SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6cjk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H8S_A_AICA1000_1
(MUTANT AL2 6E7P9G)		 6cjk
() 		6 / 12 TYR A  36
GLN A  89
PHE A  98
VAL B  37
ALA B  93
TRP B 103
 None
 0.71A 1h8sA-6cjkA:
20.6		 1h8sA-6cjkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HH9_A_VIBA702_1
(THIAMIN
PYROPHOSPHOKINASE)		 6cjk -
(-) 		5 / 9 TYR A 139
VAL A 195
SER A 176
SER A 161
ASN A 160
 None
 1.32A 2hh9A-6cjkA:
0.0
2hh9B-6cjkA:
0.0		 2hh9A-6cjkA:
undetectable
2hh9B-6cjkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HH9_B_VIBB701_1
(THIAMIN
PYROPHOSPHOKINASE)		 6cjk -
(-) 		5 / 9 VAL A 195
SER A 176
SER A 161
ASN A 160
TYR A 139
 None
 1.32A 2hh9A-6cjkA:
0.0
2hh9B-6cjkA:
0.0		 2hh9A-6cjkA:
undetectable
2hh9B-6cjkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_A_5FWA601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 6cjk -
(-) 		5 / 12 VAL B 163
VAL B 182
SER B 180
ASN B 194
ASN B 155
 None
 1.43A 2y03A-6cjkB:
undetectable		 2y03A-6cjkB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_B_5FWB601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 6cjk -
(-) 		5 / 12 VAL B 163
VAL B 182
SER B 180
ASN B 194
ASN B 155
 None
 1.46A 2y03B-6cjkB:
undetectable		 2y03B-6cjkB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 6cjk -
(-) 		4 / 5 LEU B 108
GLN B  39
THR B  89
GLU B 148
 None
 1.31A 3n58C-6cjkB:
undetectable		 3n58C-6cjkB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NYA_A_JTZA1203_1
(BETA-2 ADRENERGIC
RECEPTOR, LYSOZYME)		 6cjk -
(-) 		5 / 12 THR B 160
VAL B 163
VAL B 182
SER B 180
ASN B 194
 None
 1.34A 3nyaA-6cjkB:
undetectable		 3nyaA-6cjkB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NYA_A_JTZA1203_1
(BETA-2 ADRENERGIC
RECEPTOR, LYSOZYME)		 6cjk -
(-) 		5 / 12 VAL B 163
VAL B 182
SER B 180
ASN B 194
ASN B 155
 None
 1.41A 3nyaA-6cjkB:
undetectable		 3nyaA-6cjkB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6cjk -
(-) 		5 / 11 VAL B 111
ALA B  85
PHE B  67
LEU B  20
VAL B 109
 None
 1.46A 4eilA-6cjkB:
undetectable		 4eilA-6cjkB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6cjk -
(-) 		5 / 11 VAL B 111
ALA B  85
PHE B  67
LEU B  20
VAL B 109
 None
 1.45A 4eilC-6cjkB:
undetectable		 4eilC-6cjkB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 6cjk -
(-) 		3 / 3 GLN A 154
THR A 156
THR A 155
 None
 0.81A 4fu9A-6cjkA:
undetectable		 4fu9A-6cjkA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUF_A_ACTA310_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 6cjk -
(-) 		3 / 3 GLN A 154
THR A 156
THR A 155
 None
 0.78A 4fufA-6cjkA:
undetectable		 4fufA-6cjkA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_1
(THYROXINE-BINDING
GLOBULIN)		 6cjk -
(-) 		5 / 10 SER B  31
SER B  30
LEU B 102
LEU B   4
SER B  74
 None
None
PCA  B   3 ( 4.5A)
PCA  B   3 ( 3.7A)
None
 1.15A 4yiaA-6cjkB:
undetectable		 4yiaA-6cjkB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		 6cjk -
(-) 		4 / 8 THR A  74
SER A  63
THR A  72
SER A  65
 None
 0.90A 5l4eA-6cjkA:
undetectable
5l4eB-6cjkA:
undetectable
5l4eC-6cjkA:
undetectable
5l4eD-6cjkA:
undetectable
5l4eE-6cjkA:
undetectable		 5l4eA-6cjkA:
undetectable
5l4eB-6cjkA:
undetectable
5l4eC-6cjkA:
undetectable
5l4eD-6cjkA:
undetectable
5l4eE-6cjkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CJK_C_ACTC301_0
(IMMUNOGLOBULIN FAB
LIGHT CHAIN)		 6cjk -
(-) 		4 / 4 VAL A  15
GLY A 108
ASP A 109
ASP A 169
 None
 0.13A 6cjkC-6cjkA:
30.2		 6cjkC-6cjkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNK_B_NCTB402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 6cjk
() 		4 / 7 TYR A  36
CSS B  35
CSS B  50
TRP B 103
 None
 1.05A 6cnkB-6cjkA:
undetectable
6cnkC-6cjkA:
undetectable		 6cnkB-6cjkA:
undetectable
6cnkC-6cjkA:
undetectable