SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6ckc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F86_B_T44B528_1
(TRANSTHYRETIN
THR119MET VARIANT)		 6ckc METHYLOSOME PROTEIN
50
(Homo
sapiens) 		4 / 4 LYS B  62
LEU B  60
ALA B  41
LEU B  43
 None
 0.81A 1f86B-6ckcB:
undetectable		 1f86B-6ckcB:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JST_A_HLTA101_1
(FOUR-ALPHA-HELIX
BUNDLE)		 6ckc METHYLOSOME PROTEIN
50
(Homo
sapiens) 		4 / 5 ALA B  23
TRP B  59
LEU B  58
ALA B  75
 None
 1.11A 2jstA-6ckcB:
undetectable
2jstB-6ckcB:
undetectable		 2jstA-6ckcB:
24.39
2jstB-6ckcB:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z9X_A_PXLA1503_1
(ASPARTATE
AMINOTRANSFERASE)		 6ckc METHYLOSOME PROTEIN
50
(Homo
sapiens) 		5 / 10 GLU B 226
CYH B 199
VAL B 182
SER B 181
LYS B 179
 None
 1.41A 2z9xA-6ckcB:
0.0		 2z9xA-6ckcB:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z9X_B_PXLB2503_1
(ASPARTATE
AMINOTRANSFERASE)		 6ckc METHYLOSOME PROTEIN
50
(Homo
sapiens) 		5 / 11 GLU B 226
CYH B 199
VAL B 182
SER B 181
LYS B 179
 None
 1.39A 2z9xB-6ckcB:
undetectable		 2z9xB-6ckcB:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 6ckc METHYLOSOME PROTEIN
50
(Homo
sapiens) 		4 / 8 LEU B 214
ARG B 191
ALA B 168
ALA B 167
 None
 0.84A 3ax9B-6ckcB:
undetectable		 3ax9B-6ckcB:
5.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_0
(YAEB-LIKE PROTEIN
RPA0152)		 6ckc METHYLOSOME PROTEIN
50
(Homo
sapiens) 		5 / 12 LEU B 287
LEU B 261
GLY B 260
THR B 259
SER B 275
 None
 1.26A 3okxA-6ckcB:
undetectable		 3okxA-6ckcB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_1
(YAEB-LIKE PROTEIN
RPA0152)		 6ckc METHYLOSOME PROTEIN
50
(Homo
sapiens) 		5 / 12 LEU B 287
LEU B 261
GLY B 260
THR B 259
SER B 275
 None
 1.24A 3okxB-6ckcB:
undetectable		 3okxB-6ckcB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 6ckc METHYLOSOME PROTEIN
50
(Homo
sapiens) 		4 / 7 PHE B 228
TRP B 220
ALA B 174
LEU B 218
 None
 1.01A 4xk8A-6ckcB:
undetectable		 4xk8A-6ckcB:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_O_BEZO801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 6ckc METHYLOSOME PROTEIN
50
(Homo
sapiens) 		4 / 6 PHE B 291
SER B 273
HIS B 254
LEU B 283
 None
 1.39A 5dzka-6ckcB:
undetectable
5dzko-6ckcB:
undetectable		 5dzka-6ckcB:
undetectable
5dzko-6ckcB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 6ckc METHYLOSOME PROTEIN
50
(Homo
sapiens) 		4 / 6 PHE B 291
SER B 273
ALA B 272
HIS B 254
 None
 1.15A 5dzkB-6ckcB:
undetectable
5dzkP-6ckcB:
undetectable		 5dzkB-6ckcB:
undetectable
5dzkP-6ckcB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 6ckc METHYLOSOME PROTEIN
50
(Homo
sapiens) 		4 / 7 PHE B 291
SER B 273
ALA B 272
HIS B 254
 None
 1.13A 5dzkD-6ckcB:
undetectable
5dzkR-6ckcB:
undetectable		 5dzkD-6ckcB:
undetectable
5dzkR-6ckcB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_U_BEZU801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 6ckc METHYLOSOME PROTEIN
50
(Homo
sapiens) 		4 / 6 PHE B 291
SER B 273
ALA B 272
HIS B 254
 None
 1.14A 5dzkg-6ckcB:
undetectable
5dzku-6ckcB:
undetectable		 5dzkg-6ckcB:
undetectable
5dzku-6ckcB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_B_SAMB501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 6ckc METHYLOSOME PROTEIN
50
(Homo
sapiens) 		5 / 12 LEU B 194
ALA B 203
ILE B 206
ASP B 189
SER B 185
 None
 1.15A 5nfjB-6ckcB:
undetectable		 5nfjB-6ckcB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_C_SAMC501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 6ckc METHYLOSOME PROTEIN
50
(Homo
sapiens) 		5 / 12 LEU B 194
ALA B 203
ILE B 206
ASP B 189
SER B 185
 None
 1.16A 5nfjC-6ckcB:
undetectable		 5nfjC-6ckcB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_B_SAMB601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 6ckc METHYLOSOME PROTEIN
50
(Homo
sapiens) 		4 / 7 ALA B  46
GLY B  56
GLY B  82
GLU B  28
 None
 0.82A 5ybbB-6ckcB:
undetectable		 5ybbB-6ckcB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC607_0
(ALPHA-AMYLASE)		 6ckc METHYLOSOME PROTEIN
50
(Homo
sapiens) 		4 / 6 GLY B  45
ASP B  85
GLY B  56
GLY B  82
 None
 0.76A 6ag0C-6ckcB:
undetectable		 6ag0C-6ckcB:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_B_ACTB804_0
(UNCHARACTERIZED
PROTEIN)		 6ckc METHYLOSOME PROTEIN
50
(Homo
sapiens) 		4 / 4 HIS B 325
VAL B 300
LEU B 280
ALA B 295
 None
 1.37A 6d8pB-6ckcB:
undetectable		 6d8pB-6ckcB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA413_0
(AROMATIC
PEROXYGENASE)		 6ckc METHYLOSOME PROTEIN
50
(Homo
sapiens) 		4 / 7 ASP B 180
SER B 136
GLY B 137
VAL B  89
 None
 0.62A 6ekzA-6ckcB:
undetectable		 6ekzA-6ckcB:
20.69