SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6cip'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_A_DVAA6_0
(GRAMICIDIN A)		 6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Moorella
thermoacetica) 		3 / 3 ALA A1089
VAL A1093
TRP A1098
 None
 0.80A 1bdwA-6cipA:
undetectable
1bdwB-6cipA:
undetectable		 1bdwA-6cipA:
undetectable
1bdwB-6cipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Moorella
thermoacetica) 		5 / 12 LEU A 150
ALA A 151
ALA A  16
THR A  80
VAL A 106
 None
 1.09A 1cbrA-6cipA:
undetectable		 1cbrA-6cipA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_B_REAB200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Moorella
thermoacetica) 		5 / 12 LEU A 150
ALA A 151
ALA A  16
THR A  80
VAL A 106
 None
 1.09A 1cbrB-6cipA:
undetectable		 1cbrB-6cipA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_D_ESTD352_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Moorella
thermoacetica) 		4 / 6 VAL A 295
GLY A 296
TYR A 261
GLU A 290
 None
 0.84A 1fduD-6cipA:
2.4		 1fduD-6cipA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_1
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN))		 6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Moorella
thermoacetica) 		4 / 6 LEU A 288
PHE A 376
TYR A 261
VAL A 372
 None
 1.23A 1ibgH-6cipA:
undetectable		 1ibgH-6cipA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JS3_A_142A701_1
(DOPA DECARBOXYLASE)		 6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Moorella
thermoacetica) 		5 / 9 TRP A  41
TYR A  17
THR A  10
HIS A 155
THR A  80
 None
 1.47A 1js3A-6cipA:
1.3
1js3B-6cipA:
1.3		 1js3A-6cipA:
10.86
1js3B-6cipA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JS3_B_142B702_1
(DOPA DECARBOXYLASE)		 6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Moorella
thermoacetica) 		5 / 9 TRP A  41
TYR A  17
THR A  10
HIS A 155
THR A  80
 None
 1.48A 1js3A-6cipA:
1.3
1js3B-6cipA:
1.3		 1js3A-6cipA:
10.86
1js3B-6cipA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA733_1
(ALPHA AMYLASE)		 6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Moorella
thermoacetica) 		4 / 6 SER A 143
THR A 174
LEU A   6
ASP A   7
 None
 1.26A 1mxdA-6cipA:
undetectable		 1mxdA-6cipA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q13_A_TESA501_1
(PROSTAGLANDIN-E2
9-REDUCTASE)		 6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Moorella
thermoacetica) 		4 / 6 TYR A 476
HIS A 464
GLU A 283
PRO A 411
 None
 1.27A 1q13A-6cipA:
undetectable		 1q13A-6cipA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_2
(POL POLYPROTEIN)		 6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Moorella
thermoacetica) 		4 / 7 ASP A 994
GLY A 836
ILE A 840
THR A 815
 None
HTL  A1204 (-3.4A)
None
None
 0.79A 1t7iB-6cipA:
undetectable		 1t7iB-6cipA:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_2
(POL POLYPROTEIN)		 6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Moorella
thermoacetica) 		4 / 7 ASP A 994
GLY A 836
ILE A 840
THR A 815
 None
HTL  A1204 (-3.4A)
None
None
 0.79A 1t7jB-6cipA:
undetectable		 1t7jB-6cipA:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB6_0
(GRAMICIDIN A)		 6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Moorella
thermoacetica) 		3 / 3 ALA A1095
VAL A1093
TRP A1098
 None
 0.86A 1tkqB-6cipA:
undetectable		 1tkqB-6cipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_B_SAMB301_0
(HYPOTHETICAL PROTEIN
PH0226)		 6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Moorella
thermoacetica) 		5 / 12 TYR A1038
ALA A 986
GLY A1065
ALA A 877
SER A 984
 None
 1.15A 1ve3B-6cipA:
3.8		 1ve3B-6cipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Moorella
thermoacetica) 		5 / 12 GLY A 965
GLY A 966
GLY A 968
PHE A 872
SER A 838
 None
HTL  A1204 (-3.5A)
HTL  A1204 (-3.3A)
None
HTL  A1204 ( 4.6A)
