SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6ci9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_A_URFA1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 6ci9 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 ILE A  94
ASN A 115
SER A 160
THR A 145
 None
None
None
F3V  A 302 (-3.9A)
 1.19A 1h7xA-6ci9A:
5.4		 1h7xA-6ci9A:
6.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_B_URFB1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 6ci9 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 ILE A  94
ASN A 115
SER A 160
THR A 145
 None
None
None
F3V  A 302 (-3.9A)
 1.21A 1h7xB-6ci9A:
5.8		 1h7xB-6ci9A:
6.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_C_URFC1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 6ci9 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 ILE A  94
ASN A 115
SER A 160
THR A 145
 None
None
None
F3V  A 302 (-3.9A)
 1.20A 1h7xC-6ci9A:
4.4		 1h7xC-6ci9A:
6.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_D_URFD1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 6ci9 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 ILE A  94
ASN A 115
SER A 160
THR A 145
 None
None
None
F3V  A 302 (-3.9A)
 1.20A 1h7xD-6ci9A:
5.8		 1h7xD-6ci9A:
6.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTX_A_CVIA200_0
(HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR IN QACA
5'REGION)		 6ci9 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ILE A 144
ILE A 148
ILE A  23
ALA A 225
THR A 240
 None
 1.16A 1jtxA-6ci9A:
undetectable		 1jtxA-6ci9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_2
(PROTEASE)		 6ci9 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 ASP A  43
GLY A  18
ILE A  19
ILE A  36
 None
NAP  A 301 (-3.2A)
NAP  A 301 (-3.8A)
None
 0.94A 1n49D-6ci9A:
undetectable		 1n49D-6ci9A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 6ci9 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 TYR A 157
THR A 141
ALA A 162
SER A 160
GLY A 188
 NAP  A 301 ( 4.3A)
NAP  A 301 (-3.9A)
CL  A 303 ( 4.1A)
None
F3V  A 302 ( 4.8A)
 1.31A 1nbiD-6ci9A:
6.4		 1nbiD-6ci9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 6ci9 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		5 / 10 THR A  13
THR A 141
ALA A 184
VAL A 138
GLY A 118
 None
NAP  A 301 (-3.9A)
None
None
None
 1.00A 2f16K-6ci9A:
undetectable
2f16L-6ci9A:
undetectable		 2f16K-6ci9A:
18.45
2f16L-6ci9A:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 6ci9 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		5 / 10 THR A  13
THR A 141
ALA A 184
VAL A 138
GLY A 118
 None
NAP  A 301 (-3.9A)
None
None
None
 0.99A 2f16Y-6ci9A:
undetectable
2f16Z-6ci9A:
undetectable		 2f16Y-6ci9A:
18.45
2f16Z-6ci9A:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_A_SALA506_1
(SALICYLATE
SYNTHETASE, IRP9)		 6ci9 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 ILE A  36
GLU A  25
GLY A  18
LEU A  51
GLY A  15
 None
None
NAP  A 301 (-3.2A)
None
NAP  A 301 ( 4.7A)
 1.39A 2fn1A-6ci9A:
undetectable		 2fn1A-6ci9A:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_B_SALB1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 6ci9 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		5 / 10 THR A 192
ILE A  19
GLY A  18
GLY A 194
PRO A 187
 NAP  A 301 (-2.9A)
NAP  A 301 (-3.8A)
NAP  A 301 (-3.2A)
NAP  A 301 (-3.2A)
NAP  A 301 (-3.6A)
 1.39A 2y7wB-6ci9A:
undetectable		 2y7wB-6ci9A:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 6ci9 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		5 / 10 ILE A  23
VAL A  58
LYS A  57
GLY A  56
LEU A 226
 None
 1.26A 3em0A-6ci9A:
undetectable		 3em0A-6ci9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 6ci9 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ILE A  23
VAL A  58
LYS A  57
GLY A  56
LEU A 226
 None
 1.12A 3em0B-6ci9A:
undetectable		 3em0B-6ci9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_A_ADNA901_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 6ci9 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		5 / 9 ARG A  39
GLY A  38
ASP A  43
LEU A  44
ASN A  40
 NAP  A 301 (-3.9A)
NAP  A 301 (-3.6A)
None
None
None
 1.32A 3wdmA-6ci9A:
3.6		 3wdmA-6ci9A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_B_DXCB1473_0
(MJ0495-LIKE PROTEIN)		 6ci9 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 ILE A  23
ILE A  19
GLY A  18
VAL A 243
GLY A 216
 None
NAP  A 301 (-3.8A)
NAP  A 301 (-3.2A)
None
None
 0.95A 4ac9B-6ci9A:
6.4
4ac9C-6ci9A:
6.2		 4ac9B-6ci9A:
undetectable
4ac9C-6ci9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1477_0
(MJ0495-LIKE PROTEIN)		 6ci9 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 THR A  66
GLY A 118
ARG A  73
ILE A 122
 NAP  A 301 ( 4.3A)
None
None
None
 1.25A 4ac9C-6ci9A:
6.2		 4ac9C-6ci9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 6ci9 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 THR A  66
GLY A 118
ARG A  73
ILE A 122
 NAP  A 301 ( 4.3A)
None
None
None
 1.24A 4acaC-6ci9A:
4.3		 4acaC-6ci9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 6ci9 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		4 / 7 ILE A  19
THR A 192
VAL A 140
PHE A  95
 NAP  A 301 (-3.8A)
NAP  A 301 (-2.9A)
None
F3V  A 302 (-3.8A)
 0.81A 4iarA-6ci9A:
undetectable		 4iarA-6ci9A:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_G_TMQG202_1
(DIHYDROFOLATE
REDUCTASE)		 6ci9 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ILE A 180
ALA A 126
ILE A 122
GLN A 124
ILE A 182
 None
 1.08A 4m2xG-6ci9A:
2.4		 4m2xG-6ci9A:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_2
(CYTOCHROME P450 3A4)		 6ci9 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 ARG A  55
PHE A  27
ILE A  36
THR A  59
 None
 1.15A 5vceA-6ci9A:
undetectable		 5vceA-6ci9A:
11.96