SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6cjb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Q_C_BEZC1502_0
(ANTHRANILATE
SYNTHASE)		 6cjb CYSTATHIONINE
BETA-LYASE
(Legionella
pneumophila) 		5 / 10 ILE A 362
GLY A 360
GLU A 358
HIS A 338
GLY A 356
 None
 1.49A 1i7qC-6cjbA:
undetectable		 1i7qC-6cjbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		 6cjb CYSTATHIONINE
BETA-LYASE
(Legionella
pneumophila) 		5 / 10 GLY A 203
TYR A  58
SER A 246
ARG A 253
ALA A 197
 LLP  A 199 ( 3.2A)
None
None
None
None
 1.27A 1pbcA-6cjbA:
undetectable		 1pbcA-6cjbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_B_T44B602_1
(TRANSTHYRETIN)		 6cjb CYSTATHIONINE
BETA-LYASE
(Legionella
pneumophila) 		4 / 7 ALA A 340
LYS A 314
LEU A 310
ALA A 313
 None
 1.17A 1sn0B-6cjbA:
undetectable
1sn0D-6cjbA:
undetectable		 1sn0B-6cjbA:
19.17
1sn0D-6cjbA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUF_B_AZ1B503_1
(DIAMINOPIMELATE
DECARBOXYLASE)		 6cjb CYSTATHIONINE
BETA-LYASE
(Legionella
pneumophila) 		4 / 6 GLU A 327
SER A 346
ARG A 106
TYR A 101
 None
None
None
LLP  A 199 (-3.7A)
 1.48A 1tufA-6cjbA:
undetectable
1tufB-6cjbA:
undetectable		 1tufA-6cjbA:
9.47
1tufB-6cjbA:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA802_1
(TRANSPORTER)		 6cjb CYSTATHIONINE
BETA-LYASE
(Legionella
pneumophila) 		4 / 6 ILE A 347
SER A 346
ARG A 106
PHE A 122
 None
 1.15A 2q72A-6cjbA:
undetectable		 2q72A-6cjbA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 6cjb CYSTATHIONINE
BETA-LYASE
(Legionella
pneumophila) 		4 / 6 PHE A 120
PHE A 122
GLY A 103
GLY A 102
 None
 0.98A 2qr2A-6cjbA:
2.9
2qr2B-6cjbA:
3.0		 2qr2A-6cjbA:
14.35
2qr2B-6cjbA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B236_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 6cjb CYSTATHIONINE
BETA-LYASE
(Legionella
pneumophila) 		4 / 5 GLY A 103
GLY A 102
PHE A 120
PHE A 122
 None
 0.98A 2qr2A-6cjbA:
2.7
2qr2B-6cjbA:
3.0		 2qr2A-6cjbA:
14.35
2qr2B-6cjbA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		 6cjb CYSTATHIONINE
BETA-LYASE
(Legionella
pneumophila) 		5 / 12 LEU A 290
LEU A 154
LEU A 152
MET A  97
LEU A 157
 None
 1.50A 2w8yB-6cjbA:
undetectable		 2w8yB-6cjbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN7_A_T44A1355_1
(THYROXINE-BINDING
GLOBULIN)		 6cjb CYSTATHIONINE
BETA-LYASE
(Legionella
pneumophila) 		5 / 10 ALA A  13
LEU A 250
SER A  64
LEU A  65
LEU A 247
 None
 1.09A 2xn7A-6cjbA:
undetectable
2xn7B-6cjbA:
undetectable		 2xn7A-6cjbA:
11.55
2xn7B-6cjbA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 6cjb CYSTATHIONINE
BETA-LYASE
(Legionella
pneumophila) 		5 / 12 MET A 125
ILE A 192
GLU A 145
LEU A 142
VAL A  84
 None
None
LLP  A 199 ( 3.7A)
None
None
 1.23A 3fpjB-6cjbA:
4.1		 3fpjB-6cjbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 6cjb CYSTATHIONINE
BETA-LYASE
(Legionella
pneumophila) 		5 / 12 MET A 125
ILE A 192
VAL A 193
GLU A 145
LEU A 142
 None
None
None
LLP  A 199 ( 3.7A)
None
 1.22A 3fpjB-6cjbA:
4.1		 3fpjB-6cjbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_1
(FIV PROTEASE)		 6cjb CYSTATHIONINE
BETA-LYASE
(Legionella
pneumophila) 		5 / 10 LEU A 201
ALA A  10
ILE A  11
GLY A  14
LEU A 247
 None
 1.05A 3ogpA-6cjbA:
undetectable		 3ogpA-6cjbA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_0
(N-METHYLTRANSFERASE)		 6cjb CYSTATHIONINE
BETA-LYASE
(Legionella
pneumophila) 		5 / 12 GLY A 236
LEU A 242
ASP A 206
PHE A  74
SER A 209
 None
 1.32A 3pfgA-6cjbA:
2.2		 3pfgA-6cjbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_0
(N-METHYLTRANSFERASE)		 6cjb CYSTATHIONINE
BETA-LYASE
(Legionella
pneumophila) 		5 / 12 TYR A  58
GLY A 236
LEU A 242
ASP A 206
PHE A  74
 None
 1.23A 3pfgA-6cjbA:
2.2		 3pfgA-6cjbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 6cjb CYSTATHIONINE
BETA-LYASE
(Legionella
pneumophila) 		4 / 6 TYR A 101
GLY A 103
