SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6ckg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4007_1
(SERUM ALBUMIN)		 6ckg D-GLYCERATE 3-KINASE
(Cryptococcus
neoformans) 		4 / 8 LEU A 212
HIS A 213
LEU A 173
LEU A 178
 None
 0.82A 1e7cA-6ckgA:
undetectable		 1e7cA-6ckgA:
8.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EUP_A_ASDA452_1
(CYTOCHROME P450ERYF)		 6ckg D-GLYCERATE 3-KINASE
(Cryptococcus
neoformans) 		4 / 8 TYR A 275
SER A 214
ILE A 215
LEU A  91
 None
 0.90A 1eupA-6ckgA:
undetectable		 1eupA-6ckgA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZ4_A_BEZA784_0
(MALT REGULATORY
PROTEIN)		 6ckg D-GLYCERATE 3-KINASE
(Cryptococcus
neoformans) 		4 / 6 HIS A 213
LEU A 281
LEU A 173
PRO A 172
 None
 1.24A 1hz4A-6ckgA:
undetectable		 1hz4A-6ckgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_A_CQAA403_0
(HISTAMINE
N-METHYLTRANSFERASE)		 6ckg D-GLYCERATE 3-KINASE
(Cryptococcus
neoformans) 		4 / 8 ASP A  77
GLY A 145
ASP A  69
TYR A  72
 None
 0.95A 2aouA-6ckgA:
2.7		 2aouA-6ckgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1C_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 6ckg D-GLYCERATE 3-KINASE
(Cryptococcus
neoformans) 		5 / 10 ILE A 162
ASP A 230
ILE A 229
LEU A  32
HIS A  19
 None
 1.21A 3o1cA-6ckgA:
undetectable		 3o1cA-6ckgA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1X_A_ADNA1450_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 6ckg D-GLYCERATE 3-KINASE
(Cryptococcus
neoformans) 		5 / 10 ILE A 162
ASP A 230
ILE A 229
LEU A  32
HIS A  19
 None
 1.21A 3o1xA-6ckgA:
undetectable		 3o1xA-6ckgA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGZ_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 6ckg D-GLYCERATE 3-KINASE
(Cryptococcus
neoformans) 		5 / 10 ILE A 162
ASP A 230
ILE A 229
LEU A  32
HIS A  19
 None
 1.16A 3qgzA-6ckgA:
undetectable		 3qgzA-6ckgA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_A_LURA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6ckg D-GLYCERATE 3-KINASE
(Cryptococcus
neoformans) 		5 / 12 LEU A  68
LEU A  73
GLY A  98
ALA A  97
LEU A 219
 None
 1.06A 4rrxA-6ckgA:
undetectable		 4rrxA-6ckgA:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_B_LURB706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6ckg D-GLYCERATE 3-KINASE
(Cryptococcus
neoformans) 		5 / 12 LEU A  68
LEU A  73
GLY A  98
ALA A  97
LEU A 219
 None
 1.07A 4rrxB-6ckgA:
undetectable		 4rrxB-6ckgA:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_A_MZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		 6ckg D-GLYCERATE 3-KINASE
(Cryptococcus
neoformans) 		5 / 12 ASP A 230
VAL A  33
VAL A 161
LEU A 109
ALA A 110
 None
 1.24A 4yhaA-6ckgA:
undetectable		 4yhaA-6ckgA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 6ckg D-GLYCERATE 3-KINASE
(Cryptococcus
neoformans) 		3 / 3 ASN A 116
PRO A 157
GLN A 155
 None
 0.94A 6jnhA-6ckgA:
undetectable		 6jnhA-6ckgA:
undetectable