SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6ck9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 6ck9 GP120 OF ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		5 / 10 ARG G 344
GLY G 451
HIS G 287
THR G 341
ILE G 449
 NAG  G2891 (-3.7A)
None
None
None
None
 1.40A 1c9sB-6ck9G:
undetectable
1c9sC-6ck9G:
undetectable		 1c9sB-6ck9G:
undetectable
1c9sC-6ck9G:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_H_TRPH81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 6ck9 GP120 OF ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		5 / 10 ARG G 344
GLY G 451
HIS G 287
THR G 341
ILE G 449
 NAG  G2891 (-3.7A)
None
None
None
None
 1.38A 1c9sG-6ck9G:
undetectable
1c9sH-6ck9G:
undetectable		 1c9sG-6ck9G:
undetectable
1c9sH-6ck9G:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 6ck9 GP120 OF ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		5 / 10 ARG G 344
GLY G 451
HIS G 287
THR G 341
ILE G 449
 NAG  G2891 (-3.7A)
None
None
None
None
 1.40A 1gtfC-6ck9G:
undetectable
1gtfD-6ck9G:
undetectable		 1gtfC-6ck9G:
undetectable
1gtfD-6ck9G:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_H_TRPH81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 6ck9 GP120 OF ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		5 / 10 ARG G 344
GLY G 451
HIS G 287
THR G 341
ILE G 449
 NAG  G2891 (-3.7A)
None
None
None
None
 1.40A 1gtfG-6ck9G:
undetectable
1gtfH-6ck9G:
undetectable		 1gtfG-6ck9G:
undetectable
1gtfH-6ck9G:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_I_TRPI81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 6ck9 GP120 OF ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		5 / 10 ARG G 344
GLY G 451
HIS G 287
THR G 341
ILE G 449
 NAG  G2891 (-3.7A)
None
None
None
None
 1.39A 1gtfH-6ck9G:
undetectable
1gtfI-6ck9G:
undetectable		 1gtfH-6ck9G:
undetectable
1gtfI-6ck9G:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 6ck9 GP120 OF ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		5 / 12 LEU G 453
ILE G 272
ILE G 333
ILE G 449
LEU G 288
 None
 1.06A 1oipA-6ck9G:
undetectable		 1oipA-6ck9G:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_A_STIA3_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6ck9 35O22 SCFV LIGHT
CHAIN PORTION
(Homo
sapiens) 		4 / 5 TYR E  68
LYS E  66
VAL E  97
ILE E  33
 None
 1.13A 1opjA-6ck9E:
undetectable		 1opjA-6ck9E:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_B_PPFB3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 6ck9 GP120 OF ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		4 / 7 LYS G 227
LYS G 485
HIS G 249
SER G 264
 None
 1.48A 2rk8B-6ck9G:
undetectable		 2rk8B-6ck9G:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFL_A_5CHA693_1
(LACTOTRANSFERRIN)		 6ck9 GP120 OF ENVELOPE
GLYCOPROTEIN GP160
GP41 ECTODOMAIN OF
ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		4 / 4 THR G  37
VAL G  42
GLY B 531
THR B 529
 None
 1.05A 3cflA-6ck9G:
undetectable		 3cflA-6ck9G:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCM_X_SAMX5452_0
(UNCHARACTERIZED
PROTEIN TM_1570)		 6ck9 GP41 ECTODOMAIN OF
ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		5 / 11 ALA B 533
GLY B 521
GLY B 524
LEU B 537
VAL B 539
 None
 0.96A 3dcmX-6ck9B:
undetectable		 3dcmX-6ck9B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 6ck9 35O22 SCFV LIGHT