THR A 104
LEU A 100
 LLP  A 199 (-3.7A)
None
None
None
 1.02A 3ps9A-6cjbA:
undetectable		 3ps9A-6cjbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA604_0
(GBAA_1210 PROTEIN)		 6cjb CYSTATHIONINE
BETA-LYASE
(Legionella
pneumophila) 		4 / 6 GLY A  77
VAL A 208
SER A  76
THR A 198
 LLP  A 199 ( 3.2A)
LLP  A 199 ( 4.8A)
LLP  A 199 ( 3.5A)
LLP  A 199 ( 3.3A)
 1.09A 3tj7A-6cjbA:
undetectable
3tj7B-6cjbA:
undetectable		 3tj7A-6cjbA:
undetectable
3tj7B-6cjbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC606_0
(GBAA_1210 PROTEIN)		 6cjb CYSTATHIONINE
BETA-LYASE
(Legionella
pneumophila) 		4 / 6 GLY A  77
VAL A 208
SER A  76
THR A 198
 LLP  A 199 ( 3.2A)
LLP  A 199 ( 4.8A)
LLP  A 199 ( 3.5A)
LLP  A 199 ( 3.3A)
 1.08A 3tj7C-6cjbA:
undetectable
3tj7D-6cjbA:
undetectable		 3tj7C-6cjbA:
undetectable
3tj7D-6cjbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_D_ACTD605_0
(GBAA_1210 PROTEIN)		 6cjb CYSTATHIONINE
BETA-LYASE
(Legionella
pneumophila) 		4 / 6 VAL A 208
SER A  76
THR A 198
GLY A  77
 LLP  A 199 ( 4.8A)
LLP  A 199 ( 3.5A)
LLP  A 199 ( 3.3A)
LLP  A 199 ( 3.2A)
 1.07A 3tj7C-6cjbA:
undetectable
3tj7D-6cjbA:
undetectable		 3tj7C-6cjbA:
undetectable
3tj7D-6cjbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_2
(MDR769 HIV-1
PROTEASE)		 6cjb CYSTATHIONINE
BETA-LYASE
(Legionella
pneumophila) 		4 / 6 ASP A  98
GLY A 356
PRO A 339
THR A 343
 None
None
None
FMT  A 401 (-3.6A)
 1.05A 4l1aB-6cjbA:
undetectable		 4l1aB-6cjbA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_2
(ADENOSINE KINASE)		 6cjb CYSTATHIONINE
BETA-LYASE
(Legionella
pneumophila) 		4 / 5 ASN A 202
SER A 196
LEU A 329
ASN A 149
 None
LLP  A 199 ( 2.7A)
LLP  A 199 (-4.3A)
FMT  A 401 (-3.2A)
 1.12A 4n09C-6cjbA:
undetectable		 4n09C-6cjbA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_B_MXMB807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 6cjb CYSTATHIONINE
BETA-LYASE
(Legionella
pneumophila) 		5 / 12 LEU A 364
ILE A 274
LEU A 306
ALA A 381
LEU A 378
 None
 0.89A 4o1zB-6cjbA:
undetectable		 4o1zB-6cjbA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM9_B_ADNB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 6cjb CYSTATHIONINE
BETA-LYASE
(Legionella
pneumophila) 		5 / 12 ILE A 224
LEU A 220
VAL A 172
ALA A 173
HIS A 195
 None
 1.15A 5km9B-6cjbA:
undetectable		 5km9B-6cjbA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 6cjb CYSTATHIONINE
BETA-LYASE
(Legionella
pneumophila) 		4 / 4 SER A  76
ALA A  79
GLN A 228
THR A  83
 LLP  A 199 ( 3.5A)
None
None
None
 1.44A 5n0wA-6cjbA:
2.3		 5n0wA-6cjbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6N_A_SALA505_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 6cjb CYSTATHIONINE
BETA-LYASE
(Legionella
pneumophila) 		4 / 8 SER A 148
GLN A 287
MET A 295
MET A  97
 None
 1.44A 5u6nA-6cjbA:
3.4		 5u6nA-6cjbA:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_1
(CYTOCHROME P450 2C9)		 6cjb CYSTATHIONINE
BETA-LYASE
(Legionella
pneumophila) 		5 / 12 VAL A 243
VAL A 234
GLY A 210
ALA A 197
LEU A 247
 None
 1.04A 5xxiA-6cjbA:
undetectable		 5xxiA-6cjbA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 6cjb CYSTATHIONINE
BETA-LYASE
(Legionella
pneumophila) 		5 / 12 LEU A 188
PHE A   6
THR A 146
LEU A 144
ALA A 173
 None
 1.11A 6djzC-6cjbA:
undetectable		 6djzC-6cjbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FDY_U_DB8U302_1
(-)		 6cjb CYSTATHIONINE
BETA-LYASE
(Legionella
pneumophila) 		5 / 9 LEU A 186
PRO A 180
VAL A 213
SER A 196
LEU A 201
 None
None
None
LLP  A 199 ( 2.7A)
None
 1.41A 6fdyU-6cjbA:
undetectable		 6fdyU-6cjbA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FDY_U_DB8U302_1
(-)		 6cjb CYSTATHIONINE
BETA-LYASE
(Legionella
pneumophila) 		5 / 9 LEU A 186
VAL A 213
SER A 196
LEU A 201
ILE A  62
 None
None
LLP  A 199 ( 2.7A)
None
None
 1.17A 6fdyU-6cjbA:
undetectable		 6fdyU-6cjbA:
13.21