SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6ckt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_2
(HIV-1 PROTEASE)		 6ckt 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E
(Legionella
pneumophila) 		5 / 9 ALA A 162
VAL A 140
GLY A 147
VAL A 156
ILE A 158
 None
 1.03A 1hpvB-6cktA:
undetectable		 1hpvB-6cktA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 6ckt 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E
(Legionella
pneumophila) 		4 / 5 GLY A 114
ILE A 130
VAL A  45
SER A 148
 None
None
None
EDO  A 302 (-3.8A)
 1.20A 1rs7A-6cktA:
undetectable		 1rs7A-6cktA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_0
(HEMK PROTEIN)		 6ckt 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E
(Legionella
pneumophila) 		5 / 12 THR A 121
ILE A 164
GLY A 153
ILE A 134
VAL A 196
 None
 1.03A 1sg9B-6cktA:
undetectable		 1sg9B-6cktA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_A_GBNA502_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 6ckt 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E
(Legionella
pneumophila) 		4 / 8 GLY A 163
THR A 145
ALA A 144
VAL A 138
 None
 0.83A 2a1hA-6cktA:
undetectable
2a1hB-6cktA:
undetectable		 2a1hA-6cktA:
13.20
2a1hB-6cktA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q5K_A_AB1A201_1
(PROTEASE)		 6ckt 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E
(Legionella
pneumophila) 		5 / 9 ALA A 162
VAL A 140
GLY A 147
VAL A 156
ILE A 158
 None
 1.04A 2q5kA-6cktA:
undetectable		 2q5kA-6cktA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKV_A_478A200_2
(PROTEASE)		 6ckt 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E
(Legionella
pneumophila) 		5 / 9 ALA A 162
VAL A 140
GLY A 147
VAL A 156
ILE A 158
 None
 1.08A 3ekvB-6cktA:
undetectable		 3ekvB-6cktA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWW_A_SFXA801_1
(TRANSPORTER)		 6ckt 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E
(Legionella
pneumophila) 		5 / 12 GLY A 166
LEU A 168
ILE A 130
PHE A  67
ASP A  84
 None
EDO  A 302 ( 4.4A)
None
EDO  A 302 (-4.3A)
None
 1.11A 3gwwA-6cktA:
undetectable		 3gwwA-6cktA:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_H_TRUH800_1
(GLUTAMATE RECEPTOR 2)		 6ckt 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E
(Legionella
pneumophila) 		3 / 3 ILE A 164
SER A 188
SER A 159
 None
 0.62A 3iltH-6cktA:
undetectable		 3iltH-6cktA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1W_A_017A104_2
(ASPARTYL PROTEASE)		 6ckt 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E
(Legionella
pneumophila) 		5 / 10 ALA A 162
VAL A 140
GLY A 147
VAL A 156
ILE A 158
 None
 1.10A 4q1wB-6cktA:
undetectable		 4q1wB-6cktA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVG_A_SAMA503_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 6ckt 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E
(Legionella
pneumophila) 		5 / 12 ILE A 164
GLY A 147
ASN A 129
ALA A 115
ILE A 158
 None
None
EDO  A 302 (-3.2A)
None
None
 1.14A 4rvgA-6cktA:
undetectable		 4rvgA-6cktA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y1D_D_DVAD5_0
(CYCLIC HEXAPEPTIDE
CYC[NDPOPPKID]
INTEGRASE)		 6ckt 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E
(Legionella
pneumophila) 		3 / 3 GLU A 136
LYS A 154
ASN A 120
 None
 0.93A 4y1dA-6cktA:
undetectable
4y1dD-6cktA:
undetectable		 4y1dA-6cktA:
undetectable
4y1dD-6cktA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_S_PCFS603_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 6ckt 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E
(Legionella
pneumophila) 		4 / 7 GLY A  41
PHE A  43
VAL A  45
SER A  36
 None
 1.06A 6hu9S-6cktA:
undetectable
6hu9q-6cktA:
undetectable		 6hu9S-6cktA:
undetectable
6hu9q-6cktA:
undetectable