CHAIN PORTION
(Homo
sapiens) 		4 / 5 PRO E  26
VAL E  27
THR E 102
GLY E 101
 None
 1.05A 3elzB-6ck9E:
undetectable		 3elzB-6ck9E:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)		 6ck9 GP41 ECTODOMAIN OF
ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		5 / 11 LEU B 646
LEU B 645
GLU B 648
GLY B 594
LEU B 592
 None
 1.36A 3hm1B-6ck9B:
undetectable		 3hm1B-6ck9B:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_H_LFXH101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 6ck9 35O22 SCFV HEAVY
CHAIN PORTION
35O22 SCFV LIGHT
CHAIN PORTION
GP41 ECTODOMAIN OF
ENVELOPE
GLYCOPROTEIN GP160
(Homo
sapiens;
Human
immunodeficiency
virus
1) 		4 / 5 SER B 534
GLY D 100
GLU E  53
GLU E  50
 None
MAN  G 884 (-3.7A)
None
None
 1.16A 3raeB-6ck9B:
undetectable
3raeD-6ck9B:
undetectable		 3raeB-6ck9B:
10.26
3raeD-6ck9B:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U88_A_CHDA611_0
(MENIN)		 6ck9 GP120 OF ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		3 / 3 SER G 375
PHE G 382
LYS G 421
 None
 0.98A 3u88A-6ck9G:
undetectable		 3u88A-6ck9G:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_1
(PUTATIVE REGULATORY
PROTEIN)		 6ck9 GP41 ECTODOMAIN OF
ENVELOPE
GLYCOPROTEIN GP160
GP120 OF ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1;
Human
immunodeficiency
virus
1) 		3 / 3 TYR G  40
MET B 629
LEU B 523
 None
 0.99A 3vw1D-6ck9G:
undetectable		 3vw1D-6ck9G:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3P_A_ACTA1223_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 6ck9 GP41 ECTODOMAIN OF
ENVELOPE
GLYCOPROTEIN GP160
35O22 SCFV HEAVY
CHAIN PORTION
(Human
immunodeficiency
virus
1;
Homo
sapiens) 		4 / 5 ASP B 624
THR D 100
LEU D  97
GLU B 620
 None
NAG  G 882 (-4.0A)
None
None
 1.12A 4a3pA-6ck9B:
undetectable		 4a3pA-6ck9B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA409_0
(FAD:PROTEIN FMN
TRANSFERASE)		 6ck9 35O22 SCFV LIGHT
CHAIN PORTION
(Homo
sapiens) 		4 / 5 VAL E  19
ILE E  21
VAL E 104
THR E 102
 None
 0.60A 4xdtA-6ck9E:
undetectable		 4xdtA-6ck9E:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 6ck9 GP120 OF ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		3 / 3 ALA G 224
TYR G 223
PRO G 493
 None
 0.58A 4zdyA-6ck9G:
undetectable		 4zdyA-6ck9G:
11.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		 6ck9 35O22 SCFV LIGHT
CHAIN PORTION
(Homo
sapiens) 		4 / 7 SER E  34
TYR E  36
TYR E  49
GLU E  50
 None
 0.83A 5aclA-6ck9E:
15.8		 5aclA-6ck9E:
46.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6ck9 GP120 OF ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		5 / 10 ARG G 344
GLY G 451
HIS G 287
THR G 341
ILE G 449
 NAG  G2891 (-3.7A)
None
None
None
None
 1.38A 5eeuH-6ck9G:
undetectable
5eeuI-6ck9G:
undetectable		 5eeuH-6ck9G:
undetectable
5eeuI-6ck9G:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6ck9 GP120 OF ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		5 / 10 ARG G 344
GLY G 451
HIS G 287
THR G 341
ILE G 449
 NAG  G2891 (-3.7A)
None
None
None
None
 1.39A 5eeuJ-6ck9G:
undetectable
5eeuK-6ck9G:
undetectable		 5eeuJ-6ck9G:
undetectable
5eeuK-6ck9G:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6ck9 GP120 OF ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		5 / 10 ARG G 344
