SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6cia'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_C_DVAC6_0
(GRAMICIDIN A)		 6cia ALDO/KETO REDUCTASE
(Klebsiella
pneumoniae) 		3 / 3 ALA A  86
VAL A 124
TRP A 139
 None
 0.79A 1av2C-6ciaA:
undetectable
1av2D-6ciaA:
undetectable		 1av2C-6ciaA:
undetectable
1av2D-6ciaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGS_A_SALA256_1
(MULTIPLE ANTIBIOTIC
RESISTANCE PROTEIN
MARR)		 6cia ALDO/KETO REDUCTASE
(Klebsiella
pneumoniae) 		4 / 7 PRO A  15
VAL A  14
LEU A 238
LEU A 256
 None
 0.96A 1jgsA-6ciaA:
undetectable		 1jgsA-6ciaA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_C_DVAC6_0
(GRAMICIDIN D)		 6cia ALDO/KETO REDUCTASE
(Klebsiella
pneumoniae) 		3 / 3 ALA A  86
VAL A 124
TRP A 139
 None
 0.80A 1w5uC-6ciaA:
undetectable
1w5uD-6ciaA:
undetectable		 1w5uC-6ciaA:
undetectable
1w5uD-6ciaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_A_CLUA808_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 6cia ALDO/KETO REDUCTASE
(Klebsiella
pneumoniae) 		4 / 7 ALA A  52
TYR A  55
MET A 191
HIS A 113
 None
NDP  A 301 (-4.6A)
None
NDP  A 301 (-4.3A)
 1.03A 2pncA-6ciaA:
undetectable		 2pncA-6ciaA:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECNB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 6cia ALDO/KETO REDUCTASE
(Klebsiella
pneumoniae) 		5 / 9 LEU A  99
GLY A  58
ALA A  60
THR A  21
ILE A  49
 None
None
None
NDP  A 301 (-4.9A)
None
 1.44A 3jusB-6ciaA:
undetectable		 3jusB-6ciaA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_C_DVAC6_0
(GRAMICIDIN D)		 6cia ALDO/KETO REDUCTASE
(Klebsiella
pneumoniae) 		3 / 3 ALA A  86
VAL A 124
TRP A 139
 None
 0.85A 3l8lC-6ciaA:
undetectable
3l8lD-6ciaA:
undetectable		 3l8lC-6ciaA:
undetectable
3l8lD-6ciaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F84_A_SAMA501_0
(GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E)		 6cia ALDO/KETO REDUCTASE
(Klebsiella
pneumoniae) 		5 / 12 GLY A 158
THR A 155
LEU A 120
GLN A 121
VAL A 141
 None
 1.23A 4f84A-6ciaA:
undetectable		 4f84A-6ciaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_ACTA303_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 6cia ALDO/KETO REDUCTASE
(Klebsiella
pneumoniae) 		3 / 3 TYR A 168
HIS A 234
ARG A 233
 None
 1.03A 4htfA-6ciaA:
undetectable		 4htfA-6ciaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)		 6cia ALDO/KETO REDUCTASE
(Klebsiella
pneumoniae) 		4 / 6 GLU A  53
ARG A 101
GLU A  61
SER A  79
 None
 0.94A 4kr3A-6ciaA:
undetectable		 4kr3A-6ciaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_2
(ANDROGEN RECEPTOR)		 6cia ALDO/KETO REDUCTASE
(Klebsiella
pneumoniae) 		4 / 8 LEU A 144
ASN A 164
MET A 109
ILE A 240
 None
None
None
NDP  A 301 (-4.7A)
 1.00A 4ok1A-6ciaA:
undetectable		 4ok1A-6ciaA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 6cia ALDO/KETO REDUCTASE
(Klebsiella
pneumoniae) 		4 / 6 TYR A 110
GLN A 165
GLU A  61
ALA A  94
 None
NDP  A 301 (-4.2A)
None
None
 1.20A 6djzB-6ciaA:
undetectable		 6djzB-6ciaA:
undetectable