO
(Methanopyrus
kandleri) 		4 / 4 ARG A 351
GLU A 132
GLU A 357
ARG A 364
 None
 1.25A 6fk2A-6ci7A:
undetectable		 6fk2A-6ci7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FK2_A_SORA302_0
(GALECTIN-3)		 6ci7 YCAO
(Methanopyrus
kandleri) 		4 / 4 ARG A 364
GLU A 357
GLU A 132
ARG A 351
 None
 1.14A 6fk2A-6ci7A:
undetectable		 6fk2A-6ci7A:
undetectable