GLY G 451
HIS G 287
THR G 341
ILE G 449
 NAG  G2891 (-3.7A)
None
None
None
None
 1.39A 5eevJ-6ck9G:
undetectable
5eevK-6ck9G:
undetectable		 5eevJ-6ck9G:
undetectable
5eevK-6ck9G:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6ck9 GP120 OF ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		5 / 10 ARG G 344
GLY G 451
HIS G 287
THR G 341
ILE G 449
 NAG  G2891 (-3.7A)
None
None
None
None
 1.38A 5eewH-6ck9G:
undetectable
5eewI-6ck9G:
undetectable		 5eewH-6ck9G:
undetectable
5eewI-6ck9G:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6ck9 GP120 OF ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		5 / 10 ARG G 344
GLY G 451
HIS G 287
THR G 341
ILE G 449
 NAG  G2891 (-3.7A)
None
None
None
None
 1.39A 5eewJ-6ck9G:
undetectable
5eewK-6ck9G:
undetectable		 5eewJ-6ck9G:
undetectable
5eewK-6ck9G:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6ck9 GP120 OF ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		5 / 10 ARG G 344
GLY G 451
HIS G 287
THR G 341
ILE G 449
 NAG  G2891 (-3.7A)
None
None
None
None
 1.38A 5eexH-6ck9G:
undetectable
5eexI-6ck9G:
undetectable		 5eexH-6ck9G:
undetectable
5eexI-6ck9G:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6ck9 GP120 OF ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		5 / 10 ARG G 344
GLY G 451
HIS G 287
THR G 341
ILE G 449
 NAG  G2891 (-3.7A)
None
None
None
None
 1.39A 5eexJ-6ck9G:
undetectable
5eexK-6ck9G:
undetectable		 5eexJ-6ck9G:
undetectable
5eexK-6ck9G:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6ck9 GP120 OF ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		5 / 10 ARG G 344
GLY G 451
HIS G 287
THR G 341
ILE G 449
 NAG  G2891 (-3.7A)
None
None
None
None
 1.39A 5eeyJ-6ck9G:
undetectable
5eeyK-6ck9G:
undetectable		 5eeyJ-6ck9G:
undetectable
5eeyK-6ck9G:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_F_FK5F201_1
(FK506-BINDING
PROTEIN 1)		 6ck9 GP120 OF ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		5 / 12 PHE G 159
ILE G 181
ILE G 423
ILE G 201
ILE G 309
 None
 1.03A 5hw8B-6ck9G:
undetectable
5hw8F-6ck9G:
undetectable
5hw8G-6ck9G:
undetectable		 5hw8B-6ck9G:
16.39
5hw8F-6ck9G:
16.39
5hw8G-6ck9G:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNW_D_GCSD302_1
(25 KDA PROTEIN
ELICITOR)		 6ck9 GP120 OF ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		5 / 7 ASP G 477
GLY G 472
HIS G 105
ASP G 474
ASN G 478
 None
 1.35A 5nnwD-6ck9G:
undetectable		 5nnwD-6ck9G:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW2_A_ACTA511_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 6ck9 35O22 SCFV LIGHT
CHAIN PORTION
(Homo
sapiens) 		3 / 3 ARG E  54
ILE E  58
SER E  59
 None
 0.77A 5zw2A-6ck9E:
undetectable		 5zw2A-6ck9E:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_B_SAMB401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 6ck9 35O22 SCFV LIGHT
CHAIN PORTION
(Homo
sapiens) 		5 / 12 TYR E  86
GLY E  64
SER E   7
VAL E  11
VAL E  19
 None
 1.33A 6bxlB-6ck9E:
undetectable		 6bxlB-6ck9E:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IE8_A_CHDA201_0
(REGULATORY PROTEIN)		 6ck9 GP120 OF ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		5 / 12 LEU G 349
THR G 283
ILE G 284
LEU G 453
LEU G 288
 None
 1.27A 6ie8A-6ck9G:
undetectable		 6ie8A-6ck9G:
undetectable