 0.99A 1wg8B-6cipA:
2.9		 1wg8B-6cipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_C_NCAC1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Moorella
thermoacetica) 		4 / 6 ARG A 327
SER A 276
SER A 273
PHE A 367
 None
 1.48A 2c8aC-6cipA:
undetectable		 2c8aC-6cipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_A_ADNA2001_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Moorella
thermoacetica) 		4 / 7 ARG A1087
GLU A1133
ALA A1124
ALA A1095
 None
 0.96A 2ejfA-6cipA:
undetectable		 2ejfA-6cipA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H77_A_T3A1_1
(THRA PROTEIN)		 6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Moorella
thermoacetica) 		5 / 12 ILE A 566
ALA A 567
ALA A 575
LEU A 606
ILE A 576
 None
 1.14A 2h77A-6cipA:
undetectable		 2h77A-6cipA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_A_J01A1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Moorella
thermoacetica) 		5 / 12 ILE A 240
ALA A 157
VAL A 163
ALA A 137
LEU A 258
 None
 1.26A 2japA-6cipA:
2.9		 2japA-6cipA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_C_J01C1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Moorella
thermoacetica) 		5 / 12 ILE A 240
ALA A 157
VAL A 163
ALA A 137
LEU A 258
 None
 1.25A 2japC-6cipA:
2.9		 2japC-6cipA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_D_J01D1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Moorella
thermoacetica) 		5 / 12 ILE A 240
ALA A 157
VAL A 163
ALA A 137
LEU A 258
 None
 1.27A 2japD-6cipA:
2.9		 2japD-6cipA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA2_0
(FERROCHELATASE)		 6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Moorella
thermoacetica) 		4 / 8 LEU A 802
ARG A 854
PRO A 703
SER A 693
 None
 1.13A 2qd2A-6cipA:
undetectable		 2qd2A-6cipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_B_CHDB504_0
(FERROCHELATASE)		 6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Moorella
thermoacetica) 		4 / 6 ILE A 964
PRO A1074
SER A1085
MET A1046
 None
 1.35A 2qd3B-6cipA:
undetectable		 2qd3B-6cipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Moorella
thermoacetica) 		4 / 7 GLN A 800
ARG A 921
LEU A 802
ASP A 827
 None
 1.03A 2qqcB-6cipA:
undetectable
2qqcC-6cipA:
undetectable		 2qqcB-6cipA:
22.73
2qqcC-6cipA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Moorella
thermoacetica) 		4 / 7 LEU A 802
ASP A 827
GLN A 800
ARG A 921
 None
 1.03A 2qqcG-6cipA:
undetectable
2qqcJ-6cipA:
undetectable		 2qqcG-6cipA:
18.75
2qqcJ-6cipA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Moorella
thermoacetica) 		4 / 7 LEU A 802
ASP A 827
GLN A 800
ARG A 921
 None
 1.05A 2qqcI-6cipA:
undetectable
2qqcL-6cipA:
undetectable		 2qqcI-6cipA:
18.75
2qqcL-6cipA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VJ1_A_BEZA1303_0
(SARS CORONAVIRUS
MAIN PROTEINASE)		 6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Moorella
thermoacetica) 		3 / 3 HIS A 125
MET A 129
MET A 274
 None
 1.29A 2vj1A-6cipA:
undetectable		 2vj1A-6cipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_A_X2NA1480_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Moorella
thermoacetica) 		5 / 12 PHE A 136
ALA A 137
ALA A  63
ALA A  65
THR A  24
 None
 1.25A 2x2nA-6cipA:
undetectable		 2x2nA-6cipA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_B_X2NB1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Moorella
thermoacetica) 		5 / 12 PHE A 136
ALA A 137
ALA A  63
ALA A  65
THR A  24
 None
 1.29A 2x2nB-6cipA:
undetectable		 2x2nB-6cipA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_1
(WNT INHIBITORY
FACTOR 1)		 6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Moorella
thermoacetica) 		4 / 5 ILE A 403
PHE A 367
VAL A 342
PHE A 376
 None
 1.19A 2ygnA-6cipA:
undetectable		 2ygnA-6cipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZT7_A_GLYA1300_0
(GLYCYL-TRNA
SYNTHETASE)		 6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Moorella
thermoacetica) 		4 / 7 GLU A 279
TYR A 256
ARG A 301
SER A 143
 None
 0.96A 2zt7A-6cipA:
undetectable		 2zt7A-6cipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_3
(PHOSPHOLIPASE A2)		 6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Moorella
thermoacetica) 		3 / 3 PRO A 615
PHE A 537
LYS A 613
 None
 1.25A 3bjwG-6cipA:
undetectable		 3bjwG-6cipA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CWK_A_REAA300_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Moorella
thermoacetica) 		5 / 12 PHE A1126
LEU A1130
LEU A1150
ALA A1154
ALA A1158
 None
 1.01A 3cwkA-6cipA:
0.0		 3cwkA-6cipA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_B_KKKB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Moorella
thermoacetica) 		5 / 12 PHE A 303
TYR A 360
PHE A 388
ALA A 374
ILE A 271
 None
 1.21A 3ld6B-6cipA:
undetectable		 3ld6B-6cipA:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LW5_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Moorella
thermoacetica) 		5 / 10 ILE A 484
SER A 617
ARG A 528
ALA A 524
ALA A 531
 None
 0.95A 3lw5B-6cipA:
2.3		 3lw5B-6cipA:
7.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Moorella
thermoacetica) 		4 / 6 LEU A 119
ILE A 840
THR A1001
THR A  29
 None
None
HTL  A1204 ( 4.2A)
None
 0.88A 3mdrA-6cipA:
undetectable		 3mdrA-6cipA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_2
(PROTEASE)		 6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Moorella
thermoacetica) 		4 / 6 ILE A 961
ASP A 994
ILE A1070
VAL A 818
 None
 0.94A 3n3iA-6cipA:
undetectable		 3n3iA-6cipA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_0
(16S RRNA METHYLASE)		 6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Moorella
thermoacetica) 		5 / 12 GLY A  87
ALA A 126
ALA A 113
PHE A 866
THR A 116
 HTL  A1204 ( 4.6A)
None
None
HTL  A1204 (-4.2A)
None
 0.98A 3p2kA-6cipA:
undetectable		 3p2kA-6cipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Moorella
thermoacetica) 		5 / 12 ALA A1060
TYR A 971
LEU A 982
ALA A1042
VAL A1039
 None
 1.05A 3rukA-6cipA:
undetectable		 3rukA-6cipA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_A_NCAA1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Moorella
thermoacetica) 		4 / 7 THR A 284
ASN A 368
TYR A 476
TYR A 287
 None
 1.36A 4a3uA-6cipA:
undetectable		 4a3uA-6cipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_NCAB1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Moorella
thermoacetica) 		4 / 7 THR A 284
ASN A 368
TYR A 476
TYR A 287
 None
 1.33A 4a3uB-6cipA:
undetectable		 4a3uB-6cipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_B_SAMB1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Moorella
thermoacetica) 		5 / 12 HIS A 125
GLY A 171
SER A 364
GLY A 275
ASP A 124
 None
 1.22A 4blvB-6cipA:
undetectable		 4blvB-6cipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_1
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Moorella
thermoacetica) 		5 / 11 VAL A  56
LEU A  54
THR A  53
GLU A  40
ALA A  38
 None
 1.23A 4e0fA-6cipA:
undetectable		 4e0fA-6cipA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_2
(MEMBRANE LIPOPROTEIN
TPN38(B))		 6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Moorella
thermoacetica) 		4 / 8 ASN A 368
PRO A 369
GLN A 447
ILE A 478
 None
 0.76A 4iilA-6cipA:
4.1		 4iilA-6cipA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Moorella
thermoacetica) 		4 / 7 LEU A 802
ARG A 854
PRO A 703
SER A 693
 None
 1.00A 4klrA-6cipA:
2.1		 4klrA-6cipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Moorella
thermoacetica) 		4 / 5 LEU A 802
ARG A 854
PRO A 703
SER A 693
 None
 1.21A 4kmmB-6cipA:
undetectable		 4kmmB-6cipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)		 6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Moorella
thermoacetica) 		4 / 6 GLU A 279
ARG A 301
GLU A 146
SER A 143
 None
 1.46A 4kr3A-6cipA:
2.9		 4kr3A-6cipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_2
(PROTEASE)		 6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Moorella
thermoacetica) 		5 / 12 ALA A 575
VAL A 569
ILE A 570
GLY A 439
ILE A 438
 None
 1.00A 4q5mA-6cipA:
undetectable		 4q5mA-6cipA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_D_QDND602_1
(CYTOCHROME P450 2D6)		 6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Moorella
thermoacetica) 		5 / 10 GLY A  87
GLN A  86
ALA A 126
ASP A 124
ALA A 111
 HTL  A1204 ( 4.6A)
None
None
None
None
 1.36A 4wnuD-6cipA:
undetectable		 4wnuD-6cipA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_0
(PROLINE--TRNA LIGASE)		 6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Moorella
thermoacetica) 		5 / 12 PHE A 122
PRO A  30
THR A  29
ARG A 112
GLY A 836
 None
None
None
HTL  A1204 (-3.1A)
HTL  A1204 (-3.4A)
 1.22A 4ydqB-6cipA:
2.7		 4ydqB-6cipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		 6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Moorella
thermoacetica) 		4 / 6 LEU A 606
ILE A 576
ALA A 575
ALA A 567
 None
 0.77A 4zf8A-6cipA:
undetectable		 4zf8A-6cipA:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZXI_A_GLYA1402_0
(TYROCIDINE
SYNTHETASE 3)		 6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Moorella
thermoacetica) 		4 / 7 PHE A 376
ILE A 271
GLY A 296
THR A 284
 None
 1.09A 4zxiA-6cipA:
5.1		 4zxiA-6cipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_1
(SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Moorella
thermoacetica) 		4 / 6 SER A 796
PRO A 790
PHE A 788
GLU A 727
 None
 1.27A 5b8iA-6cipA:
undetectable		 5b8iA-6cipA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_B_0HKB1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Moorella
thermoacetica) 		3 / 3 ASP A 482
ASN A 568
PHE A 564
 None
 0.80A 5dsgB-6cipA:
undetectable		 5dsgB-6cipA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_A_BEZA201_0
(HYDROXYNITRILE LYASE)		 6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Moorella
thermoacetica) 		5 / 9 VAL A 492
ILE A 530
PHE A 537
TRP A 513
LEU A 509
 None
 1.07A 5e4dA-6cipA:
undetectable		 5e4dA-6cipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB201_0
(HYDROXYNITRILE LYASE)		 6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Moorella
thermoacetica) 		5 / 11 VAL A 492
ILE A 530
PHE A 537
TRP A 513
LEU A 509
 None
 1.06A 5e4dB-6cipA:
undetectable		 5e4dB-6cipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Moorella
thermoacetica) 		4 / 8 LEU A 325
LEU A 297
ILE A 407
THR A 284
 None
 0.97A 5ljbA-6cipA:
undetectable		 5ljbA-6cipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_2
(TUBULIN BETA CHAIN)		 6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Moorella
thermoacetica) 		5 / 12 LEU A 508
ALA A 485
ALA A 542
ALA A 562
ILE A 555
 None
 1.01A 5xiwD-6cipA:
undetectable		 5xiwD-6cipA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11802_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
UL4
RIBOSOMAL PROTEIN
UL15
RIBOSOMAL PROTEIN
EL15)		 6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Moorella
thermoacetica) 		3 / 3 ARG A 416
LYS A 533
ARG A 466
 None
 1.38A 6az3C-6cipA:
undetectable
6az3L-6cipA:
undetectable
6az3M-6cipA:
undetectable		 6az3C-6cipA:
20.22
6az3L-6cipA:
14.77
6az3M-6cipA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB303_1
(BIFUNCTIONAL PROTEIN
FOLD)		 6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Moorella
thermoacetica) 		4 / 5 TYR A 998
GLN A1004
GLY A  64
ILE A 973
 HTL  A1204 (-4.5A)
None
None
None
 1.02A 6debB-6cipA:
2.5		 6debB-6cipA:
19.54